- The Lions are a 2.5-point home favorite against the Bills.
- The Lions have won each of their last 11 games.
- My Lions vs. Bills prediction is for Buffalo to cover the spread.
A potential Super Bowl matchup takes place on Sunday in Detroit as the Lions will be looking for a 12th straight win when they host the Bills.
Detroit won on Thursday against Green Bay, their 11th straight victory. As a result, Detroit is the favorite in the Super Bowl odds.
The Bills fell 44-42 as road favorites in Los Angeles on Sunday, ending a seven-game winning streak for Buffalo.
Bet on Lions vs. Bills and other NFL matchups with up-to-date NFL odds.
NFL Week 15 Odds: Lions vs. Bills
2024-12-15T21:25:00ZBills at Lions
Lions vs. Bills Prediction
Based on the Lions’ defensive injury issues and Josh Allen’s record as an underdog, my Lions vs. Bills prediction is the Bills Spread (+2.5, +100).
I’d prefer to grab the Bills +3 in order to get a key number. However, it’s Buffalo or nothing for me on Sunday in Detroit.
The Rams needed to play perfectly on Sunday as home dogs just to win by two points against the Bills. Can the Lions do the same with nearly half the defense on IR?
Detroit may have successfully overcome its injury absentees against Green Bay. However, it’s a different story taking on a Bills team off a 42-point performance in Los Angeles.
Plus, the best you can say about Buffalo’s defense is that they’re battle-tested.
Prior to Sunday’s game, Buffalo ranked seventh in defensive DVOA against the 18th-hardest set of opposing offenses, per ftnfantasy.com.
The Lions rank second in defensive DVOA, but it has come against the 24th-hardest set of offenses. Add in the defensive absentees, and I question how Detroit holds up.
Josh Allen is 18-10-2 ATS as an underdog in his career, while Sean McDermott is 23-20-2 ATS in that spot.
Buffalo also matches a historically profitable betting system.
Since 2003, road dogs between +2.5 and +3 off a loss are 60% ATS, including 62% when the opponent is coming off a win.
Shrink the sample down to games since the 2021 NFL season and it becomes 39-17-3 ATS (69.6%).
Take the Bills to cover the spread on Sunday in Detroit.
Betting Lions vs. Bills: NFL Public Betting
Check back on Friday for Lions vs. Bills public betting data and insights.
