Padres vs Tigers Prediction, Odds & Player Prop Bets Today – MLB, Apr 21

Detroit Tigers' Spencer Torkelson celebrates his three-run home run against the Kansas City Royals in the seventh inning of a baseball game, Thursday, Sept. 28, 2023, in Detroit.
(AP Photo/Paul Sancya)
  • The Tigers are -130 favorites vs the Padres
  • Padres vs Tigers Over / Under today: 8 Runs
  • Padres / Tigers TV Channel: FS1 | PDTV | FDDX

The San Diego Padres (+120) visit Comerica Park to take on the Detroit Tigers (-145) on Monday, April 21, 2025. First pitch is scheduled for 6:40pm EDT in Detroit, MI, MI.

This season, the Padres are 16-6 against the spread (ATS), while the Tigers are 14-8 ATS.

Padres vs Tigers Starting Pitchers Today:

  • Padres starting pitcher: Randy Vasquez 1-1, 1.74 ERA
  • Tigers starting pitcher: Keider Montero 0-1, 9.01 ERA

Padres vs. Tigers Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Padres+1.5 -175O 8 -110+120
Tigers -1.5 +145U 8 -110-145

Padres vs Tigers Prediction for Today’s Game

Based on recent trends the model predicts the Tigers will win Monday‘s MLB game with 52.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Padres players for Monday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Bets Today:

  • Fernando Tatis Jr. has hit the Home Runs Over in 5 of his last 9 games (+12.10 Units / 134% ROI)
  • Fernando Tatis Jr. has hit the RBIs Over in 12 of his last 20 games (+11.85 Units / 59% ROI)
  • Randy Vasquez has hit the Strikeouts Under in 16 of his last 20 games (+11.50 Units / 41% ROI)
  • Fernando Tatis Jr. has hit the Hits Over in 14 of his last 20 games (+11.20 Units / 35% ROI)
  • Fernando Tatis Jr. has hit the Hits Runs and RBIs Over in 18 of his last 25 games (+9.70 Units / 31% ROI)

And here are some favorite MLB player prop bets for Tigers players for Monday‘s game, looking at profitable historical betting trends:

Best Tigers Player Prop Best Bets Today:

  • Spencer Torkelson has hit the Total Bases Over in 20 of his last 25 games at home (+15.95 Units / 46% ROI)
  • Spencer Torkelson has hit the Hits Over in 21 of his last 25 games at home (+14.60 Units / 34% ROI)
  • Spencer Torkelson has hit the Home Runs Over in 4 of his last 9 games (+13.70 Units / 152% ROI)
  • Spencer Torkelson has hit the RBIs Over in 10 of his last 15 games (+11.55 Units / 77% ROI)
  • Spencer Torkelson has hit the Runs Over in 13 of his last 20 games (+11.40 Units / 57% ROI)
  • The San Diego Padres have hit the Moneyline in 102 of their last 168 games (+21.70 Units / 9% ROI)
  • The San Diego Padres have covered the Run Line in 88 of their last 168 games (+8.15 Units / 4% ROI)
  • The San Diego Padres have covered the 1st Five Innings (F5) Run Line in 14 of their last 20 games (+7.25 Units / 31% ROI)
  • The San Diego Padres have hit the 1st Five Innings (F5) Moneyline in 12 of their last 19 games (+5.40 Units / 20% ROI)
  • The San Diego Padres have hit the Team Total Over in 13 of their last 22 games (+3.40 Units / 14% ROI)
  • The Detroit Tigers have covered the Run Line in 98 of their last 170 games (+18.95 Units / 8% ROI)
  • The Detroit Tigers have hit the Moneyline in 92 of their last 170 games (+10.80 Units / 5% ROI)
  • The Detroit Tigers have hit the Game Total Under in 44 of their last 82 games at home (+6.80 Units / 8% ROI)
  • The Detroit Tigers have hit the 1st Five Innings (F5) Moneyline in 42 of their last 82 games at home (+6.75 Units / 6% ROI)
  • The Detroit Tigers have covered the 1st Five Innings (F5) Run Line in 45 of their last 82 games at home (+3.35 Units / 3% ROI)

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 14-8 against the Run Line (+6.05 Units / 21.49% ROI).

  • 16-6 when betting on the Moneyline for +10.1 Units / 34.41% ROI
  • 9-12 when betting on the total runs Over for -4 Units / -16.74% ROI
  • 12-9 when betting on the total runs Under for +1.8 Units / 7.33% ROI

Tigers Against the Spread (ATS) Record

Against the spread this season, the Tigers are 14-8 against the Run Line (+5.35 Units / 18.38% ROI).

  • 13-9 when betting on the Moneyline for +3.75 Units / 12.78% ROI
  • 9-11 when betting on the total runs Over for -3.1 Units / -12.68% ROI
  • 11-9 when betting on the total runs Under for +1.4 Units / 5.83% ROI

Tigers vs Padres Home Run Prop Bets Today

Over Under
Fernando Tatis Jr. (SD) 0.5 +280 0.5 -350
Manny Machado (SD) 0.5 +425 0.5 -600
Kerry Carpenter (DET) 0.5 +500 0.5 -700
Spencer Torkelson (DET) 0.5 +500 0.5 -700
Dillon Dingler (DET) 0.5 +675 0.5 -1100

