- The Cardinals are -4 point favorites vs the 49ers
- Total (Over/Under): 42.5 points
- Watch this game on FOX
The San Francisco 49ers (6-10-0) visit State Farm Stadium to take on the Arizona Cardinals (7-9-0) on Jan. 5. Kickoff is scheduled for 4:25pm EST in Glendale, AZ.
The Cardinals are betting favorites in this matchup, with the spread sitting at -4 (-110).
The 49ers vs. Cardinals Over/Under is 42.5 total points for the game.
Bet now on Cardinals vs 49ers & all NFL games with BetMGM
49ers vs. Cardinals Odds, Spread, Over/Under
| Spread | Total (O/U) | Moneyline | |
| 49ers | +4 -110 | 42.5 -110 | +165 |
| Cardinals | -4 -110 | 42.5 -110 | -200 |
49ers vs. Cardinals Prediction
The winning team model predicts the Cardinals will win this game with 61.0% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.
49ers vs Cardinals Spread Prediction
Based on recent against-the-spread trends, the model predicts the 49ers will cover the spread with 59.0% confidence.
This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.
Bet now on Cardinals vs 49ers and all NFL games with BetMGM
We’ve highlighted some favorite NFL player prop bets for 49ers players this playoff game, looking at profitable historical betting trends:
Best 49ers Player Prop Bets Today
- Brock Purdy has hit the Rushing Yards Over in 13 of his last 17 games (+8.40 Units / 43% ROI)
- Brandon Aiyuk has hit the Receiving Yards Under in 8 of his last 9 games (+6.90 Units / 69% ROI)
- Brandon Aiyuk has hit the Receptions Under in 8 of his last 9 games (+6.65 Units / 60% ROI)
- Brock Purdy has hit the Carries Over in 12 of his last 17 games (+6.15 Units / 29% ROI)
- Jauan Jennings has hit the Receptions Over in 11 of his last 16 games (+6.10 Units / 31% ROI)
And here are some top NFL player prop bets for Cardinals players for this matchup, looking at profitable historical betting trends:
Best Cardinals Player Prop Best Bets Today
- Kyler Murray has hit the TD Passes Under in 14 of his last 17 games (+9.60 Units / 35% ROI)
- James Conner has hit the Receptions Over in 11 of his last 17 games (+6.30 Units / 31% ROI)
- Marvin Harrison Jr. has hit the Receptions Under in 7 of his last 8 games at home (+6.15 Units / 59% ROI)
- Greg Dortch has hit the Receiving Yards Under in 7 of his last 8 games at home (+5.85 Units / 62% ROI)
- Kyler Murray has hit the Carries Under in 7 of his last 9 games at home (+5.25 Units / 49% ROI)
49ers Best Bets:
- The San Francisco 49ers have hit the 2H Game Total Over in 12 of their last 16 games (+7.63 Units / 43% ROI)
- The San Francisco 49ers have hit the 3Q Game Total Over in 5 of their last 6 away games (+3.85 Units / 51% ROI)
- The San Francisco 49ers have hit the 4Q Game Total Over in 5 of their last 6 away games (+3.80 Units / 56% ROI)
- The San Francisco 49ers have hit the 2Q Game Total Over in 4 of their last 5 away games (+2.85 Units / 51% ROI)
- The San Francisco 49ers have hit the 1H Game Total Over in 13 of their last 22 games (+2.60 Units / 10% ROI)
Cardinals Best Bets:
- The Arizona Cardinals have covered the 2H Spread in 8 of their last 9 games at home (+7.38 Units / 71% ROI)
- The Arizona Cardinals have hit the 2H Moneyline in 7 of their last 8 games at home (+5.80 Units / 59% ROI)
- The Arizona Cardinals have hit the 3Q Moneyline in 10 of their last 17 games (+5.70 Units / 29% ROI)
- The Arizona Cardinals have covered the 3Q Spread in 7 of their last 9 games at home (+4.70 Units / 41% ROI)
- The Arizona Cardinals have covered the 1Q Spread in 7 of their last 10 games at home (+3.95 Units / 30% ROI)
49ers Against the Spread (ATS) Record
Against the spread this NFL season, the 49ers art 5-11 (-7 Units / -40% ROI).
- 49ers are 6-10 when betting on the Moneyline for -12 Units / -34.63% ROI
- 49ers are 9-7 when betting the Over for +1.3 Units / 7.39% ROI
- 49ers are 7-9 when betting the Under for -2.9 Units / ROI
Cardinals Against the Spread (ATS) Record
Against the spread this NFL season, the Cardinals are 10-6 (+3.2 Units / 17.88% ROI).
- Cardinals are 7-9 when betting on the Moneyline for -2.2 Units / -10.4% ROI
- Cardinals are 7-8 when betting the Over for -1.8 Units / -10.23% ROI
- Cardinals are 8-7 when betting the Under for +0.3 Units / 1.7% ROI
San Francisco 49ers: Keys to the Game vs. the Arizona Cardinals
The 49ers were winless (0-5) when scoring less than 22 points last season — T-worst in NFL; League Avg: .253.
The 49ers are 16-5 (.762) when rushing for 120 or more yards since the 2023 season — 10th-best in NFL. The Cardinals have allowed an average of 135.4 rushing yards per game since the 2023 season — 3rd-worst in NFL.
The 49ers were winless (0-3) when within 7 points at the two minute warning last season — worst in NFL; League Avg: .500.
