Orioles vs Nationals Prediction, Odds & Player Prop Bets Today – MLB, Apr 22

Washington Nationals' Luis Garcia hits an RBI single against the Seattle Mariners to score CJ Abrams during the third inning of a baseball game Monday, June 26, 2023, in Seattle.
(AP Photo/Lindsey Wasson)
  • The Orioles are -135 favorites vs the Nationals
  • Orioles vs Nationals Over / Under today: 9 Runs
  • Orioles / Nationals TV Channel: MASN | MAS2

The Baltimore Orioles (-135) visit Nationals Park to take on the Washington Nationals (+115) on Tuesday, April 22, 2025. First pitch is scheduled for 6:45pm EDT in Washington, D.C., DC.

This season, the Orioles are 9-12 against the spread (ATS), while the Nationals are 10-12 ATS.

Orioles vs Nationals Starting Pitchers Today:

  • Orioles starting pitcher: Dean Kremer 2-2, 6.41 ERA
  • Nationals starting pitcher: Mitchell Parker 2-1, 1.83 ERA

Orioles vs. Nationals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Orioles-1.5 +125O 9 -110-135
Nationals +1.5 -150U 9 -110+115

Orioles vs Nationals Prediction for Today’s Game

Based on recent trends the model predicts the Orioles will win Tuesday‘s MLB game with 55.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


Bet now on Orioles vs Nationals and all games with BetMGM


We’ve highlighted some favorite MLB player prop bets for Orioles players for Tuesday‘s game, looking at profitable historical betting trends:

Best Orioles Player Prop Bets Today:

  • Heston Kjerstad has hit the Home Runs Over in 3 of his last 6 games (+18.50 Units / 308% ROI)
  • Gunnar Henderson has hit the Hits Runs and RBIs Under in 19 of his last 25 away games (+13.60 Units / 48% ROI)
  • Gunnar Henderson has hit the Runs Under in 19 of his last 25 away games (+12.80 Units / 42% ROI)
  • Gunnar Henderson has hit the Hits Under in 13 of his last 20 games (+12.50 Units / 49% ROI)
  • Jordan Westburg has hit the Total Bases Under in 16 of his last 20 away games (+10.10 Units / 33% ROI)

And here are some favorite MLB player prop bets for Nationals players for Tuesday‘s game, looking at profitable historical betting trends:

Best Nationals Player Prop Best Bets Today:

  • Nate Lowe has hit the Home Runs Over in 3 of his last 8 games at home (+17.20 Units / 215% ROI)
  • Josh Bell has hit the Runs Over in 16 of his last 25 games at home (+13.45 Units / 54% ROI)
  • Keibert Ruiz has hit the Hits Over in 14 of his last 15 games at home (+11.85 Units / 41% ROI)
  • Josh Bell has hit the Total Bases Over in 17 of his last 25 games at home (+11.15 Units / 36% ROI)
  • Keibert Ruiz has hit the Singles Over in 11 of his last 15 games at home (+8.15 Units / 52% ROI)
  • The Baltimore Orioles have hit the Game Total Over in 13 of their last 21 games (+7.70 Units / 33% ROI)
  • The Baltimore Orioles have hit the Team Total Under in 5 of their last 7 away games (+3.10 Units / 41% ROI)
  • The Baltimore Orioles have covered the Run Line in 3 of their last 5 games (+2.85 Units / 57% ROI)
  • The Baltimore Orioles have hit the 1st Five Innings (F5) Team Total Over in 12 of their last 21 games (+1.60 Units / 6% ROI)
  • The Baltimore Orioles have covered the 1st Five Innings (F5) Run Line in 3 of their last 5 games (+0.70 Units / 12% ROI)
  • The Washington Nationals have hit the Team Total Over in their last 9 games at home (+9.35 Units / 85% ROI)
  • The Washington Nationals have hit the 1st Five Innings (F5) Team Total Over in their last 8 games at home (+8.20 Units / 79% ROI)
  • The Washington Nationals have hit the 1st Five Innings (F5) Moneyline in 7 of their last 9 games at home (+7.45 Units / 83% ROI)
  • The Washington Nationals have covered the 1st Five Innings (F5) Run Line in 8 of their last 9 games at home (+6.85 Units / 63% ROI)
  • The Washington Nationals have covered the Run Line in their last 5 games at home (+5.00 Units / 88% ROI)

Orioles Against the Spread (ATS) Record

Against the spread this season, the Orioles are 8-13 against the Run Line (-5.9 Units / -21.03% ROI).

