White Sox vs Padres Prediction, Odds & Player Prop Bets Today – MLB, Sep 21

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San Diego Padres' Jake Cronenworth during a baseball game against the San Francisco Giants in San Francisco, Wednesday, June 21, 2023.
(AP Photo/Jeff Chiu)
BetMGM Betting @BETMGM Sep 21, 2024, 11:00 AM
  • The Padres are -275 favorites vs the White Sox
  • White Sox vs Padres Over / Under today: 8 Runs
  • White Sox / Padres TV Channel: NSCH | PDTV

The Chicago White Sox (+240) visit Petco Park to take on the San Diego Padres (-300) on Saturday, September 21, 2024. First pitch is scheduled for 8:40pm EDT in San Diego, CA.

This season, the White Sox are 36-118 against the spread (ATS), while the Padres are 77-77 ATS.

White Sox vs Padres Starting Pitchers Today:

  • White Sox starting pitcher: Chris Flexen 2-14, 5.11 ERA
  • Padres starting pitcher: Martin Perez 4-5, 4.31 ERA

White Sox vs. Padres Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
White Sox+1.5 +115O 8 -105+240
Padres -1.5 -135U 8 -115-300

White Sox vs Padres Prediction for Today’s Game

Based on recent trends the model predicts the Padres will win Saturday‘s MLB game with 69.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for White Sox players for Saturday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

  • Andrew Benintendi has hit the Home Runs Over in 5 of his last 19 away games (+22.20 Units / 117% ROI)
  • Lenyn Sosa has hit the Total Bases Over in 9 of his last 11 away games (+8.85 Units / 60% ROI)
  • Andrew Vaughn has hit the Hits Over in 10 of his last 11 games (+8.55 Units / 35% ROI)
  • Zach DeLoach has hit the Singles Over in his last 7 games (+8.45 Units / 115% ROI)
  • Lenyn Sosa has hit the Hits Runs and RBIs Over in 16 of his last 25 games (+7.45 Units / 28% ROI)

And here are some favorite MLB player prop bets for Padres players for Saturday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Best Bets Today:

  • Jackson Merrill has hit the Home Runs Over in 11 of his last 44 games (+33.50 Units / 76% ROI)
  • Jackson Merrill has hit the Total Bases Over in 31 of his last 50 games (+17.30 Units / 32% ROI)
  • Manny Machado has hit the RBIs Over in 27 of his last 47 games (+16.80 Units / 35% ROI)
  • Manny Machado has hit the Hits Runs and RBIs Over in 32 of his last 47 games (+13.45 Units / 22% ROI)
  • Luis Arraez has hit the Singles Over in 21 of his last 25 games (+13.10 Units / 25% ROI)
  • The Chicago White Sox have hit the Team Total Under in 22 of their last 32 away games (+11.10 Units / 30% ROI)
  • The Chicago White Sox have hit the Game Total Under in 17 of their last 29 away games (+7.25 Units / 23% ROI)
  • The Chicago White Sox have covered the Run Line in 5 of their last 6 games (+3.45 Units / 44% ROI)
  • The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Under in 4 of their last 5 away games (+3.05 Units / 50% ROI)
  • The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 5 of their last 8 away games (+2.20 Units / 25% ROI)
  • The San Diego Padres have hit the Moneyline in 51 of their last 77 games (+18.30 Units / 17% ROI)
  • The San Diego Padres have hit the Game Total Over in 43 of their last 76 games (+9.10 Units / 11% ROI)
  • The San Diego Padres have covered the Run Line in 63 of their last 122 games (+6.17 Units / 4% ROI)
  • The San Diego Padres have hit the 1st Five Innings (F5) Team Total Under in 20 of their last 32 games at home (+6.05 Units / 15% ROI)
  • The San Diego Padres have hit the Team Total Under in 10 of their last 15 games at home (+4.10 Units / 23% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 63-91 against the Run Line (-35.32 Units / -19.46% ROI).

  • 36-118 when betting on the Moneyline for -62.75 Units / -40.19% ROI
  • 65-79 when betting on the total runs Over for -22.3 Units / -13.25% ROI
  • 79-65 when betting on the total runs Under for +8.15 Units / 4.9% ROI

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 77-77 against the Run Line (+3.07 Units / 1.61% ROI).

  • 88-66 when betting on the Moneyline for +6.5 Units / 3.12% ROI
  • 81-70 when betting on the total runs Over for +4.5 Units / 2.67% ROI
  • 70-81 when betting on the total runs Under for -19.95 Units / -11.68% ROI

Padres vs White Sox Home Run Prop Bets Today

Over Under
Fernando Tatis Jr. (SD) 0.5 +290 0.5 -375
Manny Machado (SD) 0.5 +375 0.5 -550
Jackson Merrill (SD) 0.5 +475 0.5 -650
Andrew Vaughn (CWS) 0.5 +500 0.5 -700
Luis Robert (CWS) 0.5 +525 0.5 -750

Padres vs White Sox Total Hits Prop Bets Today

Over Under
Jackson Merrill (SD) 0.5 -275 0.5 +195
Andrew Vaughn (CWS) 0.5 -250 0.5 +190
Luis Robert (CWS) 0.5 -225 0.5 +165
Xander Bogaerts (SD) 0.5 -225 0.5 +160
Lenyn Sosa (CWS) 0.5 -210 0.5 +155

Padres vs White Sox RBI Prop Bets Today

Over Under
Manny Machado (SD) 0.5 +125 0.5 -160
Fernando Tatis Jr. (SD) 0.5 +130 0.5 -175
Jackson Merrill (SD) 0.5 +140 0.5 -190
Andrew Vaughn (CWS) 0.5 +155 0.5 -210
Xander Bogaerts (SD) 0.5 +185 0.5 -250

Padres vs White Sox Strikeout Prop Bets Today

Over Under
Chris Flexen (CWS) 3.5 +115 3.5 -150
Martin Perez (SD) 4.5 +120 4.5 -155

Chris Flexen has an ERA of 7.40 (99.2 IP) on the road since last season — highest in MLB among starting pitchers with at least 126 total IP; League Avg: 4.26 — 0 Percentile.

