- The 49ers (12-4) are -14 point favorites vs the Cardinals (4-12)
- Total (Over/Under): 40 points
The Arizona Cardinals (4-12) visit Levi’s Stadium to take on the San Francisco 49ers (12-4) on Jan. 8. Kickoff is scheduled for 1:00pm EST in Santa Clara.
The 49ers are betting favorites in Week 18, with the spread sitting at -14 (-110).
The Cardinals vs. 49ers Over/Under is 39.5 total points for the game.
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Cardinals vs. 49ers Odds, Spread, Over/Under Week 18
| Spread | Total (O/U) | Moneyline | |
| Cardinals | +14 -110 | 39.5 -110 | +650 |
| 49ers | -14 -110 | 39.5 -110 | -1000 |
Cardinals vs. 49ers Prediction for Week 18
Based on recent trends, the winning team model predicts the 49ers will win this Week 18 game with 78.0% confidence.
Cardinals vs 49ers Spread Prediction for Week 18
Based on recent against-the-spread trends, the model predicts the Cardinals will cover the spread this Week 18 with 54.0% confidence.
Both predictions factor in up-to-date player injuries for both the Cardinals and 49ers, plus offensive & defensive matchups, recent games and key player performances this season.
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Best Cardinals Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for Cardinals players for Week 18, looking at profitable historical betting trends:
- A.J. Green has hit the Receptions Under in his last 7 games (+7.05 Units / 69% ROI)
- A.J. Green has hit the Receiving Yards Under in his last 7 games (+7.00 Units / 80% ROI)
- Kyler Murray has hit the Passing Yards Under in 10 of his last 13 games (+6.25 Units / 37% ROI)
- James Conner has hit the Carries Under in 8 of his last 10 games (+5.30 Units / 40% ROI)
- Kyler Murray has hit the Interceptions Over in his last 5 away games (+5.10 Units / 91% ROI)
Best 49ers Player Prop Best Bets Today
And here are some top NFL player prop bets for 49ers players for Week 18, looking at profitable historical betting trends:
- Brandon Aiyuk has hit the Receiving Yards Over in 13 of his last 20 games (+5.15 Units / 23% ROI)
- Christian McCaffrey has hit the Receiving Yards Over in 9 of his last 13 games (+4.75 Units / 32% ROI)
- Brandon Aiyuk has hit the Receptions Over in 6 of his last 8 games at home (+4.50 Units / 48% ROI)
- Christian McCaffrey has hit the Rushing Yards Over in 10 of his last 15 games (+4.45 Units / 27% ROI)
- Christian McCaffrey has hit the Carries Under in his last 4 games at home (+4.00 Units / 73% ROI)
Cardinals Best Bets for Week 18:
- The Arizona Cardinals have hit the 1Q Game Total Under in their last 7 games (+7.05 Units / 80% ROI)
- The Arizona Cardinals have covered the 1Q Spread in 7 of their last 8 games (+5.35 Units / 51% ROI)
- The Arizona Cardinals have covered the 1H Spread in their last 5 games (+5.00 Units / 90% ROI)
- The Arizona Cardinals have hit the 1Q Moneyline in 4 of their last 8 games (+4.40 Units / 52% ROI)
- The Arizona Cardinals have hit the 2H Game Total Over in 6 of their last 8 away games (+3.75 Units / 42% ROI)
49ers Best Bets for Week 18:
- The San Francisco 49ers have hit the Moneyline in 15 of their last 20 games (+9.50 Units / 21% ROI)
- The San Francisco 49ers have hit the 2Q Moneyline in 12 of their last 17 games (+8.05 Units / 28% ROI)
- The San Francisco 49ers have covered the 2Q Spread in 13 of their last 18 games (+7.70 Units / 38% ROI)
- The San Francisco 49ers have covered the Spread in 14 of their last 20 games (+7.40 Units / 33% ROI)
- The San Francisco 49ers have hit the 3Q Moneyline in 7 of their last 9 games (+7.00 Units / 44% ROI)
Cardinals Against the Spread (ATS) Record
Against the spread this NFL season, the Cardinals have gone 8-8 (-0.85 Units / -4.84% ROI).
- Cardinals are 4-12 when betting on the Moneyline for -7.15 Units / -41.45% ROI
- Cardinals are 8-7 when betting the Over for +0.3 Units / 1.7% ROI
- Cardinals are 7-8 when betting the Under for -1.8 Units / ROI
49ers Against the Spread (ATS) Record
Against the spread this NFL season, the 49ers have gone 10-6 (+3.4 Units / 19.32% ROI).
- 49ers are 12-4 when betting on the Moneyline for +5.25 Units / 12.79% ROI
- 49ers are 8-8 when betting the Over for -0.8 Units / -4.55% ROI
- 49ers are 8-8 when betting the Under for -0.8 Units / -4.55% ROI
Arizona Cardinals: Keys to the Game vs. the San Francisco 49ers
The Cardinals are winless (0-4) when within 7 points at the two minute warning this season — worst in NFL; League Avg: .492.
