Rams vs 49ers Prediction, Odds & Best Prop Bets โ€“ NFL, Week 15

(Kyusung Gong/AP Photo)
  • The 49ers are -3 point favorites vs the Rams
  • Total (Over/Under): 49.5 points
  • Watch this game on Amazon

The Los Angeles Rams (7-6-0) visit Levi’s Stadium to take on the San Francisco 49ers (6-7-0) on Dec. 12. Kickoff is scheduled for 8:15pm EST in Santa Clara, CA.

The 49ers are betting favorites in this matchup, with the spread sitting at -3 (+100).

The Rams vs. 49ers Over/Under is 49.5 total points for the game.

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Rams vs. 49ers Odds, Spread, Over/Under

SpreadTotal (O/U)Moneyline
Rams+3 -12049.5 -110+130
49ers -3 +10049.5 -110-155

Rams vs. 49ers Prediction

The winning team model predicts the 49ers will win this game with 63.7% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Rams vs 49ers Spread Prediction

Based on recent against-the-spread trends, the model predicts the Rams will cover the spread with 55.1% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


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We’ve highlighted some favorite NFL player prop bets for Rams players this playoff game, looking at profitable historical betting trends:

Best Rams Player Prop Bets Today

  • Matthew Stafford has hit the Rushing Yards Under in 9 of his last 10 games (+7.80 Units / 50% ROI)
  • Demarcus Robinson has hit the Receptions Under in 12 of his last 16 games (+6.10 Units / 26% ROI)
  • Kyren Williams has hit the Receiving Yards Under in 11 of his last 16 games (+5.30 Units / 28% ROI)
  • Matthew Stafford has hit the Passing Yards Over in 11 of his last 16 games (+5.20 Units / 28% ROI)
  • Joshua Karty has hit the Field Goals Under in 7 of his last 9 games (+4.90 Units / 49% ROI)

And here are some top NFL player prop bets for 49ers players for this matchup, looking at profitable historical betting trends:

Best 49ers Player Prop Best Bets Today

  • Brock Purdy has hit the TD Passes Under in 9 of his last 10 games at home (+9.10 Units / 86% ROI)
  • Jauan Jennings has hit the Receptions Over in 11 of his last 14 games (+8.15 Units / 48% ROI)
  • Brock Purdy has hit the Rushing Yards Over in 12 of his last 17 games (+6.50 Units / 34% ROI)
  • Brock Purdy has hit the Carries Over in 8 of his last 10 games at home (+5.85 Units / 50% ROI)
  • Brandon Aiyuk has hit the Receiving Yards Under in 9 of his last 12 games (+5.50 Units / 40% ROI)

First Touchdown Scorer Bet for 49ers vs Rams

Player Name 1st TD Odds
Isaac Guerendo (SF) +500
Kyren Williams (LAR) +500
Patrick Taylor (SF) +550

Receiving Props: Total Receiving Yards for 49ers vs Rams

Player Name Over Under
Kyren Williams (LAR) 9.5 -115 9.5 -115
Cooper Kupp (LAR) 63.5 -115 63.5 -115
George Kittle (SF) 55.5 -115 55.5 -115
Puka Nacua (LAR) 88.5 -115 88.5 -115
Deebo Samuel (SF) 49.5 -115 49.5 -115

Rushing Props: Total Rushing Yards for 49ers vs Rams

Player Name Over Under
Brock Purdy (SF) 21.5 -110 21.5 -120
Kyren Williams (LAR) 72.5 -130 72.5 +100
  • The Los Angeles Rams have hit the 3Q Game Total Over in 14 of their last 17 games (+10.40 Units / 48% ROI)
  • The Los Angeles Rams have hit the Moneyline in 13 of their last 20 games (+10.35 Units / 35% ROI)
  • The Los Angeles Rams have hit the 2H Game Total Over in 10 of their last 14 games (+5.48 Units / 36% ROI)
  • The Los Angeles Rams have covered the Spread in 12 of their last 20 games (+3.25 Units / 15% ROI)
  • The Los Angeles Rams have hit the 3Q Moneyline in 8 of their last 17 games (+2.80 Units / 13% ROI)
  • The San Francisco 49ers have hit the 2H Game Total Over in 12 of their last 16 games (+7.68 Units / 44% ROI)
  • The San Francisco 49ers have hit the 3Q Game Total Over in 13 of their last 19 games (+5.55 Units / 23% ROI)
  • The San Francisco 49ers have covered the 1Q Spread in 13 of their last 22 games (+4.65 Units / 19% ROI)
  • The San Francisco 49ers have hit the 1Q Moneyline in 13 of their last 22 games (+3.90 Units / 10% ROI)
  • The San Francisco 49ers have hit the 1H Game Total Over in 13 of their last 22 games (+2.60 Units / 10% ROI)

Rams Against the Spread (ATS) Record

Against the spread this NFL season, the Rams art 6-7 (-1.65 Units / -11.62% ROI).

  • Rams are 7-6 when betting on the Moneyline for +2.65 Units / 14.97% ROI
  • Rams are 7-6 when betting the Over for +0.35 Units / 2.44% ROI
  • Rams are 6-7 when betting the Under for -1.7 Units / ROI

49ers Against the Spread (ATS) Record

Against the spread this NFL season, the 49ers are 5-8 (-3.7 Units / -26.06% ROI).

