- The Chargers are -3 point favorites vs the Cardinals
- Total (Over/Under): 43.5 points
- Watch this game on ESPN+
The Los Angeles Chargers (3-2-0) visit State Farm Stadium to take on the Arizona Cardinals (2-4-0) on Oct. 21. Kickoff is scheduled for 9:00pm EDT in Glendale, AZ.
The Chargers are betting favorites in this matchup, with the spread sitting at -3 (-105).
The Chargers vs. Cardinals Over/Under is 43.5 total points for the game.
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Chargers vs. Cardinals Odds, Spread, Over/Under
| Spread | Total (O/U) | Moneyline | |
| Chargers | -3 -105 | 43.5 -110 | -155 |
| Cardinals | +3 -115 | 43.5 -110 | +125 |
Chargers vs. Cardinals Prediction
The winning team model predicts the Chargers will win this game with 68.4% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.
Chargers vs Cardinals Spread Prediction
Based on recent against-the-spread trends, the model predicts the Chargers will cover the spread with 65.8% confidence.
This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.
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We’ve highlighted some favorite NFL player prop bets for Chargers players this playoff game, looking at profitable historical betting trends:
Best Chargers Player Prop Bets Today
- D.J. Chark has hit the Longest Reception Over in his last 7 games (+7.00 Units / 85% ROI)
- Hayden Hurst has hit the Receptions Under in his last 7 games (+7.00 Units / 62% ROI)
- Will Dissly has hit the Receiving Yards Over in 7 of his last 8 games (+5.95 Units / 63% ROI)
- Justin Herbert has hit the Passing Yards Under in 10 of his last 14 games (+5.25 Units / 30% ROI)
- J.K. Dobbins has hit the Carries Over in his last 5 games (+5.00 Units / 83% ROI)
And here are some top NFL player prop bets for Cardinals players for this matchup, looking at profitable historical betting trends:
Best Cardinals Player Prop Best Bets Today
- Marvin Harrison Jr. has hit the Receptions Under in his last 6 games (+6.00 Units / 78% ROI)
- James Conner has hit the Longest Rush Over in his last 5 games (+5.00 Units / 85% ROI)
- Chris Moore has hit the Receiving Yards Over in 6 of his last 7 games (+4.85 Units / 58% ROI)
- James Conner has hit the Receiving Yards Under in 6 of his last 7 games at home (+4.75 Units / 54% ROI)
- Zay Jones has hit the Receptions Over in 5 of his last 6 games (+4.05 Units / 57% ROI)
Chargers Best Bets:
- The Los Angeles Chargers have hit the 3Q Game Total Under in 15 of their last 18 games (+12.25 Units / 57% ROI)
- The Los Angeles Chargers have hit the 1Q Moneyline in 6 of their last 10 away games (+4.35 Units / 35% ROI)
- The Los Angeles Chargers have covered the 1Q Spread in 7 of their last 10 away games (+3.80 Units / 31% ROI)
- The Los Angeles Chargers have hit the 1H Moneyline in 6 of their last 10 away games (+3.50 Units / 27% ROI)
- The Los Angeles Chargers have hit the 2H Moneyline in 3 of their last 5 games (+3.45 Units / 61% ROI)
Cardinals Best Bets:
- The Arizona Cardinals have hit the 2H Moneyline in 6 of their last 8 games (+7.10 Units / 89% ROI)
- The Arizona Cardinals have hit the 1H Game Total Over in 12 of their last 20 games (+4.05 Units / 18% ROI)
- The Arizona Cardinals have scored last in 4 of their last 5 games at home (+3.80 Units / 73% ROI)
- The Arizona Cardinals have covered the 2H Spread in 6 of their last 8 games (+3.70 Units / 42% ROI)
- The Arizona Cardinals have hit the 2Q Game Total Over in 10 of their last 16 games (+3.45 Units / 18% ROI)
Chargers Against the Spread (ATS) Record
Against the spread this NFL season, the Chargers art 3-1 (+1.9 Units / 34.55% ROI).
- Chargers are 3-2 when betting on the Moneyline for +1 Units / 13.7% ROI
- Chargers are 1-4 when betting the Over for -3.4 Units / -61.82% ROI
- Chargers are 4-1 when betting the Under for +2.9 Units / ROI
Cardinals Against the Spread (ATS) Record
Against the spread this NFL season, the Cardinals are 3-3 (-0.4 Units / -5.88% ROI).
