Padres vs Reds Prediction, Odds & Player Prop Bets Today – MLB, May 21

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Cincinnati Reds' Jonathan India celebrates after hitting a home run against the Houston Astros during the eighth inning of a baseball game Sunday, June 18, 2023, in Houston.
(AP Photo/David J. Phillip)
BetMGM Betting @BETMGM May 21, 2024, 11:01 AM
  • The Padres are -120 favorites vs the Reds
  • Padres vs Reds Over / Under today: 9 Runs
  • Padres / Reds TV Channel: BSOH | PDTV

The San Diego Padres (-120) visit Great American Ball Park to take on the Cincinnati Reds (+100) on Tuesday, May 21, 2024. First pitch is scheduled for 6:40pm EDT in Cincinnati, OH.

This season, the Padres are 25-25 against the spread (ATS), while the Reds are 26-21 ATS.

Padres vs Reds Starting Pitchers Today:

  • Padres starting pitcher: Joe Musgrove 3-3, 6.48 ERA
  • Reds starting pitcher: Andrew Abbott 2-4, 3.06 ERA

Padres vs. Reds Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Padres-1.5 +135O 9 -105-120
Reds +1.5 -165U 9 -115+100

Padres vs Reds Prediction for Today’s Game

Based on recent trends the model predicts the Padres will win Tuesday‘s MLB game with 53.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


Bet now on Padres vs Reds and all games with BetMGM


We’ve highlighted some favorite MLB player prop bets for Padres players for Tuesday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Bets Today:

  • Ha-Seong Kim has hit the Home Runs Over in 5 of his last 20 away games (+31.00 Units / 155% ROI)
  • Jurickson Profar has hit the Hits Over in 35 of his last 46 games (+18.85 Units / 22% ROI)
  • Jurickson Profar has hit the Total Bases Over in 18 of his last 23 games (+14.85 Units / 46% ROI)
  • Jurickson Profar has hit the Singles Over in 27 of his last 39 games (+14.00 Units / 32% ROI)
  • Manny Machado has hit the Runs Under in 20 of his last 26 games (+11.20 Units / 27% ROI)

And here are some favorite MLB player prop bets for Reds players for Tuesday‘s game, looking at profitable historical betting trends:

Best Reds Player Prop Best Bets Today:

  • Spencer Steer has hit the Runs Under in 23 of his last 30 games (+13.40 Units / 30% ROI)
  • Elly De La Cruz has hit the Home Runs Over in 8 of his last 37 games (+12.70 Units / 34% ROI)
  • Spencer Steer has hit the Total Bases Under in 23 of his last 31 games (+12.65 Units / 28% ROI)
  • Spencer Steer has hit the Singles Under in 27 of his last 40 games (+11.05 Units / 22% ROI)
  • Spencer Steer has hit the Hits Under in 17 of his last 31 games (+9.60 Units / 26% ROI)
  • The San Diego Padres have covered the Run Line in 18 of their last 24 away games (+13.65 Units / 43% ROI)
  • The San Diego Padres have hit the Moneyline in 15 of their last 24 away games (+7.40 Units / 27% ROI)
  • The San Diego Padres have hit the Game Total Over in 5 of their last 7 games (+2.80 Units / 36% ROI)
  • The Cincinnati Reds have hit the 1st Five Innings (F5) Team Total Under in 16 of their last 19 games at home (+12.90 Units / 54% ROI)
  • The Cincinnati Reds have hit the Game Total Under in 19 of their last 31 games (+8.10 Units / 24% ROI)
  • The Cincinnati Reds have covered the Run Line in 18 of their last 29 games (+7.30 Units / 18% ROI)
  • The Cincinnati Reds have hit the Team Total Under in their last 7 games at home (+7.10 Units / 83% ROI)
  • The Cincinnati Reds have hit the 1st Five Innings (F5) Moneyline in 2 of their last 6 games (+0.45 Units / 7% ROI)

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 26-24 against the Run Line (+3.5 Units / 5.64% ROI).

