Red Sox vs Rays Prediction, Odds & Player Prop Bets Today – MLB, May 21

Tampa Bay Rays' Brandon Lowe runs the bases while scoring from first base on a two-run triple by Randy Arozarena off Baltimore Orioles starting pitcher Kyle Bradish in the third inning of a baseball game, Thursday, Sept. 14, 2023, in Baltimore. Rays' Yandy Diaz also scored on the triple.
(AP Photo/Julio Cortez)
  • The Rays are -140 favorites vs the Red Sox
  • Red Sox vs Rays Over / Under today: 8 Runs
  • Red Sox / Rays TV Channel: NESN | BSUN

The Boston Red Sox (+120) visit Tropicana Field to take on the Tampa Bay Rays (-140) on Tuesday, May 21, 2024. First pitch is scheduled for 6:50pm EDT in St. Petersburg, FL.

This season, the Red Sox are 24-24 against the spread (ATS), while the Rays are 23-26 ATS.

Red Sox vs Rays Starting Pitchers Today:

  • Red Sox starting pitcher: Cooper Criswell 2-1, 2.80 ERA
  • Rays starting pitcher: Zack Littell 2-2, 3.47 ERA

Red Sox vs. Rays Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Red Sox+1.5 -175O 8.5 -115+120
Rays -1.5 +145U 8.5 -105-140

Red Sox vs Rays Prediction for Today’s Game

Based on recent trends the model predicts the Rays will win Tuesday‘s MLB game with 52.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Red Sox players for Tuesday‘s game, looking at profitable historical betting trends:

Best Red Sox Player Prop Bets Today:

  • Rafael Devers has hit the Home Runs Over in his last 6 games (+21.05 Units / 351% ROI)
  • Jarren Duran has hit the Singles Under in 24 of his last 36 games (+12.60 Units / 33% ROI)
  • Rafael Devers has hit the Hits Over in 19 of his last 24 games (+12.20 Units / 24% ROI)
  • Dominic Smith has hit the Runs Under in 12 of his last 13 games (+9.90 Units / 37% ROI)
  • Vaughn Grissom has hit the Total Bases Under in 10 of his last 11 games (+9.45 Units / 52% ROI)

And here are some favorite MLB player prop bets for Rays players for Tuesday‘s game, looking at profitable historical betting trends:

Best Rays Player Prop Best Bets Today:

  • Randy Arozarena has hit the Home Runs Over in 5 of his last 10 games at home (+19.00 Units / 190% ROI)
  • Yandy Diaz has hit the Runs Under in 32 of his last 46 games (+15.35 Units / 26% ROI)
  • Randy Arozarena has hit the Singles Under in 21 of his last 26 games (+13.40 Units / 34% ROI)
  • Isaac Paredes has hit the Total Bases Over in 18 of his last 24 games (+11.35 Units / 32% ROI)
  • Yandy Diaz has hit the Hits Over in 9 of his last 15 games at home (+9.15 Units / 56% ROI)
  • The Boston Red Sox have hit the Game Total Under in 23 of their last 35 games (+10.95 Units / 28% ROI)
  • The Boston Red Sox have hit the 1st Five Innings (F5) Moneyline in 26 of their last 48 games (+8.70 Units / 14% ROI)
  • The Boston Red Sox have hit the 1st Five Innings (F5) Team Total Over in 8 of their last 9 games (+7.15 Units / 61% ROI)
  • The Boston Red Sox have covered the 1st Five Innings (F5) Run Line in 16 of their last 25 away games (+6.70 Units / 22% ROI)
  • The Boston Red Sox have hit the Team Total Over in 14 of their last 22 away games (+4.90 Units / 19% ROI)
  • The Tampa Bay Rays have hit the 1st Five Innings (F5) Team Total Under in 33 of their last 46 games (+19.95 Units / 37% ROI)
  • The Tampa Bay Rays have covered the Run Line in 12 of their last 17 games (+7.30 Units / 30% ROI)
  • The Tampa Bay Rays have hit the Game Total Under in 9 of their last 13 games (+4.60 Units / 32% ROI)
  • The Tampa Bay Rays have hit the Team Total Under in 23 of their last 40 games (+4.10 Units / 9% ROI)
  • The Tampa Bay Rays have hit the Moneyline in 11 of their last 17 games (+3.90 Units / 18% ROI)

Red Sox Against the Spread (ATS) Record

Against the spread this season, the Red Sox are 22-26 against the Run Line (-8.3 Units / -12.61% ROI).

