The Sweet 16 for the 2025 NCAA Tournament will be played at four locations:
- Prudential Center in Newark, NJ (East)
- Chase Center in San Francisco (West)
- State Farm Arena in Atlanta (South)
- Lucas Oil Stadium in Indianapolis (Midwest)
2025 Sweet 16 Schedule
| Date | Matchup | Location (Region) |
|---|---|---|
| Thursday, March 27 | No. 2 Alabama vs. No. 6 BYU | Prudential Center (East) |
| Thursday, March 27 | No. 1 Florida vs. No. 4 Maryland | Chase Center (West) |
| Thursday, March 27 | No. 1 Duke vs. No. 4 Arizona | Prudential Center (East) |
| Thursday, March 27 | No. 3 Texas Tech vs. No. 10 Arkansas | Chase Center (West) |
| Friday, March 28 | No. 2 Michigan State vs. No. 6 Ole Miss | State Farm Arena (South) |
| Friday, March 28 | No. 2 Tennessee vs. No. 3 Kentucky | Lucas Oil Stadium (Midwest) |
| Friday, March 28 | No. 1 Auburn vs. No. 5 Michigan | State Farm Arena (South) |
| Friday, March 28 | No. 1 Houston vs. No. 4 Purdue | Lucas Oil Stadium (Midwest) |
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