Notre Dame vs Louisville Prediction, Odds & Best Bets Today – NCAAB, Feb. 21

Louisville head coach Kenny Payne argues with a game official during the first half of an NCAA college basketball game against Wake Forest in Louisville, Ky., Saturday, Jan. 7, 2023.
(AP Photo/Timothy D. Easley)
  • Louisville (12-13) is a -1.5 point favorite vs Notre Dame (12-13)
  • Total (Over/Under): 134.5 points
  • Notre Dame / Louisville TV channel: ESPNU

The Notre Dame Fighting Irish (12-13) visit KFC Yum! Center to take on the Louisville Cardinals (12-13) on Feb. 21. Tip off is scheduled for 7:00pm EST in Louisville, KY.

Louisville is the betting favorite in this game, with the spread sitting at -1.5 (-110).

The Notre Dame vs. Louisville Over/Under is 134.5 total points.

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Notre Dame vs. Louisville Odds, Spread, Over/Under

SpreadTotal (O/U)Moneyline
Notre Dame+1.5 -110O 134.5 -110+105
Louisville -1.5 -110U 134.5 -110-125

Notre Dame vs Louisville Prediction for Today:

The winning team model predicts Louisville will win this college basketball game with 54.5% confidence, based on game simulations, player injuries, key player performances and recent matchups.

Notre Dame vs Louisville Spread Prediction:

Based on recent against-the-spread trends, the spread model predicts Notre Dame will cover the spread with 58.0% confidence for today’s game.


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  • Notre Dame has hit the Game Total Under in 20 of their last 30 games (+9.10 Units / 28% ROI)
  • Notre Dame has hit the Team Total Under in 20 of their last 30 games (+8.50 Units / 24% ROI)
  • Notre Dame have covered the 1H Spread in 17 of their last 30 games (+4.40 Units / 13% ROI)
  • Notre Dame have covered the Spread in 7 of their last 12 away games (+1.55 Units / 12% ROI)
  • Notre Dame has hit the 1H Game Total Under in 7 of their last 12 away games (+1.25 Units / 9% ROI)
  • Louisville has hit the Team Total Over in 18 of their last 30 games (+4.20 Units / 12% ROI)
  • Louisville has hit the Game Total Over in 17 of their last 30 games (+2.75 Units / 8% ROI)
  • Louisville has hit the 1H Game Total Under in 10 of their last 17 games at home (+1.85 Units / 9% ROI)

Notre Dame Basketball Against the Spread Record (ATS)

Notre Dame has a 12-13 record against the spread this college basketball season (-2.15 Units / -7.86% ROI).

  • 8-15 when betting on the Moneyline for -5.05 Units / -13.34% ROI
  • 8-17 when betting the Over for -10.7 Units / -38.77% ROI
  • 17-8 when betting the Under for +8.3 Units / 30.29% ROI

Louisville Basketball Against the Spread Record (ATS)

Louisville has a 11-12 record against the spread this college basketball season (-2.25 Units / -7.87% ROI).

  • 8-18 when betting on the Moneyline for -1.5 Units / -3.12% ROI
  • 14-12 when betting the Over for +0.85 Units / 2.98% ROI
  • 12-14 when betting the Under for -3.4 Units / -11.87% ROI

Notre Dame Offensive Stats & Trends:

Notre Dame has averaged 4.0 assists per game (93 assists/23 games) in the second half this season — lowest among ACC Teams; League Avg: 6.7

Notre Dame is shooting 26% from three (66/258) in the second half this season — lowest among ACC Teams; League Avg: 35%

Notre Dame has averaged 1.12 points per shot (1,415 points/1,266 shots) this season — 2nd lowest among Power Conference teams; League Avg: 1.28

Notre Dame has averaged 61.5 points per game (1,415 points/23 games) this season — lowest among ACC Teams; League Avg: 75.1

Louisville Offensive Stats & Trends:

Louisville has an assist to turnover ratio of 0.6 (259 assists/ 420 TOs) in the first half since the start of the 2022-23 season — lowest among ACC Teams; League Avg: 1.2

Louisville has averaged 14.3 turnovers per game (473 turnovers/33 games) at home since the start of the 2022-23 season — highest among ACC Teams; League Avg: 10.7

Louisville has an assist to turnover ratio of 0.7 (326 assists/ 473 TOs) at home since the start of the 2022-23 season — lowest among ACC Teams; League Avg: 1.3

Louisville has averaged 14.1 turnovers per game (773 turnovers/55 games) since the start of the 2022-23 season — highest among ACC Teams; League Avg: 11.1

Notre Dame Defensive Stats & Trends:

Notre Dame has averaged 5.8 steals per game (133 steals/23 games) this season — 5th lowest among ACC Teams; League Avg: 6.7

Notre Dame has averaged 5.1 steals per game (107 steals/21 games) on the road since the start of the 2022-23 season — 3rd lowest among ACC Teams; League Avg: 5.9

Notre Dame has averaged 5.2 steals per game (177 steals/34 games) at home since the start of the 2022-23 season — 2nd lowest among ACC Teams; League Avg: 6.5

Notre Dame has forced 8.9 turnovers per game (187 turnovers/21 games) at home since the start of the 2022-23 season — lowest among ACC Teams; League Avg: 11.0

Louisville Defensive Stats & Trends:

Louisville has allowed opponents to shoot 48% (332/695) in the first half this season — highest among ACC Teams; League Avg: 41%

Louisville has averaged 4.9 steals per game (271 steals/55 games) since the start of the 2022-23 season — 4th lowest among Power Conference teams; League Avg: 6.6

Louisville has allowed opponents to shoot 47% (776/1,648) in the first half since the start of the 2022-23 season — highest among ACC Teams; League Avg: 42%

Louisville has allowed an average of 1.42 points per shot (1,771 points/1,249 shots) on the road since the start of the 2022-23 season — highest among ACC Teams; League Avg: 1.26


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.