Iowa State vs. Lipscomb: Prediction, Odds, March Madness

A season removed from a Sweet 16 exit, Iowa State begins its 2025 tournament with a game against Lipscomb. 

T.J. Otzelberger’s side finished fifth in the Big 12 this season and ranked 12th in the last AP poll. In the Big 12 conference tournament, Iowa State fell to BYU in their second game. 

Lipscomb earned an automatic bid to the NCAA Tournament as winners of the Atlantic Sun Conference. Entering the tournament, the Bisons have won six games in a row. 

Bet on Iowa State vs. Lipscomb and other March Madness matchups with up-to-date college basketball odds. 

Iowa State vs. Lipscomb Odds, March Madness

• Iowa State Moneyline: -1400
• Lipscomb Moneyline: +775
• Game Spread: Iowa State -14.5 (-110), Lipscomb +14.5 (-110)
• Game Over/Under: 142.5 Points (-115/-105)

Iowa State vs. Lipscomb Prediction

Based on one historically profitable NCAAB betting system, the Iowa State vs. Lipscomb prediction for Friday’s game is the Total Under 142.5 Points (-105).

Driving this prediction is the market’s opinion of the wide gap between these two teams. 

Historically, unders have proven a profitable wager in the NCAA tournament when the spread is relatively high. 

Since 2004, games with a total between 141 and 145 are 54-22 (71.1%) to the under, assuming the spread falls between -20.5 and -6.5. 

Naturally, games with a higher spread tend to finish under the total at a higher frequency. 

Shrink the sample down to games with a spread between -20.5 and -10.5: 24-6 to the under. 

This system has also proven more profitable recently. In the former sample, the games are 10-2 to the under over the last three years.

In the latter sample, the games are 5-0 to the under over the last three years. 

As a result, bettors should consider the under in this Friday matchup.  

Iowa State vs. Lipscomb: NCAAB Public Betting

Check back on Friday for Iowa State vs. Lipscomb public betting data and insights.