Guardians vs Cardinals Prediction, Odds & Player Prop Bets Today – MLB, Sep 22

min read
MLB betting odds, predictions and betting odds for today's games
(AP Photo)
BetMGM Betting @BETMGM Sep 22, 2024, 11:01 AM
  • The Guardians are -110 favorites vs the Cardinals
  • Guardians vs Cardinals Over / Under today: 7.5 Runs
  • Guardians / Cardinals TV Channel: BSGL | BSMW

The Cleveland Guardians (+100) visit Busch Stadium to take on the St. Louis Cardinals (-120) on Sunday, September 22, 2024. First pitch is scheduled for 2:15pm EDT in St. Louis, MO.

This season, the Guardians are against the spread (ATS), while the Cardinals are ATS.

Guardians vs Cardinals Starting Pitchers Today:

  • Guardians starting pitcher: Gavin Williams 3-10, 5.10 ERA
  • Cardinals starting pitcher: Andre Pallante 7-8, 3.85 ERA

Guardians vs. Cardinals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Guardians-1.5 +170O 7.5 -115+100
Cardinals +1.5 -210U 7.5 -105-120

Guardians vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Sunday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


Bet now on Guardians vs Cardinals and all games with BetMGM


We’ve highlighted some favorite MLB player prop bets for Guardians players for Sunday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

  • Lane Thomas has hit the Home Runs Over in 6 of his last 18 games (+21.40 Units / 119% ROI)
  • Josh Naylor has hit the Hits Under in 10 of his last 14 away games (+10.90 Units / 63% ROI)
  • Jose Ramirez has hit the RBIs Under in 19 of his last 24 games (+9.70 Units / 23% ROI)
  • Josh Naylor has hit the Singles Under in 29 of his last 45 games (+9.45 Units / 17% ROI)
  • Andres Gimenez has hit the Runs Under in 19 of his last 25 away games (+9.30 Units / 21% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Sunday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

  • Masyn Winn has hit the Home Runs Over in 5 of his last 21 games at home (+24.50 Units / 117% ROI)
  • Jordan Walker has hit the Singles Under in 18 of his last 23 games (+11.10 Units / 34% ROI)
  • Nolan Arenado has hit the Hits Over in 36 of his last 48 games (+10.80 Units / 10% ROI)
  • Masyn Winn has hit the Total Bases Over in 15 of his last 24 games at home (+10.45 Units / 42% ROI)
  • Paul Goldschmidt has hit the RBIs Under in 13 of his last 15 games (+9.00 Units / 27% ROI)
  • The Cleveland Guardians have hit the Game Total Under in 43 of their last 72 away games (+16.80 Units / 21% ROI)
  • The Cleveland Guardians have hit the Moneyline in 90 of their last 155 games (+13.82 Units / 7% ROI)
  • The Cleveland Guardians have hit the Team Total Under in 29 of their last 43 away games (+13.70 Units / 28% ROI)
  • The Cleveland Guardians have covered the Run Line in 17 of their last 27 games (+9.05 Units / 26% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in 7 of their last 8 games (+6.05 Units / 56% ROI)
  • The St. Louis Cardinals have hit the Game Total Under in 17 of their last 25 games at home (+9.20 Units / 34% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 11 of their last 14 games (+8.05 Units / 46% ROI)
  • The St. Louis Cardinals have covered the Run Line in 20 of their last 33 games (+4.70 Units / 10% ROI)
  • The St. Louis Cardinals have hit the Moneyline in 16 of their last 29 games (+4.60 Units / 14% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are against the Run Line ( Units / ROI).

  • away moneyline record when betting on the Moneyline for ML units Units / ML ROI ROI
  • away total over record when betting on the total runs Over for over units Units / over ROI ROI
  • away total under record when betting on the total runs Under for under units Units / under ROI ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are against the Run Line ( Units / ROI).

  • home moneyline record when betting on the Moneyline for ML units Units / ML ROI ROI
  • home total over record when betting on the total runs Over for over units Units / over ROI ROI
  • home total under record when betting on the total runs Under for under units Units / under ROI ROI

Cardinals vs Guardians Home Run Prop Bets Today

Over Under
Paul Goldschmidt (STL) 0.5 +550 0.5 -800
Jose Ramirez (CLE) 0.5 +600 0.5 -900
Kyle Manzardo (CLE) 0.5 +650 0.5 -1000
Jordan Walker (STL) 0.5 +650 0.5 -1000
Alec Burleson (STL) 0.5 +675 0.5 -1100

Cardinals vs Guardians Total Hits Prop Bets Today

Over Under
Masyn Winn (STL) 0.5 -250 0.5 +175
Alec Burleson (STL) 0.5 -250 0.5 +175
Jose Ramirez (CLE) 0.5 -225 0.5 +170
Will Brennan (CLE) 0.5 -200 0.5 +150
Lane Thomas (CLE) 0.5 -200 0.5 +150

Cardinals vs Guardians RBI Prop Bets Today

Over Under
Josh Naylor (CLE) 0.5 +170 0.5 -225
Jose Ramirez (CLE) 0.5 +185 0.5 -250
Lane Thomas (CLE) 0.5 +190 0.5 -250
Paul Goldschmidt (STL) 0.5 +200 0.5 -275
Nolan Arenado (STL) 0.5 +210 0.5 -275

Cardinals vs Guardians Strikeout Prop Bets Today

Over Under
Gavin Williams (CLE) 5.5 +120 5.5 -160
Andre Pallante (STL) 4.5 +125 4.5 -165

20 of Gavin Williams’ 71 breaking pitch strikeouts (28%) have been backdoor since last season — 4th highest in MLB among starting pitchers with at least 126 total IP; League Avg: 14% — 96th Percentile.

