Boston Red Sox vs San Francisco Giants Prediction, Odds & Player Prop Bets Today – MLB, Jun 22

  • The San Francisco Giants are -150 favorites vs the Boston Red Sox
  • Boston Red Sox vs San Francisco Giants Over / Under today: 7.5 Runs
  • Boston Red Sox / San Francisco Giants TV Channel: NSBA | NESN

The Boston Red Sox (+125) visit Oracle Park to take on the San Francisco Giants (-150) on Sunday, June 22, 2025. First pitch is scheduled for 4:05pm EDT in San Francisco, CA.

This season, the Boston Red Sox are 40-38 against the spread (ATS), while the San Francisco Giants are 34-43 ATS.

Boston Red Sox vs San Francisco Giants Starting Pitchers Today:

  • Boston Red Sox starting pitcher: , ERA
  • San Francisco Giants starting pitcher: , ERA

Boston Red Sox vs. San Francisco Giants Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Boston Red Sox+1.5 -185O 7.5 -115+125
San Francisco Giants -1.5 +150U 7.5 -105-150

Boston Red Sox vs San Francisco Giants Prediction for Today’s Game

Based on recent trends the model predicts the will win Sunday‘s MLB game with confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Boston Red Sox players for Sunday‘s game, looking at profitable historical betting trends:

Best Boston Red Sox Player Prop Bets Today:

  • Marcelo Mayer has hit the Home Runs Over in 3 of his last 10 games (+13.00 Units / 130% ROI)
  • Marcelo Mayer has hit the Singles Under in 13 of his last 15 games (+9.90 Units / 41% ROI)
  • Jarren Duran has hit the Hits Under in 8 of his last 10 games (+9.45 Units / 69% ROI)
  • Abraham Toro has hit the Total Bases Over in 16 of his last 25 games (+6.60 Units / 18% ROI)
  • Jarren Duran has hit the Runs Under in 16 of his last 25 games (+5.85 Units / 19% ROI)

And here are some favorite MLB player prop bets for San Francisco Giants players for Sunday‘s game, looking at profitable historical betting trends:

Best San Francisco Giants Player Prop Best Bets Today:

  • Willy Adames has hit the Hits Under in 16 of his last 25 games (+10.80 Units / 38% ROI)
  • Willy Adames has hit the Total Bases Under in 17 of his last 25 games (+10.80 Units / 36% ROI)
  • Willy Adames has hit the Singles Under in 19 of his last 25 games at home (+10.40 Units / 28% ROI)
  • Willy Adames has hit the Runs Under in 19 of his last 25 games (+9.70 Units / 24% ROI)
  • Heliot Ramos has hit the Home Runs Over in 2 of his last 4 games (+9.20 Units / 230% ROI)
  • The Boston Red Sox have covered the 1st Five Innings (F5) Run Line in 20 of their last 28 away games (+13.45 Units / 42% ROI)
  • The Boston Red Sox have hit the Team Total Under in 41 of their last 68 games (+10.30 Units / 13% ROI)
  • The Boston Red Sox have covered the Run Line in 24 of their last 39 away games (+10.05 Units / 20% ROI)
  • The Boston Red Sox have hit the Moneyline in 10 of their last 13 games (+9.60 Units / 68% ROI)
  • The Boston Red Sox have hit the 1st Five Innings (F5) Moneyline in 18 of their last 34 away games (+8.20 Units / 20% ROI)
  • The San Francisco Giants have hit the Game Total Under in 22 of their last 32 games (+12.80 Units / 36% ROI)
  • The San Francisco Giants have hit the Team Total Under in 36 of their last 58 games (+12.05 Units / 18% ROI)
  • The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Under in 21 of their last 35 games at home (+6.20 Units / 15% ROI)
  • The San Francisco Giants have hit the Moneyline in 7 of their last 10 games at home (+3.05 Units / 23% ROI)
  • The San Francisco Giants have hit the 1st Five Innings (F5) Moneyline in 11 of their last 24 games at home (+0.65 Units / 2% ROI)

Boston Red Sox Against the Spread (ATS) Record

Against the spread this season, the Boston Red Sox are 40-37 against the Run Line (+4.25 Units / 4.33% ROI).

  • 40-38 when betting on the Moneyline for -5.21 Units / -5.12% ROI
  • 35-42 when betting on the total runs Over for -11.17 Units / -13% ROI
  • 42-35 when betting on the total runs Under for +3.55 Units / 4.14% ROI

San Francisco Giants Against the Spread (ATS) Record

Against the spread this season, the San Francisco Giants are 34-43 against the Run Line (-8.3 Units / -8.66% ROI).

  • 43-34 when betting on the Moneyline for +0.25 Units / 0.23% ROI
  • 34-40 when betting on the total runs Over for -9.65 Units / -11.51% ROI
  • 40-34 when betting on the total runs Under for +1.75 Units / 2.04% ROI

San Francisco Giants vs Boston Red Sox Home Run Prop Bets Today

Over Under
Rafael Devers (SF) 0.5 +340 0.5 -450
Mike Yastrzemski (SF) 0.5 +525 0.5 -800
Heliot Ramos (SF) 0.5 +525 0.5 -750
Willy Adames (SF) 0.5 +575 0.5 -900
Romy Gonzalez (BOS) 0.5 +675 0.5 -1100

San Francisco Giants vs Boston Red Sox Total Hits Prop Bets Today

Over Under
Heliot Ramos (SF) 0.5 -235 0.5 +175
Jung-hoo Lee (SF) 0.5 -200 0.5 +150
Romy Gonzalez (BOS) 0.5 -190 0.5 +145
Rafael Devers (SF) 0.5 -190 0.5 +140
Jarren Duran (BOS) 0.5 -175 0.5 +135

San Francisco Giants vs Boston Red Sox RBI Prop Bets Today

Over Under
Rafael Devers (SF) 0.5 +160 0.5 -210
Heliot Ramos (SF) 0.5 +185 0.5 -250
Willy Adames (SF) 0.5 +200 0.5 -275
Mike Yastrzemski (SF) 0.5 +200 0.5 -275
Jung-hoo Lee (SF) 0.5 +200 0.5 -275

San Francisco Giants vs Boston Red Sox Strikeout Prop Bets Today

Over Under
Lucas Giolito (BOS) 5.5 -105 5.5 -125
Robbie Ray (SF) 7.5 +105 7.5 -140

starting pitcher – away

San Francisco Giants Starting Pitcher Stats & Trends

starting pitcher – home

Boston Red Sox Keys to the Game vs. the San Francisco Giants

keys to the game – away

San Francisco Giants Keys to the Game vs. the Boston Red Sox

keys to the game – home

team hitters – away

team hitters – home

team pitchers – away

team pitchers – home

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.