  • 25-25 when betting on the Moneyline for -5.35 Units / -8.34% ROI
  • 26-23 when betting on the total runs Over for +1 Units / 1.83% ROI
  • 23-26 when betting on the total runs Under for -5.7 Units / -10.29% ROI

Reds Against the Spread (ATS) Record

Against the spread this season, the Reds are 26-21 against the Run Line (+3.45 Units / 5.47% ROI).

  • 19-28 when betting on the Moneyline for -10.15 Units / -18.34% ROI
  • 22-23 when betting on the total runs Over for -3.8 Units / -7.28% ROI
  • 23-22 when betting on the total runs Under for -1.25 Units / -2.44% ROI

Reds vs Padres Home Run Prop Bets Today

Over Under
Manny Machado (SD) 0.5 +250 0.5 -350
Fernando Tatis Jr. (SD) 0.5 +250 0.5 -300
Mike Ford (CIN) 0.5 +340 0.5 -450
Spencer Steer (CIN) 0.5 +375 0.5 -500
Tyler Stephenson (CIN) 0.5 +400 0.5 -550

Reds vs Padres Total Hits Prop Bets Today

Over Under
Manny Machado (SD) 0.5 -250 0.5 +190
Donovan Solano (SD) 0.5 -250 0.5 +190
Jurickson Profar (SD) 0.5 -225 0.5 +175
Luis Campusano (SD) 0.5 -225 0.5 +165
Elly De La Cruz (CIN) 0.5 -210 0.5 +160

Reds vs Padres RBI Prop Bets Today

Over Under
Manny Machado (SD) 0.5 +110 0.5 -145
Fernando Tatis Jr. (SD) 0.5 +120 0.5 -160
Spencer Steer (CIN) 0.5 +125 0.5 -165
Tyler Stephenson (CIN) 0.5 +145 0.5 -190
Mike Ford (CIN) 0.5 +145 0.5 -190

Reds vs Padres Strikeout Prop Bets Today

Over Under
Joe Musgrove (SD) 4.5 -120 4.5 -105
Andrew Abbott (CIN) 4.5 +105 4.5 -135

Opponents are hitting .461 (35-for-76) against Joe Musgrove in non-two strike counts this season — 2nd highest in MLB among starting pitchers with at least 17 total IP; League Avg: .320 — first Percentile.

Joe Musgrove has allowed an OPS of 1.011 (71 PA’s) when going through the lineup the second time in a game this season — highest in MLB among starting pitchers with at least 17 total IP; League Avg: .676 — 0 Percentile.

Joe Musgrove has located his fastball inside 47% of the time (318/671) since last season — 5th highest in MLB among starting pitchers with at least 82 total IP; League Avg: 34% — 97th Percentile.

Joe Musgrove has allowed a slugging percentage of .581 (54 Total Bases / 93 ABs) against right-handed batters this season — highest in MLB among starting pitchers with at least 17 total IP; League Avg: .388 — 0 Percentile.

Reds Starting Pitcher Stats & Trends

Andrew Abbott has walked 2 of 81 batters (3%) when going through the lineup the first time in a game this season — tied for 5th best among qualified SPs in MLB; League Avg: 7% — 95th Percentile.

Opponents have a groundball rate of just 22% (33/153) against Andrew Abbott’s curve and slider since last season — lowest in MLB among starting pitchers with at least 82 total IP; League Avg: 42% — 0 Percentile.

Andrew Abbott has allowed a slugging percentage of .595 (47 Total Bases / 79 ABs) when going through the lineup the first time in a game this season — 3rd highest among qualified SPs in MLB; League Avg: .379 — third Percentile.

Opponents have a groundball rate of just 28% (63/228) against Andrew Abbott on non-fastballs since last season — lowest in MLB among starting pitchers with at least 82 total IP; League Avg: 46% — 0 Percentile.

Padres Keys to the Game vs. the Reds

The Padres are just 7-19 (.269) after a win as underdogs since the 2023 season — lowest in MLB; League Avg: .424.

The Padres are just 19-34 (.358) after a win as underdogs since the 2022 season — 4th lowest in MLB; League Avg: .414.