  • 9-12 when betting on the Moneyline for -6.15 Units / -23.65% ROI
  • 13-5 when betting on the total runs Over for +7.7 Units / 33.41% ROI
  • 5-13 when betting on the total runs Under for -9.2 Units / -39.74% ROI

Nationals Against the Spread (ATS) Record

Against the spread this season, the Nationals are 10-12 against the Run Line (-3.5 Units / -12.7% ROI).

  • 9-13 when betting on the Moneyline for -2.8 Units / -11.99% ROI
  • 12-10 when betting on the total runs Over for +1.25 Units / 5.19% ROI
  • 10-12 when betting on the total runs Under for -3.05 Units / -12.55% ROI

Nationals vs Orioles Home Run Prop Bets Today

Over Under
Tyler Oโ€™Neill (BAL) 0.5 +270 0.5 -325
Gary Sanchez (BAL) 0.5 +375 0.5 -500
Jordan Westburg (BAL) 0.5 +475 0.5 -700
James Wood (WAS) 0.5 +475 0.5 -700
Ryan Mountcastle (BAL) 0.5 +550 0.5 -800

Nationals vs Orioles Total Hits Prop Bets Today

Over Under
Adley Rutschman (BAL) 0.5 -235 0.5 +180
Luis Garcia (WAS) 0.5 -235 0.5 +180
Keibert Ruiz (WAS) 0.5 -225 0.5 +170
Jordan Westburg (BAL) 0.5 -220 0.5 +165
Tyler Oโ€™Neill (BAL) 0.5 -210 0.5 +155

Nationals vs Orioles RBI Prop Bets Today

Over Under
Tyler Oโ€™Neill (BAL) 0.5 +140 0.5 -185
Ryan Mountcastle (BAL) 0.5 +160 0.5 -210
Jordan Westburg (BAL) 0.5 +165 0.5 -220
Keibert Ruiz (WAS) 0.5 +165 0.5 -220
Gary Sanchez (BAL) 0.5 +175 0.5 -235

Nationals vs Orioles Strikeout Prop Bets Today

Over Under
Mitchell Parker (WAS) 4.5 -155 4.5 +120
Dean Kremer (BAL) 4.5 +115 4.5 -150

Opponents had a line drive rate of 35% (35/99) versus Dean Kremer with runners in scoring position in 2023 — highest in MLB among starting pitchers with at least 64 total IP; League Avg: 24% — 0 Percentile.

Dean Kremer located 57% of his pitches away (1,656/2,925) in 2023 — highest among qualified SPs in MLB; League Avg: 46% — 100th Percentile.

Dean Kremer located 57% of his pitches away (1,656/2,925) in 2023 — highest among among AL Starters; League Avg: 46% — 100th Percentile.

Opponents had a line drive rate of just 13% (11/85) versus Dean Kremer with runners in scoring position in the 2024 season — 2nd lowest in MLB among starting pitchers with at least 64 total IP; League Avg: 23% — 99th Percentile.

Nationals Starting Pitcher Stats & Trends

Mitchell Parker has allowed a slugging percentage of just .182 (6 Total Bases / 33 ABs) when going through the lineup the first time in a game this season — 2nd best among among NL Starters; League Avg: .361 — 98th Percentile.

Mitchell Parker has a strikeout rate of just 16% (16 SO in 102 PAs) this season — 7th lowest among qualified SPs in MLB; League Avg: 24% — seventh Percentile.

