Guardians vs Red Sox Prediction, Odds & Player Prop Bets Today – MLB, Apr 16

Boston Red Sox third baseman Rafael Devers looks on during the eighth inning of a baseball game against the Baltimore Orioles, Sept. 29, 2023, in Baltimore. With the Red Sox ramping up at the start of spring training, Devers made it clear Tuesday, Feb. 20, 2024, that he felt the franchise should have done more to improve the roster over the winter.
AP Photo/Julio Cortez)
  • The Guardians are -105 favorites vs the Red Sox
  • Guardians vs Red Sox Over / Under today: 9 Runs
  • Guardians / Red Sox TV Channel: BSGL | NESN

The Cleveland Guardians (-105) visit Fenway Park to take on the Boston Red Sox (-115) on Tuesday, April 16, 2024. First pitch is scheduled for 7:10pm EDT in Boston, MA.

This season, the Guardians are 11-5 against the spread (ATS), while the Red Sox are 9-8 ATS.

Guardians vs Red Sox Starting Pitchers Today:

  • Guardians starting pitcher: Tanner Bibee 1-0, 6.08 ERA
  • Red Sox starting pitcher: Garrett Whitlock 1-0, 1.26 ERA

Guardians vs. Red Sox Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Guardians-1.5 +155O 8.5 -105-105
Red Sox +1.5 -190U 8.5 -115-115

Guardians vs Red Sox Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Tuesday‘s MLB game with 51.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Guardians players for Tuesday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

  • Myles Straw has hit the Runs Under in his last 11 away games (+11.00 Units / 40% ROI)
  • Tanner Bibee has hit the Earned Runs Under in 18 of his last 25 games (+8.75 Units / 28% ROI)
  • Kole Calhoun has hit the Singles Under in 18 of his last 24 games (+8.75 Units / 21% ROI)
  • Triston McKenzie has hit the Strikeouts Under in his last 6 games (+6.00 Units / 65% ROI)
  • David Fry has hit the Singles Under in 10 of his last 13 away games (+5.35 Units / 23% ROI)

And here are some favorite MLB player prop bets for Red Sox players for Tuesday‘s game, looking at profitable historical betting trends:

Best Red Sox Player Prop Best Bets Today:

  • Pablo Reyes has hit the Hits Under in 9 of his last 12 games at home (+10.25 Units / 85% ROI)
  • Pablo Reyes has hit the Hits Runs and RBIs Under in 11 of his last 12 games at home (+9.95 Units / 64% ROI)
  • Pablo Reyes has hit the Total Bases Under in 12 of his last 16 games (+8.85 Units / 38% ROI)
  • Pablo Reyes has hit the Singles Under in 10 of his last 12 games at home (+7.45 Units / 47% ROI)
  • Brayan Bello has hit the Earned Runs Under in 12 of his last 16 games at home (+7.15 Units / 33% ROI)
  • The Cleveland Guardians have hit the Game Total Under in 85 of their last 146 games (+21.85 Units / 14% ROI)
  • The Cleveland Guardians have covered the Run Line in 34 of their last 60 away games (+6.30 Units / 8% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Over in 21 of their last 35 games (+5.72 Units / 13% ROI)
  • The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 25 of their last 44 away games (+5.36 Units / 11% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Moneyline in 22 of their last 44 away games (+5.35 Units / 11% ROI)
  • The Boston Red Sox have hit the Game Total Under in 15 of their last 19 games (+10.60 Units / 50% ROI)
  • The Boston Red Sox have hit the 1st Five Innings (F5) Team Total Under in 10 of their last 15 games (+5.49 Units / 34% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 11-5 against the Run Line (+5.7 Units / 26.15% ROI).

  • 11-5 when betting on the Moneyline for +5.65 Units / 25.51% ROI
  • 9-6 when betting on the total runs Over for +2.3 Units / 12.96% ROI
  • 6-9 when betting on the total runs Under for -4 Units / -22.86% ROI

Red Sox Against the Spread (ATS) Record

Against the spread this season, the Red Sox are 9-8 against the Run Line (+0.25 Units / 1.07% ROI).

