Red Sox vs Pirates Prediction, Odds & Player Prop Bets Today – MLB, Apr 21

Pirates player Andrew McCutchen smiling while running.
(AP Photo/Charles Rex Arbogast)
  • The Pirates are -150 favorites vs the Red Sox
  • Red Sox vs Pirates Over / Under today: 8.5 Runs
  • Red Sox / Pirates TV Channel: NESN | SNPT

The Boston Red Sox (+125) visit PNC Park to take on the Pittsburgh Pirates (-150) on Sunday, April 21, 2024. First pitch is scheduled for 1:35pm EDT in Pittsburgh, PA.

This season, the Red Sox are 12-10 against the spread (ATS), while the Pirates are 12-9 ATS.

Red Sox vs Pirates Starting Pitchers Today:

  • Red Sox starting pitcher: Josh Winckowski 1-1, 4.50 ERA
  • Pirates starting pitcher: Martin Perez 1-0, 2.56 ERA

Red Sox vs. Pirates Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Red Sox+1.5 -160O 8.5 -110+125
Pirates -1.5 +135U 8.5 -110-150

Red Sox vs Pirates Prediction for Today’s Game

Based on recent trends the model predicts the Pirates will win Sunday‘s MLB game with 55.3% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Red Sox players for Sunday‘s game, looking at profitable historical betting trends:

Best Red Sox Player Prop Bets Today:

  • Pablo Reyes has hit the Hits Under in 11 of his last 18 games (+8.70 Units / 48% ROI)
  • Pablo Reyes has hit the Total Bases Under in 10 of his last 13 games (+7.65 Units / 40% ROI)
  • Pablo Reyes has hit the Hits Runs and RBIs Under in 13 of his last 18 games (+6.35 Units / 26% ROI)
  • Brayan Bello has hit the Pitching Outs Over in 16 of his last 25 games (+6.10 Units / 20% ROI)
  • David Hamilton has hit the Hits Under in 12 of his last 19 games (+5.85 Units / 29% ROI)

And here are some favorite MLB player prop bets for Pirates players for Sunday‘s game, looking at profitable historical betting trends:

Best Pirates Player Prop Best Bets Today:

  • Henry Davis has hit the Hits Runs and RBIs Under in 15 of his last 19 games (+10.50 Units / 40% ROI)
  • Henry Davis has hit the Total Bases Under in 11 of his last 13 games at home (+8.10 Units / 38% ROI)
  • Henry Davis has hit the Hits Under in 7 of his last 11 games at home (+5.15 Units / 47% ROI)
  • Alika Williams has hit the Total Bases Over in 6 of his last 7 games (+5.00 Units / 62% ROI)
  • Alika Williams has hit the Hits Over in 6 of his last 7 games (+4.95 Units / 61% ROI)
  • The Boston Red Sox have hit the Game Total Under in 15 of their last 19 games (+10.60 Units / 50% ROI)
  • The Boston Red Sox have hit the 1st Five Innings (F5) Team Total Under in 37 of their last 66 away games (+7.03 Units / 9% ROI)
  • The Boston Red Sox have hit the Team Total Under in 34 of their last 61 away games (+5.05 Units / 7% ROI)
  • The Boston Red Sox have covered the 1st Five Innings (F5) Run Line in 5 of their last 7 away games (+2.95 Units / 38% ROI)
  • The Boston Red Sox have hit the 1st Five Innings (F5) Moneyline in 3 of their last 6 away games (+1.53 Units / 24% ROI)
  • The Pittsburgh Pirates have hit the Moneyline in 35 of their last 67 games (+15.85 Units / 22% ROI)
  • The Pittsburgh Pirates have hit the Game Total Over in 69 of their last 120 games (+15.10 Units / 11% ROI)
  • The Pittsburgh Pirates have hit the Team Total Under in 76 of their last 134 games (+11.44 Units / 7% ROI)
  • The Pittsburgh Pirates have hit the 1st Five Innings (F5) Moneyline in 29 of their last 65 games (+10.67 Units / 15% ROI)
  • The Pittsburgh Pirates have covered the Run Line in 39 of their last 63 games (+10.50 Units / 13% ROI)

Red Sox Against the Spread (ATS) Record

Against the spread this season, the Red Sox are 13-9 against the Run Line (+3.75 Units / 12% ROI).