  • 24-24 when betting on the Moneyline for -1.9 Units / -3.34% ROI
  • 18-28 when betting on the total runs Over for -12.15 Units / -23.28% ROI
  • 28-18 when betting on the total runs Under for +8.2 Units / 15.34% ROI

Rays Against the Spread (ATS) Record

Against the spread this season, the Rays are 23-26 against the Run Line (-3.25 Units / -5.11% ROI).

  • 25-24 when betting on the Moneyline for -6.65 Units / -10.38% ROI
  • 25-24 when betting on the total runs Over for -1.2 Units / -2.24% ROI
  • 24-25 when betting on the total runs Under for -3.6 Units / -6.64% ROI

Rays vs Red Sox Home Run Prop Bets Today

Over Under
Rafael Devers (BOS) 0.5 +260 0.5 -350
Tyler O'Neill (BOS) 0.5 +400 0.5 -550
Wilyer Abreu (BOS) 0.5 +425 0.5 -650
Brandon Lowe (TB) 0.5 +450 0.5 -650
Jarren Duran (BOS) 0.5 +475 0.5 -700

Rays vs Red Sox Total Hits Prop Bets Today

Over Under
Rafael Devers (BOS) 0.5 -250 0.5 +190
Josh Lowe (TB) 0.5 -250 0.5 +175
Randy Arozarena (TB) 0.5 -210 0.5 +155
Wilyer Abreu (BOS) 0.5 -200 0.5 +150
Tyler O'Neill (BOS) 0.5 -200 0.5 +155

Rays vs Red Sox RBI Prop Bets Today

Over Under
Rafael Devers (BOS) 0.5 +125 0.5 -165
Brandon Lowe (TB) 0.5 +155 0.5 -200
Tyler O'Neill (BOS) 0.5 +170 0.5 -225
Wilyer Abreu (BOS) 0.5 +175 0.5 -225
Randy Arozarena (TB) 0.5 +175 0.5 -250

Rays vs Red Sox Strikeout Prop Bets Today

Over Under
Cooper Criswell (BOS) 3.5 -165 3.5 +130
Zack Littell (TB) 5.5 +130 5.5 -165

Opponents have a two strike miss rate of just 18% (36/200) against Cooper Criswell since last season — 4th lowest among in MLB; League Avg: 27% — fourth Percentile.

Opponents have a miss rate of just 20% (95/488) against Cooper Criswell since last season — tied for 9th lowest among qualified RPs in MLB*; League Avg: 28% — fifth Percentile.

Opponents have a groundball rate of 79% (27/34) against Cooper Criswell’s changeup this season — highest in MLB among starting pitchers with at least 17 total IP; League Avg: 50% — 100th Percentile.

Opponents are hitting .201 (28-for-139) against Cooper Criswell with two-strikes since last season — tied for 8th highest among in MLB; League Avg: .159 — 10th Percentile.

Rays Starting Pitcher Stats & Trends

Zack Littell has walked 1 of 81 batters (1%) when going through the lineup the second time in a game this season — best among in MLB; League Avg: 6% — 100th Percentile.

5 of Zack Littell’s 16 breaking pitch strikeouts (31%) have been backdoor this season — 2nd highest among qualified SPs in MLB; League Avg: 13% — 98th Percentile.

5 of Zack Littell’s breaking pitch strikeouts are backdoor on breaking pitches this season — tied for 3rd most among in MLB; League Avg: nan — 94th Percentile.

Zack Littell has walked 1 of 81 batters (1%) when going through the lineup the second time in a game this season — tied for best among qualified SPs in MLB; League Avg: 7% — 100th Percentile.

Red Sox Keys to the Game vs. the Rays

The Red Sox are just 3-160 (.018) when trailing entering the 9th inning since the 2022 season — tied for 2nd lowest in MLB; League Avg: .050.

The Red Sox are just 16-148 (.098) when trailing entering the 7th inning since the 2022 season — 5th lowest in MLB; League Avg: .133.

The Red Sox are just 43-55 (.439) after a home loss since the 2022 season — tied for 5th lowest in MLB; League Avg: .517.

The Red Sox are just 1-94 (.011) when trailing entering the 9th inning since the 2023 season — tied for 2nd lowest in MLB; League Avg: .053.

Rays Keys to the Game vs. the Red Sox

The Rays are just 16-33 (.327) after a win as underdogs since the 2022 season — lowest in MLB; League Avg: .414.

The Rays are 19-8 (.704) when tied entering the 7th inning since the 2023 season — 2nd best in MLB; League Avg: .500.

