Red Sox vs Guardians Prediction, Odds & Player Prop Bets Today – MLB, Apr 25

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Cleveland Guardians' Josh Naylor runs the base path during a spring training baseball game against the San Diego Padres, Monday, Feb. 26, 2024, in Peoria, Ariz.
(AP Photo/Lindsey Wasson)
BetMGM Betting @BETMGM Apr 25, 2024, 12:17 PM
  • The Guardians are -160 favorites vs the Red Sox
  • Red Sox vs Guardians Over / Under today: 7.5 Runs
  • Red Sox / Guardians TV Channel: BSGL | NESN | MLBN

The Boston Red Sox (+115) visit Progressive Field to take on the Cleveland Guardians (-135) on Thursday, April 25, 2024. First pitch is scheduled for 1:10pm EDT in Cleveland, OH.

This season, the Red Sox are 14-11 against the spread (ATS), while the Guardians are 16-8 ATS.

Red Sox vs Guardians Starting Pitchers Today:

  • Red Sox starting pitcher: Chase Anderson 0-0, 2.77 ERA
  • Guardians starting pitcher: Triston McKenzie 2-2, 4.91 ERA

Red Sox vs. Guardians Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Red Sox+1.5 -190O 7.5 -115+115
Guardians -1.5 +155U 7.5 -105-135

Red Sox vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Thursday‘s MLB game with 55.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Red Sox players for Thursday‘s game, looking at profitable historical betting trends:

  • The Boston Red Sox have hit the Game Total Under in 15 of their last 19 games (+10.60 Units / 50% ROI)
  • The Boston Red Sox have hit the 1st Five Innings (F5) Team Total Under in 37 of their last 66 away games (+7.03 Units / 9% ROI)
  • The Boston Red Sox have hit the Team Total Under in 34 of their last 61 away games (+5.05 Units / 7% ROI)
  • The Boston Red Sox have covered the 1st Five Innings (F5) Run Line in 5 of their last 7 away games (+2.95 Units / 38% ROI)
  • The Boston Red Sox have hit the 1st Five Innings (F5) Moneyline in 3 of their last 6 away games (+1.53 Units / 24% ROI)
  • The Cleveland Guardians have hit the Game Total Under in 46 of their last 71 games at home (+19.80 Units / 26% ROI)
  • The Cleveland Guardians have covered the Run Line in 64 of their last 120 games (+6.20 Units / 4% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Over in 20 of their last 34 games (+4.72 Units / 12% ROI)
  • The Cleveland Guardians have hit the Moneyline in 35 of their last 62 games at home (+4.25 Units / 5% ROI)

Red Sox Against the Spread (ATS) Record

Against the spread this season, the Red Sox are 15-10 against the Run Line (+0 Units / 0% ROI).

  • 14-11 when betting on the Moneyline for +0 Units / 0% ROI
  • 10-13 when betting on the total runs Over for +0 Units / 0% ROI
  • 13-10 when betting on the total runs Under for +0 Units / 0% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 16-8 against the Run Line (+0 Units / 0% ROI).

  • 17-7 when betting on the Moneyline for +0 Units / 0% ROI
  • 14-8 when betting on the total runs Over for +0 Units / 0% ROI
  • 8-14 when betting on the total runs Under for +0 Units / 0% ROI

Guardians vs Red Sox Home Run Prop Bets Today

Over Under
Rafael Devers (BOS) 0.5 +360 0.5 -500
Tyler O'Neill (BOS) 0.5 +475 0.5 -650
Wilyer Abreu (BOS) 0.5 +625 0.5 -1000
Enmanuel Valdez (BOS) 0.5 +650 0.5 -1000
Josh Naylor (CLE) 0.5 +675 0.5 -1100

Guardians vs Red Sox Total Hits Prop Bets Today

Over Under
Steven Kwan (CLE) 0.5 -250 0.5 +190
Jarren Duran (BOS) 0.5 -250 0.5 +180
Josh Naylor (CLE) 0.5 -210 0.5 +155
Jose Ramirez (CLE) 0.5 -210 0.5 +155
Rafael Devers (BOS) 0.5 -210 0.5 +160

Guardians vs Red Sox RBI Prop Bets Today

Over Under
Rafael Devers (BOS) 0.5 +150 0.5 -200
Josh Naylor (CLE) 0.5 +160 0.5 -210
Tyler O'Neill (BOS) 0.5 +170 0.5 -225
Jose Ramirez (CLE) 0.5 +175 0.5 -250
Masataka Yoshida (BOS) 0.5 +200 0.5 -275

Guardians vs Red Sox Strikeout Prop Bets Today

Over Under

Chase Anderson has a first-pitch strike rate of 74% (37/50) this season — 5th highest among qualified RPs in MLB; League Avg: 61% — 96th Percentile.

Chase Anderson has a strike rate of 70% (40/57) in two strike counts this season — tied for 9th highest among qualified RPs in MLB; League Avg: 64% — 92nd Percentile.

Right-handed hitters have a groundball rate of just 22% (5/23) against Chase Anderson this season — 6th lowest among qualified RPs in MLB; League Avg: 45% — fourth Percentile.

Chase Anderson has struck out just 11% (3/27) of right-handed batters he faced this season — tied for 7th lowest among in MLB; League Avg: 23% — ninth Percentile.

Guardians Starting Pitcher Stats & Trends

Triston McKenzie has walked 15 of 83 batters (18%) this season — 5th highest in MLB among starting pitchers with at least 9 total IP; League Avg: 8% — third Percentile.

