Blue Jays vs Astros Prediction, Odds & Player Prop Bets Today – MLB, Apr 21

Houston Astros' Yordan Alvarez runs up the first base line against the Los Angeles Angels during the fourth inning of a baseball game Sunday, June 4, 2023, in Houston.
(AP Photo/David J. Phillip)
  • The Astros are -140 favorites vs the Blue Jays
  • Blue Jays vs Astros Over / Under today: 7.5 Runs
  • Blue Jays / Astros TV Channel: RSN1 | SCHN | MLBN

The Toronto Blue Jays (+118) visit Minute Maid Park to take on the Houston Astros (-140) on Monday, April 21, 2025. First pitch is scheduled for 8:10pm EDT in Houston, TX, TX.

This season, the Blue Jays are 12-10 against the spread (ATS), while the Astros are 11-10 ATS.

Blue Jays vs Astros Starting Pitchers Today:

  • Blue Jays starting pitcher: Kevin Gausman 2-1, 2.52 ERA
  • Astros starting pitcher: Hunter Brown 2-1, 1.48 ERA

Blue Jays vs. Astros Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Blue Jays+1.5 -200O 7.5 -115+118
Astros -1.5 +165U 7.5 -105-140

Blue Jays vs Astros Prediction for Today’s Game

Based on recent trends the model predicts the Astros will win Monday‘s MLB game with 55.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Blue Jays players for Monday‘s game, looking at profitable historical betting trends:

Best Blue Jays Player Prop Bets Today:

  • Andres Gimenez has hit the Hits Under in 9 of his last 15 games (+8.50 Units / 57% ROI)
  • Kevin Gausman has hit the Earned Runs Under in 12 of his last 15 away games (+8.30 Units / 41% ROI)
  • George Springer has hit the Hits Runs and RBIs Over in 11 of his last 15 games (+7.15 Units / 43% ROI)
  • Alejandro Kirk has hit the Runs Under in 9 of his last 10 games (+6.95 Units / 31% ROI)
  • Kevin Gausman has hit the Strikeouts Under in 16 of his last 25 games (+6.60 Units / 22% ROI)

And here are some favorite MLB player prop bets for Astros players for Monday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Best Bets Today:

  • Hunter Brown has hit the Pitching Outs Over in 22 of his last 25 games (+19.30 Units / 53% ROI)
  • Hunter Brown has hit the Earned Runs Under in 20 of his last 25 games (+15.45 Units / 48% ROI)
  • Yordan Alvarez has hit the Runs Under in 17 of his last 20 games (+13.60 Units / 55% ROI)
  • Isaac Paredes has hit the Home Runs Over in 3 of his last 6 games at home (+13.40 Units / 223% ROI)
  • Christian Walker has hit the RBIs Under in 21 of his last 25 games (+12.00 Units / 23% ROI)
  • The Toronto Blue Jays have hit the 1st Five Innings (F5) Team Total Under in 46 of their last 76 away games (+11.25 Units / 12% ROI)
  • The Toronto Blue Jays have covered the Run Line in 16 of their last 21 games (+10.00 Units / 31% ROI)
  • The Toronto Blue Jays have covered the 1st Five Innings (F5) Run Line in 14 of their last 19 games (+7.60 Units / 31% ROI)
  • The Toronto Blue Jays have hit the Game Total Under in 13 of their last 19 games (+6.45 Units / 30% ROI)
  • The Toronto Blue Jays have hit the 1st Five Innings (F5) Moneyline in 10 of their last 19 games (+5.15 Units / 24% ROI)
  • The Houston Astros have hit the Game Total Under in 92 of their last 162 games (+20.00 Units / 11% ROI)
  • The Houston Astros have covered the Run Line in 84 of their last 162 games (+7.70 Units / 4% ROI)

Blue Jays Against the Spread (ATS) Record

Against the spread this season, the Blue Jays are 16-6 against the Run Line (+9 Units / 27.31% ROI).

  • 12-10 when betting on the Moneyline for +2.8 Units / 11.22% ROI
  • 9-13 when betting on the total runs Over for -4.95 Units / -20.67% ROI
  • 13-9 when betting on the total runs Under for +3.2 Units / 13.09% ROI

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 11-10 against the Run Line (+1.7 Units / 6.15% ROI).

  • 10-11 when betting on the Moneyline for -3.25 Units / -12.45% ROI
  • 8-11 when betting on the total runs Over for -4.15 Units / -17.93% ROI
  • 11-8 when betting on the total runs Under for +2.15 Units / 9.33% ROI

Astros vs Blue Jays Home Run Prop Bets Today

Over Under
Yordan Alvarez (HOU) 0.5 +300 0.5 -375
Christian Walker (HOU) 0.5 +375 0.5 -525
Anthony Santander (TOR) 0.5 +425 0.5 -600
Yainer Diaz (HOU) 0.5 +525 0.5 -750
Isaac Paredes (HOU) 0.5 +550 0.5 -800

Astros vs Blue Jays Total Hits Prop Bets Today

Over Under
Jose Altuve (HOU) 0.5 -250 0.5 +195
Yainer Diaz (HOU) 0.5 -235 0.5 +180
Yordan Alvarez (HOU) 0.5 -225 0.5 +170
Jeremy Pena (HOU) 0.5 -220 0.5 +165
Christian Walker (HOU) 0.5 -190 0.5 +145

