- The Bills are -6 point favorites vs the Cardinals
- Total (Over/Under): 48.5 points
- Watch this game on CBS
The Arizona Cardinals (0-0-0) visit Highmark Stadium to take on the Buffalo Bills (0-0-0) on Sep. 8. Kickoff is scheduled for 1:00pm EDT in Orchard Park, NY.
The Bills are betting favorites in this matchup, with the spread sitting at -6 (-110).
The Cardinals vs. Bills Over/Under is 48.5 total points for the game.
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Cardinals vs. Bills Odds, Spread, Over/Under
| Spread | Total (O/U) | Moneyline | |
| Cardinals | +6 -110 | 48.5 -110 | +200 |
| Bills | -6 -110 | 48.5 -110 | -250 |
Cardinals vs. Bills Prediction
The winning team model predicts the Bils will win this game with 71.8% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.
Cardinals vs Bills Spread Prediction
Based on recent against-the-spread trends, the model predicts the Bills will cover the spread with 55.5% confidence.
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Best Cardinals Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for Cardinals players this playoff game, looking at profitable historical betting trends:
- James Conner has hit the Receiving Yards Under in 10 of his last 13 games (+6.00 Units / 35% ROI)
- James Conner has hit the Longest Reception Under in 7 of his last 8 games (+5.75 Units / 58% ROI)
- James Conner has hit the Longest Rush Over in his last 5 games (+5.00 Units / 85% ROI)
- Chris Moore has hit the Receiving Yards Over in 6 of his last 7 games (+4.85 Units / 58% ROI)
- Zay Jones has hit the Receptions Over in his last 4 games (+4.40 Units / 96% ROI)
Best Bills Player Prop Best Bets Today
And here are some top NFL player prop bets for Bills players for this matchup, looking at profitable historical betting trends:
- Josh Allen has hit the Interceptions Over in 12 of his last 15 games (+7.55 Units / 36% ROI)
- Khalil Shakir has hit the Receptions Over in 9 of his last 12 games (+6.95 Units / 50% ROI)
- Dawson Knox has hit the Longest Reception Under in his last 6 games at home (+6.00 Units / 80% ROI)
- Dawson Knox has hit the Receiving Yards Under in his last 6 games at home (+6.00 Units / 74% ROI)
- Mack Hollins has hit the Receiving Yards Over in his last 5 games at home (+5.00 Units / 88% ROI)
First Touchdown Scorer Bet for Bills vs Cardinals
| Player Name | 1st TD Odds |
|---|---|
| Josh Allen (Buf) | +600 |
| James Cook (Buf) | +700 |
Anytime Touchdown Scorer Bet for Bills vs Cardinals
| Player Name | Anytime TD Odds |
|---|---|
| Josh Allen (Buf) | -105 |
| James Cook (Buf) | +110 |
Receiving Props: Total Receiving Yards for Bills vs Cardinals
| Player Name | Over | Under |
|---|---|---|
| Marvin Harrison Jr. (ARI) | 61.5 -115 | 61.5 -115 |
| Trey Mcbride (ARI) | 49.5 -120 | 49.5 -110 |
| James Conner (ARI) | 10.5 -120 | 10.5 -110 |
| Michael Wilson (ARI) | 30.5 -115 | 30.5 -115 |
| Greg Dortch (ARI) | 26.5 -120 | 26.5 -110 |
Rushing Props: Total Rushing Yards for Bills vs Cardinals
| Player Name | Over | Under |
|---|---|---|
| Kyler Murray (ARI) | 32.5 -115 | 32.5 -115 |
| James Conner (ARI) | 51.5 -120 | 51.5 -110 |
| James Cook (BUF) | 63.5 -115 | 63.5 -120 |
| Josh Allen (BUF) | 33.5 -115 | 33.5 -115 |
Cardinals Best Bets:
- The Arizona Cardinals have hit the 2H Moneyline in 6 of their last 8 games (+7.10 Units / 89% ROI)
- The Arizona Cardinals have hit the 2Q Game Total Over in 12 of their last 17 games (+6.85 Units / 36% ROI)
- The Arizona Cardinals have hit the 3Q Moneyline in 5 of their last 9 away games (+5.65 Units / 63% ROI)
- The Arizona Cardinals have hit the 3Q Game Total Under in 7 of their last 9 away games (+5.00 Units / 48% ROI)
- The Arizona Cardinals have covered the 2H Spread in their last 4 away games (+4.00 Units / 94% ROI)
Bills Best Bets:
- The Buffalo Bills have hit the 2Q Game Total Over in 9 of their last 10 games (+9.05 Units / 80% ROI)
- The Buffalo Bills have hit the 3Q Moneyline in 10 of their last 18 games (+8.95 Units / 28% ROI)
- The Buffalo Bills have hit the 3Q Game Total Under in 7 of their last 9 games at home (+4.50 Units / 41% ROI)
- The Buffalo Bills have covered the 3Q Spread in 9 of their last 13 games (+4.40 Units / 28% ROI)
- The Buffalo Bills have covered the 2Q Spread in 12 of their last 19 games (+3.80 Units / 17% ROI)
Cardinals Against the Spread (ATS) Record
Against the spread this NFL preseason, the Cardinals went 1-2 (-1.2 Units / -36.36% ROI).
