Twins vs Guardians Prediction, Odds & Player Prop Bets Today – MLB, Sep 16

(AP Photo/Ryan Sun)
  • The Twins are -115 favorites vs the Guardians
  • Twins vs Guardians Over / Under today: 8 Runs
  • Twins / Guardians TV Channel: BSGL | BSNO | ESPN+

The Minnesota Twins (-115) visit Progressive Field to take on the Cleveland Guardians (-105) on Monday, September 16, 2024. First pitch is scheduled for 6:40pm EDT in Cleveland, OH.

This season, the Twins are 79-70 against the spread (ATS), while the Guardians are 76-74 ATS.

Twins vs Guardians Starting Pitchers Today:

  • Twins starting pitcher: Pablo Lopez 15-8, 3.92 ERA
  • Guardians starting pitcher: Matthew Boyd 2-1, 2.16 ERA

Twins vs. Guardians Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Twins-1.5 +150O 7.5 -105-115
Guardians +1.5 -185U 7.5 -115-105

Twins vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Twins will win Monday‘s MLB game with 51.7% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Twins players for Monday‘s game, looking at profitable historical betting trends:

Best Twins Player Prop Bets Today:

  • Pablo Lopez has hit the Walks Allowed Under in 23 of his last 29 games (+15.00 Units / 36% ROI)
  • Jose Miranda has hit the RBIs Under in 16 of his last 17 away games (+14.05 Units / 38% ROI)
  • Carlos Santana has hit the Home Runs Over in 4 of his last 10 games (+13.50 Units / 135% ROI)
  • Royce Lewis has hit the Runs Under in 15 of his last 17 games (+12.40 Units / 52% ROI)
  • Edouard Julien has hit the Walks Under in his last 11 games (+11.00 Units / 54% ROI)

And here are some favorite MLB player prop bets for Guardians players for Monday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

  • Brayan Rocchio has hit the Home Runs Over in 2 of his last 10 games (+15.50 Units / 155% ROI)
  • Lane Thomas has hit the Hits Under in 14 of his last 25 games at home (+10.30 Units / 39% ROI)
  • Lane Thomas has hit the Runs Under in 18 of his last 24 games at home (+9.90 Units / 27% ROI)
  • Jose Ramirez has hit the RBIs Under in 15 of his last 18 games (+9.80 Units / 32% ROI)
  • Jose Ramirez has hit the Hits Runs and RBIs Over in 18 of his last 24 games at home (+9.80 Units / 30% ROI)
  • The Minnesota Twins have hit the Game Total Over in 48 of their last 83 games (+14.20 Units / 16% ROI)
  • The Minnesota Twins have hit the 1st Five Innings (F5) Team Total Under in 14 of their last 18 games (+10.45 Units / 49% ROI)
  • The Minnesota Twins have hit the 1st Five Innings (F5) Moneyline in 12 of their last 23 away games (+1.10 Units / 4% ROI)
  • The Minnesota Twins have covered the Run Line in 3 of their last 5 games (+1.05 Units / 19% ROI)
  • The Minnesota Twins have covered the 1st Five Innings (F5) Run Line in 6 of their last 11 away games (+0.55 Units / 4% ROI)
  • The Cleveland Guardians have hit the Game Total Under in 35 of their last 58 games (+12.90 Units / 20% ROI)
  • The Cleveland Guardians have hit the Moneyline in 86 of their last 150 games (+11.22 Units / 6% ROI)
  • The Cleveland Guardians have covered the Run Line in 34 of their last 68 games at home (+10.75 Units / 14% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in 7 of their last 11 games (+2.85 Units / 21% ROI)

Twins Against the Spread (ATS) Record

Against the spread this season, the Twins are 68-81 against the Run Line (-17.4 Units / -9.23% ROI).

  • 79-70 when betting on the Moneyline for -10.05 Units / -4.72% ROI
  • 76-65 when betting on the total runs Over for +4.8 Units / 2.95% ROI
  • 65-76 when betting on the total runs Under for -18.85 Units / -11.55% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 76-74 against the Run Line (+4.45 Units / 2.38% ROI).

  • 86-64 when betting on the Moneyline for +11.22 Units / 5.76% ROI
  • 67-74 when betting on the total runs Over for -14.85 Units / -8.96% ROI
  • 74-67 when betting on the total runs Under for +0.35 Units / 0.21% ROI

Guardians vs Twins Home Run Prop Bets Today

Over Under
Byron Buxton (MIN) 0.5 +340 0.5 -450
Royce Lewis (MIN) 0.5 +475 0.5 -650
Jose Miranda (MIN) 0.5 +475 0.5 -650
Carlos Santana (MIN) 0.5 +525 0.5 -750
Matt Wallner (MIN) 0.5 +550 0.5 -800

Guardians vs Twins Total Hits Prop Bets Today

Over Under
Steven Kwan (CLE) 0.5 -275 0.5 +195
Andres Gimenez (CLE) 0.5 -250 0.5 +180
Carlos Correa (MIN) 0.5 -250 0.5 +175
Manuel Margot (MIN) 0.5 -225 0.5 +165
Jose Ramirez (CLE) 0.5 -225 0.5 +165

Guardians vs Twins RBI Prop Bets Today

Over Under
Jose Ramirez (CLE) 0.5 +165 0.5 -225
Jose Miranda (MIN) 0.5 +165 0.5 -225
Josh Naylor (CLE) 0.5 +170 0.5 -225
Byron Buxton (MIN) 0.5 +175 0.5 -250
Royce Lewis (MIN) 0.5 +185 0.5 -250

Guardians vs Twins Strikeout Prop Bets Today

Over Under
Pablo Lopez (MIN) 5.5 -110 5.5 -120
Matthew Boyd (CLE) 5.5 +100 5.5 -130

Opponents are hitting just .132 (14-for-106) against Pablo Lopez’s elevated fastball this season — 2nd best among qualified SPs in MLB; League Avg: .207 — 97th Percentile.

