Titans vs Colts Prediction, Odds & Best Prop Bets โ€“ NFL, Week 16

(AP Photo/Zach Bolinger)
  • The Colts are -3.5 point favorites vs the Titans
  • Total (Over/Under): 42.5 points
  • Watch this game on CBS

The Tennessee Titans (3-11-0) visit Lucas Oil Stadium to take on the Indianapolis Colts (6-8-0) on Dec. 22. Kickoff is scheduled for 1:00pm EST in Indianapolis, IN.

The Colts are betting favorites in this matchup, with the spread sitting at -3.5 (-110).

The Titans vs. Colts Over/Under is 42.5 total points for the game.

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Titans vs. Colts Odds, Spread, Over/Under

SpreadTotal (O/U)Moneyline
Titans+3.5 -11042.5 -110+155
Colts -3.5 -11042.5 -110-190

Titans vs. Colts Prediction

The winning team model predicts the Colts will win this game with 64.0% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Titans vs Colts Spread Prediction

Based on recent against-the-spread trends, the model predicts the Colts will cover the spread with 61.0% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


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We’ve highlighted some favorite NFL player prop bets for Titans players this playoff game, looking at profitable historical betting trends:

Best Titans Player Prop Bets Today

  • Tyjae Spears has hit the Rushing Yards Under in 10 of his last 13 games (+6.50 Units / 43% ROI)
  • Mason Rudolph has hit the TD Passes Over in 6 of his last 7 games (+5.90 Units / 50% ROI)
  • Nick Westbrook has hit the Receiving Yards Over in his last 5 games (+5.00 Units / 87% ROI)
  • Josh Whyle has hit the Receiving Yards Under in 6 of his last 7 games (+4.85 Units / 61% ROI)
  • Mason Rudolph has hit the Passing Yards Over in 6 of his last 7 games (+4.70 Units / 58% ROI)

And here are some top NFL player prop bets for Colts players for this matchup, looking at profitable historical betting trends:

Best Colts Player Prop Best Bets Today

  • Jonathan Taylor has hit the Receptions Under in 11 of his last 14 games (+8.50 Units / 50% ROI)
  • Kylen Granson has hit the Receptions Under in 9 of his last 11 games (+8.00 Units / 49% ROI)
  • Matt Gay has hit the Field Goals Over in 12 of his last 16 games (+6.80 Units / 34% ROI)
  • Adonai Mitchell has hit the Receptions Under in 7 of his last 8 games (+6.75 Units / 66% ROI)
  • Anthony Richardson has hit the Passing Yards Under in 7 of his last 8 games (+5.85 Units / 64% ROI)
  • The Tennessee Titans have hit the 1Q Moneyline in 10 of their last 20 games (+7.05 Units / 30% ROI)
  • The Tennessee Titans have hit the 1H Moneyline in 11 of their last 20 games (+7.00 Units / 28% ROI)
  • The Tennessee Titans have hit the Game Total Over in 7 of their last 9 away games (+4.80 Units / 48% ROI)
  • The Tennessee Titans have hit the 2Q Game Total Over in 6 of their last 8 away games (+3.85 Units / 42% ROI)
  • The Tennessee Titans have hit the 4Q Game Total Over in 6 of their last 8 away games (+3.50 Units / 38% ROI)
  • The Indianapolis Colts have hit the 1Q Moneyline in 11 of their last 20 games (+7.70 Units / 31% ROI)
  • The Indianapolis Colts have covered the 1Q Spread in 14 of their last 20 games (+7.55 Units / 29% ROI)
  • The Indianapolis Colts have hit the 3Q Game Total Under in 11 of their last 17 games (+4.15 Units / 21% ROI)
  • The Indianapolis Colts have hit the 1Q Game Total Over in 12 of their last 20 games (+3.75 Units / 16% ROI)
  • The Indianapolis Colts have hit the 4Q Game Total Over in 5 of their last 8 games at home (+1.65 Units / 18% ROI)

Titans Against the Spread (ATS) Record

Against the spread this NFL season, the Titans art 2-12 (-11.15 Units / -73.11% ROI).

  • Titans are 3-11 when betting on the Moneyline for -7.1 Units / -43.43% ROI
  • Titans are 8-5 when betting the Over for +2.5 Units / 16.23% ROI
  • Titans are 5-8 when betting the Under for -3.8 Units / ROI

Colts Against the Spread (ATS) Record

Against the spread this NFL season, the Colts are 8-6 (+1.4 Units / 9.18% ROI).

  • Colts are 6-8 when betting on the Moneyline for -1.25 Units / -8.06% ROI
  • Colts are 6-7 when betting the Over for -1.7 Units / -11.04% ROI
  • Colts are 7-6 when betting the Under for +0.4 Units / 2.6% ROI

Tennessee Titans: Keys to the Game vs. the Indianapolis Colts

The Titans were 1-2 (.333) when forcing 2 or more turnovers last season — T-2nd-worst in NFL; League Avg: .707.

