Boston Red Sox vs San Francisco Giants Prediction, Odds & Player Prop Bets Today – MLB, Jun 21

  • The Boston Red Sox are +100 favorites vs the San Francisco Giants
  • Boston Red Sox vs San Francisco Giants Over / Under today: 7.5 Runs
  • Boston Red Sox / San Francisco Giants TV Channel: NSBA | NESN

The Boston Red Sox (+100) visit Oracle Park to take on the San Francisco Giants (-120) on Saturday, June 21, 2025. First pitch is scheduled for 4:05pm EDT in San Francisco, CA, CA.

This season, the Boston Red Sox are 40-37 against the spread (ATS), while the San Francisco Giants are 34-42 ATS.

Boston Red Sox vs San Francisco Giants Starting Pitchers Today:

  • Boston Red Sox starting pitcher: , ERA
  • San Francisco Giants starting pitcher: , ERA

Boston Red Sox vs. San Francisco Giants Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Boston Red Sox-1.5 +170O 7.5 -102+100
San Francisco Giants +1.5 -210U 7.5 -118-120

Boston Red Sox vs San Francisco Giants Prediction for Today’s Game

Based on recent trends the model predicts the will win Saturday‘s MLB game with confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Boston Red Sox players for Saturday‘s game, looking at profitable historical betting trends:

Best Boston Red Sox Player Prop Bets Today:

  • David Hamilton has hit the Home Runs Over in 2 of his last 8 away games (+15.00 Units / 188% ROI)
  • David Hamilton has hit the Hits Under in 16 of his last 25 games (+7.50 Units / 28% ROI)
  • Marcelo Mayer has hit the Singles Under in 9 of his last 10 games (+7.30 Units / 43% ROI)
  • David Hamilton has hit the Total Bases Under in 16 of his last 25 games (+6.95 Units / 25% ROI)
  • Wilyer Abreu has hit the Hits Runs and RBIs Under in 11 of his last 15 games (+6.55 Units / 37% ROI)

And here are some favorite MLB player prop bets for San Francisco Giants players for Saturday‘s game, looking at profitable historical betting trends:

Best San Francisco Giants Player Prop Best Bets Today:

  • Willy Adames has hit the Hits Under in 11 of his last 15 games at home (+10.30 Units / 68% ROI)
  • Rafael Devers has hit the Walks Over in 16 of his last 25 games at home (+9.85 Units / 35% ROI)
  • Willy Adames has hit the Singles Under in 16 of his last 20 games at home (+9.80 Units / 32% ROI)
  • Willy Adames has hit the Total Bases Under in 12 of his last 15 games at home (+9.70 Units / 51% ROI)
  • Casey Schmitt has hit the Home Runs Over in 3 of his last 10 games (+9.40 Units / 94% ROI)
  • The Boston Red Sox have covered the 1st Five Innings (F5) Run Line in 20 of their last 27 away games (+15.00 Units / 49% ROI)
  • The Boston Red Sox have hit the Moneyline in 10 of their last 12 games (+10.60 Units / 81% ROI)
  • The Boston Red Sox have hit the 1st Five Innings (F5) Moneyline in 18 of their last 33 away games (+9.45 Units / 23% ROI)
  • The Boston Red Sox have hit the Team Total Under in 40 of their last 67 games (+9.30 Units / 12% ROI)
  • The Boston Red Sox have covered the Run Line in 23 of their last 38 away games (+9.05 Units / 18% ROI)
  • The San Francisco Giants have hit the Game Total Under in 21 of their last 31 games (+11.80 Units / 34% ROI)
  • The San Francisco Giants have hit the Team Total Under in 35 of their last 57 games (+11.05 Units / 17% ROI)
  • The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Under in 21 of their last 34 games at home (+7.20 Units / 18% ROI)
  • The San Francisco Giants have hit the Moneyline in 6 of their last 9 games at home (+2.05 Units / 17% ROI)

Boston Red Sox Against the Spread (ATS) Record

Against the spread this season, the Boston Red Sox are 39-37 against the Run Line (+3.25 Units / 3.38% ROI).

  • 40-37 when betting on the Moneyline for -4.21 Units / -4.17% ROI
  • 35-41 when betting on the total runs Over for -10.07 Units / -11.87% ROI
  • 41-35 when betting on the total runs Under for +2.55 Units / 3.01% ROI

San Francisco Giants Against the Spread (ATS) Record

Against the spread this season, the San Francisco Giants are 34-42 against the Run Line (-7.3 Units / -7.7% ROI).

  • 42-34 when betting on the Moneyline for -0.75 Units / -0.71% ROI
  • 34-39 when betting on the total runs Over for -8.55 Units / -10.33% ROI
  • 39-34 when betting on the total runs Under for +0.75 Units / 0.89% ROI

San Francisco Giants vs Boston Red Sox Home Run Prop Bets Today

Over Under
Rafael Devers (SF) 0.5 +425 0.5 -600
Wilyer Abreu (BOS) 0.5 +525 0.5 -750
Mike Yastrzemski (SF) 0.5 +650 0.5 -1100
Willy Adames (SF) 0.5 +675 0.5 -1100
Jarren Duran (BOS) 0.5 +675 0.5 -1100

San Francisco Giants vs Boston Red Sox Total Hits Prop Bets Today

Over Under
Jung-hoo Lee (SF) 0.5 -250 0.5 +185
Jarren Duran (BOS) 0.5 -250 0.5 +185
Rafael Devers (SF) 0.5 -225 0.5 +170
Heliot Ramos (SF) 0.5 -225 0.5 +175
Willy Adames (SF) 0.5 -210 0.5 +160

San Francisco Giants vs Boston Red Sox RBI Prop Bets Today

Over Under
Rafael Devers (SF) 0.5 +155 0.5 -210
Heliot Ramos (SF) 0.5 +165 0.5 -220
Wilyer Abreu (BOS) 0.5 +185 0.5 -250
Jarren Duran (BOS) 0.5 +185 0.5 -250
Jung-hoo Lee (SF) 0.5 +190 0.5 -250

San Francisco Giants vs Boston Red Sox Strikeout Prop Bets Today

Over Under
Brayan Bello (BOS) 4.5 -105 4.5 -125
Landen Roupp (SF) 5.5 +120 5.5 -160

starting pitcher – away

San Francisco Giants Starting Pitcher Stats & Trends

starting pitcher – home

Boston Red Sox Keys to the Game vs. the San Francisco Giants

keys to the game – away

San Francisco Giants Keys to the Game vs. the Boston Red Sox

keys to the game – home

team hitters – away

team hitters – home

team pitchers – away

team pitchers – home

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.