Opposing hitters have a chase rate of 36% (232/646) against Pablo Lopez when he’s behind in the count since the 2022 season — highest in MLB among starting pitchers with at least 188 total IP; League Avg: 25% — 100th Percentile.

Opposing hitters have a chase rate of 35% (132/379) against Pablo Lopez when he’s behind in the count since last season — 2nd highest in MLB among starting pitchers with at least 124 total IP; League Avg: 25% — 99th Percentile.

Pablo Lopez has a strikeout rate of 27% (223 SO in 833 PAs) when going through the lineup the second time in a game since the 2022 season — 4th best among qualified SPs in MLB; League Avg: 23% — 87th Percentile.

Guardians Starting Pitcher Stats & Trends

Matthew Boyd has a strikeout rate of 39% (7 SO in 18 PAs) when going through the lineup the first time in a game this month (2 games) — tied for 9th best in MLB among starting pitchers with at least 4 total IP; League Avg: 24% — 94th Percentile.

Matthew Boyd has a strikeout rate of 33% (15 SO in 45 PAs) this month (2 games) — tied for 13th best in MLB among starting pitchers with at least 4 total IP; League Avg: 23% — 92nd Percentile.

Matthew Boyd has thrown his changeup 35% of the time (47/134) against right-handed batters this month (2 games) — 7th highest in MLB among starting pitchers with at least 4 total CH; League Avg: 14% — 94th Percentile.

Opponents have a miss rate of 36% (32/89) against Matthew Boyd this month (2 games) — 6th best in MLB among starting pitchers with at least 4 total IP; League Avg: 26% — 96th Percentile.

Twins Keys to the Game vs. the Guardians

The Twins are 137-2 (.986) when leading entering the 9th inning since the 2023 season — best in MLB; League Avg: .948.

The Twins are just 1-61 (.016) when trailing entering the 9th inning this season — 4th lowest in MLB; League Avg: .052.

The Twins are 205-5 (.976) when leading entering the 9th inning since the 2022 season — 2nd best in MLB; League Avg: .950.

The Twins are 62-25 (.713) when they’ve scored in the first inning since the 2023 season — 4th best in MLB; League Avg: .626.

Guardians Keys to the Game vs. the Twins

The Guardians are 24-29 (.453) when allowing 2 or more home runs this season — best in MLB; League Avg: .294.

The Guardians are 14-6 (.700) when tied entering the 7th inning this season — 2nd best in MLB; League Avg: .500.

The Guardians are 67-2 (.971) when leading entering the 7th inning this season — best in MLB; League Avg: .857.

The Guardians are 39-10 (.796) when they’ve hit 2 or more home runs this season — 5th best in MLB; League Avg: .706.

Twins hitters have an OBP of .324 (13,208 PA’s) against RHP since the 2022 season — tied for 2nd best in MLB; League Avg: .314.

Twins hitters have an OPS of .742 (13,208 PA’s) against RHP since the 2022 season — 5th best in MLB; League Avg: .716.

Twins hitters have an OPS of .727 (5,624 PA’s) in innings 7-9 since the 2022 season — 5th best in MLB; League Avg: .694.

The Twins are batting just .121 when facing the starting pitcher for the 3rd time in a game this month (13 games) — lowest in MLB; League Avg: .250.

The Guardians are batting just .291 on the first pitch of at-bats this season — 2nd lowest in MLB; League Avg: .331.

Guardians hitters have put just 34% of balls in play to the left side of the field since last season — tied for lowest in MLB; League Avg: 38%.

Guardians hitters have just 2,359 strikeouts in 12,712 PA’s (19%) against RHP since the 2022 season — best in MLB; League Avg: 23%.

The Guardians have barrels in 4% of PA’s since last season (439/11,629) — lowest in MLB; League Avg: 5%.

Twins pitchers have walked 829 of 11,560 batters (7%) since last season — 2nd best in MLB; League Avg: 8%.

Twins pitchers have walked 386 of 5,532 batters (7%) this season — tied for 2nd best in MLB; League Avg: 8%.

Twins pitchers have a strikeout rate of 24% this season — tied for 3rd best in MLB; League Avg: 22%.

Twins pitchers have a strikeout rate of 25% since last season — 2nd best in MLB; League Avg: 23%.

Opponents have a groundball batting average of just .222 against Guardians pitchers this season — best in MLB; League Avg: .249.

Opponents have a groundball batting average of just .203 against Guardians pitchers with runners on base this season — best in MLB; League Avg: .262.

Guardians pitchers have walked 5 of 114 batters (4%) when facing the leadoff batter in the inning over the last 14 days — 2nd best in MLB; League Avg: 8%.

Guardians pitchers have walked 5 of 123 batters (4%) when facing the leadoff batter in the inning this month (14 games) — best in MLB; League Avg: 8%.

Guardians vs. Twins Injuries Tonight That May Affect Prop Bets 

  • Cleveland Guardians – No Injuries Reported
  • Minnesota Twins – No Injuries Reported

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About the Author

Shane Jackson

Read More @Sjacksonmgm

Shane Jackson is a Web Content Writer for BetMGM, covering MLB and NBA. After graduating from the University of Kansas, his previous stops include MLB.com, Lawrence Journal-World, Manhattan Mercury, Bet Chicago Sports, WynnBET, and Sportsbook Review.

Shane Jackson is a Web Content Writer for BetMGM, covering MLB and NBA. After graduating from the University of Kansas, his previous stops include MLB.com, Lawrence Journal-World, Manhattan Mercury, Bet Chicago Sports, WynnBET, and Sportsbook Review.