The Padres are just 1-89 (.011) when trailing entering the 9th inning since the 2023 season — tied for 2nd lowest in MLB; League Avg: .053.

The Padres are just 4-150 (.026) when trailing entering the 9th inning since the 2022 season — 4th lowest in MLB; League Avg: .050.

Reds Keys to the Game vs. the Padres

The Reds are just 56-43 (.566) when they’ve hit 2 or more home runs since the 2022 season — lowest in MLB; League Avg: .698.

The Reds are just 80-104 (.435) at home since the 2022 season — 4th lowest in MLB; League Avg: .526.

The Reds are just 24-27 (.471) after a loss as favorites since the 2022 season — lowest in MLB; League Avg: .586.

The Reds are 22-9 (.710) after a win as favorites since the 2023 season — best in MLB; League Avg: .576.

The Padres are batting .287 on the road this season — best in MLB; League Avg: .239.

Padres hitters have just 267 strikeouts in 1,382 PA’s (19%) against RHP this season — 4th best in MLB; League Avg: 22%.

Games involving the Padres went UNDER in 73% of their games (39.5% ROI) when moneyline underdogs of +150 or more since the 2022 season — highest in MLB; League Avg: 49%.

Padres hitters have an OPS of .753 (1,382 PA’s) against RHP this season — 4th best in MLB; League Avg: .699.

The Reds are batting just .129 with two-strikes this season — lowest in MLB; League Avg: .168.

The Reds are batting just .107 on pitches out of the zone this season — 2nd lowest in MLB; League Avg: .154.

The Reds are batting just .166 on breaking pitches this season — lowest in MLB; League Avg: .221.

The Reds are batting just .217 this season — tied for lowest in MLB; League Avg: .240.

Padres pitchers have a strikeout rate of 24% this season — 5th best in MLB; League Avg: 22%.

Padres pitchers have a strikeout rate of 29% over the last 14 days — best in MLB; League Avg: 22%.

Padres pitchers have a strikeout rate of 48% with two-strikes over the last 14 days — best in MLB; League Avg: 41%.

Opponents have a groundball batting average of just .199 against Padres pitchers with the shift since the 2022 season — 2nd best in MLB; League Avg: .231.

Opponents have a groundball rate of just 39% against Reds pitchers since last season — tied for lowest in MLB; League Avg: 43%.

Opponents have a groundball batting average of .297 against Reds pitchers with runners on base since the 2022 season — highest in MLB; League Avg: .253.

Opponents have a groundball rate of just 40% against Reds pitchers since the 2022 season — lowest in MLB; League Avg: 43%.

Opponents have a groundball rate of just 38% against Reds pitchers this season — 2nd lowest in MLB; League Avg: 43%.

Reds vs. Padres Injuries Tonight That May Affect Prop Bets 

  • Austin Wynns (Cincinnati Reds): Shoulder, Day-To-Day
  • Sam Moll (Cincinnati Reds): Shoulder, 15-Day IL
  • Noelvi Marte (Cincinnati Reds): Suspension, Suspension
  • Matt McLain (Cincinnati Reds): Shoulder, 60-Day IL
  • Joey Votto (Cincinnati Reds): Ankle, Out
  • Nick Lodolo (Cincinnati Reds): Calf, 15-Day IL
  • TJ Friedl (Cincinnati Reds): Wrist, 10-Day IL
  • Reiver Sanmartin (Cincinnati Reds): Elbow, Out
  • Alex Young (Cincinnati Reds): Back, 15-Day IL
  • Ian Gibaut (Cincinnati Reds): Forearm, 15-Day IL
  • Brandon Williamson (Cincinnati Reds): Shoulder, 15-Day IL
  • Connor Overton (Cincinnati Reds): Elbow, Out
  • Glenn Otto (San Diego Padres): Shoulder, 15-Day IL
  • Reiss Knehr (San Diego Padres): Elbow, Out
  • Drew Carlton (San Diego Padres): Elbow, Out
  • Luis Patino (San Diego Padres): Elbow, 15-Day IL
  • Tucupita Marcano (San Diego Padres): Knee, 10-Day IL

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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.