10 of Gavin Williams’ 31 breaking pitch strikeouts (32%) have been backdoor this season — 5th highest in MLB among starting pitchers with at least 61 total IP; League Avg: 14% — 96th Percentile.

Left-handed hitters have a groundball rate of just 29% (6/21) against Gavin Williams this month (4 games) — 5th lowest among qualified SPs in MLB; League Avg: 41% — eighth Percentile.

Gavin Williams has struck out just 15% (6/40) of right-handed batters he faced this month (4 games) — 6th lowest among qualified SPs in MLB; League Avg: 24% — eighth Percentile.

Cardinals Starting Pitcher Stats & Trends

Opponents have a groundball rate of 68% (131/194) against Andre Pallante in two-strike counts since last season — highest in MLB among starting pitchers with at least 126 total IP; League Avg: 45% — 100th Percentile.

Opponents have a groundball rate of 68% (246/363) against Andre Pallante in non-two strike counts since last season — highest in MLB among starting pitchers with at least 126 total IP; League Avg: 42% — 100th Percentile.

Left-handed hitters have a groundball rate of 76% (216/284) against Andre Pallante since last season — highest in MLB among starting pitchers with at least 126 total IP; League Avg: 42% — 100th Percentile.

Opposing hitters have a groundball rate of 66% (91/139) against Andre Pallante when he’s behind in the count since last season — highest in MLB among starting pitchers with at least 126 total IP; League Avg: 40% — 100th Percentile.

Guardians Keys to the Game vs. the Cardinals

The Guardians are 74-2 (.974) when leading entering the 8th inning this season — best in MLB; League Avg: .901.

The Guardians are 68-2 (.971) when leading entering the 7th inning this season — best in MLB; League Avg: .857.

The Guardians are 87-26 (.770) when they’ve hit 2 or more home runs since the 2022 season — 4th best in MLB; League Avg: .702.

The Guardians are 63-9 (.875) when they’ve had 5 or more XBH since the 2022 season — tied for 3rd best in MLB; League Avg: .800.

Cardinals Keys to the Game vs. the Guardians

The Cardinals are just 24-38 (.387) after a win as favorites since the 2023 season — 3rd lowest in MLB; League Avg: .574.

The Cardinals are 21-13 (.618) after a loss as underdogs this season — best in MLB; League Avg: .434.

The Cardinals are 39-20 (.661) when tied entering the 8th inning since the 2022 season — best in MLB; League Avg: .500.

The Cardinals are just 57-63 (.475) after a win as favorites since the 2022 season — 5th lowest in MLB; League Avg: .584.

Guardians hitters have put just 34% of balls in play to the left side of the field since last season — tied for lowest in MLB; League Avg: 38%.

The Guardians are batting just .297 on the first pitch of at-bats this season — 2nd lowest in MLB; League Avg: .332.

Guardians hitters had a Hard-Hit Rate of just 33% in the 2023 season — lowest in MLB; League Avg: 40%.

Guardians hitters have put just 35% of balls in play to the left side of the field since the 2022 season — lowest in MLB; League Avg: 38%.

Cardinals hitters have an OPS of just .688 (3,253 PA’s) against LHP since last season — 3rd lowest in MLB; League Avg: .727.

Cardinals hitters are slugging just .381 against LHP since last season — 3rd lowest in MLB; League Avg: .409.

The Cardinals are batting just .238 against LHP since last season — 5th lowest in MLB; League Avg: .250.

Cardinals hitters have an OPS of just .661 (1,693 PA’s) against LHP this season — 4th lowest in MLB; League Avg: .712.

Opponents have a groundball batting average of just .205 against Guardians pitchers with runners on base this season — best in MLB; League Avg: .263.

Opponents have a groundball batting average of just .222 against Guardians pitchers this season — best in MLB; League Avg: .250.

Guardians pitchers have walked 6 of 178 batters (3%) when facing the leadoff batter in the inning this month (20 games) — best in MLB; League Avg: 8%.

Guardians pitchers have won 41% of games in which they have allowed their opponent to score in three different innings this season — highest in MLB; League Avg: 26%.

Opponents have a groundball rate of 46% against Cardinals pitchers since the 2022 season — 2nd highest in MLB; League Avg: 43%.

Cardinals pitchers have a strikeout rate of just 20% since the 2022 season — tied for 2nd lowest in MLB; League Avg: 23%.

Opponents have a miss rate of just 23% against Cardinals pitchers since the 2022 season — 2nd lowest in MLB; League Avg: 26%.

Opponents have a groundball rate of 45% against Cardinals pitchers since last season — 3rd highest in MLB; League Avg: 43%.

Cardinals vs. Guardians Injuries Tonight That May Affect Prop Bets 

  • St. Louis Cardinals – No Injuries Reported
  • Cleveland Guardians – No Injuries Reported

Bet now on Guardians vs Cardinals and all games with BetMGM


Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.

First Bet Offer BetMGM State Promo Pages $1,500
About the Author

BetMGM Betting

Read More @BETMGM

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.