The 49ers are winless (0-12) when scoring less than 22 points since the 2023 season — worst in NFL; League Avg: .244.
Arizona Cardinals: Keys to the Game vs. the San Francisco 49ers
The Cardinals were winless (0-3) when forcing 2 or more turnovers last season — worst in NFL; League Avg: .707.
The Cardinals were 1-12 (.077) when converting less than 50% of third down conversion opportunities last season — worst in NFL; League Avg: .430.
The Cardinals were winless (0-5) when allowing 250 or more passing yards last season — T-worst in NFL; League Avg: .414.
The Cardinals were 1-6 (.143) when sacking the QB 3 or more times last season — 2nd-worst in NFL; League Avg: .650.
Additional Matchup Notes for San Francisco 49ers vs. Arizona Cardinals
The Cardinals have been successful on 48.1% of plays they have run with motion this season — 5th-best in NFL. The 49ers have allowed their opponents to be successful on 46.9% of plays against motion this season — 4th-worst in NFL.
The Cardinals were successful on 57.6% of plays they ran with motion last week — 5th-best in NFL. The 49ers allowed their opponents to be successful on 59.1% of plays against motion last week — 4th-worst in NFL.
The Cardinals have run successful plays on just 33.9% of pass attempts against a heavy rush since the 2023 season — 2nd-worst in NFL. The 49ers have allowed successful plays on just 35.7% of pass attempts with a heavy rush since the 2023 season — 4th-best in NFL.
The 49ers have been successful on 48.8% of plays they have run against a base front since the 2023 season — 2nd-best in NFL. The Cardinals have allowed their opponents to be successful on 47.8% of plays with a base front since the 2023 season — worst in NFL.
The 49ers have averaged 0.12 epa per play against a light front since the 2023 season — 4th-best in NFL. The Cardinals have allowed 0.06 epa per play with a light front since the 2023 season — T-3rd-worst in NFL.
The 49ers have run 53.3% offensive plays on their opponent’s side of the field since the 2023 season — best in NFL. The Cardinals have allowed their opponents to run 50.6% of plays in their territory since the 2023 season — 2nd-worst in NFL.
San Francisco 49ers Offense: Important Stats
The 49ers ran successful plays on 53% of rush attempts against a base front last season — best in NFL; League Avg: 41%.
The 49ers averaged 9.3 yards per attempt (4,577 yards/491 attempts) last season — best in NFL; League Avg: 7.0.
The 49ers have averaged 11.5 yards per play against open coverage since the 2023 season — best in NFL; League Avg: 9.3.
The 49ers ran successful plays on 51% of plays last season — best in NFL; League Avg: 42%.
Arizona Cardinals Offense: Important Stats
The Cardinals had 23 rushes of 20+ yards last season — most in NFL.
The Cardinals have run successful plays on 23% of rush attempts on play action passes this season — worst in NFL; League Avg: 53%.
The Cardinals have targeted TEs 33% of the time (346 Pass Attempts/1,063 plays) since the 2023 season — highest in NFL; League Avg: 21%.
The Cardinals have run successful plays on 37% of rush attempts against a base rush this season — 2nd-worst in NFL; League Avg: 51%.
San Francisco 49ers Defense: Important Stats
The 49ers defense allowed successful plays on 10% of plays with a light rush last season — best in NFL; League Avg: 39%.
The 49ers defense have allowed just 5.9 yards per play against play action passes this season — 2nd-best in NFL; League Avg: 7.6.
The 49ers defense allowed scores on 20% of opponent drives in the 4th quarter last season — best in NFL; League Avg: 33%.
The 49ers defense have allowed just 6.2 yards per play against play action passes since the 2023 season — 2nd-best in NFL; League Avg: 7.6.
Arizona Cardinals Defense: Important Stats
19% of the plays ran against the Cardinals were in the red zone last season — worst in NFL; League Avg: 14%.
The Cardinals defense has allowed a passer rating of just 39.6 with a stacked front (2 Pass Attempts) this season — 2nd-best in NFL; League Avg: 112.6.
The Cardinals defense allowed 25 TD passes in the red zone last season — T-most in NFL.
The Cardinals defense allowed 6 TD passes when the opposing QB was scrambling last season — most in NFL.
Looking to place a bet on this game with a First Bet Offer up to $1,500? Bet now on Cardinals vs 49ers and all NFL games with BetMGM
More NFL Betting Predictions:
- Anytime & First Touchdown Scorer Predictions
- Receiving Yards Prop Predictions
- Rushing Yards Prop Predictions
- Passing Yards Prop Predictions
- Receptions Made Prop Predictions
- Rushing Attempts Prop Predictions
- Passing Touchdowns Prop Predictions
- QB Interception Prop Predictions
- Field Goals Made Prop Predictions
- NFL Betting Previews: Every Game
More NFL Odds at BetMGM
Take your football entertainment to the next level with NFL betting at the online sportsbook.
From futures like Chiefs Super Bowl odds, Lions odds to win the division, or Ravens playoff odds, to weekly odds like spreads, moneylines, and over/under totals, there’s something for everyone.
And with the best sportsbook promotions, you could land a welcome offer, sports betting Odds Boost, or a Parlay Boost! You can also check out NFL picks and predictions and updated Super Bowl predictions throughout the year.
Log in to your BetMGM account today — or sign up for a new account via the online sportsbook or BetMGM iOS app or BetMGM Android app — to start betting!
