Guardians vs Cardinals Prediction, Odds & Player Prop Bets Today – MLB, Sep 22

MLB betting odds, predictions and betting odds for today's games
(AP Photo)
  • The Guardians are -110 favorites vs the Cardinals
  • Guardians vs Cardinals Over / Under today: 7.5 Runs
  • Guardians / Cardinals TV Channel: BSGL | BSMW

The Cleveland Guardians (+100) visit Busch Stadium to take on the St. Louis Cardinals (-120) on Sunday, September 22, 2024. First pitch is scheduled for 2:15pm EDT in St. Louis, MO.

This season, the Guardians are against the spread (ATS), while the Cardinals are ATS.

Guardians vs Cardinals Starting Pitchers Today:

  • Guardians starting pitcher: Gavin Williams 3-10, 5.10 ERA
  • Cardinals starting pitcher: Andre Pallante 7-8, 3.85 ERA

Guardians vs. Cardinals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Guardians-1.5 +170O 7.5 -115+100
Cardinals +1.5 -210U 7.5 -105-120

Guardians vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Sunday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Guardians players for Sunday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

  • Lane Thomas has hit the Home Runs Over in 6 of his last 18 games (+21.40 Units / 119% ROI)
  • Josh Naylor has hit the Hits Under in 10 of his last 14 away games (+10.90 Units / 63% ROI)
  • Jose Ramirez has hit the RBIs Under in 19 of his last 24 games (+9.70 Units / 23% ROI)
  • Josh Naylor has hit the Singles Under in 29 of his last 45 games (+9.45 Units / 17% ROI)
  • Andres Gimenez has hit the Runs Under in 19 of his last 25 away games (+9.30 Units / 21% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Sunday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

  • Masyn Winn has hit the Home Runs Over in 5 of his last 21 games at home (+24.50 Units / 117% ROI)
  • Jordan Walker has hit the Singles Under in 18 of his last 23 games (+11.10 Units / 34% ROI)
  • Nolan Arenado has hit the Hits Over in 36 of his last 48 games (+10.80 Units / 10% ROI)
  • Masyn Winn has hit the Total Bases Over in 15 of his last 24 games at home (+10.45 Units / 42% ROI)
  • Paul Goldschmidt has hit the RBIs Under in 13 of his last 15 games (+9.00 Units / 27% ROI)
  • The Cleveland Guardians have hit the Game Total Under in 43 of their last 72 away games (+16.80 Units / 21% ROI)
  • The Cleveland Guardians have hit the Moneyline in 90 of their last 155 games (+13.82 Units / 7% ROI)
  • The Cleveland Guardians have hit the Team Total Under in 29 of their last 43 away games (+13.70 Units / 28% ROI)
  • The Cleveland Guardians have covered the Run Line in 17 of their last 27 games (+9.05 Units / 26% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in 7 of their last 8 games (+6.05 Units / 56% ROI)
  • The St. Louis Cardinals have hit the Game Total Under in 17 of their last 25 games at home (+9.20 Units / 34% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 11 of their last 14 games (+8.05 Units / 46% ROI)
  • The St. Louis Cardinals have covered the Run Line in 20 of their last 33 games (+4.70 Units / 10% ROI)
  • The St. Louis Cardinals have hit the Moneyline in 16 of their last 29 games (+4.60 Units / 14% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are against the Run Line ( Units / ROI).

  • away moneyline record when betting on the Moneyline for ML units Units / ML ROI ROI
  • away total over record when betting on the total runs Over for over units Units / over ROI ROI
  • away total under record when betting on the total runs Under for under units Units / under ROI ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are against the Run Line ( Units / ROI).

  • home moneyline record when betting on the Moneyline for ML units Units / ML ROI ROI
  • home total over record when betting on the total runs Over for over units Units / over ROI ROI
  • home total under record when betting on the total runs Under for under units Units / under ROI ROI

Cardinals vs Guardians Home Run Prop Bets Today

Over Under
Paul Goldschmidt (STL) 0.5 +550 0.5 -800
Jose Ramirez (CLE) 0.5 +600 0.5 -900
Kyle Manzardo (CLE) 0.5 +650 0.5 -1000
Jordan Walker (STL) 0.5 +650 0.5 -1000
Alec Burleson (STL) 0.5 +675 0.5 -1100

Cardinals vs Guardians Total Hits Prop Bets Today

Over Under
Masyn Winn (STL) 0.5 -250 0.5 +175
Alec Burleson (STL) 0.5 -250 0.5 +175
Jose Ramirez (CLE) 0.5 -225 0.5 +170
Will Brennan (CLE) 0.5 -200 0.5 +150
Lane Thomas (CLE) 0.5 -200 0.5 +150

Cardinals vs Guardians RBI Prop Bets Today

Over Under
Josh Naylor (CLE) 0.5 +170 0.5 -225
Jose Ramirez (CLE) 0.5 +185 0.5 -250
Lane Thomas (CLE) 0.5 +190 0.5 -250
Paul Goldschmidt (STL) 0.5 +200 0.5 -275
Nolan Arenado (STL) 0.5 +210 0.5 -275

Cardinals vs Guardians Strikeout Prop Bets Today

Over Under
Gavin Williams (CLE) 5.5 +120 5.5 -160
Andre Pallante (STL) 4.5 +125 4.5 -165

20 of Gavin Williams’ 71 breaking pitch strikeouts (28%) have been backdoor since last season — 4th highest in MLB among starting pitchers with at least 126 total IP; League Avg: 14% — 96th Percentile.

