Cardinals vs Red Sox Prediction, Odds & Player Prop Bets Today – MLB, Apr 4

Boston Red Sox's Jarren Duran plays against the Toronto Blue Jays during the first inning of a baseball game, Saturday, Aug. 5, 2023, in Boston.
(AP Photo/Michael Dwyer)
  • The Red Sox are -135 favorites vs the Cardinals
  • Cardinals vs Red Sox Over / Under today: 9 Runs
  • Cardinals / Red Sox TV Channel: FDMW | NESN | MLBN

The St. Louis Cardinals (+110) visit Fenway Park to take on the Boston Red Sox (-130) on Friday, April 4, 2025. First pitch is scheduled for 2:10pm EDT in Boston, MA.

This season, the Cardinals are 4-2 against the spread (ATS), while the Red Sox are 5-2 ATS.

Cardinals vs Red Sox Starting Pitchers Today:

  • Cardinals starting pitcher: Erick Fedde 1-0, 1.50 ERA
  • Red Sox starting pitcher: Walker Buehler 0-1, 8.32 ERA

Cardinals vs. Red Sox Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Cardinals-1.5 +160O 9 -110+110
Red Sox +1.5 -210U 9 -110-130

Cardinals vs Red Sox Prediction for Today’s Game

Based on recent trends the model predicts the Red Sox will win Friday‘s MLB game with 54.9% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Cardinals players for Friday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

  • Lars Nootbaar has hit the Home Runs Over in 3 of his last 6 away games (+19.90 Units / 332% ROI)
  • Erick Fedde has hit the Earned Runs Under in 17 of his last 25 games (+8.50 Units / 28% ROI)
  • Masyn Winn has hit the Singles Under in 10 of his last 15 away games (+8.10 Units / 54% ROI)
  • Nolan Arenado has hit the RBIs Over in 5 of his last 6 games (+7.75 Units / 129% ROI)
  • Masyn Winn has hit the Runs Over in 8 of his last 9 away games (+7.65 Units / 72% ROI)

And here are some favorite MLB player prop bets for Red Sox players for Friday‘s game, looking at profitable historical betting trends:

Best Red Sox Player Prop Best Bets Today:

  • Kristian Campbell has hit the Home Runs Over in 2 of his last 5 games (+11.60 Units / 232% ROI)
  • Kristian Campbell has hit the Runs Over in his last 5 games (+7.20 Units / 144% ROI)
  • Kristian Campbell has hit the Hits Runs and RBIs Over in his last 6 games (+6.10 Units / 95% ROI)
  • Rafael Devers has hit the Hits Under in 5 of his last 7 games (+6.00 Units / 86% ROI)
  • Connor Wong has hit the Total Bases Under in his last 4 games (+5.10 Units / 127% ROI)
  • The St. Louis Cardinals have covered the Run Line in 26 of their last 41 games (+9.15 Units / 16% ROI)
  • The St. Louis Cardinals have hit the Moneyline in 22 of their last 37 games (+8.90 Units / 21% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 12 of their last 15 away games (+8.20 Units / 43% ROI)
  • The St. Louis Cardinals have hit the Game Total Under in 29 of their last 51 games (+6.75 Units / 12% ROI)
  • The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 9 of their last 14 away games (+3.45 Units / 20% ROI)
  • The Boston Red Sox have hit the 1st Five Innings (F5) Team Total Under in 4 of their last 5 games (+3.20 Units / 57% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 4-2 against the Run Line (+2.45 Units / 29.7% ROI).

  • 4-2 when betting on the Moneyline for +1 Units / 12.99% ROI
  • 5-1 when betting on the total runs Over for +3.9 Units / 60% ROI
  • 1-5 when betting on the total runs Under for -4.6 Units / -68.66% ROI

Red Sox Against the Spread (ATS) Record

Against the spread this season, the Red Sox are 5-2 against the Run Line (+3.15 Units / 31.34% ROI).

  • 3-4 when betting on the Moneyline for -1.1 Units / -14.19% ROI
  • 2-5 when betting on the total runs Over for -3.4 Units / -44.74% ROI
  • 5-2 when betting on the total runs Under for +2.8 Units / 35.9% ROI

Red Sox vs Cardinals Home Run Prop Bets Today

Over Under
Alex Bregman (BOS) 0.5 +450 0.5 -650
Rafael Devers (BOS) 0.5 +450 0.5 -625
Willson Contreras (STL) 0.5 +525 0.5 -750
Wilyer Abreu (BOS) 0.5 +550 0.5 -800
Jarren Duran (BOS) 0.5 +650 0.5 -1000

Red Sox vs Cardinals Total Hits Prop Bets Today

Over Under
Alex Bregman (BOS) 0.5 -275 0.5 +200
Alec Burleson (STL) 0.5 -275 0.5 +195
Lars Nootbaar (STL) 0.5 -250 0.5 +180
Brendan Donovan (STL) 0.5 -250 0.5 +180
Nolan Arenado (STL) 0.5 -235 0.5 +175

Red Sox vs Cardinals RBI Prop Bets Today

Over Under
Alex Bregman (BOS) 0.5 +145 0.5 -190
Nolan Arenado (STL) 0.5 +150 0.5 -200
Rafael Devers (BOS) 0.5 +160 0.5 -210
Alec Burleson (STL) 0.5 +175 0.5 -235
Jordan Walker (STL) 0.5 +180 0.5 -235

Red Sox vs Cardinals Strikeout Prop Bets Today

Over Under
Erick Fedde (STL) 4.5 -135 4.5 +100
Walker Buehler (BOS) 4.5 +145 4.5 -190

Erick Fedde has a strike rate of just 58% (535/928) in two strike counts since last season — 2nd lowest among qualified SPs in MLB; League Avg: 65% — third Percentile.

