Cardinals vs 49ers Prediction, Odds & Best Prop Bets – NFL, Week 18

min read
San Francisco 49ers head coach Kyle Shanahan stands on the sidelines during the second half of an NFL football game against the Los Angeles Rams Sunday, Oct. 30, 2022, in Inglewood, Calif. (AP Photo/Ashley Landis)
(AP Photo/Ashley Landis)
BetMGM Betting @BETMGM Jan 06, 2023, 4:15 PM
  • The 49ers (12-4) are -14 point favorites vs the Cardinals (4-12)
  • Total (Over/Under): 40 points

The Arizona Cardinals (4-12) visit Levi’s Stadium to take on the San Francisco 49ers (12-4) on Jan. 8. Kickoff is scheduled for 1:00pm EST in Santa Clara.

The 49ers are betting favorites in Week 18, with the spread sitting at -14 (-110).

The Cardinals vs. 49ers Over/Under is 39.5 total points for the game.

Bet now on 49ers vs Cardinals & all NFL games with BetMGM

Cardinals vs. 49ers Odds, Spread, Over/Under Week 18

SpreadTotal (O/U)Moneyline
Cardinals+14 -11039.5 -110+650
49ers -14 -11039.5 -110-1000

Cardinals vs. 49ers Prediction for Week 18

Based on recent trends, the winning team model predicts the 49ers will win this Week 18 game with 78.0% confidence.

Cardinals vs 49ers Spread Prediction for Week 18

Based on recent against-the-spread trends, the model predicts the Cardinals will cover the spread this Week 18 with 54.0% confidence.

Both predictions factor in up-to-date player injuries for both the Cardinals and 49ers, plus offensive & defensive matchups, recent games and key player performances this season.


Bet now on 49ers vs Cardinals and all NFL games with BetMGM


Best Cardinals Player Prop Bets Today

We’ve highlighted some favorite NFL player prop bets for Cardinals players for Week 18, looking at profitable historical betting trends:

  • A.J. Green has hit the Receptions Under in his last 7 games (+7.05 Units / 69% ROI)
  • A.J. Green has hit the Receiving Yards Under in his last 7 games (+7.00 Units / 80% ROI)
  • Kyler Murray has hit the Passing Yards Under in 10 of his last 13 games (+6.25 Units / 37% ROI)
  • James Conner has hit the Carries Under in 8 of his last 10 games (+5.30 Units / 40% ROI)
  • Kyler Murray has hit the Interceptions Over in his last 5 away games (+5.10 Units / 91% ROI)

Best 49ers Player Prop Best Bets Today

And here are some top NFL player prop bets for 49ers players for Week 18, looking at profitable historical betting trends:

  • Brandon Aiyuk has hit the Receiving Yards Over in 13 of his last 20 games (+5.15 Units / 23% ROI)
  • Christian McCaffrey has hit the Receiving Yards Over in 9 of his last 13 games (+4.75 Units / 32% ROI)
  • Brandon Aiyuk has hit the Receptions Over in 6 of his last 8 games at home (+4.50 Units / 48% ROI)
  • Christian McCaffrey has hit the Rushing Yards Over in 10 of his last 15 games (+4.45 Units / 27% ROI)
  • Christian McCaffrey has hit the Carries Under in his last 4 games at home (+4.00 Units / 73% ROI)
  • The Arizona Cardinals have hit the 1Q Game Total Under in their last 7 games (+7.05 Units / 80% ROI)
  • The Arizona Cardinals have covered the 1Q Spread in 7 of their last 8 games (+5.35 Units / 51% ROI)
  • The Arizona Cardinals have covered the 1H Spread in their last 5 games (+5.00 Units / 90% ROI)
  • The Arizona Cardinals have hit the 1Q Moneyline in 4 of their last 8 games (+4.40 Units / 52% ROI)
  • The Arizona Cardinals have hit the 2H Game Total Over in 6 of their last 8 away games (+3.75 Units / 42% ROI)
  • The San Francisco 49ers have hit the Moneyline in 15 of their last 20 games (+9.50 Units / 21% ROI)
  • The San Francisco 49ers have hit the 2Q Moneyline in 12 of their last 17 games (+8.05 Units / 28% ROI)
  • The San Francisco 49ers have covered the 2Q Spread in 13 of their last 18 games (+7.70 Units / 38% ROI)
  • The San Francisco 49ers have covered the Spread in 14 of their last 20 games (+7.40 Units / 33% ROI)
  • The San Francisco 49ers have hit the 3Q Moneyline in 7 of their last 9 games (+7.00 Units / 44% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this NFL season, the Cardinals have gone 8-8 (-0.85 Units / -4.84% ROI).

  • Cardinals are 4-12 when betting on the Moneyline for -7.15 Units / -41.45% ROI
  • Cardinals are 8-7 when betting the Over for +0.3 Units / 1.7% ROI
  • Cardinals are 7-8 when betting the Under for -1.8 Units / ROI

49ers Against the Spread (ATS) Record

Against the spread this NFL season, the 49ers have gone 10-6 (+3.4 Units / 19.32% ROI).