10 of Gavin Williams’ 31 breaking pitch strikeouts (32%) have been backdoor this season — 5th highest in MLB among starting pitchers with at least 61 total IP; League Avg: 14% — 96th Percentile.

Left-handed hitters have a groundball rate of just 29% (6/21) against Gavin Williams this month (4 games) — 5th lowest among qualified SPs in MLB; League Avg: 41% — eighth Percentile.

Gavin Williams has struck out just 15% (6/40) of right-handed batters he faced this month (4 games) — 6th lowest among qualified SPs in MLB; League Avg: 24% — eighth Percentile.

Cardinals Starting Pitcher Stats & Trends

Opponents have a groundball rate of 68% (131/194) against Andre Pallante in two-strike counts since last season — highest in MLB among starting pitchers with at least 126 total IP; League Avg: 45% — 100th Percentile.

Opponents have a groundball rate of 68% (246/363) against Andre Pallante in non-two strike counts since last season — highest in MLB among starting pitchers with at least 126 total IP; League Avg: 42% — 100th Percentile.

Left-handed hitters have a groundball rate of 76% (216/284) against Andre Pallante since last season — highest in MLB among starting pitchers with at least 126 total IP; League Avg: 42% — 100th Percentile.

Opposing hitters have a groundball rate of 66% (91/139) against Andre Pallante when he’s behind in the count since last season — highest in MLB among starting pitchers with at least 126 total IP; League Avg: 40% — 100th Percentile.

Guardians Keys to the Game vs. the Cardinals

The Guardians are 74-2 (.974) when leading entering the 8th inning this season — best in MLB; League Avg: .901.

The Guardians are 68-2 (.971) when leading entering the 7th inning this season — best in MLB; League Avg: .857.

The Guardians are 87-26 (.770) when they’ve hit 2 or more home runs since the 2022 season — 4th best in MLB; League Avg: .702.

The Guardians are 63-9 (.875) when they’ve had 5 or more XBH since the 2022 season — tied for 3rd best in MLB; League Avg: .800.

Cardinals Keys to the Game vs. the Guardians

The Cardinals are just 24-38 (.387) after a win as favorites since the 2023 season — 3rd lowest in MLB; League Avg: .574.

The Cardinals are 21-13 (.618) after a loss as underdogs this season — best in MLB; League Avg: .434.

The Cardinals are 39-20 (.661) when tied entering the 8th inning since the 2022 season — best in MLB; League Avg: .500.

The Cardinals are just 57-63 (.475) after a win as favorites since the 2022 season — 5th lowest in MLB; League Avg: .584.

Guardians hitters have put just 34% of balls in play to the left side of the field since last season — tied for lowest in MLB; League Avg: 38%.

The Guardians are batting just .297 on the first pitch of at-bats this season — 2nd lowest in MLB; League Avg: .332.

Guardians hitters had a Hard-Hit Rate of just 33% in the 2023 season — lowest in MLB; League Avg: 40%.

Guardians hitters have put just 35% of balls in play to the left side of the field since the 2022 season — lowest in MLB; League Avg: 38%.

Cardinals hitters have an OPS of just .688 (3,253 PA’s) against LHP since last season — 3rd lowest in MLB; League Avg: .727.

Cardinals hitters are slugging just .381 against LHP since last season — 3rd lowest in MLB; League Avg: .409.

The Cardinals are batting just .238 against LHP since last season — 5th lowest in MLB; League Avg: .250.

Cardinals hitters have an OPS of just .661 (1,693 PA’s) against LHP this season — 4th lowest in MLB; League Avg: .712.

Opponents have a groundball batting average of just .205 against Guardians pitchers with runners on base this season — best in MLB; League Avg: .263.

Opponents have a groundball batting average of just .222 against Guardians pitchers this season — best in MLB; League Avg: .250.

Guardians pitchers have walked 6 of 178 batters (3%) when facing the leadoff batter in the inning this month (20 games) — best in MLB; League Avg: 8%.

Guardians pitchers have won 41% of games in which they have allowed their opponent to score in three different innings this season — highest in MLB; League Avg: 26%.

Opponents have a groundball rate of 46% against Cardinals pitchers since the 2022 season — 2nd highest in MLB; League Avg: 43%.

Cardinals pitchers have a strikeout rate of just 20% since the 2022 season — tied for 2nd lowest in MLB; League Avg: 23%.

Opponents have a miss rate of just 23% against Cardinals pitchers since the 2022 season — 2nd lowest in MLB; League Avg: 26%.

Opponents have a groundball rate of 45% against Cardinals pitchers since last season — 3rd highest in MLB; League Avg: 43%.

Cardinals vs. Guardians Injuries Tonight That May Affect Prop Bets 

  • St. Louis Cardinals – No Injuries Reported
  • Cleveland Guardians – No Injuries Reported

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About the Author

Shane Jackson

Read More @Sjacksonmgm

Shane Jackson is a Web Content Writer for BetMGM, covering MLB and NBA. After graduating from the University of Kansas, his previous stops include MLB.com, Lawrence Journal-World, Manhattan Mercury, Bet Chicago Sports, WynnBET, and Sportsbook Review.

Shane Jackson is a Web Content Writer for BetMGM, covering MLB and NBA. After graduating from the University of Kansas, his previous stops include MLB.com, Lawrence Journal-World, Manhattan Mercury, Bet Chicago Sports, WynnBET, and Sportsbook Review.