Seahawks vs 49ers Prediction, Odds & Best Prop Bets – NFL, Week 2

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BetMGM Betting @BETMGM Sep 18, 2022, 8:42 AM
  • The 49ers (0-1) are -8.5 point favorites vs the Seahawks (1-0)
  • Total (Over/Under): 41.5 points
  • Watch the game on FOX

The Seattle Seahawks (1-0) visit Levi’s Stadium to take on the San Francisco 49ers (0-1) on Sep. 18. Kickoff is scheduled for 4:05pm EDT in Santa Clara.

The 49ers are betting favorites in Week 2, with the spread sitting at -8.5 (-110).

The Seahawks vs. 49ers Over/Under is 41.5 total points for the game.

Bet now on 49ers vs Seahawks & all NFL games with BetMGM

Seahawks vs. 49ers Odds, Spread, Over/Under Week 2

SpreadTotal (O/U)Moneyline
Seattle Seahawks+8.5 -11041.5 -110+325
San Francisco 49ers -8.5 -11041.5 -110-450

Seahawks vs. 49ers Prediction for Week 2

Based on recent trends, the winning team model predicts the 49ers will win this Week 2 game with 82.0% confidence.

Seahawks vs 49ers Spread Prediction for Week 2

Based on recent against-the-spread trends, the model predicts the 49ers will cover the spread this Week 2 with 51.0% confidence.

Both predictions factor in up-to-date player injuries for both the Seahawks and 49ers, plus offensive & defensive matchups, recent games and key player performances this season.


Best Seahawks Player Prop Bets Today

We’ve highlighted some favorite NFL player prop bets for Seahawks players for Week 2, looking at profitable historical betting trends:

  • Tyler Lockett has hit the Receptions Under in 12 of his last 15 games (+8.90 Units / 46% ROI)
  • DK Metcalf has hit the Receiving Yards Under in his last 7 away games (+7.00 Units / 83% ROI)
  • Geno Smith has hit the Passing Yards Under in his last 4 games (+4.00 Units / 82% ROI)
  • Geno Smith has hit the Pass Attempts Under in his last 4 games (+4.00 Units / 68% ROI)
  • Geno Smith has hit the Completions Over in 3 of his last 4 games (+1.90 Units / 44% ROI)

Best 49ers Player Prop Best Bets Today

And here are some top NFL player prop bets for 49ers players for Week 2, looking at profitable historical betting trends:

  • Deebo Samuel has hit the Receptions Under in 15 of his last 19 games (+8.85 Units / 31% ROI)
  • Jimmy Garoppolo has hit the Completions Under in 11 of his last 14 games (+7.50 Units / 42% ROI)
  • George Kittle has hit the Receptions Under in his last 6 games (+6.00 Units / 74% ROI)
  • Jimmy Garoppolo has hit the Rushing Yards Under in 8 of his last 10 games (+5.25 Units / 40% ROI)
  • Deebo Samuel has hit the Receiving Yards Over in 6 of his last 7 games at home (+4.85 Units / 59% ROI)

Receiving Props: Total Receiving Yards for 49ers vs Seahawks

Player Name Over Under
DK Metcalf 57.5 -115 57.5 -110
Tyler Lockett 47.5 -115 47.5 -110
Will Dissly 14.5 -110 14.5 -115
Rashaad Penny 7.5 -115 7.5 -115
Fant 24.5 -110 24.5 -115

Rushing Props: Total Rushing Yards for 49ers vs Seahawks

Player Name Over Under
Geno Smith 12.5 -110 12.5 -115
Trey Lance 38.5 -110 38.5 -115
Rashaad Penny 54.5 -115 54.5 -110
Jeff Wilson Jr. 51.5 -115 51.5 -115
  • The Seattle Seahawks have covered the 1Q Spread in 11 of their last 14 games (+7.50 Units / 46% ROI)
  • The Seattle Seahawks have hit the 1H Moneyline in 5 of their last 6 games (+6.45 Units / 58% ROI)
  • The Seattle Seahawks have hit the 2Q Moneyline in 5 of their last 7 games (+5.90 Units / 59% ROI)
  • The Seattle Seahawks have covered the 1H Spread in their last 5 games (+5.00 Units / 94% ROI)
  • The Seattle Seahawks have hit the 2Q Game Total Under in their last 5 away games (+5.00 Units / 91% ROI)
  • The San Francisco 49ers have hit the 1H Game Total Under in their last 7 games (+7.00 Units / 92% ROI)
  • The San Francisco 49ers have hit the 1Q Game Total Under in 8 of their last 9 games (+7.00 Units / 69% ROI)
  • The San Francisco 49ers have hit the Game Total Under in 8 of their last 9 games (+6.90 Units / 70% ROI)
  • The San Francisco 49ers have covered the Spread in 10 of their last 13 games (+6.85 Units / 48% ROI)
  • The San Francisco 49ers have covered the 3Q Spread in 10 of their last 13 games (+6.85 Units / 46% ROI)

Seahawks Against the Spread (ATS) Record

Against the spread this NFL season, the Seahawks have gone ( Units / ROI).