Tigers vs Padres Total Hits Prop Bets Today

Over Under
Gleyber Torres (DET) 0.5 -250 0.5 +180
Manny Machado (SD) 0.5 -250 0.5 +190
Jose Iglesias (SD) 0.5 -250 0.5 +190
Zach McKinstry (DET) 0.5 -235 0.5 +180
Riley Greene (DET) 0.5 -225 0.5 +170

Tigers vs Padres RBI Prop Bets Today

Over Under
Manny Machado (SD) 0.5 +130 0.5 -175
Fernando Tatis Jr. (SD) 0.5 +135 0.5 -185
Spencer Torkelson (DET) 0.5 +140 0.5 -190
Riley Greene (DET) 0.5 +165 0.5 -220
Kerry Carpenter (DET) 0.5 +180 0.5 -235

Tigers vs Padres Strikeout Prop Bets Today

Over Under
Keider Montero (DET) 3.5 -160 3.5 +125

Randy Vasquez has struck out just 7% (17/242) of left-handed batters he faced since last season — lowest in MLB among starting pitchers with at least 72 total IP; League Avg: 22% — 0 Percentile.

Randy Vasquez struck out just 8% (16/198) of left-handed batters he faced in the 2024 season — 2nd lowest in MLB among starting pitchers with at least 64 total IP; League Avg: 22% — first Percentile.

Left-handed hitters had a line drive rate of 34% (56/163) against Randy Vasquez in the 2024 season — highest in MLB among starting pitchers with at least 64 total IP; League Avg: 24% — first Percentile.

Randy Vasquez has struck out just 8% (27/322) of left-handed batters he faced since the 2023 season — lowest in MLB among starting pitchers with at least 137 total IP; League Avg: 22% — 0 Percentile.

Tigers Starting Pitcher Stats & Trends

Opponents have a line drive rate of just 14% (18/130) against Keider Montero on breaking pitches since last season — 2nd lowest in MLB among starting pitchers with at least 72 total IP; League Avg: 23% — 99th Percentile.

Opponents had a line drive rate of just 14% (18/126) versus Keider Montero on breaking pitches in the 2024 season — 2nd lowest in MLB among starting pitchers with at least 64 total IP; League Avg: 24% — 99th Percentile.

Keider Montero has allowed a slugging percentage of .485 (194 Total Bases / 400 ABs) since last season — 15th highest in MLB among starting pitchers with at least 72 total IP; League Avg: .402 — eighth Percentile.

Opponents have a line drive rate of 32% (48/151) against Keider Montero on fastballs since last season — tied for highest in MLB among starting pitchers with at least 72 total IP; League Avg: 24% — first Percentile.

Padres Keys to the Game vs. the Tigers

The Padres are 2-4 (.333) when trailing entering the 7th inning this season — tied for best in MLB; League Avg: .116.

The Padres are 12-1 (.923) at home this season — best in MLB; League Avg: .602.

The Padres are 16-6 (.727) this season — best in MLB; League Avg: .500.

The Padres were 48-33 (.593) on the road in the 2024 season — 2nd best in MLB; League Avg: .478.

Tigers Keys to the Game vs. the Padres

The Tigers are 1-8 (.111) when trailing entering the 9th inning this season — tied for 3rd best in MLB; League Avg: .034.

The Tigers were 18-54 (.250) when trailing entering the 7th inning in the 2024 season — best in MLB; League Avg: .143.

The Tigers are 14-62 (.184) when trailing entering the 8th inning since last season — best in MLB; League Avg: .097.

The Tigers were 13-55 (.191) when trailing entering the 8th inning in the 2024 season — best in MLB; League Avg: .100.

Padres hitters struck out just 278 times in 1,617 PA’s (17%) against LHP in the 2024 season — best in MLB; League Avg: 23%.

Padres hitters have struck out in just 17% of it’s PA’s this season — best in MLB; League Avg: 22%.

Padres hitters struck out in just 18% of it’s PA’s in the 2024 season — best in MLB; League Avg: 23%.

The Padres are batting .275 on the road since last season — best in MLB; League Avg: .240.

Tigers hitters are slugging just .380 against LHP since the 2023 season — 2nd lowest in MLB; League Avg: .406.

Tigers hitters have an OPS of just .686 (3,052 PA’s) against LHP since the 2023 season — 2nd lowest in MLB; League Avg: .724.

Tigers hitters have an OPS of just .665 (1,679 PA’s) against LHP since last season — 5th lowest in MLB; League Avg: .707.

The Tigers are batting just .130 on pitches out of the zone since last season — 3rd lowest in MLB; League Avg: .149.

The Padres pitchers have allowed an average Exit Velocity of just 88.2 MPH since the 2023 season (8,398 balls in play) — best in MLB; League Avg: 88.9

Opponents had a groundball rate of 45% against Padres pitchers in 2023 — 3rd highest in MLB; League Avg: 43%.

Padres pitchers have allowed a slugging percentage of just .316 this season — 2nd best in MLB; League Avg: .387.

The Padres have allowed 0.36 runs per game (8/22) in late innings this season — best in MLB; League Avg: 1.30.

Tigers pitchers walked 416 of 5,969 batters (7%) in the 2024 season — 2nd best in MLB; League Avg: 8%.

Tigers pitchers have walked 7% of batters since last season — tied for 2nd best in MLB; League Avg: 8%.

Tigers pitchers had an ERA of 2.93 (464.0 IP) against division opponents in 2023 — best in MLB; League Avg: 4.32.

Tigers pitchers had an ERA of 3.63 (1447.0 IP) in the 2024 season — 4th best in MLB; League Avg: 4.08.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.