The Cardinals are 2-8 (.200) when throwing at least 1 interception this season — eighth-worst in NFL. The 49ers have intercepted 17 passes this season — tied for third-most in NFL.
The Cardinals are winless (0-11) when allowing 100 or more rushing yards this season — tied for worst in NFL; League Avg: .397.
The Cardinals are winless (0-10) when scoring less than 22 points this season — tied for worst in NFL; League Avg: .274.
San Francisco 49ers: Keys to the Game vs. the Arizona Cardinals
The 49ers are undefeated (3-0) when within 7 points at the two minute warning this season — tied for best in NFL; League Avg: .492.
The 49ers are undefeated (11-0) vs bottom 10 run offenses since the 2021 season — best in NFL; League Avg: .548.
The 49ers are undefeated (8-0) when the opposing team converts less than 55% of its red zone chances into touchdowns this season — best in NFL; League Avg: .567.
The 49ers are 12-2 (.857) when allowing less than 5 yards per rush this season — best in NFL; League Avg: .522.
Additional Matchup Notes for Arizona Cardinals vs. San Francisco 49ers
The 49ers have run successful plays on 51.2% of pass attempts this season — fourth-best in NFL. Cardinals have allowed successful plays on 51.3% of pass attempts this season — worst in NFL.
49ers RBs have rushed for 10 or more yards on 13.1% of 360 carries this season — third-best in NFL. The Cardinals have allowed 10+ yards on 13.9% of carries to RBs this season — third-worst in NFL.
The 49ers ran 21.7% offensive plays in the red zone last week — fourth-best in NFL. Cardinals allowed their opponent to run 23.3% of plays in the red zone in Week 14 — second-worst in NFL.
The Cardinals have run just 11.7% offensive plays in the red zone this season — tied for third-worst in NFL. 49ers has allowed their opponent to run just 10.5% of plays in the red zone this season — best in NFL.
The Cardinals have gained at least 5 yards on just 37.7% of first down plays this season — third-worst in NFL. The 49ers have allowed at least 5 yards on just 36.0% of first down plays this season — best in NFL.
The Cardinals are 2-8 (.200) when throwing at least 1 interception this season — eighth-worst in NFL. The 49ers have intercepted 17 passes this season — tied for third-most in NFL.
Arizona Cardinals Offense: Important Stats for Week 18
The Cardinals are averaging 18.5 drives per TD in the 1st quarter this season — 3rd-worst Drives Per TD rate in NFL; League Avg: 6.2.
The Cardinals have an average drive start position from the 19.8 yard line in the 3rd quarter this season — worst in NFL; League Avg: 26.0.
The Cardinals have averaged 26.4 offensive penalty yards per game (423/16) this season — 2nd-worst in NFL; League Avg: 19.5.
The Cardinals have run successful plays on 54% of rush attempts in the 4th quarter this season — best in NFL; League Avg: 42%.
San Francisco 49ers Offense: Important Stats for Week 18
The 49ers have 8 TDs that were 20+ yards since Week 14 — most in NFL.
The 49ers ran successful plays on 73% of rush attempts in the 2nd half in Week 17 — best in NFL; League Avg: 41%.
The 49ers have a third down conversion rate of 29% on third and 10+ yards to go since the 2021 season — 3rd-best in NFL; League Avg: 19%.
The 49ers have averaged 8.3 yards per attempt (5,981 yards/722 attempts) on Early Downs since the 2021 season — best in NFL; League Avg: 7.1.
Arizona Cardinals Defense: Important Stats for Week 18
The Cardinals defense has allowed a Completion Pct of 60% (63 completions/105 attempts) when they have pressured the QB this season — worst in NFL; League Avg: 41%.
The Cardinals defense has allowed a Completion Pct of 55% (112 completions/205 attempts) when they have pressured the QB since the 2021 season — worst in NFL; League Avg: 42%.
The Cardinals defense has tackled opponents for a loss on 22 of 112 rushing attempts (20% TFL%) since Week 14. — best in NFL; League Avg: 11%.
The Cardinals defense has allowed successful plays on 49% of plays in the 4th quarter this season — worst in NFL; League Avg: 42%.
San Francisco 49ers Defense: Important Stats for Week 18
The 49ers defense allowed 9 receptions for 20+ yards in Week 17 — most in NFL.
The 49ers defense has allowed successful plays on 27% of rush attempts in the 1st quarter this season — best in NFL; League Avg: 42%.
The 49ers defense has allowed 16.6 Points per Game (266/16) this season — best in NFL; League Avg: 21.8.
The 49ers defense allowed 9 completions for 20+ yards in Week 17 — most in NFL.
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