  • Seahawks are when betting on the Moneyline for Units / ROI
  • Seahawks are when betting the Over for Units / ROI
  • Seahawks are when betting the Under for Units / ROI

49ers Against the Spread (ATS) Record

Against the spread this NFL season, the 49ers have gone ( Units / ROI).

  • 49ers are when betting on the Moneyline for Units / ROI
  • 49ers are when betting the Over for Units / ROI
  • 49ers are when betting the Under for Units / ROI

Seattle Seahawks: Keys to the Game vs. the San Francisco 49ers

The Seahawks were winless (0-8) when scoring less than 22 points last season — tied for worst in NFL; League Avg: .222.

The Seahawks were 1-6 (.143) when within 7 points at the two minute warning last season — 3rd-worst in NFL; League Avg: .495.

The Seahawks are winless (0-3) when averaging less than 5 yards per rush since Week 11 — tied for worst in NFL; League Avg: .500.

The Seahawks were 3-6 (.333) when within 7 points entering the 4th quarter last season — tied for 6th-worst in NFL; League Avg: .491.

San Francisco 49ers: Keys to the Game vs. the Seattle Seahawks

The 49ers are undefeated (6-0) when the opposing team converts less than 55% of its red zone chances into touchdowns since the 2021 season — tied for best in NFL; League Avg: .531.

The 49ers were 1-2 (.333) when the opposing team rushes more than 30 times last season — tied for 3rd-best in NFL; League Avg: .165.

The 49ers were undefeated (6-0) when the opposing team converts less than 55% of its red zone chances into touchdowns last season — tied for best in NFL; League Avg: .533.

The 49ers were 9-2 (.818) when rushing for 120 or more yards last season — tied for 8th-best in NFL; League Avg: .670.

Additional Matchup Notes for Seattle Seahawks vs. San Francisco 49ers

The 49ers have an average drive start position from the 23.8 yard line since the 2021 season — tied for worst in NFL. The Seahawks have allowed an average drive start position from the 23.2 yard line since the 2021 season — best in NFL.

The 49ers gained at least 5 yards on 46.3% of first down plays last season — fourth-best in NFL. The Seahawks allowed at least 5 yards on 46.5% of first down plays last season — second-worst in NFL.

49ers WRs have averaged 7.6 yards after the catch since Week 16 of the 2021 Season — second-best in NFL. The Seahawks have allowed 6.1 yards after catch per reception to WRs since Week 16 of the 2021 Season — worst in NFL.

The Seahawks ran successful plays on just 25.0% of rush attempts last week — worst in NFL. 49ers allowed successful plays on just 29.4% of rush attempts in Week 1 — tied for fourth-best in NFL.

The Seahawks were successful on just 34.8% of plays they have run last week — fourth-worst in NFL. 49ers allowed their opponents to be successful on just 28.3% of plays in Week 1 — tied for best in NFL.

The Seahawks are averaging just 3.8 yards per carry on first down since the 2021 season — fifth-worst in NFL. The 49ers have allowed just 4.0 yards per carry on first down since the 2021 season — fourth-best in NFL.

Seattle Seahawks Offense: Important Stats for Week 2

The Seahawks ran 946 plays last season — fewest in NFL.

The Seahawks have 19 TDs that were 20+ yards since the 2021 season — 2nd-most in NFL.

The Seahawks had 17 TDs that were 20+ yards last season — tied for 2nd-most in NFL.

The Seahawks have run 992 plays since the 2021 season — fewest in NFL.

San Francisco 49ers Offense: Important Stats for Week 2

The 49ers started 12 drives inside their own 10 yard line in the 2nd half last season — most in NFL.

The 49ers started 19 drives inside their own 20 yard line in the 4th quarter last season — most in NFL.

The 49ers had an average drive start position from the 18.6 yard line in the 3rd quarter last season — worst in NFL; League Avg: 25.6.

The 49ers have started 21 drives inside their own 20 yard line in the 4th quarter since the 2021 season — most in NFL.

Seattle Seahawks Defense: Important Stats for Week 2

The Seahawks defense allowed 6.7 yards per dropback (1,333 yards/200 attempts) when targeted at a depth of 1-5 yards last season — worst in NFL; League Avg: 5.6.

Offenses facing the Seahawks targeted WRs 36% of the time (15 Pass Attempts/42 plays) in Week 1 — lowest in NFL; League Avg: 57%.

The Seahawks defense has allowed 62.5 receiving yards per game (1,125/18) to RBs since the 2021 season — worst in NFL; League Avg: 36.4.

23% of the plays ran against the Seahawks were in the red zone in the 4th quarter last season — 3rd-worst in NFL; League Avg: 17%.

San Francisco 49ers Defense: Important Stats for Week 2

Offenses facing the 49ers threw the ball 30% of the time (17 Pass Attempts/56 plays) in Week 1 — lowest in NFL; League Avg: 55%.

The 49ers defense have averaged 37.9 defensive penalty yards per game (683/18) since the 2021 season — worst in NFL; League Avg: 23.1.

The 49ers defense allowed successful plays on 37% of rush attempts last season — 2nd-best in NFL; League Avg: 43%.

The 49ers defense allowed just 4.6 yards per dropback (784 yards/172 attempts) when targeted at a depth of 1-5 yards last season — best in NFL; League Avg: 5.6.

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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.