  • 9-8 when betting on the Moneyline for +0.4 Units / 1.98% ROI
  • 7-9 when betting on the total runs Over for -2.9 Units / -15.38% ROI
  • 9-7 when betting on the total runs Under for +1.35 Units / 7.28% ROI

Red Sox vs Guardians Home Run Prop Bets Today

Over Under
Jarren Duran (BOS) 0.5 +525 0.5 -750
Triston Casas (BOS) 0.5 +525 0.5 -750
Josh Naylor (CLE) 0.5 +550 0.5 -800
Jose Ramirez (CLE) 0.5 +550 0.5 -800
Enmanuel Valdez (BOS) 0.5 +550 0.5 -800

Red Sox vs Guardians Total Hits Prop Bets Today

Over Under
Andres Gimenez (CLE) 0.5 -250 0.5 +180
Will Brennan (CLE) 0.5 -250 0.5 +190
Enmanuel Valdez (BOS) 0.5 -200 0.5 +155
Gabriel Arias (CLE) 0.5 -190 0.5 +140
Brayan Rocchio (CLE) 0.5 -190 0.5 +145

Red Sox vs Guardians RBI Prop Bets Today

Over Under
Jose Ramirez (CLE) 0.5 +120 0.5 -155
Josh Naylor (CLE) 0.5 +130 0.5 -165
Jarren Duran (BOS) 0.5 +160 0.5 -225
Triston Casas (BOS) 0.5 +160 0.5 -210
Enmanuel Valdez (BOS) 0.5 +185 0.5 -250

Red Sox vs Guardians Strikeout Prop Bets Today

Over Under
Tanner Bibee (CLE) 5.5 -105 5.5 -120
Garrett Whitlock (BOS) 4.5 +110 4.5 -140

Opponents are hitting .520 (13-for-25) against Tanner Bibee’s fastball this season — highest in MLB among starting pitchers with at least 6 total IP; League Avg: .265 — 0 Percentile.

Tanner Bibee allowed an OPS of just .542 (270 PA’s) vs left-handed batters in the 2023 season — 2nd best in MLB among starting pitchers with at least 64 total IP; League Avg: .746 — 98th Percentile.

Tanner Bibee has allowed a slugging percentage of .920 (23 Total Bases / 25 ABs) on fastballs this season — highest in MLB among starting pitchers with at least 6 total IP; League Avg: .426 — 0 Percentile.

Hitters have chased just 1 of Tanner Bibee’s 35 elevated fastballs out of the zone (3%) this season — lowest in MLB among starting pitchers with at least 6 total IP; League Avg: 27% — 0 Percentile.

Red Sox Starting Pitcher Stats & Trends

Garrett Whitlock has allowed a slugging percentage of just .033 (1 Total Bases / 30 ABs) with two-strikes this season — 3rd best in MLB among starting pitchers with at least 6 total IP; League Avg: .255 — 98th Percentile.

Opponents are hitting just .033 (1-for-30) against Garrett Whitlock with two-strikes this season — 3rd best in MLB among starting pitchers with at least 6 total IP; League Avg: .167 — 98th Percentile.

Opponents have a miss rate of just 7% (2/29) against Garrett Whitlock on sliders this season — lowest in MLB among starting pitchers with at least 6 total IP; League Avg: 33% — first Percentile.

Garrett Whitlock has not allowed a hit to any of the last 33 batters he’s faced after reaching two strikes. — Lucas Erceg has the longest active streak at 49.

Guardians Keys to the Game vs. the Red Sox

The Guardians were just 5-15 (.250) when tied entering the 8th inning in 2023 — 2nd lowest in MLB; League Avg: .500.

The Guardians are just 8-16 (.333) when tied entering the 7th inning since the 2023 season — tied for lowest in MLB; League Avg: .497.

The Guardians were just 5-15 (.250) when tied entering the 7th inning in 2023 — lowest in MLB; League Avg: .500.

The Guardians are 23-124 (.155) when trailing entering the 8th inning since the 2022 season — 3rd best in MLB; League Avg: .093.

Red Sox Keys to the Game vs. the Guardians

The Red Sox are just 18-30 (.375) after a home loss since the 2023 season — tied for 2nd lowest in MLB; League Avg: .508.

The Red Sox were just 17-27 (.386) after a home loss in 2023 — 2nd lowest in MLB; League Avg: .508.

The Red Sox are just 42-140 (.230) when scoring 4 or fewer runs since the 2022 season — tied for 5th lowest in MLB; League Avg: .280.