Chris Flexen has allowed a slugging percentage of .573 (327 Total Bases / 571 ABs) on fastballs since the 2022 season — 3rd highest in MLB among starting pitchers with at least 190 total IP; League Avg: .431 — second Percentile.

Chris Flexen has located his pitches away 61% of the time (1,588/2,605) this season — highest in MLB among starting pitchers with at least 61 total IP; League Avg: 48% — 100th Percentile.

Chris Flexen has allowed an OBP of .378 (609 PA’s) against right-handed batters since last season — highest in MLB among starting pitchers with at least 126 total IP; League Avg: .305 — first Percentile.

Padres Starting Pitcher Stats & Trends

Opponents are hitting .373 (41-for-110) against Martin Perez when going through the lineup the third time in a game this season — highest in MLB among starting pitchers with at least 61 total IP; League Avg: .259 — first Percentile.

Martin Perez has allowed an OPS of 1.080 (118 PA’s) when going through the lineup the third time in a game this season — highest in MLB among starting pitchers with at least 61 total IP; League Avg: .750 — first Percentile.

Martin Perez has allowed a slugging percentage of .673 (74 Total Bases / 110 ABs) when going through the lineup the third time in a game this season — highest in MLB among starting pitchers with at least 61 total IP; League Avg: .428 — first Percentile.

Hitters have chased just 75 of Martin Perez’s 499 elevated fastballs out of the zone (15%) since the 2022 season — 3rd lowest in MLB among starting pitchers with at least 190 total IP; League Avg: 29% — second Percentile.

White Sox Keys to the Game vs. the Padres

The White Sox are just 16-60 (.211) on the road this season — lowest in MLB; League Avg: .475.

The White Sox are just 35-118 (.229) this season — lowest in MLB; League Avg: .500.

The White Sox are just 2-15 (.118) after a road win this season — lowest in MLB; League Avg: .463.

The White Sox are just 15-17 (.469) when they’ve had 10 or more hits this season — lowest in MLB; League Avg: .751.

Padres Keys to the Game vs. the White Sox

The Padres are 27-19 (.587) after a road win this season — 3rd best in MLB; League Avg: .463.

The Padres are 68-20 (.773) when allowing 4 or fewer runs this season — 5th best in MLB; League Avg: .723.

The Padres are 32-13 (.711) when they’ve scored in the first inning this season — 5th best in MLB; League Avg: .644.

The Padres are 19-45 (.297) when allowing 5 or more runs this season — best in MLB; League Avg: .197.

White Sox hitters have an OBP of just .283 (8,779 PA’s) against RHP since last season — lowest in MLB; League Avg: .315.

White Sox hitters have an OPS of just .646 (8,779 PA’s) against RHP since last season — lowest in MLB; League Avg: .722.

White Sox hitters have an OBP of just .285 (11,556 PA’s) since last season — lowest in MLB; League Avg: .316.

The White Sox have a winning percentage of just 23% this season — lowest in MLB; League Avg: 50%.

Padres hitters have just 273 strikeouts in 1,571 PA’s (17%) against LHP this season — best in MLB; League Avg: 23%.

Padres hitters have just 745 strikeouts in 4,246 PA’s (17%) against RHP this season — best in MLB; League Avg: 23%.

Padres hitters have just 1,018 strikeouts in 5,817 PA’s (17%) this season — best in MLB; League Avg: 23%.

Padres hitters have just 72 strikeouts in 503 PA’s (14%) in lefty-lefty matchups this season — best in MLB; League Avg: 24%.

The White Sox have won just 10% of games in which their opponents scored first this season — lowest in MLB; League Avg: 32%.

White Sox pitchers have walked 606 of 5,954 batters (10%) this season — highest in MLB; League Avg: 8%.

In games when their opponents have scored three or more runs in an inning, the White Sox have won just just 3% of the time this season — lowest in MLB; League Avg: 24%.

The White Sox have won just 11% of home games in which their opponents scored first this season — lowest in MLB; League Avg: 36%.

The Padres pitchers allowed an average Exit Velocity of just 87.9 MPH in the 2023 season (3,922 balls in play) — best in MLB; League Avg: 89.0

The Padres pitchers have allowed an average Exit Velocity of just 88.1 MPH since last season (7,685 balls in play) — best in MLB; League Avg: 88.9

Padres pitchers allowed an average Exit Velocity of 87.9 MPH (3,922 batted balls) in the 2023 season — best in MLB; League Avg: 89.0.

Opponents have a miss rate of 27% against Padres pitchers this season — 3rd best in MLB; League Avg: 25%.

Padres vs. White Sox Injuries Tonight That May Affect Prop Bets 

  • San Diego Padres – No Injuries Reported
  • Chicago White Sox – No Injuries Reported

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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.