Cardinals vs Red Sox Prediction, Odds & Player Prop Bets Today – MLB, Apr 6

Boston Red Sox's Masataka Yoshida bats during the first inning of a baseball game against the Minnesota Twins, Tuesday, June 20, 2023, in Minneapolis.
(AP Photo/Abbie Parr)
  • The Cardinals are -102 favorites vs the Red Sox
  • Cardinals vs Red Sox Over / Under today: 9 Runs
  • Cardinals / Red Sox TV Channel: ESPN

The St. Louis Cardinals (-102) visit Fenway Park to take on the Boston Red Sox (-118) on Sunday, April 6, 2025. First pitch is scheduled for 7:10pm EDT in Boston, MA, MA.

This season, the Cardinals are 4-3 against the spread (ATS), while the Red Sox are 6-2 ATS.

Cardinals vs Red Sox Starting Pitchers Today:

  • Cardinals starting pitcher: Andre Pallante 1-0, 3.60 ERA
  • Red Sox starting pitcher: Sean Newcomb 0-1, 9.00 ERA

Cardinals vs. Red Sox Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Cardinals-1.5 +155O 9 -115-102
Red Sox +1.5 -190U 9 -105-118

Cardinals vs Red Sox Prediction for Today’s Game

Based on recent trends the model predicts the Red Sox will win Sunday‘s MLB game with 51.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Cardinals players for Sunday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

  • Lars Nootbaar has hit the Home Runs Over in 3 of his last 7 away games (+18.90 Units / 270% ROI)
  • Masyn Winn has hit the Runs Over in 9 of his last 10 away games (+9.30 Units / 80% ROI)
  • Lars Nootbaar has hit the Total Bases Over in 15 of his last 20 away games (+8.90 Units / 31% ROI)
  • Masyn Winn has hit the Singles Under in 10 of his last 15 away games (+7.60 Units / 49% ROI)
  • Nolan Arenado has hit the Hits Runs and RBIs Over in 14 of his last 20 away games (+7.45 Units / 31% ROI)

And here are some favorite MLB player prop bets for Red Sox players for Sunday‘s game, looking at profitable historical betting trends:

Best Red Sox Player Prop Best Bets Today:

  • Trevor Story has hit the Home Runs Over in 2 of his last 3 games (+13.90 Units / 463% ROI)
  • Kristian Campbell has hit the Runs Over in his last 6 games (+8.75 Units / 146% ROI)
  • Romy Gonzalez has hit the Total Bases Under in 13 of his last 20 games (+7.15 Units / 26% ROI)
  • Kristian Campbell has hit the Hits Runs and RBIs Over in his last 7 games (+7.10 Units / 95% ROI)
  • Romy Gonzalez has hit the Hits Over in 18 of his last 25 games (+7.05 Units / 16% ROI)
  • The St. Louis Cardinals have covered the Run Line in 26 of their last 41 games (+9.15 Units / 16% ROI)
  • The St. Louis Cardinals have hit the Moneyline in 22 of their last 37 games (+8.90 Units / 21% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 12 of their last 15 away games (+8.20 Units / 43% ROI)
  • The St. Louis Cardinals have hit the Game Total Under in 29 of their last 51 games (+6.75 Units / 12% ROI)
  • The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 9 of their last 14 away games (+3.45 Units / 20% ROI)
  • The Boston Red Sox have hit the 1st Five Innings (F5) Team Total Under in 4 of their last 5 games (+3.20 Units / 57% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 4-3 against the Run Line (+0.5 Units / 4.9% ROI).

  • 4-3 when betting on the Moneyline for -0.1 Units / -1.14% ROI
  • 6-1 when betting on the total runs Over for +4.9 Units / 64.47% ROI
  • 1-6 when betting on the total runs Under for -5.7 Units / -73.08% ROI

Red Sox Against the Spread (ATS) Record

Against the spread this season, the Red Sox are 6-2 against the Run Line (+4.8 Units / 43.44% ROI).

  • 4-4 when betting on the Moneyline for -0.1 Units / -1.13% ROI
  • 3-5 when betting on the total runs Over for -2.4 Units / -27.59% ROI
  • 5-3 when betting on the total runs Under for +1.7 Units / 19.1% ROI

Red Sox vs Cardinals Home Run Prop Bets Today

Over Under
Willson Contreras (STL) 0.5 +475 0.5 -650
Rafael Devers (BOS) 0.5 +525 0.5 -750
Luken Baker (STL) 0.5 +525 0.5 -750
Alex Bregman (BOS) 0.5 +600 0.5 -900
Jordan Walker (STL) 0.5 +625 0.5 -1000

Red Sox vs Cardinals Total Hits Prop Bets Today

Over Under
Nolan Arenado (STL) 0.5 -275 0.5 +195
Willson Contreras (STL) 0.5 -235 0.5 +180
Ivan Herrera (STL) 0.5 -235 0.5 +175
Brendan Donovan (STL) 0.5 -225 0.5 +170
Trevor Story (BOS) 0.5 -225 0.5 +175

Red Sox vs Cardinals RBI Prop Bets Today

Over Under
Nolan Arenado (STL) 0.5 +140 0.5 -190
Alex Bregman (BOS) 0.5 +140 0.5 -185
Jordan Walker (STL) 0.5 +160 0.5 -210
Rafael Devers (BOS) 0.5 +165 0.5 -220
Willson Contreras (STL) 0.5 +165 0.5 -220

Red Sox vs Cardinals Strikeout Prop Bets Today

Over Under
Sean Newcomb (BOS) 3.5 -135 3.5 +105
Andre Pallante (STL) 4.5 +125 4.5 -165

Opponents have a two strike miss rate of just 14% (76/540) against Miles Mikolas since last season — lowest among qualified SPs in MLB; League Avg: 25% — first Percentile.