The Red Sox are 70-4 (.946) when leading entering the 8th inning since the 2023 season — 3rd best in MLB; League Avg: .898.

Guardians hitters put just 34% of balls in play to the left side of the field in the 2023 season — lowest in MLB; League Avg: 39%.

Guardians hitters have put just 34% of balls in play to the left side of the field since last season — lowest in MLB; League Avg: 39%.

Guardians hitters had an OPS of just .662 (1,910 PA’s) against LHP in the 2023 season — lowest in MLB; League Avg: .742.

Guardians hitters have an OPS of just .660 (3,636 PA’s) against LHP since the 2022 season — 2nd lowest in MLB; League Avg: .726.

The Red Sox batted .182 on pitches out of the zone in the 2023 season — best in MLB; League Avg: .151.

Red Sox hitters slugged .266 on pitches out of the zone in the 2023 season — best in MLB; League Avg: .211.

The Red Sox batted .300 when facing the starting pitcher for the 3rd time in a game in the 2023 season — 2nd best in MLB; League Avg: .267.

Red Sox hitters have 61 strikeouts in 206 PA’s (30%) against LHP this season — 3rd highest in MLB; League Avg: 22%.

Opponents have a miss rate of 29% against Guardians pitchers this season — best in MLB; League Avg: 25%.

Guardians pitchers have a strikeout rate of 30% with runners in scoring position this season — best in MLB; League Avg: 21%.

Guardians pitchers had a strikeout rate of just 40% with two-strikes in the 2023 season — tied for 5th lowest in MLB; League Avg: 43%.

The Guardians have allowed 0.50 runs per game (8/16) in late innings this season — 2nd best in MLB; League Avg: 1.33.

Red Sox pitchers have an ERA of 1.49 (90.1 IP) on the road this season — best in MLB; League Avg: 4.03.

Red Sox pitchers have walked 8 of 155 batters (5%) when facing the leadoff batter in the inning this season — 5th best in MLB; League Avg: 9%.

Red Sox pitchers have walked 113 of 1,590 batters (7%) when facing the leadoff batter in the inning since last season — tied for 5th best in MLB; League Avg: 8%.

Red Sox pitchers have walked 45 of 648 batters (7%) this season — tied for 3rd best in MLB; League Avg: 9%.

Red Sox vs. Guardians Injuries Tonight That May Affect Prop Bets 

  • Wyatt Mills (Boston Red Sox): Elbow, 60-Day IL
  • Vaughn Grissom (Boston Red Sox): Hamstring, 10-Day IL
  • Michael Fulmer (Boston Red Sox): Elbow, 60-Day IL
  • Zack Kelly (Boston Red Sox): Oblique, Day-To-Day
  • Bryan Mata (Boston Red Sox): Hamstring, 15-Day IL
  • Chris Murphy (Boston Red Sox): Elbow, 60-Day IL
  • Kenley Jansen (Boston Red Sox): Back, Day-To-Day
  • Brandon Walter (Boston Red Sox): Shoulder, 7-Day IL
  • Lucas Giolito (Boston Red Sox): Elbow, 60-Day IL
  • Rob Refsnyder (Boston Red Sox): Toe, 10-Day IL
  • Yu Chang (Boston Red Sox): Oblique, Out
  • Daniel Espino (Cleveland Guardians): Shoulder, Out
  • Gavin Williams (Cleveland Guardians): Elbow, 15-Day IL
  • Ben Lively (Cleveland Guardians): Illness, 15-Day IL
  • Luis Ortiz (Cleveland Guardians): Ankle, 15-Day IL
  • Xzavion Curry (Cleveland Guardians): Illness, 15-Day IL
  • Joey Cantillo (Cleveland Guardians): Hamstring, Out
  • Angel Martinez (Cleveland Guardians): Foot, 10-Day IL
  • Sam Hentges (Cleveland Guardians): Finger, 15-Day IL
  • Trevor Stephan (Cleveland Guardians): Elbow, 60-Day IL
  • George Valera (Cleveland Guardians): Hamstring, Out
  • James Karinchak (Cleveland Guardians): Shoulder, 60-Day IL

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Our BetMGM editors and authors are sports experts with a wealth of knowledge of the sports industry at all levels. Their coverage includes sports news, previews and predictions, fun facts, and betting.