- The San Francisco 49ers (+140) are favorites to win the NFC West.
- The San Francisco 49ers have won three of the previous four division titles.
- I predict a case exists for the San Francisco 49ers (+140) to win the NFC West.
A year removed from a disastrous, injury-plagued 2024 season, the 49ers saw a massive dropoff to win the division.
On the heels of a Super Bowl loss, San Francisco regressed to 6-11 in 2024, good for last in the division. Accordingly, their price to win the division went from -225 in 2024 to +140 in 2025.
With a division title this year, San Francisco would capture their third NFC West title in their previous four years.
Here’s a look at the NFL odds for the NFC West division winner and my NFC West prediction.
NFC West Odds, 2025 Division Winner
- San Francisco 49ers: +140
- Los Angeles Rams: +165
- Seattle Seahawks: +600
- Arizona Cardinals: +600
NFC West Prediction
Based on San Francisco’s easy schedule and the public overreaction to their transactions, I predict the 49ers Win the NFC West (+140).
I can make the case for any of the 49ers, Rams and Cardinals. Full transparency: I’ll likely fade the Seahawks in the division and take the under on their season win total.
The case for the 49ers is simple: they go from a brutal strength of schedule – second hardest in 2024 – to one of the easiest schedules in 2025.
Excluding the divisional opponents, San Francisco faces both the AFC and NFC South with three unique games against the Bears, Giants and Browns.
It would be foolish not to acknowledge some of the departures. However, this remains a team with Christian McCaffrey and Trent Williams leading a good offense.
Despite so many injuries in 2024, San Francisco finished ninth in offensive DVOA, per ftnfantasy.com. That came a year after leading the league at full health.
The bigger drop-off came defensively: San Francisco fell from fourth in 2023 to 13th in 2024. However, some of that can be attributed to rising eight spots in opponent offensive strength.
While the departures of Charvarius Ward, Talanoa Hufanga and Dre Greenlaw negatively impact the 49ers, the arrival of Robert Saleh as defensive coordinator is a positive in my mind.
Plus, despite all the injuries in 2024, San Francisco ran unlucky compared to the rest of the division.
Per ftnfantasy.com, San Francisco finished 6-11 against a 9-8 expected record. Contributing to that underperformance? A 1-3 record in field goal games and a 2-6 record in touchdown games.
All of that said, stepping in front of the Rams and Cardinals scares me.
Los Angeles, based on free agency, made the biggest improvements of the offseason, while Arizona possesses a strong offense and improving defense.
As a result, it leads me to consider alternative futures markets with the 49ers that place a bigger onus on the team.
For example, I’d rather consider the over on San Francisco’s win total or taking a piece of them to make the playoffs.
While the win total feels oddly high on a team that has lost a bunch of talent this offseason, the lack of opponent strength reassures me this is an achievable number.
From a division perspective, it would be the 49ers or Cardinals (+600).
NFC West Standings & Live Odds
| Position | Team | Preseason Odds |
|---|---|---|
| 1 | San Francisco 49ers | +140 |
| 2 | Los Angeles Rams | +165 |
| 3 | Arizona Cardinals | +600 |
| 4 | Seattle Seahawks | +600 |
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