Triston McKenzie has not struck out any hitters in 24 PA’s in PAs ending on elevated fastballs this season — tied for lowest in MLB among starting pitchers with at least 9 total IP; League Avg: 24% — second Percentile.

Triston McKenzie has walked 11 of 53 batters (21%) versus hitters not batting 3-4-5 in the order this season — 2nd highest in MLB among starting pitchers with at least 9 total IP; League Avg: 8% — first Percentile.

Triston McKenzie has allowed an OBP of .415 (41 PA’s) with two-strikes this season — highest in MLB among starting pitchers with at least 9 total IP; League Avg: .246 — 0 Percentile.

Red Sox Keys to the Game vs. the Guardians

The Red Sox are 35-38 (.479) after a win as underdogs since the 2022 season — 5th best in MLB; League Avg: .412.

The Red Sox are just 3-148 (.020) when trailing entering the 9th inning since the 2022 season — 3rd lowest in MLB; League Avg: .049.

The Red Sox are just 40-52 (.435) after a home loss since the 2022 season — tied for 4th lowest in MLB; League Avg: .518.

The Red Sox are just 19-31 (.380) after a home loss since the 2023 season — 3rd lowest in MLB; League Avg: .512.

Guardians Keys to the Game vs. the Red Sox

The Guardians are 24-127 (.159) when trailing entering the 8th inning since the 2022 season — 2nd best in MLB; League Avg: .093.

The Guardians are 8-77 (.094) when trailing entering the 9th inning since the 2023 season — 2nd best in MLB; League Avg: .052.

The Guardians are just 9-16 (.360) when tied entering the 7th inning since the 2023 season — 2nd lowest in MLB; League Avg: .500.

The Guardians are 35-120 (.226) when trailing entering the 7th inning since the 2022 season — best in MLB; League Avg: .132.

Red Sox hitters are slugging .826 on the first pitch of at-bats this season — 2nd best in MLB; League Avg: .561.

Red Sox hitters have 74 strikeouts in 244 PA’s (30%) against LHP this season — highest in MLB; League Avg: 22%.

Red Sox hitters have an OBP of .332 (3,369 PA’s) against LHP since the 2022 season — 5th best in MLB; League Avg: .319.

The Red Sox are batting .294 when facing the starting pitcher for the 3rd time in a game since last season — 2nd best in MLB; League Avg: .267.

Guardians hitters have missed on just 22% of swings since the 2022 season — best in MLB; League Avg: 26%.

Guardians hitters have put 46% of balls in play to the right side of the field this season — highest in MLB; League Avg: 37%.

Guardians hitters have put just 34% of balls in play to the left side of the field since last season — lowest in MLB; League Avg: 39%.

Guardians hitters have just 2,446 strikeouts in 13,181 PA’s (19%) since the 2022 season — best in MLB; League Avg: 23%.

Red Sox pitchers have an ERA of 1.54 (134.1 IP) on the road this season — best in MLB; League Avg: 3.98.

Red Sox pitchers have walked 65 of 938 batters (7%) this season — 3rd best in MLB; League Avg: 9%.

Red Sox pitchers have an ERA of 3.85 (834.1 IP) on the road since last season — 3rd best in MLB; League Avg: 4.38.

Red Sox pitchers have walked 10 of 228 batters (4%) when facing the leadoff batter in the inning this season — tied for 2nd best in MLB; League Avg: 8%.

Guardians pitchers have a strikeout rate of 29% with runners in scoring position this season — best in MLB; League Avg: 21%.

Opponents have a miss rate of 30% against Guardians pitchers this season — best in MLB; League Avg: 25%.

Opponents have a groundball batting average of just .175 against Guardians pitchers with runners on base this season — best in MLB; League Avg: .260.

Guardians pitchers have a strikeout rate of 25% this season — 3rd best in MLB; League Avg: 22%.

Guardians vs. Red Sox Injuries Tonight That May Affect Prop Bets 

  • Daniel Espino (Cleveland Guardians): Shoulder, Out
  • Gavin Williams (Cleveland Guardians): Elbow, 15-Day IL
  • Ben Lively (Cleveland Guardians): Illness, 15-Day IL
  • Luis Ortiz (Cleveland Guardians): Ankle, 15-Day IL
  • Xzavion Curry (Cleveland Guardians): Illness, 15-Day IL
  • Joey Cantillo (Cleveland Guardians): Hamstring, Out
  • Angel Martinez (Cleveland Guardians): Foot, 10-Day IL
  • Sam Hentges (Cleveland Guardians): Finger, 15-Day IL
  • Trevor Stephan (Cleveland Guardians): Elbow, 60-Day IL
  • George Valera (Cleveland Guardians): Hamstring, Out
  • James Karinchak (Cleveland Guardians): Shoulder, 60-Day IL
  • Wyatt Mills (Boston Red Sox): Elbow, 60-Day IL
  • Vaughn Grissom (Boston Red Sox): Hamstring, 10-Day IL
  • Michael Fulmer (Boston Red Sox): Elbow, 60-Day IL
  • Zack Kelly (Boston Red Sox): Oblique, Day-To-Day
  • Bryan Mata (Boston Red Sox): Hamstring, 15-Day IL
  • Chris Murphy (Boston Red Sox): Elbow, 60-Day IL
  • Kenley Jansen (Boston Red Sox): Back, Day-To-Day
  • Brandon Walter (Boston Red Sox): Shoulder, 7-Day IL
  • Lucas Giolito (Boston Red Sox): Elbow, 60-Day IL
  • Rob Refsnyder (Boston Red Sox): Toe, 10-Day IL
  • Yu Chang (Boston Red Sox): Oblique, Out

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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.