Red Sox vs Guardians Prediction, Odds & Player Prop Bets Today – MLB, Apr 26

Cleveland Guardians' Steven Kwan tosses his bat after walking against the New York Yankees during the first inning in Game 4 of the baseball AL Championship Series Friday, Oct. 18, 2024, in Cleveland. (AP Photo/Sue Ogrocki)
  • The Red Sox are -115 favorites vs the Guardians
  • Red Sox vs Guardians Over / Under today: 8 Runs
  • Red Sox / Guardians TV Channel: GDTV | NESN

The Boston Red Sox (-115) visit Progressive Field to take on the Cleveland Guardians (-105) on Saturday, April 26, 2025. First pitch is scheduled for 6:10pm EDT in Cleveland, OH, OH.

This season, the Red Sox are 14-13 against the spread (ATS), while the Guardians are 13-11 ATS.

Red Sox vs Guardians Starting Pitchers Today:

  • Red Sox starting pitcher: Tanner Houck 0-2, 7.67 ERA
  • Guardians starting pitcher: Ben Lively 1-2, 3.91 ERA

Red Sox vs. Guardians Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Red Sox-1.5 +150O 7.5 -102-115
Guardians +1.5 -185U 7.5 -118-105

Red Sox vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Red Sox will win Saturday‘s MLB game with 51.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Red Sox players for Saturday‘s game, looking at profitable historical betting trends:

Best Red Sox Player Prop Bets Today:

  • Carlos Narvaez has hit the Home Runs Over in 2 of his last 5 games (+17.50 Units / 350% ROI)
  • Rafael Devers has hit the Hits Under in 17 of his last 25 away games (+17.40 Units / 66% ROI)
  • Rafael Devers has hit the Total Bases Under in 20 of his last 25 away games (+16.15 Units / 49% ROI)
  • Rafael Devers has hit the Runs Under in 21 of his last 25 away games (+14.55 Units / 40% ROI)
  • Rafael Devers has hit the Hits Runs and RBIs Under in 20 of his last 25 away games (+13.95 Units / 47% ROI)

And here are some favorite MLB player prop bets for Guardians players for Saturday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

  • Kyle Manzardo has hit the Home Runs Over in 4 of his last 10 games (+17.00 Units / 170% ROI)
  • Nolan Jones has hit the Runs Under in 18 of his last 20 games (+14.55 Units / 40% ROI)
  • Steven Kwan has hit the Singles Over in 16 of his last 20 games (+10.25 Units / 35% ROI)
  • Nolan Jones has hit the Hits Runs and RBIs Under in 12 of his last 15 games (+8.10 Units / 38% ROI)
  • Steven Kwan has hit the Hits Over in his last 7 games at home (+8.00 Units / 53% ROI)
  • The Boston Red Sox have hit the Team Total Under in 13 of their last 17 games (+8.00 Units / 36% ROI)
  • The Boston Red Sox have hit the 1st Five Innings (F5) Moneyline in 13 of their last 22 games (+5.80 Units / 16% ROI)
  • The Boston Red Sox have covered the 1st Five Innings (F5) Run Line in 7 of their last 9 games (+4.55 Units / 39% ROI)
  • The Boston Red Sox have hit the 1st Five Innings (F5) Team Total Under in 5 of their last 6 away games (+4.00 Units / 45% ROI)
  • The Boston Red Sox have hit the Game Total Under in 15 of their last 27 games (+2.95 Units / 10% ROI)
  • The Cleveland Guardians have hit the Moneyline in 11 of their last 15 games (+7.95 Units / 42% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Over in 15 of their last 24 games (+5.35 Units / 18% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Moneyline in 9 of their last 14 games (+4.50 Units / 26% ROI)
  • The Cleveland Guardians have covered the Run Line in 9 of their last 13 games (+4.30 Units / 23% ROI)
  • The Cleveland Guardians have hit the Team Total Under in 13 of their last 21 games (+4.30 Units / 17% ROI)

Red Sox Against the Spread (ATS) Record

Against the spread this season, the Red Sox are 13-14 against the Run Line (-1.1 Units / -3.18% ROI).

  • 14-13 when betting on the Moneyline for -4.85 Units / -11.59% ROI
  • 11-15 when betting on the total runs Over for -5.25 Units / -17.8% ROI
  • 15-11 when betting on the total runs Under for +2.95 Units / 9.87% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 13-11 against the Run Line (+0.1 Units / 0.29% ROI).

  • 14-10 when betting on the Moneyline for +4.8 Units / 16.55% ROI
  • 11-11 when betting on the total runs Over for -0.7 Units / -2.69% ROI
  • 11-11 when betting on the total runs Under for -1.05 Units / -3.92% ROI

Guardians vs Red Sox Home Run Prop Bets Today

Over Under
Wilyer Abreu (BOS) 0.5 +425 0.5 -600
Rafael Devers (BOS) 0.5 +425 0.5 -600
Alex Bregman (BOS) 0.5 +500 0.5 -750
Trevor Story (BOS) 0.5 +575 0.5 -900
Kyle Manzardo (CLE) 0.5 +600 0.5 -900

Guardians vs Red Sox Total Hits Prop Bets Today

Over Under
Alex Bregman (BOS) 0.5 -225 0.5 +170
Nolan Jones (CLE) 0.5 -210 0.5 +155
Trevor Story (BOS) 0.5 -200 0.5 +150
Rafael Devers (BOS) 0.5 -190 0.5 +145
Kyle Manzardo (CLE) 0.5 -175 0.5 +135