  • 49ers are 6-7 when betting on the Moneyline for -8.25 Units / -26.7% ROI
  • 49ers are 7-6 when betting the Over for +0.4 Units / 2.8% ROI
  • 49ers are 6-7 when betting the Under for -1.7 Units / -11.89% ROI

Los Angeles Rams: Keys to the Game vs. the San Francisco 49ers

The Rams are undefeated (4-0) when within 7 points entering the 4th quarter this season — best in NFL; League Avg: .500.

The Rams were 9-4 (.692) when allowing less than 5 yards per rush last season — T-8th-best in NFL; League Avg: .536.

The Rams are 4-1 (.800) when within 3 points at the two minute warning since the 2023 season — 2nd-best in NFL; League Avg: .500.

The Rams are undefeated (5-0) when making 3 or more explosive runs in a game since the 2023 season — T-best in NFL; League Avg: .606.

San Francisco 49ers: Keys to the Game vs. the Los Angeles Rams

The 49ers were winless (0-3) when within 7 points at the two minute warning last season — worst in NFL; League Avg: .500.

The 49ers were winless (0-5) when scoring less than 22 points last season — T-worst in NFL; League Avg: .253.

The 49ers are winless (0-5) when passing for less than 200 yards since the 2023 season — worst in NFL; League Avg: .411.

The 49ers were winless (0-4) when trailing at the end of the third quarter last season — T-worst in NFL; League Avg: .148.

Additional Matchup Notes for Los Angeles Rams vs. San Francisco 49ers

The 49ers have been successful on 49.7% of plays they have run with motion since the 2023 season — best in NFL. The Rams have allowed their opponents to be successful on 45.9% of plays against motion since the 2023 season — 5th-worst in NFL.

The 49ers have run successful plays on 50.0% of pass attempts against a light front this season — T-4th-best in NFL. The Rams have allowed successful plays on 49.5% of pass attempts with a light front this season — 2nd-worst in NFL.

The 49ers have run successful plays on 49.1% of rush attempts against a base front since the 2023 season — best in NFL. The Rams have allowed successful plays on 45.4% of rush attempts with a base front since the 2023 season — 5th-worst in NFL.

The Rams have run successful plays on 48.5% of pass attempts against a light front since the 2023 season — 4th-best in NFL. The 49ers have allowed successful plays on 47.6% of pass attempts with a light front since the 2023 season — 4th-worst in NFL.

The Rams have been successful on 44.9% of plays they have run against a light front since the 2023 season — 4th-best in NFL. The 49ers have allowed their opponents to be successful on 44.2% of plays with a light front since the 2023 season — 4th-worst in NFL.

Rams TEs have just 26.8 receiving yards per game this season — 2nd-worst in NFL. The 49ers have allowed an average ofjust 34.9 receiving yards per game to TEs this season — 2nd-best in NFL.

Los Angeles Rams Offense: Important Stats

The Rams have run successful plays on 82% of plays against a light rush this season — best in NFL; League Avg: 43%.

The Rams have run successful plays on 90% of pass attempts against a light rush this season — best in NFL; League Avg: 45%.

The Rams have averaged 0.93 epa per play against a light rush this season — best in NFL; League Avg: 0.02.

The Rams have run successful plays on 29% of rush attempts against a base rush this season — worst in NFL; League Avg: 51%.

San Francisco 49ers Offense: Important Stats

The 49ers ran successful plays on 53% of plays against a base front last season — best in NFL; League Avg: 42%.

The 49ers ran successful plays on 53% of rush attempts against a base front last season — best in NFL; League Avg: 41%.

The 49ers averaged 9.3 yards per attempt (4,577 yards/491 attempts) last season — best in NFL; League Avg: 7.0.

The 49ers ran successful plays on 21% of rush attempts against a light front last season — worst in NFL; League Avg: 47%.

Los Angeles Rams Defense: Important Stats

The Rams defense has allowed a passer rating of just 33.9 on 3rd and long (48 Pass Attempts) this season — best in NFL; League Avg: 81.7.

The Rams defense have allowed 0.61 epa per play open coverage this season — worst in NFL; League Avg: 0.41.

Offenses facing the Rams threw deep balls on 29% of pass attempts (23/79) on 3rd and long last season — highest in NFL; League Avg: 15%.

The Rams defense has allowed 12 TDs on first drive of the game since the 2023 season — T-most in NFL.

San Francisco 49ers Defense: Important Stats

The 49ers defense sacked opposing QBs on 23% of pass attempts (7/31) in Week 14 — best in NFL; League Avg: 6%.

The 49ers defense allowed successful plays on 10% of plays with a light rush last season — best in NFL; League Avg: 39%.

The 49ers defense sacked opponents 7 times in Week 14 — most in NFL.

The 49ers defense has allowed a third down conversion rate of 47% with a light front since the 2023 season — worst in NFL; League Avg: 31%.

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Our BetMGM editors and authors are sports experts with a wealth of knowledge of the sports industry at all levels. Their coverage includes sports news, previews and predictions, fun facts, and betting.

Our BetMGM editors and authors are sports experts with a wealth of knowledge of the sports industry at all levels. Their coverage includes sports news, previews and predictions, fun facts, and betting.