The Rays are 44-14 (.759) vs the bottom 10 runs allowed teams since the 2023 season — best in MLB; League Avg: .573.

The Rays are just 9-19 (.321) after a win as underdogs since the 2023 season — 2nd lowest in MLB; League Avg: .424.

The Red Sox are batting .266 with two outs this season — best in MLB; League Avg: .230.

Red Sox hitters have 139 strikeouts in 479 PA’s (29%) against LHP this season — highest in MLB; League Avg: 22%.

Red Sox hitters have put just 31% of their swings in play against LHP this season — lowest in MLB; League Avg: 37%.

Red Sox hitters have an OBP of .333 (3,604 PA’s) against LHP since the 2022 season — tied for 4th best in MLB; League Avg: .318.

The Rays scored first in 64% of their games in the 2023 season — highest in MLB; League Avg: 50%.

Rays hitters have 9 strikeouts in 21 PA’s (43%) against LHP over the past seven days (5 games) — highest in MLB; League Avg: 21%.

Rays hitters have 164 strikeouts in 501 PA’s (33%) in lefty-lefty matchups since the 2022 season — 2nd highest in MLB; League Avg: 24%.

The Rays scored first in 71% of their games against division opponents in the 2023 season — highest in MLB; League Avg: 50%.

Red Sox pitchers have an ERA of 2.99 (430.1 IP) this season — 2nd best in MLB; League Avg: 3.97.

Red Sox pitchers have walked 122 of 1,768 batters (7%) this season — 2nd best in MLB; League Avg: 8%.

Red Sox pitchers have an ERA of 2.65 (217.1 IP) on the road this season — best in MLB; League Avg: 4.10.

Red Sox pitchers have walked 25 of 431 batters (6%) when facing the leadoff batter in the inning this season — tied for 3rd best in MLB; League Avg: 8%.

The Rays pitchers allowed their opponents to score first in just 36% of their games in the 2023 season — lowest in MLB; League Avg: 50%.

The Rays pitchers allowed division opponents to score first in just 29% of their games in the 2023 season — lowest in MLB; League Avg: 50%.

The Rays pitchers allowed their opponents to score first in just 41% of their games at home in the 2023 season — lowest in MLB; League Avg: 56%.

Rays pitchers have walked 132 of 1,887 batters (7%) when facing the leadoff batter in the inning since last season — tied for 5th best in MLB; League Avg: 8%.

Rays vs. Red Sox Injuries Tonight That May Affect Prop Bets 

  • Taylor Walls (Tampa Bay Rays): Hip, 10-Day IL
  • Jonny DeLuca (Tampa Bay Rays): Hand, 10-Day IL
  • Jeffrey Springs (Tampa Bay Rays): Elbow, 60-Day IL
  • Shane Baz (Tampa Bay Rays): Elbow, 15-Day IL
  • Jonathan Aranda (Tampa Bay Rays): Finger, 10-Day IL
  • Taj Bradley (Tampa Bay Rays): Pectoral, 15-Day IL
  • Josh Lowe (Tampa Bay Rays): Oblique, 10-Day IL
  • Junior Caminero (Tampa Bay Rays): Quadriceps, Day-To-Day
  • Garrett Acton (Tampa Bay Rays): Elbow, Out
  • Drew Rasmussen (Tampa Bay Rays): Elbow, 60-Day IL
  • Shane McClanahan (Tampa Bay Rays): Elbow, 60-Day IL
  • Wander Franco (Tampa Bay Rays): Personal, Suspension
  • Wyatt Mills (Boston Red Sox): Elbow, 60-Day IL
  • Vaughn Grissom (Boston Red Sox): Hamstring, 10-Day IL
  • Michael Fulmer (Boston Red Sox): Elbow, 60-Day IL
  • Zack Kelly (Boston Red Sox): Oblique, Day-To-Day
  • Bryan Mata (Boston Red Sox): Hamstring, 15-Day IL
  • Chris Murphy (Boston Red Sox): Elbow, 60-Day IL
  • Kenley Jansen (Boston Red Sox): Back, Day-To-Day
  • Brandon Walter (Boston Red Sox): Shoulder, 7-Day IL
  • Lucas Giolito (Boston Red Sox): Elbow, 60-Day IL
  • Rob Refsnyder (Boston Red Sox): Toe, 10-Day IL
  • Yu Chang (Boston Red Sox): Oblique, Out

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Our BetMGM editors and authors are sports experts with a wealth of knowledge of the sports industry at all levels. Their coverage includes sports news, previews and predictions, fun facts, and betting.