Mitchell Parker has a strikeout rate of just 10% (2 SO in 21 PAs) in PAs ending on elevated fastballs this season — 6th lowest among qualified SPs in MLB; League Avg: 24% — seventh Percentile.

Mitchell Parker has allowed a slugging percentage of just .091 (4 Total Bases / 44 ABs) with two-strikes this season — tied for 2nd best among among NL Starters; League Avg: .248 — 97th Percentile.

Orioles Keys to the Game vs. the Nationals

The Orioles are just 0-11 (.000) when scoring 4 or fewer runs this season — lowest in MLB; League Avg: .288.

The Orioles are 72-7 (.911) when they’ve had 5 or more XBH since the 2023 season — tied for best in MLB; League Avg: .800.

The Orioles are 165-14 (.922) when leading entering the 7th inning since the 2023 season — best in MLB; League Avg: .860.

The Orioles are 51-40 (.560) on the road since last season — 4th best in MLB; League Avg: .467.

Nationals Keys to the Game vs. the Orioles

The Nationals were just 20-43 (.317) vs top 10 scoring offenses in the 2024 season They play the Dodgers (second best runs scored) today.

The Nationals are just 45-156 (.224) when scoring 4 or fewer runs since the 2023 season — 5th lowest in MLB; League Avg: .273.

The Nationals are just 5-7 (.417) after a loss this season — tied for 5th lowest in MLB; League Avg: .523.

The Nationals are just 144-170 (.459) when allowing 5 or more extra base hits since the 2023 season — 5th lowest in MLB; League Avg: .538.

Orioles hitters have put just 33% of balls in play to the left side of the field since last season — lowest in MLB; League Avg: 38%.

Orioles hitters have put just 35% of balls in play to the left side of the field since the 2023 season — 2nd lowest in MLB; League Avg: 38%.

Orioles hitters are slugging .475 against RHP this season — 2nd best in MLB; League Avg: .394.

Orioles hitters grounded into 71 double plays in 1,127 opportunities (6%) in the 2024 season — best in MLB; League Avg: 10%.

Nationals hitters have an OPS of just .948 (2,372 PA’s) with the pitcher behind in the count since the 2023 season — lowest in MLB; League Avg: 1.083.

Nationals hitters put 41% of their swings in play against LHP in 2023 — highest in MLB; League Avg: 37%.

The Nationals batted just .226 when facing the starting pitcher for the 3rd time in a game in the 2024 season — 2nd lowest in MLB; League Avg: .263.

Nationals hitters struck out just 340 times in 1,868 PA’s (18%) against LHP in 2023 — tied for best in MLB; League Avg: 23%.

Orioles pitchers have walked 16% of batters when facing the leadoff batter in the inning this season — highest in MLB; League Avg: 9%.

Orioles pitchers have a strikeout rate of just 18% this season — 2nd lowest in MLB; League Avg: 23%.

Orioles pitchers have walked 19% of batters when facing the leadoff batter in the inning over the last 14 days — highest in MLB; League Avg: 9%.

Orioles pitchers have an ERA of 6.39 (100.0 IP) at home this season — highest in MLB; League Avg: 3.52.

Nationals pitchers had a strikeout rate of just 38% with two-strikes in 2023 — tied for 2nd lowest in MLB; League Avg: 43%.

Nationals pitchers have a strikeout rate of just 39% with two-strikes since the 2023 season — 2nd lowest in MLB; League Avg: 42%.

Opponents had a miss rate of just 23% against Nationals pitchers in 2023 — 3rd lowest in MLB; League Avg: 26%.

Batters facing the Nationals pitchers have struck out in the zone 57% of the time this season — 3rd highest in MLB; League Avg: 51%. this season — 3rd highest in MLB; League Avg: 51%.

More MLB Reading:


Bet now on Orioles vs Nationals and all games with BetMGM


Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.

Split First Bet Offer FBO March Matchups 1080x610
About the Author

BetMGM Betting

Read More @BETMGM

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.