Cubs vs Cardinals Prediction, Odds & Player Prop Bets Today – MLB, May 25

min read
St. Louis Cardinals second baseman Nolan Gorman throws out Cincinnati Reds' Elly De La Cruz at first base during the fifth inning of a baseball game, Friday, Sept. 8, 2023, in Cincinnati. (AP Photo/Joshua A. Bickel)
(AP Photo/Joshua A. Bickel)
BetMGM Betting @BETMGM May 25, 2024, 11:01 AM
  • The Cardinals are -115 favorites vs the Cubs
  • Cubs vs Cardinals Over / Under today: 8.5 Runs
  • Cubs / Cardinals TV Channel: FOX

The Chicago Cubs (-105) visit Busch Stadium to take on the St. Louis Cardinals (-115) on Saturday, May 25, 2024. First pitch is scheduled for 7:15pm EDT in St. Louis, MO.

This season, the Cubs are 27-24 against the spread (ATS), while the Cardinals are 25-24 ATS.

Cubs vs Cardinals Starting Pitchers Today:

  • Cubs starting pitcher: Jameson Taillon 3-2, 2.21 ERA
  • Cardinals starting pitcher: Miles Mikolas 3-5, 5.82 ERA

Cubs vs. Cardinals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Cubs-1.5 +155O 8 -105-105
Cardinals +1.5 -190U 8 -115-115

Cubs vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Saturday‘s MLB game with 52.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Cubs players for Saturday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Bets Today:

  • Ian Happ has hit the Hits Runs and RBIs Under in 28 of his last 36 games (+18.05 Units / 39% ROI)
  • Michael Busch has hit the Runs Over in 13 of his last 17 away games (+14.80 Units / 87% ROI)
  • Christopher Morel has hit the RBIs Over in 13 of his last 20 games (+12.90 Units / 64% ROI)
  • Christopher Morel has hit the Hits Under in 21 of his last 39 games (+12.20 Units / 31% ROI)
  • Michael Busch has hit the Home Runs Over in 5 of his last 17 away games (+12.10 Units / 71% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Saturday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

  • Nolan Gorman has hit the Home Runs Over in 3 of his last 4 games (+11.05 Units / 276% ROI)
  • Nolan Gorman has hit the Runs Over in 7 of his last 8 games (+9.95 Units / 123% ROI)
  • Ivan Herrera has hit the Singles Over in 8 of his last 9 games (+7.90 Units / 87% ROI)
  • Ivan Herrera has hit the Total Bases Over in 8 of his last 9 games (+6.75 Units / 48% ROI)
  • Ivan Herrera has hit the Hits Over in 8 of his last 9 games (+6.25 Units / 41% ROI)
  • The Chicago Cubs have hit the Game Total Under in 25 of their last 39 games (+10.55 Units / 25% ROI)
  • The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Under in 18 of their last 25 games (+10.20 Units / 36% ROI)
  • The Chicago Cubs have hit the Team Total Under in 17 of their last 25 games (+7.95 Units / 27% ROI)
  • The Chicago Cubs have covered the 1st Five Innings (F5) Run Line in 15 of their last 23 away games (+6.05 Units / 21% ROI)
  • The Chicago Cubs have hit the Moneyline in 27 of their last 49 games (+6.00 Units / 10% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 22 of their last 35 games (+7.30 Units / 17% ROI)
  • The St. Louis Cardinals have hit the Team Total Under in 25 of their last 41 games (+7.25 Units / 15% ROI)
  • The St. Louis Cardinals have covered the Run Line in 7 of their last 10 games (+4.60 Units / 35% ROI)
  • The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 4 of their last 6 games (+1.65 Units / 22% ROI)

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 26-25 against the Run Line (-5.15 Units / -7.17% ROI).

  • 27-24 when betting on the Moneyline for +4 Units / 6.51% ROI
  • 21-29 when betting on the total runs Over for -11 Units / -19.59% ROI
  • 29-21 when betting on the total runs Under for +5.85 Units / 10.43% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 25-24 against the Run Line (-0.95 Units / -1.47% ROI).

  • 23-26 when betting on the Moneyline for -7.15 Units / -12.17% ROI
  • 22-23 when betting on the total runs Over for -3.6 Units / -6.76% ROI
  • 23-22 when betting on the total runs Under for -0.9 Units / -1.72% ROI

Jameson Taillon has a first-pitch strike rate of 70% (558/793) since last season — highest in MLB among starting pitchers with at least 84 total IP; League Avg: 62% — 100th Percentile.

Opponents have a line drive rate of just 14% (15/106) against Jameson Taillon this season — 3rd lowest in MLB among starting pitchers with at least 19 total IP; League Avg: 24% — 98th Percentile.

Jameson Taillon has walked 11 of 401 right-handed batters (3%) since last season — 3rd best in MLB among starting pitchers with at least 84 total IP; League Avg: 7% — 98th Percentile.

Jameson Taillon has allowed three-ball counts to 12% of batters they faced (46/401 PA’s) against right-handed batters since last season — 4th lowest in MLB among starting pitchers with at least 84 total IP; League Avg: 19% — 97th Percentile.

