Guardians vs Cardinals Prediction, Odds & Player Prop Bets Today – MLB, Sep 21

(AP Photo/Michael Dwyer)
  • The Guardians are -135 favorites vs the Cardinals
  • Guardians vs Cardinals Over / Under today: 8 Runs
  • Guardians / Cardinals TV Channel: BSGL | BSMW

The Cleveland Guardians (-135) visit Busch Stadium to take on the St. Louis Cardinals (+115) on Saturday, September 21, 2024. First pitch is scheduled for 7:15pm EDT in St. Louis, MO.

This season, the Guardians are 90-65 against the spread (ATS), while the Cardinals are 78-76 ATS.

Guardians vs Cardinals Starting Pitchers Today:

  • Guardians starting pitcher: Matthew Boyd 2-1, 2.50 ERA
  • Cardinals starting pitcher: Miles Mikolas 8-11, 5.53 ERA

Guardians vs. Cardinals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Guardians-1.5 +135O 8 -115-135
Cardinals +1.5 -160U 8 -105+115

Guardians vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Saturday‘s MLB game with 55.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


Bet now on Guardians vs Cardinals and all games with BetMGM


We’ve highlighted some favorite MLB player prop bets for Guardians players for Saturday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

  • Lane Thomas has hit the Home Runs Over in 6 of his last 17 games (+22.40 Units / 132% ROI)
  • Jose Ramirez has hit the RBIs Under in 19 of his last 23 games (+11.65 Units / 29% ROI)
  • Jose Ramirez has hit the Total Bases Under in 13 of his last 15 away games (+10.30 Units / 49% ROI)
  • Lane Thomas has hit the Hits Over in 17 of his last 22 games (+9.40 Units / 23% ROI)
  • Josh Naylor has hit the Singles Under in 28 of his last 44 games (+8.45 Units / 15% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Saturday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

  • Masyn Winn has hit the Home Runs Over in 5 of his last 20 games at home (+25.50 Units / 127% ROI)
  • Nolan Arenado has hit the Total Bases Over in 17 of his last 25 games at home (+11.70 Units / 36% ROI)
  • Miles Mikolas has hit the Walks Allowed Under in 20 of his last 26 games (+10.85 Units / 24% ROI)
  • Jordan Walker has hit the Singles Under in 17 of his last 22 games (+10.10 Units / 33% ROI)
  • Nolan Arenado has hit the Hits Over in 35 of his last 47 games (+9.80 Units / 10% ROI)
  • The Cleveland Guardians have hit the Game Total Under in 43 of their last 72 away games (+16.80 Units / 21% ROI)
  • The Cleveland Guardians have hit the Moneyline in 90 of their last 155 games (+13.82 Units / 7% ROI)
  • The Cleveland Guardians have hit the Team Total Under in 29 of their last 43 away games (+13.70 Units / 28% ROI)
  • The Cleveland Guardians have covered the Run Line in 17 of their last 27 games (+9.05 Units / 26% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in 7 of their last 8 games (+6.05 Units / 56% ROI)
  • The St. Louis Cardinals have hit the Game Total Under in 17 of their last 25 games at home (+9.20 Units / 34% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 11 of their last 14 games (+8.05 Units / 46% ROI)
  • The St. Louis Cardinals have covered the Run Line in 20 of their last 33 games (+4.70 Units / 10% ROI)
  • The St. Louis Cardinals have hit the Moneyline in 16 of their last 29 games (+4.60 Units / 14% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 79-76 against the Run Line (+5.45 Units / 2.79% ROI).

  • 90-65 when betting on the Moneyline for +13.82 Units / 6.88% ROI
  • 68-77 when betting on the total runs Over for -17.15 Units / -10.01% ROI
  • 77-68 when betting on the total runs Under for +2.25 Units / 1.33% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 78-76 against the Run Line (-6.3 Units / -3.01% ROI).

  • 77-77 when betting on the Moneyline for -10.2 Units / -5.52% ROI
  • 70-78 when betting on the total runs Over for -16.37 Units / -9.71% ROI
  • 78-70 when betting on the total runs Under for +0.75 Units / 0.45% ROI

Cardinals vs Guardians Home Run Prop Bets Today

Over Under
Paul Goldschmidt (STL) 0.5 +400 0.5 -550
Jose Ramirez (CLE) 0.5 +425 0.5 -600
Kyle Manzardo (CLE) 0.5 +450 0.5 -650
Luken Baker (STL) 0.5 +450 0.5 -650
Nolan Arenado (STL) 0.5 +475 0.5 -700

Cardinals vs Guardians Total Hits Prop Bets Today

Over Under
Josh Naylor (CLE) 0.5 -250 0.5 +180
Lane Thomas (CLE) 0.5 -225 0.5 +175
Andres Gimenez (CLE) 0.5 -225 0.5 +170
Paul Goldschmidt (STL) 0.5 -210 0.5 +160
Masyn Winn (STL) 0.5 -200 0.5 +150

Cardinals vs Guardians RBI Prop Bets Today

Over Under
Jose Ramirez (CLE) 0.5 +145 0.5 -200
Josh Naylor (CLE) 0.5 +160 0.5 -225
Lane Thomas (CLE) 0.5 +175 0.5 -250
Jhonkensy Noel (CLE) 0.5 +175 0.5 -250
Paul Goldschmidt (STL) 0.5 +180 0.5 -250

Cardinals vs Guardians Strikeout Prop Bets Today

Over Under
Miles Mikolas (STL) 3.5 +105 3.5 -135
Matthew Boyd (CLE) 5.5 +115 5.5 -150

Matthew Boyd has 7 three-pitch strikeouts this month (3 games) — tied for 2nd most among pitchers in MLB — 99th Percentile.