- Cardinals are 0-3 when betting on the Moneyline for -3.4 Units / -100% ROI
- Cardinals are 1-2 when betting the Over for -1.2 Units / -36.36% ROI
- Cardinals are 2-1 when betting the Under for +0.9 Units / ROI
Bills Against the Spread (ATS) Record
Against the spread this NFL preseason, the Bills went 2-1 (+0.9 Units / 27.27% ROI).
- Bills are 1-2 when betting on the Moneyline for -1.3 Units / -35.62% ROI
- Bills are 2-1 when betting the Over for +0.9 Units / 27.27% ROI
- Bills are 1-2 when betting the Under for -1.2 Units / -36.36% ROI
Arizona Cardinals: Keys to the Game vs. the Buffalo Bills
The Cardinals were 1-6 (.143) when sacking the QB 3 or more times last season — 2nd-worst in NFL; League Avg: .650.
The Cardinals were winless (0-3) when forcing 2 or more turnovers last season — worst in NFL; League Avg: .707.
The Cardinals were winless (0-5) when allowing 250 or more passing yards last season — T-worst in NFL; League Avg: .414.
The Cardinals were 1-12 (.077) when converting less than 50% of third down conversion opportunities last season — worst in NFL; League Avg: .430.
Buffalo Bills: Keys to the Game vs. the Arizona Cardinals
The Bills were 8-2 (.800) when rushing for 120 or more yards last season — T-9th-best in NFL. The Cardinals allowed an average of 143.6 rushing yards per game last season — worst in NFL.
The Bills are 18-4 (.818) when rushing for 120 or more yards since the 2022 season — 6th-best in NFL. The Cardinals have allowed an average of 131.6 rushing yards per game since the 2022 season — 5th-worst in NFL.
The Bills are undefeated (10-0) when allowing an average of less than 5 yards on first down plays since the 2022 season — best in NFL; League Avg: .603.
The Bills are 6-1 (.857) vs top 10 pass defenses since the 2022 season — best in NFL; League Avg: .497.
Additional Matchup Notes for Arizona Cardinals vs. Buffalo Bills
The Bills ran 16.5% offensive plays in the red zone last season — 5th-best in NFL. The Cardinals allowed their opponent to run 19.1% of plays in the red zone last season — worst in NFL.
The Bills ran successful plays on 51.9% of pass attempts against a base front last season — 3rd-best in NFL. The Cardinals allowed successful plays on 53.8% of pass attempts with a base front last season — worst in NFL.
The Bills ran successful plays on 54.2% of pass attempts with motion last season — 3rd-best in NFL. The Cardinals allowed successful plays on 54.1% of pass attempts against motion last season — worst in NFL.
The Cardinals have averaged just 0.19 epa per play against open coverage since the 2022 season — 2nd-worst in NFL. The Bills have allowed just 0.27 epa per play with open coverage since the 2022 season — 4th-best in NFL.
Cardinals RBs rushed for 10 or more yards on 14.2% of 339 carries last season — 2nd-best in NFL. The Bills allowed 10+ yards on 11.5% of carries to RBs last season — 5th-worst in NFL.
The Cardinals ran successful plays on just 40.6% of pass attempts against a stacked front last season — 4th-worst in NFL. The Bills pressured opposing QBs on 68.8% of pass attempts with a stacked front last season — best in NFL.
Arizona Cardinals Offense: Important Stats
The Cardinals had 23 rushes of 20+ yards last season — most in NFL.
The Cardinals ran successful plays on 75% of rush attempts against a base rush last season — best in NFL; League Avg: 57%.
The Cardinals ran successful plays on 30% of pass attempts against a heavy rush last season — worst in NFL; League Avg: 45%.
The Cardinals went for two on 36% of PATs last season — highest in NFL; League Avg: 10%.
Buffalo Bills Offense: Important Stats
The Bills went three and out on 12% of their drives last season — best in NFL; League Avg: 22%.
The Bills ran successful plays on 51% of plays in the 4th quarter last season — best in NFL; League Avg: 40%.
The Bills ran successful plays on 50% of rush attempts against a base front last season — 2nd-best in NFL; League Avg: 41%.
The Bills ran successful plays on 50% of plays in the 2nd half last season — best in NFL; League Avg: 41%.
Arizona Cardinals Defense: Important Stats
The Cardinals defense has allowed successful plays on 35% of rush attempts with a stacked front since the 2022 season — best in NFL; League Avg: 44%.
19% of the plays ran against the Cardinals were in the red zone last season — worst in NFL; League Avg: 14%.
The Cardinals defense allowed 6 TD passes when the opposing QB was scrambling last season — most in NFL.
18% of the plays run against the Cardinals have been in the red zone since the 2022 season — worst in NFL; League Avg: 14%.
Buffalo Bills Defense: Important Stats
The Bills defense allowed -0.67 epa per play with a light rush last season — best in NFL; League Avg: -0.04.
The Bills defense allowed successful plays on 11% of plays with a light rush last season — 2nd-best in NFL; League Avg: 39%.
The Bills defense allowed successful plays on 11% of pass attempts with a light rush last season — best in NFL; League Avg: 40%.
The Bills defense allowed a passer rating of just 63.6 with a base front (95 Pass Attempts) in the last 4 weeks of the regular season — best in NFL; League Avg: 91.3.
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