Astros vs Blue Jays RBI Prop Bets Today

Over Under
Yordan Alvarez (HOU) 0.5 +140 0.5 -185
Christian Walker (HOU) 0.5 +150 0.5 -200
Anthony Santander (TOR) 0.5 +175 0.5 -235
Yainer Diaz (HOU) 0.5 +175 0.5 -225
Jeremy Pena (HOU) 0.5 +200 0.5 -275

Astros vs Blue Jays Strikeout Prop Bets Today

Over Under
Kevin Gausman (TOR) 4.5 -150 4.5 +110
Hunter Brown (HOU) 5.5 +125 5.5 -160

Kevin Gausman has allowed an OBP of just .116 (43 PA’s) against right-handed batters this season — best among qualified SPs in MLB; League Avg: .286 — 100th Percentile.

Kevin Gausman has allowed an OBP of just .198 (91 PA’s) this season — best among qualified SPs in MLB; League Avg: .294 — 100th Percentile.

Kevin Gausman’s has 11 strikeouts and no walks against right-handed batters this season — tied for best K:BB ratio among qualified SPs in MLB; League Avg: 3.4 — 100th Percentile.

Kevin Gausman located his fastball up for a strike 75% (358/478) of the time in the 2024 season — highest among qualified SPs in MLB; League Avg: 61% — 100th Percentile.

Astros Starting Pitcher Stats & Trends

Opponents are hitting just .132 against Hunter Brown vs right-handed batters this season — fifth best among qualified SPs– 95th Percentile. Right handed batters hit .279 (85-for-305) against him last season — fifth worst among qualified SPs– ninth Percentile.

Hunter Brown has induced opposing hitters to ground into 5 double plays in 10 opportunities (50%) this season — best among qualified SPs in MLB; League Avg: 10% — 100th Percentile.

55% of Hunter Brown’s strikeouts have come on 97+ MPH fastballs this season — highest among qualified SPs in MLB; League Avg: 8% — 100th Percentile.

Opponents had a Hard-Hit Rate of just 29% (69/237) against Hunter Brown on fastballs in the 2024 season — best among qualified SPs in MLB; League Avg: 45% — 100th Percentile.

Blue Jays Keys to the Game vs. the Astros

The Blue Jays are 28-15 (.651) when tied entering the 7th inning since the 2023 season — best in MLB; League Avg: .499.

The Blue Jays were just 4-74 (.051) when trailing entering the 8th inning in the 2024 season — 3rd lowest in MLB; League Avg: .100.

The Blue Jays are just 0-7 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .034.

The Blue Jays are just 7-81 (.080) when trailing entering the 7th inning since last season — 4th lowest in MLB; League Avg: .140.

Astros Keys to the Game vs. the Blue Jays

The Astros were just 0-56 (.000) when trailing entering the 9th inning in the 2024 season — tied for lowest in MLB; League Avg: .050.

The Astros are just 1-9 (.100) after a win this season — 2nd lowest in MLB; League Avg: .481.

The Astros are 8-2 (.800) after a loss this season — 2nd best in MLB; League Avg: .522.

The Astros are just 6-13 (.316) when tied entering the 8th inning since last season — 3rd lowest in MLB; League Avg: .500.

Blue Jays hitters have an OBP of .400 (188 PA’s) against LHP this season — best in MLB; League Avg: .307.

The Blue Jays are batting just .189 on the first pitch of at-bats this season — lowest in MLB; League Avg: .341.

Blue Jays hitters have struck out in just 18% of it’s PA’s this season — 2nd best in MLB; League Avg: 22%.

Blue Jays hitters are slugging just .477 on the first pitch of at-bats since last season — lowest in MLB; League Avg: .563.

Astros hitters averaged just 3.65 pitches per plate appearance against RHP in the 2024 season — lowest in MLB; League Avg: 3.89.

Astros hitters are slugging .490 in lefty-lefty matchups since the 2023 season — best in MLB; League Avg: .370.

Astros hitters have struck out in just 19% of it’s PA’s against LHP since the 2023 season — best in MLB; League Avg: 23%.

Astros hitters averaged just 3.66 pitches per plate appearance in the 2024 season — lowest in MLB; League Avg: 3.89.

Opponents have a groundball batting average of just .043 against Blue Jays pitchers with the shift this season — best in MLB; League Avg: .231.

Blue Jays pitchers have an ERA of 2.32 (81.1 IP) on the road this season — best in MLB; League Avg: 4.45.

Opponents had a miss rate of just 24% against Blue Jays pitchers in the 2024 season — tied for 2nd lowest in MLB; League Avg: 25%.

Opponents have a miss rate of 28% against Blue Jays pitchers this season — 3rd best in MLB; League Avg: 26%.

Opponents have a miss rate of 28% against Astros pitchers since the 2023 season — 2nd best in MLB; League Avg: 26%.

Opponents had a miss rate of 27% against Astros pitchers in the 2024 season — 2nd best in MLB; League Avg: 25%.

Astros pitchers have a strikeout rate of 24% since the 2023 season — tied for 3rd best in MLB; League Avg: 23%.

Opponents have a miss rate of 28% against Astros pitchers since last season — 2nd best in MLB; League Avg: 25%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.