Astros vs Padres Prediction, Odds & Player Prop Bets Today – MLB, Sep 18

(AP Photo/Derrick Tuskan)
  • The Astros are -115 favorites vs the Padres
  • Astros vs Padres Over / Under today: 7 Runs
  • Astros / Padres TV Channel: SCHN | PDTV

The Houston Astros (-115) visit Petco Park to take on the San Diego Padres (-105) on Wednesday, September 18, 2024. First pitch is scheduled for 6:40pm EDT in San Diego, CA.

This season, the Astros are 82-69 against the spread (ATS), while the Padres are 76-76 ATS.

Astros vs Padres Starting Pitchers Today:

  • Astros starting pitcher: Framber Valdez 14-6, 2.91 ERA
  • Padres starting pitcher: Dylan Cease 13-11, 3.60 ERA

Astros vs. Padres Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Astros-1.5 +155O 6.5 +100-115
Padres +1.5 -190U 6.5 -120-105

Astros vs Padres Prediction for Today’s Game

Based on recent trends the model predicts the Astros will win Wednesday‘s MLB game with 51.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Astros players for Wednesday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Bets Today:

  • Jeremy Pena has hit the Home Runs Over in 6 of his last 25 away games (+28.40 Units / 114% ROI)
  • Yainer Diaz has hit the Hits Over in 25 of his last 48 games (+16.70 Units / 30% ROI)
  • Yainer Diaz has hit the Total Bases Over in 29 of his last 49 games (+11.25 Units / 22% ROI)
  • Yainer Diaz has hit the Hits Runs and RBIs Over in 31 of his last 49 games (+9.50 Units / 15% ROI)
  • Shay Whitcomb has hit the Runs Under in his last 8 games (+8.00 Units / 50% ROI)

And here are some favorite MLB player prop bets for Padres players for Wednesday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Best Bets Today:

  • Jackson Merrill has hit the Home Runs Over in 11 of his last 42 games (+35.50 Units / 85% ROI)
  • Luis Arraez has hit the Singles Over in 28 of his last 34 games (+17.55 Units / 26% ROI)
  • Manny Machado has hit the RBIs Over in 26 of his last 45 games (+16.05 Units / 35% ROI)
  • Jackson Merrill has hit the Total Bases Over in 30 of his last 50 games (+14.95 Units / 28% ROI)
  • Luis Arraez has hit the Hits Over in 20 of his last 34 games (+14.05 Units / 39% ROI)
  • The Houston Astros have hit the Game Total Under in 78 of their last 134 games (+19.25 Units / 13% ROI)
  • The Houston Astros have covered the Run Line in 54 of their last 93 games (+17.85 Units / 15% ROI)
  • The Houston Astros have covered the 1st Five Innings (F5) Run Line in their last 16 games (+16.00 Units / 74% ROI)
  • The Houston Astros have hit the 1st Five Innings (F5) Moneyline in their last 16 games (+16.00 Units / 49% ROI)
  • The Houston Astros have hit the Moneyline in 49 of their last 78 games (+11.10 Units / 10% ROI)
  • The San Diego Padres have hit the Moneyline in 49 of their last 75 games (+16.30 Units / 16% ROI)
  • The San Diego Padres have hit the Game Total Over in 43 of their last 74 games (+11.35 Units / 14% ROI)
  • The San Diego Padres have covered the Run Line in 62 of their last 120 games (+6.47 Units / 4% ROI)
  • The San Diego Padres have hit the 1st Five Innings (F5) Team Total Over in 30 of their last 52 games (+6.00 Units / 10% ROI)
  • The San Diego Padres have hit the Team Total Under in 9 of their last 13 games at home (+4.50 Units / 29% ROI)

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 77-74 against the Run Line (+5.1 Units / 2.75% ROI).

  • 82-69 when betting on the Moneyline for -8.9 Units / -4.05% ROI
  • 61-86 when betting on the total runs Over for -32.88 Units / -19.93% ROI
  • 86-61 when betting on the total runs Under for +18.4 Units / 10.98% ROI

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 76-76 against the Run Line (+3.37 Units / 1.8% ROI).

  • 86-66 when betting on the Moneyline for +4.5 Units / 2.2% ROI
  • 81-68 when betting on the total runs Over for +6.75 Units / 4.06% ROI
  • 68-81 when betting on the total runs Under for -21.95 Units / -13.02% ROI

Padres vs Astros Home Run Prop Bets Today

Over Under
Yordan Alvarez (HOU) 0.5 +310 0.5 -400
Kyle Tucker (HOU) 0.5 +400 0.5 -550
Manny Machado (SD) 0.5 +575 0.5 -900
Fernando Tatis Jr. (SD) 0.5 +575 0.5 -900
Alex Bregman (HOU) 0.5 +600 0.5 -900

Padres vs Astros Total Hits Prop Bets Today

Over Under
Yainer Diaz (HOU) 0.5 -275 0.5 +200
Yordan Alvarez (HOU) 0.5 -225 0.5 +170
Jose Altuve (HOU) 0.5 -225 0.5 +165
Jeremy Pena (HOU) 0.5 -225 0.5 +165
Jurickson Profar (SD) 0.5 -210 0.5 +160

Padres vs Astros RBI Prop Bets Today

Over Under
Yordan Alvarez (HOU) 0.5 +155 0.5 -210
Yainer Diaz (HOU) 0.5 +170 0.5 -225
Kyle Tucker (HOU) 0.5 +175 0.5 -250
Manny Machado (SD) 0.5 +175 0.5 -225
Alex Bregman (HOU) 0.5 +175 0.5 -250

Padres vs Astros Strikeout Prop Bets Today

Over Under
Framber Valdez (HOU) 4.5 -160 4.5 +125
Dylan Cease (SD) 5.5 -120 5.5 -105

Opponents have a groundball rate of 61% (265/433) against Framber Valdez this season — highest among qualified SPs in MLB; League Avg: 44% — 100th Percentile.