The Titans are winless (0-6) whe trailing at the end of the frist half this season — T-worst in NFL; League Avg: .256.

The Titans are 1-7 (.125) when the opposing team commits less than 60 yards in penalties this season — T-2nd-worst in NFL; League Avg: .473.

The Titans are winless (0-9) when allowing 10 or more rushes of four or more yards this season — T-worst in NFL; League Avg: .398.

Indianapolis Colts: Keys to the Game vs. the Tennessee Titans

The Colts were winless (0-7) when trailing at the end of the third quarter last season — T-worst in NFL; League Avg: .148.

The Colts were 5-3 (.625) when within 7 points at the two minute warning last season — 8th-best in NFL; League Avg: .500.

The Colts were 5-1 (.833) when the opposing team converts less than 55% of its red zone chances into touchdowns last season — 3rd-best in NFL; League Avg: .536.

The Colts were 7-2 (.778) when not losing a fumble last season — T-7th-best in NFL; League Avg: .578.

Additional Matchup Notes for Tennessee Titans vs. Indianapolis Colts

The Colts have run successful plays on just 33.3% of rush attempts with motion this season — 2nd-worst in NFL. The Titans have allowed successful plays on just 36.7% of rush attempts against motion this season — 3rd-best in NFL.

The Colts have run successful plays on just 32.2% of rush attempts against a stacked front since the 2023 season — worst in NFL. The Titans have allowed successful plays on just 36.0% of rush attempts with a stacked front since the 2023 season — best in NFL.

The Colts have run successful plays on just 28.1% of rush attempts against a stacked front this season — 2nd-worst in NFL. The Titans have allowed successful plays on just 21.1% of rush attempts with a stacked front this season — best in NFL.

The Titans ran successful plays on 65.5% of pass attempts against a base front last week — 5th-best in NFL. The Colts pressured opposing QBs on 7.7% of pass attempts with a base front last week — 5th-worst in NFL.

The Titans ran successful plays on 64.3% of pass attempts against a base rush last week — 3rd-best in NFL. The Colts pressured opposing QBs on 3.4% of pass attempts with a base rush last week — worst in NFL.

Titans WRs have averaged just 3.5 yards after the catch since the 2023 season — T-worst in NFL. The Colts have allowed just 3.8 yards after catch per reception to WRs since the 2023 season — T-2nd-best in NFL.

Tennessee Titans Offense: Important Stats

The Titans have run 36% of their plays in their opponent’s territory in the 2nd half since the 2023 season — worst in NFL; League Avg: 47%.

The Titans have run 37% of their plays in their opponent’s territory in the 4th quarter this season — worst in NFL; League Avg: 53%.

The Titans ran 33% of their plays in their opponent’s territory in the 3rd quarter last season — worst in NFL; League Avg: 41%.

The Titans have run 37% of their plays in their opponent’s territory in the 2nd half this season — worst in NFL; League Avg: 49%.

Indianapolis Colts Offense: Important Stats

The Colts turned the ball over on downs 6 times in the red zone last season — most in NFL.

The Colts have averaged -1.30 epa per play against a light front since Week 12 — worst in NFL; League Avg: 0.00.

The Colts have run successful plays on 20% of pass attempts on play action passes since Week 12 — worst in NFL; League Avg: 54%.

The Colts have thrown 58% of their pass attempts 1 to 10 yards downfield this season — lowest in NFL; League Avg: 70%.

Tennessee Titans Defense: Important Stats

The Titans defense has allowed 6.5 yards from scrimmage per touch (4,346 yards / 665 touches) this season — best in NFL; League Avg: 7.3.

The Titans defense has allowed successful plays on 21% of rush attempts with a stacked front this season — best in NFL; League Avg: 46%.

The Titans defense allowed scores on 43% of opponent drives last season — 3rd-worst in NFL; League Avg: 35%.

The Titans defense has allowed a Completion Pct of just 28% (15 completions/54 attempts) when they have pressured the QB this season — best in NFL; League Avg: 43%.

Indianapolis Colts Defense: Important Stats

The Colts defense has allowed successful plays on 54% of plays on contested throws this season — worst in NFL; League Avg: 35%.

The Colts defense has allowed successful plays on 53% of pass attempts on contested throws this season — worst in NFL; League Avg: 35%.

The Colts defense has allowed successful plays on 73% of pass attempts with a stacked front since the 2023 season — worst in NFL; League Avg: 50%.

The Colts defense has forced 6 turnovers in the red zone this season — most in NFL.

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About the Author

Nick Hennion

Read More @nickhennion

Nick Hennion is a senior content writer for BetMGM. His previous stops include VSiN, NBC Sports, The Action Network and Forbes Betting. He owns a bachelor's degree from Syracuse University and a master's degree from Northwestern University.

Nick Hennion is a senior content writer for BetMGM. His previous stops include VSiN, NBC Sports, The Action Network and Forbes Betting. He owns a bachelor's degree from Syracuse University and a master's degree from Northwestern University.