Matthew Boyd has allowed a slugging percentage of just .114 (4 Total Bases / 35 ABs) with two-strikes this month (3 games) — tied for 10th best in MLB among starting pitchers with at least 6 total IP; League Avg: .251 — 92nd Percentile.

Matthew Boyd has not induced opposing hitters to ground into a double play in 7 opportunities (0%) this month (3 games) — tied for lowest in MLB among starting pitchers with at least 6 total IP; League Avg: 10% — 25th Percentile.

Opponents have a miss rate of 34% (42/123) against Matthew Boyd this month (3 games) — 14th best in MLB among starting pitchers with at least 6 total IP; League Avg: 26% — 91st Percentile.

Cardinals Starting Pitcher Stats & Trends

Right-handed hitters have a miss rate of just 15% (104/685) against Miles Mikolas this season — lowest among qualified SPs in MLB; League Avg: 26% — first Percentile.

Opponents are hitting .362 (46-for-127) against Miles Mikolas with runners in scoring position this season — highest among qualified SPs in MLB; League Avg: .243 — second Percentile.

Miles Mikolas has an ERA of 5.49 (160.2 IP)this season — 2nd highest among qualified SPs in MLB; League Avg: 3.66 — third Percentile.

Opponents are hitting .299 (76-for-254) against Miles Mikolas when going through the lineup the second time in a game this season — 2nd highest among qualified SPs in MLB; League Avg: .231 — third Percentile.

Guardians Keys to the Game vs. the Cardinals

The Guardians are 24-29 (.453) when allowing 2 or more home runs this season — best in MLB; League Avg: .292.

The Guardians are 68-2 (.971) when leading entering the 7th inning this season — best in MLB; League Avg: .856.

The Guardians are 79-0 (1.000) when leading entering the 9th inning this season — best in MLB; League Avg: .949.

The Guardians are 40-171 (.190) when trailing entering the 7th inning since the 2022 season — 2nd best in MLB; League Avg: .134.

Cardinals Keys to the Game vs. the Guardians

The Cardinals are 39-20 (.661) when tied entering the 8th inning since the 2022 season — best in MLB; League Avg: .500.

The Cardinals are just 24-38 (.387) after a win as favorites since the 2023 season — 3rd lowest in MLB; League Avg: .574.

The Cardinals are 21-13 (.618) after a loss as underdogs this season — best in MLB; League Avg: .434.

The Cardinals are just 23-29 (.442) vs bottom 10 scoring offenses since the 2023 season — 3rd lowest in MLB; League Avg: .560.

The Guardians are batting just .295 on the first pitch of at-bats this season — 2nd lowest in MLB; League Avg: .332.

Guardians hitters have put just 34% of balls in play to the left side of the field with runners in scoring position since the 2022 season — lowest in MLB; League Avg: 38%.

Guardians hitters have put just 34% of balls in play to the left side of the field since last season — 2nd lowest in MLB; League Avg: 38%.

Guardians hitters have just 2,401 strikeouts in 12,873 PA’s (19%) against RHP since the 2022 season — best in MLB; League Avg: 23%.

The Cardinals are just 44-70 (.373) against the run line (-30.5% ROI) after a road win since the 2022 season — lowest in MLB; League Avg: .490.

Cardinals hitters have an OBP of just .295 (1,671 PA’s) against LHP this season — 3rd lowest in MLB; League Avg: .314.

The Cardinals are batting .249 with two outs since the 2022 season — 3rd best in MLB; League Avg: .236.

The Cardinals are just 24-38 (-36.7% ROI) after a win as favorites since the 2023 season — 3rd lowest in MLB; League Avg: 57%.

Opponents have a groundball batting average of just .204 against Guardians pitchers with runners on base this season — best in MLB; League Avg: .263.

Opponents have a groundball batting average of just .221 against Guardians pitchers this season — best in MLB; League Avg: .250.

The Guardians have allowed 0.86 runs per game (133/155) in late innings this season — best in MLB; League Avg: 1.29.

Guardians pitchers have walked 5 of 170 batters (3%) when facing the leadoff batter in the inning this month (19 games) — best in MLB; League Avg: 8%.

Opponents have a miss rate of just 23% against Cardinals pitchers since the 2022 season — 2nd lowest in MLB; League Avg: 26%.

Opponents have a groundball rate of 46% against Cardinals pitchers since the 2022 season — 2nd highest in MLB; League Avg: 43%.

Opponents have a groundball rate of 45% against Cardinals pitchers since last season — tied for 2nd highest in MLB; League Avg: 43%.

Opponents have a miss rate of just 23% against Cardinals pitchers since last season — 2nd lowest in MLB; League Avg: 26%.

Cardinals vs. Guardians Injuries Tonight That May Affect Prop Bets 

  • St. Louis Cardinals – No Injuries Reported
  • Cleveland Guardians – No Injuries Reported

Bet now on Guardians vs Cardinals and all games with BetMGM


Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.

First Bet Offer BetMGM State Promo Pages $1,500
About the Author

Shane Jackson

Read More @Sjacksonmgm

Shane Jackson is a Web Content Writer for BetMGM, covering MLB and NBA. After graduating from the University of Kansas, his previous stops include MLB.com, Lawrence Journal-World, Manhattan Mercury, Bet Chicago Sports, WynnBET, and Sportsbook Review.

Shane Jackson is a Web Content Writer for BetMGM, covering MLB and NBA. After graduating from the University of Kansas, his previous stops include MLB.com, Lawrence Journal-World, Manhattan Mercury, Bet Chicago Sports, WynnBET, and Sportsbook Review.