Opponents have a groundball rate of 73% (25/34) against Framber Valdez in his last two starts — 2nd highest in MLB over the last two weeks; League Avg: 43% — 98th Percentile.

Framber Valdez has thrown inside pitches 41% of the time (1,002/2,414) this season — highest among among AL Starters; League Avg: 30% — 100th Percentile.

Framber Valdez has allowed a slugging percentage of just .284 (202 Total Bases / 712 ABs) when going through the lineup the second time in a game since the 2022 season — best among qualified SPs in MLB; League Avg: .384 — 100th Percentile.

Padres Starting Pitcher Stats & Trends

Opponents are hitting just .157 (37-for-235) against Dylan Cease when going through the lineup the second time in a game this season — 2nd best among qualified SPs in MLB; League Avg: .232 — 98th Percentile.

Dylan Cease has walked 62 of 565 batters (11%) when going through the lineup the second time in a game since last season — highest among qualified SPs in MLB; League Avg: 7% — third Percentile.

25 of Dylan Cease’s breaking pitch strikeouts are backdoor this season — 2nd most among qualified SPs in MLB; League Avg: nan — 98th Percentile.

Right-handed hitters have a miss rate of 37% (271/737) against Dylan Cease this season — best among qualified SPs in MLB; League Avg: 26% — 100th Percentile.

Astros Keys to the Game vs. the Padres

The Astros are just 4-10 (.286) after a loss as underdogs this season — 2nd lowest in MLB; League Avg: .434.

The Astros are just 11-22 (.333) when tied entering the 8th inning since the 2023 season — tied for lowest in MLB; League Avg: .500.

The Astros are just 0-52 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .051.

The Astros are just 4-12 (.250) when tied entering the 8th inning this season — tied for lowest in MLB; League Avg: .500.

Padres Keys to the Game vs. the Astros

The Padres are 10-56 (.152) when trailing entering the 8th inning this season — 4th best in MLB; League Avg: .100.

The Padres are 62-8 (.886) when scoring 5 or more runs this season — 2nd best in MLB; League Avg: .803.

The Padres are 124-21 (.855) when scoring 5 or more runs since the 2023 season — 3rd best in MLB; League Avg: .791.

The Padres are 19-45 (.297) when allowing 5 or more runs this season — best in MLB; League Avg: .197.

Astros hitters are averaging just 3.64 pitches per plate appearance against RHP this season — lowest in MLB; League Avg: 3.89.

15% of Astros’ hitters plate appearances have lasted only one pitch (888/5,726 PA’s) this season — highest in MLB; League Avg: 12%.

14% of Astros’ hitters plate appearances have lasted only one pitch (1,708/11,979 PA’s) since last season — highest in MLB; League Avg: 11%.

Astros hitters have put 42% of balls in play to the left side of the field since the 2022 season — highest in MLB; League Avg: 38%.

Padres hitters have just 257 strikeouts in 1,522 PA’s (17%) against LHP this season — best in MLB; League Avg: 22%.

Padres hitters have just 743 strikeouts in 4,222 PA’s (18%) against RHP this season — best in MLB; League Avg: 22%.

The Padres are batting .279 on the road this season — best in MLB; League Avg: .242.

The Padres are batting .487 when facing the starting pitcher for the 3rd time in a game this month (10 games) — best in MLB; League Avg: .254.

The Astros have allowed 3.77 runs per game (901/239) on the road since the 2022 season — best in MLB; League Avg: 4.44.

Astros pitchers have an ERA of 3.51 (4233.2 IP) since the 2022 season — best in MLB; League Avg: 4.13.

Astros pitchers have a strikeout rate of 24% this season — 2nd best in MLB; League Avg: 22%.

The average home run distance against the Astros pitchers this season is 388.1 feet — best in MLB; League Avg: 397.5

The Padres pitchers allowed an average Exit Velocity of just 87.9 MPH in the 2023 season (3,922 balls in play) — best in MLB; League Avg: 89.0

The Padres pitchers have allowed an average Exit Velocity of just 88.1 MPH since last season (7,637 balls in play) — best in MLB; League Avg: 88.9

Padres pitchers allowed an average Exit Velocity of 87.9 MPH (3,922 batted balls) in the 2023 season — best in MLB; League Avg: 89.0.

Opponents have a groundball batting average of just .171 against Padres pitchers this month (14 games) — best in MLB; League Avg: .249.

Padres vs. Astros Injuries Tonight That May Affect Prop Bets 

  • San Diego Padres – No Injuries Reported
  • Houston Astros – No Injuries Reported

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About the Author

Shane Jackson

Read More @Sjacksonmgm

Shane Jackson is a Web Content Writer for BetMGM, covering MLB and NBA. After graduating from the University of Kansas, his previous stops include MLB.com, Lawrence Journal-World, Manhattan Mercury, Bet Chicago Sports, WynnBET, and Sportsbook Review.

Shane Jackson is a Web Content Writer for BetMGM, covering MLB and NBA. After graduating from the University of Kansas, his previous stops include MLB.com, Lawrence Journal-World, Manhattan Mercury, Bet Chicago Sports, WynnBET, and Sportsbook Review.