Guardians vs Red Sox RBI Prop Bets Today

Over Under
Jose Ramirez (CLE) 0.5 +145 0.5 -200
Kyle Manzardo (CLE) 0.5 +150 0.5 -200
Alex Bregman (BOS) 0.5 +155 0.5 -200
Rafael Devers (BOS) 0.5 +170 0.5 -225
Wilyer Abreu (BOS) 0.5 +185 0.5 -250

Guardians vs Red Sox Strikeout Prop Bets Today

Over Under
Ben Lively (CLE) 4.5 -110 4.5 -115
Tanner Houck (BOS) 4.5 -110 4.5 -118

Walker Buehler has located his sliders away 85% of the time (59/69) this season — highest among among AL Starters; League Avg: 54% — 100th Percentile.

Tanner Houck has allowed a .520 SLG this season — tied for sixth worst among qualified SPs– sixth Percentile. He allowed a SLG of just .320 last season — fourth best among qualified SPs– 94th Percentile.

Walker Buehler has walked 28% of batters when going through the lineup the second time in a game over the last 14 days — highest among AL Starters over the last two weeks; League Avg: 8% — second Percentile.

Opponents had a groundball rate of 56% (293/524) against Tanner Houck in the 2024 season — 5th highest among qualified SPs in MLB; League Avg: 43% — 93rd Percentile.

Guardians Starting Pitcher Stats & Trends

Ben Lively has induced opposing hitters to ground into 5 double plays in 17 opportunities (29%) this season — 2nd best among qualified SPs in MLB; League Avg: 10% — 98th Percentile.

Right-handed hitters have a miss rate of just 15% (16/104) against Ben Lively this season — 4th lowest among qualified SPs in MLB; League Avg: 26% — fifth Percentile.

14 of Ben Lively’s 44 breaking pitch strikeouts (32%) have been backdoor since last season — 2nd highest in MLB among starting pitchers with at least 74 total IP; League Avg: 14% — 99th Percentile.

Opponents have a miss rate of just 3% (1/36) against Ben Lively with runners in scoring position this season — lowest among qualified SPs in MLB; League Avg: 27% — first Percentile.

Red Sox Keys to the Game vs. the Guardians

The Red Sox are 7-0 (1.000) when they’ve had 10 or more hits this season — tied for best in MLB; League Avg: .747.

The Red Sox were just 5-58 (.079) when trailing entering the 7th inning in the 2024 season — 3rd lowest in MLB; League Avg: .143.

The Red Sox are just 14-139 (.092) when trailing entering the 7th inning since the 2023 season — 3rd lowest in MLB; League Avg: .140.

The Red Sox are 55-11 (.833) when they’ve had 10 or more hits since last season — tied for 3rd best in MLB; League Avg: .749.

Guardians Keys to the Game vs. the Red Sox

The Guardians were 82-0 (1.000) when leading entering the 9th inning in the 2024 season — best in MLB; League Avg: .949.

The Guardians are 95-0 (1.000) when leading entering the 9th inning since last season — best in MLB; League Avg: .950.

The Guardians were just 3-61 (.047) when trailing entering the 8th inning in the 2024 season — 2nd lowest in MLB; League Avg: .100.

The Guardians were 77-2 (.975) when leading entering the 8th inning in the 2024 season — best in MLB; League Avg: .899.

Red Sox hitters struck out 506 times in 1,816 PA’s (28%) against LHP in the 2024 season — highest in MLB; League Avg: 23%.

The Red Sox batted .182 on pitches out of the zone in 2023 — best in MLB; League Avg: .151.

The Red Sox batted .300 when facing the starting pitcher for the 3rd time in a game in 2023 — 2nd best in MLB; League Avg: .267.

Red Sox hitters are averaging 4.30 pitches per plate appearance against LHP this season — highest in MLB; League Avg: 3.91.

Guardians hitters slugged just .367 against LHP in the 2023 season — lowest in MLB; League Avg: .419.

Guardians hitters have put 41% of balls in play to the right side of the field since the 2023 season — highest in MLB; League Avg: 37%.

The Guardians batted just .232 against LHP in the 2023 season — tied for lowest in MLB; League Avg: .254.

Guardians hitters struck out just 351 times in 1,910 PA’s (18%) against LHP in 2023 — 3rd best in MLB; League Avg: 23%.

Red Sox pitchers walked 98 of 1,456 batters (7%) when facing the leadoff batter in the inning in the 2024 season — tied for 5th best in MLB; League Avg: 7%.

Opponents had a miss rate of just 24% against Red Sox pitchers in the 2024 season — tied for 2nd lowest in MLB; League Avg: 25%.

Opponents have a groundball rate of 47% against Red Sox pitchers this season — 5th highest in MLB; League Avg: 43%.

Opponents have a miss rate of just 24% against Red Sox pitchers since last season — tied for 2nd lowest in MLB; League Avg: 25%.

Opponents had a groundball batting average of just .207 against Guardians pitchers with runners on base in the 2024 season — best in MLB; League Avg: .262.

The Guardians allowed 0.87 runs per game (140/161) in late innings in the 2024 season — best in MLB; League Avg: 1.29.

Opponents have a groundball batting average of just .213 against Guardians pitchers with runners on base since last season — best in MLB; League Avg: .263.

Opponents had a groundball batting average of just .223 against Guardians pitchers in the 2024 season — best in MLB; League Avg: .249.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.