  • 12-10 when betting on the Moneyline for +1.1 Units / 4.25% ROI
  • 10-11 when betting on the total runs Over for -2.05 Units / -8.44% ROI
  • 11-10 when betting on the total runs Under for +0.05 Units / 0.21% ROI

Pirates Against the Spread (ATS) Record

Against the spread this season, the Pirates are 12-9 against the Run Line (+1.1 Units / 3.72% ROI).

  • 11-10 when betting on the Moneyline for +1.65 Units / 7.19% ROI
  • 12-9 when betting on the total runs Over for +2.1 Units / 9.11% ROI
  • 9-12 when betting on the total runs Under for -4.25 Units / -18.36% ROI

Pirates vs Red Sox Home Run Prop Bets Today

Over Under
Bobby Dalbec (BOS) 0.5 +425 0.5 -600
Jack Suwinski (PIT) 0.5 +550 0.5 -800
Ceddanne Rafaela (BOS) 0.5 +625 0.5 -1000
Connor Wong (BOS) 0.5 +625 0.5 -1000
Bryan Reynolds (PIT) 0.5 +625 0.5 -1000

Pirates vs Red Sox Total Hits Prop Bets Today

Over Under
Ke'Bryan Hayes (PIT) 0.5 -250 0.5 +175
Rob Refsnyder (BOS) 0.5 -250 0.5 +190
Bryan Reynolds (PIT) 0.5 -225 0.5 +170
Ceddanne Rafaela (BOS) 0.5 -210 0.5 +155
Masataka Yoshida (BOS) 0.5 -210 0.5 +155

Pirates vs Red Sox RBI Prop Bets Today

Over Under
Ke'Bryan Hayes (PIT) 0.5 +165 0.5 -225
Bobby Dalbec (BOS) 0.5 +165 0.5 -225
Jack Suwinski (PIT) 0.5 +170 0.5 -225
Rob Refsnyder (BOS) 0.5 +170 0.5 -225
Ceddanne Rafaela (BOS) 0.5 +175 0.5 -250

Opponents are hitting just .130 against Josh Winckowski vs right-handed batters this season — tied for eighth best among qualified RPs– 93rd Percentile. Right handed batters hit .287 (56-for-195) against him last season — 10th worst among qualified RPs– 10th Percentile.

Left-handed batters are hitting .481 (13-for-27) against Josh Winckowski this season — highest among qualified RPs in MLB; League Avg: .229 — 0 Percentile.

Josh Winckowski allowed a batting average of just .130 vs right-handed batters (tied for eighth best)– 93rd Percentile and .481 vs left-handed batters this season (worst among qualified RPs)– 0 Percentile.

Opponents are hitting .285 (190-for-666) against Josh Winckowski since the 2022 season — 5th highest among qualified RPs in MLB*; League Avg: .230 — second Percentile.

Pirates Starting Pitcher Stats & Trends

Martin Perez has located his fastball inside 62% of the time (87/141) this season — 2nd highest among qualified SPs in MLB; League Avg: 34% — 98th Percentile.

Martin Perez has located his fastball inside 62% of the time (87/141) this season — highest among in NL; League Avg: 35% — 100th Percentile.

Martin Perez has located his fastball inside 62% of the time (87/141) this season — highest among in NL; League Avg: 35% — 100th Percentile.

Martin Perez has thrown inside pitches 47% of the time (42/90) with two-strikes this season — highest among in NL; League Avg: 31% — 100th Percentile.

Red Sox Keys to the Game vs. the Pirates

The Red Sox are just 19-31 (.380) after a home loss since the 2023 season — 3rd lowest in MLB; League Avg: .509.

The Red Sox are just 1-81 (.012) when trailing entering the 9th inning since the 2023 season — 2nd lowest in MLB; League Avg: .052.

The Red Sox are just 35-65 (.350) after a loss as underdogs since the 2022 season — 3rd lowest in MLB; League Avg: .409.

The Red Sox are just 3-147 (.020) when trailing entering the 9th inning since the 2022 season — 3rd lowest in MLB; League Avg: .049.

Pirates Keys to the Game vs. the Red Sox

The Pirates are just 49-168 (.226) when scoring 4 or fewer runs since the 2022 season — 5th lowest in MLB; League Avg: .280.

The Pirates are 15-8 (.652) after a loss as favorites since the 2022 season — 4th best in MLB; League Avg: .589.