Cardinals Starting Pitcher Stats & Trends

Miles Mikolas has allowed a slugging percentage of .571 (68 Total Bases / 119 ABs) on non-fastballs this season — highest among qualified SPs in MLB; League Avg: .343 — first Percentile.

Opponents are hitting .328 (39-for-119) against Miles Mikolas’ non-fastballs this season — 2nd highest among qualified SPs in MLB; League Avg: .214 — third Percentile.

Miles Mikolas has allowed a slugging percentage of .456 (47 Total Bases / 103 ABs) with two-strikes this season — highest among qualified SPs in MLB; League Avg: .256 — first Percentile.

Opponents are hitting .305 (111-for-364) against Miles Mikolas when going through the lineup the first time in a game since last season — 2nd highest among qualified SPs in MLB; League Avg: .233 — sixth Percentile.

Cubs Keys to the Game vs. the Cardinals

The Cubs are just 5-81 (.058) when trailing entering the 8th inning since the 2023 season — 5th lowest in MLB; League Avg: .102.

The Cubs are just 16-31 (.340) after a win as underdogs since the 2023 season — 4th lowest in MLB; League Avg: .426.

The Cubs are just 40-39 (.506) after a loss as favorites since the 2022 season — 4th lowest in MLB; League Avg: .585.

The Cubs are 26-22 (.542) after a loss as underdogs since the 2023 season — 4th best in MLB; League Avg: .427.

Cardinals Keys to the Game vs. the Cubs

The Cardinals are 28-12 (.700) when tied entering the 8th inning since the 2022 season — best in MLB; League Avg: .500.

The Cardinals are just 17-28 (.378) after a win as favorites since the 2023 season — 3rd lowest in MLB; League Avg: .575.

The Cardinals are just 46-58 (.442) at home since the 2023 season — 5th lowest in MLB; League Avg: .519.

The Cardinals are just 5-100 (.048) when trailing entering the 8th inning since the 2023 season — 3rd lowest in MLB; League Avg: .102.

The Cubs are batting .289 in lefty-lefty matchups since last season — 2nd best in MLB; League Avg: .237.

Cubs hitters are slugging .462 in lefty-lefty matchups since last season — 2nd best in MLB; League Avg: .368.

The Cubs are batting just .203 with two outs this season — 2nd lowest in MLB; League Avg: .229.

Cubs hitters are averaging just 3.71 pitches per plate appearance against LHP this season — 3rd lowest in MLB; League Avg: 3.87.

The Cardinals are batting just .205 against LHP this season — 2nd lowest in MLB; League Avg: .244.

Cardinals hitters are slugging just .378 against LHP since last season — 3rd lowest in MLB; League Avg: .411.

Cardinals hitters are slugging just .320 against LHP this season — 2nd lowest in MLB; League Avg: .388.

The Cardinals have scored first in just 31% of their road games this season — lowest in MLB; League Avg: 55%.

Cubs pitchers have induced opposing hitters to ground into just 22 double plays in 388 opportunities (6%) this season — lowest in MLB; League Avg: 10%.

Cubs pitchers have allowed opponents to score in three different innings in 31% of their games this season — 2nd lowest in MLB; League Avg: 43%.

Cubs pitchers have an ERA of 3.22 (235.0 IP) at home this season — 4th best in MLB; League Avg: 3.89.

The Cubs pitchers have allowed an average Exit Velocity of just 88.5 MPH since last season (5,324 balls in play) — 3rd best in MLB; League Avg: 89.0

Opponents have a miss rate of just 23% against Cardinals pitchers since the 2022 season — 2nd lowest in MLB; League Avg: 26%.

Opponents have a miss rate of just 23% against Cardinals pitchers since last season — 3rd lowest in MLB; League Avg: 26%.

Cardinals pitchers have a strikeout rate of just 20% since last season — 3rd lowest in MLB; League Avg: 23%.

Cardinals pitchers have walked 120 of 1,865 batters (6%) when facing the leadoff batter in the inning since last season — tied for 2nd best in MLB; League Avg: 8%.

Cardinals vs. Cubs Injuries Tonight That May Affect Prop Bets 

  • Dylan Carlson (St. Louis Cardinals): Shoulder, 10-Day IL
  • Keynan Middleton (St. Louis Cardinals): Forearm, 15-Day IL
  • Lars Nootbaar (St. Louis Cardinals): Ribs, 10-Day IL
  • Drew Rom (St. Louis Cardinals): Biceps, 15-Day IL
  • Sonny Gray (St. Louis Cardinals): Hamstring, 15-Day IL
  • Riley O’Brien (St. Louis Cardinals): Forearm, 15-Day IL
  • Tommy Edman (St. Louis Cardinals): Wrist, 10-Day IL
  • Packy Naughton (St. Louis Cardinals): Elbow, Out
  • Patrick Wisdom (Chicago Cubs): Back, 10-Day IL
  • Justin Steele (Chicago Cubs): Hamstring, 15-Day IL
  • Brennen Davis (Chicago Cubs): Undisclosed, Out
  • Tyler Duffey (Chicago Cubs): Back, Day-To-Day
  • Jameson Taillon (Chicago Cubs): Back, 15-Day IL
  • Caleb Kilian (Chicago Cubs): Shoulder, 60-Day IL

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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.