Bills vs. Jaguars Prediction, Odds, Pick: Week 3, MNF

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Buffalo Bills quarterback Josh Allen (17) signals touchdown during the first half of an NFL football game against the Arizona Cardinals in Orchard Park N.Y., Sunday Sept. 8, 2024.
(AP Photo/ Jeffrey T. Barnes)
Nick Hennion @nickhennion Sep 19, 2024, 12:22 PM
  • The Bills are predicted to be -5.5-point favorites against the Jaguars.
  • Josh Allen is 20-5 SU as a home favorite of -4 or higher.
  • My prediction for Mondayโ€™s game is the game total under 45.5 points.

Monday Night Footballโ€™s first game of a doubleheader kicks off from Buffalo with the Bills battling the Jaguars.ย 

Buffalo is off to another strong start. Theyโ€™ve started the season 2-0, including a 31-10 thumping of the Dolphins on Thursday night in Week 2.ย 

Jacksonville, meanwhile, has started 0-2 after losses to the Dolphins and the Browns. In good news, Jacksonville gets a Bills team they beat 25-20 in London last season.ย 

Hereโ€™s a look at the NFL betting lines and my Bills vs. Jaguars prediction.ย 

Bills vs. Jaguars Odds

  • Buffalo Bills Moneyline: -250
  • Jacksonville Jaguars Moneyline: +200
  • Game Spread: Buffalo Bills -5.5 (-110)
  • Game Over/Under: 45.5 Points

Bills vs. Jaguars Prediction, MNF

My prediction for Bills vs. Jaguars on MNF is the Total Under 45.5 Points (-110).ย 

From a matchup standpoint, my concerns about Jacksonvilleโ€™s defense are quelled.ย 

Jacksonville is 17th in yards per play through two weeks. However, dive deeper into the splits and bettors will find theyโ€™re seventh in yards per rush attempt and 22nd in yards per pass attempt.ย 

On Monday, theyโ€™ll get a Bills offense that deploys a run-heavy offensive game plan.ย 

Through two weeks, offensive coordinator Joe Brady has run the ball at the sixth-highest rate.ย 

Buffalo does lead the league in PFFโ€™s rushing grades, but it came against Arizona and Miami. Those fronts arenโ€™t exactly what I would describe as trustworthy.ย 

At the same time, bettors should expect a run-heavy approach from the Jags.ย 

Buffalo is far worse against the run compared to the pass โ€” 15th in yards/rush attempt and fifth in yards per pass attempt.ย 

Plus, I donโ€™t trust Jacksonvilleโ€™s offensive line โ€” 25th and 29th in pass- and run-blocking grades โ€” against a good Bills front thatโ€™s fourth in pressure success rate.ย 

Finally, this game matches a historically profitable system.ย 

Since 2003, conference games with a total between 44 and 57 points are 59.5% to the under when both teams have at least eight days between games.ย 

Since 2019, that system improves to a 66.1% under rate, including 17-7 (71%) when the home team scored 30 or more points in the previous game.ย 

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About the Author

Nick Hennion

Read More @nickhennion

Nick Hennion is a senior content writer for BetMGM. His previous stops include VSiN, NBC Sports, The Action Network and Forbes Betting. He owns a bachelor's degree from Syracuse University and a master's degree from Northwestern University.

Nick Hennion is a senior content writer for BetMGM. His previous stops include VSiN, NBC Sports, The Action Network and Forbes Betting. He owns a bachelor's degree from Syracuse University and a master's degree from Northwestern University.