Left-handed hitters had a groundball rate of 77% (102/132) against Andre Pallante in 2023 — highest among qualified RPs in MLB; League Avg: 45% — 100th Percentile.

Left-handed hitters had a groundball rate of 77% (102/132) against Andre Pallante in 2023 — highest among NL Relievers; League Avg: 45% — 100th Percentile.

Opponents had a groundball rate of 73% (55/75) against Andre Pallante in two-strike counts in 2023 — highest among qualified RPs in MLB; League Avg: 45% — 100th Percentile.

Red Sox Starting Pitcher Stats & Trends

Sean Newcomb has allowed an OBP of .556 (18 PA’s) this season — highest in MLB among starting pitchers with at least 2 total IP; League Avg: .307 — 0 Percentile.

Opponents are hitting .500 (8-for-16) against Sean Newcomb this season — highest in MLB among starting pitchers with at least 2 total IP; League Avg: .236 — 0 Percentile.

Sean Newcomb has allowed a BABIP of .667 this season — highest in MLB among starting pitchers with at least 2 total IP; League Avg: .274 — 0 Percentile.

Sean Newcomb has thrown his curveball 38% of the time (11/29) with runners in scoring position this season — 4th highest in MLB among starting pitchers with at least 2 total CB; League Avg: 15% — 95th Percentile.

Cardinals Keys to the Game vs. the Red Sox

The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.

The Cardinals were 18-9 (.667) when tied entering the 7th inning in the 2024 season — tied for 3rd best in MLB; League Avg: .498.

The Cardinals are just 10-143 (.065) when trailing entering the 8th inning since last season — 4th lowest in MLB; League Avg: .099.

The Cardinals are just 49-50 (.495) vs bottom 10 scoring offenses since last season They play the Red Sox (ninth best runs scored) today.

Red Sox Keys to the Game vs. the Cardinals

The Red Sox are just 3-146 (.020) when trailing entering the 9th inning since last season — 2nd lowest in MLB; League Avg: .049.

The Red Sox were just 5-58 (.079) when trailing entering the 7th inning in the 2024 season — 3rd lowest in MLB; League Avg: .143.

The Red Sox were just 18-69 (.207) when they scored 4 or fewer runs in the 2024 season — 4th lowest in MLB; League Avg: .276.

The Red Sox are just 14-133 (.095) when trailing entering the 7th inning since last season — 3rd lowest in MLB; League Avg: .141.

The Cardinals are batting .325 on the road this season — 2nd best in MLB; League Avg: .222.

The Cardinals have scored 3.14 runs per game (22/7) in late innings this season — best in MLB; League Avg: 1.38.

Cardinals hitters have an OPS of .879 (290 PA’s) this season — 2nd best in MLB; League Avg: .707.

The Cardinals are batting .250 on pitches out of the zone this season — best in MLB; League Avg: .147.

Red Sox hitters struck out 506 times in 1,816 PA’s (28%) against LHP in the 2024 season — highest in MLB; League Avg: 23%.

Red Sox hitters have 525 strikeouts in 1,896 PA’s (28%) against LHP since last season — highest in MLB; League Avg: 23%.

The Red Sox batted .182 on pitches out of the zone in 2023 — best in MLB; League Avg: .151.

The Red Sox are batting .382 in hitter’s counts since last season — best in MLB; League Avg: .337.

The Cardinals have allowed 13.00 runs per game (13/1) on the road this season — highest in MLB; League Avg: 4.63.

Cardinals pitchers have an ERA of 14.63 (8.0 IP) on the road this season — highest in MLB; League Avg: 4.45.

Opponents had a miss rate of just 23% against Cardinals pitchers in 2023 — 2nd lowest in MLB; League Avg: 26%.

Cardinals pitchers had a strikeout rate of just 19% in 2023 — 2nd lowest in MLB; League Avg: 23%.

Opponents had a miss rate of just 24% against Red Sox pitchers in the 2024 season — tied for 2nd lowest in MLB; League Avg: 25%.

Red Sox pitchers have walked 16 of 279 batters (6%) this season — 2nd best in MLB; League Avg: 9%.

Opponents have a miss rate of just 25% against Red Sox pitchers since the 2023 season — tied for 5th lowest in MLB; League Avg: 26%.

Red Sox pitchers walked 16 of 279 batters (6%) over the last 14 days of the regular season (8 games) — 2nd best in MLB; League Avg: 9%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.