- Cardinals are 2-4 when betting on the Moneyline for -0.9 Units / -13.14% ROI
- Cardinals are 3-2 when betting the Over for +0.8 Units / 12.12% ROI
- Cardinals are 2-3 when betting the Under for -1.3 Units / -19.7% ROI
Los Angeles Chargers: Keys to the Game vs. the Arizona Cardinals
The Chargers were winless (0-9) when converting less than 55% of its red zone chances into touchdowns last season — T-worst in NFL; League Avg: .464.
The Chargers were 1-8 (.111) when not forcing a fumble last season — 2nd-worst in NFL; League Avg: .422.
The Chargers were 1-7 (.125) when allowing 5 or more explosive passes last season — T-3rd-worst in NFL; League Avg: .427.
The Chargers were undefeated (4-0) when allowing less than 30% of third down conversion opportunities last season — T-best in NFL; League Avg: .654.
Arizona Cardinals: Keys to the Game vs. the Los Angeles Chargers
The Cardinals were winless (0-3) when forcing 2 or more turnovers last season — worst in NFL; League Avg: .707.
The Cardinals are 2-6 (.250) when sacking the QB 3 or more times since the 2023 season — 2nd-worst in NFL; League Avg: .648.
The Cardinals were 1-6 (.143) when sacking the QB 3 or more times last season — 2nd-worst in NFL; League Avg: .650.
The Cardinals were winless (0-10) when scoring less than 22 points last season — T-worst in NFL; League Avg: .253.
Los Angeles Chargers Offense: Important Stats
The Chargers have run successful plays on 18% of rush attempts against a light front this season — 2nd-worst in NFL; League Avg: 46%.
The Chargers have thrown the ball 10% of the time (2 Pass Attempts/19 plays) on 3rd and short this season — 2nd-lowest in NFL; League Avg: 42%.
The Chargers have run successful plays on 29% of plays in the 4th quarter this season — worst in NFL; League Avg: 41%.
The Chargers ran successful plays on 29% of pass attempts against a stacked front last season — 2nd-worst in NFL; League Avg: 50%.
Arizona Cardinals Offense: Important Stats
The Cardinals had 23 rushes of 20+ yards last season — most in NFL.
The Cardinals went for two on 36% of PATs last season — highest in NFL; League Avg: 10%.
The Cardinals targeted RBs 38% of the time (12 Pass Attempts/32 plays) in Week 6 — highest in NFL; League Avg: 17%.
The Cardinals have a third down conversion rate of 0% on third and 10+ yards to go this season — T-worst in NFL; League Avg: 17%.
Los Angeles Chargers Defense: Important Stats
Only 6% of the plays run against the Chargers have been in the red zone this season — best in NFL; League Avg: 14%.
The Chargers defense has allowed scores on 10% of opponent drives in the 1st half this season — best in NFL; League Avg: 40%.
Offenses facing the Chargers targeted WRs 44% of the time (67 Pass Attempts/153 plays) this season — lowest in NFL; League Avg: 59%.
Only 2% of the plays run against the Chargers have been in the red zone in the 1st half this season — best in NFL; League Avg: 14%.
Arizona Cardinals Defense: Important Stats
The Cardinals defense has allowed a third down conversion rate of 53% on third and 10+ yards to go this season — worst in NFL; League Avg: 17%.
19% of the plays run against the Cardinals have been in the red zone since the 2023 season — worst in NFL; League Avg: 14%.
The Cardinals defense has allowed successful plays on 55% of pass attempts in the 1st half since the 2023 season — worst in NFL; League Avg: 46%.
The Cardinals defense have allowed 0.15 epa per play with a base rush since the 2023 season — worst in NFL; League Avg: -0.01.
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More NFL Betting Predictions:
- Anytime & First Touchdown Scorer Predictions
- Receiving Yards Prop Predictions
- Rushing Yards Prop Predictions
- Passing Yards Prop Predictions
- Receptions Made Prop Predictions
- Rushing Attempts Prop Predictions
- Passing Touchdowns Prop Predictions
- QB Interception Prop Predictions
- Field Goals Made Prop Predictions
- NFL Betting Previews: Every Game
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