Erick Fedde had a strike rate of just 57% (522/908) in two strike counts in the 2024 season — 2nd lowest among qualified SPs in MLB; League Avg: 65% — third Percentile.

Erick Fedde has located his fastballs down 68% of the time (17/25) this season — highest among qualified SPs in MLB; League Avg: 25% — 100th Percentile.

Erick Fedde has a strike rate of just 50% (553/1,104) when ahead in the count since last season — lowest among qualified SPs in MLB; League Avg: 61% — first Percentile.

Red Sox Starting Pitcher Stats & Trends

Walker Buehler has a first-pitch strike rate of just 41% (9/22) this season — 3rd lowest in MLB among starting pitchers with at least 2 total IP; League Avg: 62% — second Percentile.

Opponents have a swing rate of 81% (13/16) against Walker Buehler on sliders this season — highest in MLB among starting pitchers with at least 2 total IP; League Avg: 48% — 100th Percentile.

Opponents have a swing rate of 80% (12/15) against Walker Buehler on low breaking pitches this season — highest in MLB among starting pitchers with at least 2 total IP; League Avg: 46% — 100th Percentile.

Walker Buehler has allowed a slugging percentage of .511 (167 Total Bases / 327 ABs) since last season — 8th highest in MLB among starting pitchers with at least 66 total IP; League Avg: .403 — fourth Percentile.

Cardinals Keys to the Game vs. the Red Sox

The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.

The Cardinals are just 10-142 (.066) when trailing entering the 8th inning since last season — 4th lowest in MLB; League Avg: .099.

The Cardinals are just 49-50 (.495) vs bottom 10 scoring offenses since last season They play the Red Sox (ninth best runs scored) today.

The Cardinals are 29-18 (.617) when tied entering the 7th inning since last season — 3rd best in MLB; League Avg: .499.

Red Sox Keys to the Game vs. the Cardinals

The Red Sox are just 3-146 (.020) when trailing entering the 9th inning since last season — 2nd lowest in MLB; League Avg: .050.

The Red Sox are just 14-133 (.095) when trailing entering the 7th inning since last season — 3rd lowest in MLB; League Avg: .142.

The Red Sox were just 5-58 (.079) when trailing entering the 7th inning in the 2024 season — 3rd lowest in MLB; League Avg: .143.

The Red Sox were just 17-33 (.340) vs top 10 scoring offenses in the 2024 season They play the Cardinals (22nd best runs scored) today.

Cardinals hitters struck out just 351 times in 1,755 PA’s (20%) against LHP in the 2024 season — tied for 5th best in MLB; League Avg: 23%.

Cardinals hitters are slugging .359 on pitches out of the zone this season — best in MLB; League Avg: .199.

Cardinals hitters are slugging 1.071 on the first pitch of at-bats this season — 3rd best in MLB; League Avg: .586.

Cardinals hitters have just 368 strikeouts in 1,837 PA’s (20%) against LHP since last season — 5th best in MLB; League Avg: 23%.

Red Sox hitters struck out 506 times in 1,816 PA’s (28%) against LHP in the 2024 season — highest in MLB; League Avg: 23%.

Red Sox hitters have 523 strikeouts in 1,870 PA’s (28%) against LHP since last season — highest in MLB; League Avg: 23%.

Red Sox hitters have put just 22% of their swings in play against LHP this season — 2nd lowest in MLB; League Avg: 35%.

Red Sox hitters are averaging 4.70 pitches per plate appearance against LHP this season — highest in MLB; League Avg: 3.89.

Opponents have a groundball rate of 46% against Cardinals pitchers since the 2023 season — 2nd highest in MLB; League Avg: 43%.

Opponents had a miss rate of just 23% against Cardinals pitchers in 2023 — 2nd lowest in MLB; League Avg: 26%.

Opponents have a groundball rate of 46% against Cardinals pitchers since last season — 4th highest in MLB; League Avg: 43%.

Cardinals pitchers walked 95 of 1,431 batters (7%) when facing the leadoff batter in the inning in 2023 — 2nd best in MLB; League Avg: 8%.

Red Sox pitchers have walked 11 of 200 batters (6%) this season — 2nd best in MLB; League Avg: 9%.

Red Sox pitchers have a strikeout rate of just 18% this season — 4th lowest in MLB; League Avg: 23%.

Red Sox pitchers have walked 204 of 2,941 batters (7%) when facing the leadoff batter in the inning since the 2023 season — 5th best in MLB; League Avg: 8%.

Red Sox pitchers walked 11 of 200 batters (6%) over the last 14 days of the regular season (6 games) — 2nd best in MLB; League Avg: 9%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.