The Pirates are just 12-19 (.387) when tied entering the 8th inning since the 2022 season — 3rd lowest in MLB; League Avg: .500.

The Pirates are just 120-61 (.663) when allowing 4 or fewer runs since the 2022 season — tied for 3rd lowest in MLB; League Avg: .720.

Red Sox hitters are slugging .800 on the first pitch of at-bats this season — 2nd best in MLB; League Avg: .559.

Red Sox hitters have an OPS of .749 (5,220 PA’s) against RHP since last season — 5th best in MLB; League Avg: .728.

The Red Sox are batting .288 with two outs this season — best in MLB; League Avg: .230.

The Red Sox are batting .177 on pitches out of the zone since last season — 2nd best in MLB; League Avg: .152.

The Pirates are batting just .233 against LHP since the 2022 season — 2nd lowest in MLB; League Avg: .249.

Pirates hitters have 381 strikeouts in 1,128 PA’s (34%) in lefty-lefty matchups since the 2022 season — highest in MLB; League Avg: 24%.

Pirates hitters are slugging just .178 on pitches out of the zone since the 2022 season — 2nd lowest in MLB; League Avg: .213.

Pirates hitters have 72 strikeouts in 260 PA’s (28%) against LHP this season — 5th highest in MLB; League Avg: 22%.

Red Sox pitchers have an ERA of 1.50 (108.1 IP) on the road this season — best in MLB; League Avg: 4.08.

Red Sox pitchers have a strikeout rate of 33% when going through the lineup the third time in a game this season — best in MLB; League Avg: 19%.

Opponents have a groundball rate of 45% against Red Sox pitchers since last season — tied for 5th highest in MLB; League Avg: 43%.

Red Sox pitchers have a strikeout rate of 25% this season — tied for 5th best in MLB; League Avg: 23%.

Pirates pitchers are throwing just 3.61 pitches per plate appearance this season — lowest in MLB; League Avg: 3.92.

Pirates pitchers have a strikeout rate of 44% with two-strikes this season — 5th best in MLB; League Avg: 42%.

The Pirates have won 42% of road games in which their opponents scored first since last season — 5th highest in MLB; League Avg: 30%.

Pirates pitchers have walked 1,244 of 13,297 batters (9%) since the 2022 season — 5th highest in MLB; League Avg: 8%.

Pirates vs. Red Sox Injuries Tonight That May Affect Prop Bets 

  • Miguel Andujar (Pittsburgh Pirates): Knee, 10-Day IL
  • Colin Holderman (Pittsburgh Pirates): Illness, 15-Day IL
  • Johan Oviedo (Pittsburgh Pirates): Elbow, 60-Day IL
  • Dauri Moreta (Pittsburgh Pirates): Elbow, 60-Day IL
  • Carmen Mlodzinski (Pittsburgh Pirates): Elbow, 15-Day IL
  • Vince Velasquez (Pittsburgh Pirates): Elbow, Out
  • Mike Burrows (Pittsburgh Pirates): Elbow, Out
  • JT Brubaker (Pittsburgh Pirates): Elbow, 60-Day IL
  • Max Kranick (Pittsburgh Pirates): Hamstring, 15-Day IL
  • Endy Rodriguez (Pittsburgh Pirates): Elbow, 60-Day IL
  • Ji Hwan Bae (Pittsburgh Pirates): Hip, 10-Day IL
  • Wyatt Mills (Boston Red Sox): Elbow, 60-Day IL
  • Vaughn Grissom (Boston Red Sox): Hamstring, 10-Day IL
  • Michael Fulmer (Boston Red Sox): Elbow, 60-Day IL
  • Zack Kelly (Boston Red Sox): Oblique, Day-To-Day
  • Bryan Mata (Boston Red Sox): Hamstring, 15-Day IL
  • Chris Murphy (Boston Red Sox): Elbow, 60-Day IL
  • Kenley Jansen (Boston Red Sox): Back, Day-To-Day
  • Brandon Walter (Boston Red Sox): Shoulder, 7-Day IL
  • Lucas Giolito (Boston Red Sox): Elbow, 60-Day IL
  • Rob Refsnyder (Boston Red Sox): Toe, 10-Day IL
  • Yu Chang (Boston Red Sox): Oblique, Out

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Our BetMGM editors and authors are sports experts with a wealth of knowledge of the sports industry at all levels. Their coverage includes sports news, previews and predictions, fun facts, and betting.