  • 49ers are 12-4 when betting on the Moneyline for +5.25 Units / 12.79% ROI
  • 49ers are 8-8 when betting the Over for -0.8 Units / -4.55% ROI
  • 49ers are 8-8 when betting the Under for -0.8 Units / -4.55% ROI

Arizona Cardinals: Keys to the Game vs. the San Francisco 49ers

The Cardinals are winless (0-4) when within 7 points at the two minute warning this season — worst in NFL; League Avg: .492.

The Cardinals are 2-8 (.200) when throwing at least 1 interception this season — eighth-worst in NFL. The 49ers have intercepted 17 passes this season — tied for third-most in NFL.

The Cardinals are winless (0-11) when allowing 100 or more rushing yards this season — tied for worst in NFL; League Avg: .397.

The Cardinals are winless (0-10) when scoring less than 22 points this season — tied for worst in NFL; League Avg: .274.

San Francisco 49ers: Keys to the Game vs. the Arizona Cardinals

The 49ers are undefeated (3-0) when within 7 points at the two minute warning this season — tied for best in NFL; League Avg: .492.

The 49ers are undefeated (11-0) vs bottom 10 run offenses since the 2021 season — best in NFL; League Avg: .548.

The 49ers are undefeated (8-0) when the opposing team converts less than 55% of its red zone chances into touchdowns this season — best in NFL; League Avg: .567.

The 49ers are 12-2 (.857) when allowing less than 5 yards per rush this season — best in NFL; League Avg: .522.

Additional Matchup Notes for Arizona Cardinals vs. San Francisco 49ers

The 49ers have run successful plays on 51.2% of pass attempts this season — fourth-best in NFL. Cardinals have allowed successful plays on 51.3% of pass attempts this season — worst in NFL.

49ers RBs have rushed for 10 or more yards on 13.1% of 360 carries this season — third-best in NFL. The Cardinals have allowed 10+ yards on 13.9% of carries to RBs this season — third-worst in NFL.

The 49ers ran 21.7% offensive plays in the red zone last week — fourth-best in NFL. Cardinals allowed their opponent to run 23.3% of plays in the red zone in Week 14 — second-worst in NFL.

The Cardinals have run just 11.7% offensive plays in the red zone this season — tied for third-worst in NFL. 49ers has allowed their opponent to run just 10.5% of plays in the red zone this season — best in NFL.

The Cardinals have gained at least 5 yards on just 37.7% of first down plays this season — third-worst in NFL. The 49ers have allowed at least 5 yards on just 36.0% of first down plays this season — best in NFL.

The Cardinals are 2-8 (.200) when throwing at least 1 interception this season — eighth-worst in NFL. The 49ers have intercepted 17 passes this season — tied for third-most in NFL.

Arizona Cardinals Offense: Important Stats for Week 18

The Cardinals are averaging 18.5 drives per TD in the 1st quarter this season — 3rd-worst Drives Per TD rate in NFL; League Avg: 6.2.

The Cardinals have an average drive start position from the 19.8 yard line in the 3rd quarter this season — worst in NFL; League Avg: 26.0.

The Cardinals have averaged 26.4 offensive penalty yards per game (423/16) this season — 2nd-worst in NFL; League Avg: 19.5.

The Cardinals have run successful plays on 54% of rush attempts in the 4th quarter this season — best in NFL; League Avg: 42%.

San Francisco 49ers Offense: Important Stats for Week 18

The 49ers have 8 TDs that were 20+ yards since Week 14 — most in NFL.

The 49ers ran successful plays on 73% of rush attempts in the 2nd half in Week 17 — best in NFL; League Avg: 41%.

The 49ers have a third down conversion rate of 29% on third and 10+ yards to go since the 2021 season — 3rd-best in NFL; League Avg: 19%.

The 49ers have averaged 8.3 yards per attempt (5,981 yards/722 attempts) on Early Downs since the 2021 season — best in NFL; League Avg: 7.1.

Arizona Cardinals Defense: Important Stats for Week 18

The Cardinals defense has allowed a Completion Pct of 60% (63 completions/105 attempts) when they have pressured the QB this season — worst in NFL; League Avg: 41%.

The Cardinals defense has allowed a Completion Pct of 55% (112 completions/205 attempts) when they have pressured the QB since the 2021 season — worst in NFL; League Avg: 42%.

The Cardinals defense has tackled opponents for a loss on 22 of 112 rushing attempts (20% TFL%) since Week 14. — best in NFL; League Avg: 11%.

The Cardinals defense has allowed successful plays on 49% of plays in the 4th quarter this season — worst in NFL; League Avg: 42%.

San Francisco 49ers Defense: Important Stats for Week 18

The 49ers defense allowed 9 receptions for 20+ yards in Week 17 — most in NFL.

The 49ers defense has allowed successful plays on 27% of rush attempts in the 1st quarter this season — best in NFL; League Avg: 42%.

The 49ers defense has allowed 16.6 Points per Game (266/16) this season — best in NFL; League Avg: 21.8.

The 49ers defense allowed 9 completions for 20+ yards in Week 17 — most in NFL.

Looking to place a bet on this game with a First Bet Offer up to $1,000? Bet now on 49ers vs Cardinals and all NFL games with BetMGM

Bet on NFL Odds at BetMGM

At BetMGM, you can bet online with updated NFL betting odds. And with live sports betting, the best online sports betting and mobile sports betting (with the BetMGM Sportsbook app) experiences are at BetMGM.

About the Author

BetMGM Betting

Read More @BETMGM

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.