- The 49ers are -3 point favorites vs the Rams
- Total (Over/Under): 42.5 points
- Watch the game on FOX
The Los Angeles Rams (9-6) visit Levi’s Stadium to take on the San Francisco 49ers (9-7) on Jan. 7. Kickoff is scheduled for 4:25pm EST in Santa Clara, CA.
The 49ers are betting favorites in this Week 18 matchup, with the spread sitting at -3 (-110).
The Rams vs. 49ers Over/Under is 42.5 total points for the game.
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Rams vs. 49ers Odds, Spread, Over/Under
| Spread | Total (O/U) | Moneyline | |
| Rams | +3 -110 | 42.5 -110 | +140 |
| 49ers | -3 -110 | 42.5 -110 | -165 |
Rams vs. 49ers Prediction
The winning team model predicts the 49ers will win this Week 18 game with 60.6% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.
Rams vs 49ers Spread Prediction
Based on recent against-the-spread trends, the model predicts the 49ers will cover the spread with 55.2% confidence.
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Best Rams Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for Rams players this Week 18 game, looking at profitable historical betting trends:
- Matthew Stafford has hit the Passing Yards Under in 8 of his last 10 games (+5.50 Units / 45% ROI)
- Ben Skowronek has hit the Receiving Yards Over in 8 of his last 12 games (+3.50 Units / 25% ROI)
- Cooper Kupp has hit the Longest Reception Under in 7 of his last 10 games (+3.30 Units / 27% ROI)
- Matthew Stafford has hit the Rushing Yards Over in 4 of his last 5 away games (+3.00 Units / 57% ROI)
- Tyler Higbee has hit the Receiving Yards Under in 8 of his last 12 games (+3.00 Units / 19% ROI)
Best 49ers Player Prop Best Bets Today
And here are some top NFL player prop bets for 49ers players for this matchup, looking at profitable historical betting trends:
- George Kittle has hit the Longest Reception Over in 13 of his last 16 games (+9.55 Units / 51% ROI)
- Jauan Jennings has hit the Receiving Yards Over in 11 of his last 14 games (+7.70 Units / 49% ROI)
- Christian McCaffrey has hit the Carries Under in 8 of his last 9 games (+6.95 Units / 57% ROI)
- Christian McCaffrey has hit the Longest Rush Over in 12 of his last 17 games (+6.10 Units / 32% ROI)
- Deebo Samuel has hit the Longest Reception Under in 7 of his last 8 games (+5.40 Units / 51% ROI)
Rams Best Bets:
- The Los Angeles Rams have hit the 1Q Game Total Over in 7 of their last 10 away games (+3.95 Units / 36% ROI)
- The Los Angeles Rams have hit the 3Q Game Total Over in 11 of their last 17 games (+3.80 Units / 19% ROI)
- The Los Angeles Rams have scored first in 6 of their last 9 away games (+3.60 Units / 36% ROI)
- The Los Angeles Rams have hit the 1H Moneyline in 5 of their last 10 away games (+2.90 Units / 25% ROI)
- The Los Angeles Rams have hit the 2H Game Total Over in 6 of their last 9 away games (+2.45 Units / 24% ROI)
49ers Best Bets:
- The San Francisco 49ers have covered the 2H Spread in 15 of their last 20 games (+9.65 Units / 44% ROI)
- The San Francisco 49ers have hit the 4Q Moneyline in 15 of their last 20 games (+7.40 Units / 19% ROI)
- The San Francisco 49ers have covered the 4Q Spread in 14 of their last 20 games (+6.55 Units / 29% ROI)
- The San Francisco 49ers have hit the 2H Moneyline in 15 of their last 20 games (+5.65 Units / 12% ROI)
- The San Francisco 49ers have scored first in 8 of their last 10 games at home (+3.65 Units / 18% ROI)
Rams Against the Spread (ATS) Record
Against the spread this NFL season, the Rams went 8-6 (+1.4 Units / 7.95% ROI).
- Rams are 9-7 when betting on the Moneyline for +2.1 Units / 8.08% ROI
- Rams are 8-8 when betting the Over for -0.8 Units / -4.55% ROI
- Rams are 8-8 when betting the Under for -0.8 Units / ROI
49ers Against the Spread (ATS) Record
Against the spread this NFL season, the 49ers went 9-6 (+2.5 Units / 14.33% ROI).
- 49ers are 12-4 when betting on the Moneyline for -0.65 Units / -0.86% ROI
- 49ers are 8-7 when betting the Over for +0.3 Units / 1.7% ROI
- 49ers are 7-8 when betting the Under for -1.8 Units / -10.23% ROI
Los Angeles Rams: Keys to the Game vs. the San Francisco 49ers
The Rams are winless (0-6) when playing in cold weather since the 2022 season — worst in NFL; League Avg: .497.
The Rams are winless (0-3) vs top 10 pass offenses this season — T-worst in NFL; League Avg: .400.
The Rams are winless (0-6) vs top 10 run defenses since the 2022 season — worst in NFL; League Avg: .441.
The Rams were 1-7 (.125) when within 7 points entering the 4th quarter in the 2022 season — worst in NFL; League Avg: .497.
San Francisco 49ers: Keys to the Game vs. the Los Angeles Rams
The 49ers are winless (0-4) when scoring less than 22 points this season — T-worst in NFL; League Avg: .246.
The 49ers are 5-1 (.833) when playing in cold weather since the 2022 season — best in NFL; League Avg: .497.
The 49ers are 10-2 (.833) after a home win since the 2022 season — best in NFL; League Avg: .482.
The 49ers are 3-1 (.750) vs top 10 pass offenses this season — T-3rd-best in NFL; League Avg: .400.
Additional Matchup Notes for Los Angeles Rams vs. San Francisco 49ers
The 49ers have run 49.9% offensive plays in on their opponent’s side of the field since the 2022 season — 4th-best in NFL. Rams have allowed their opponents to run 45.9% of plays in their territory since the 2022 season — 5th-worst in NFL.
The 49ers have run successful plays on 50.2% of pass attempts on their opponent’s side of the field since the 2022 season — best in NFL. Rams have allowed successful plays on 50.4% of pass attempts on their own side of the field since the 2022 season — 4th-worst in NFL.
49ers TEs have gained 1,044 yards on 68 receptions (15.4 YPR) this season — best in NFL. The Rams have allowed 11.9 Yards Per Reception to TEs this season — 3rd-worst in NFL.
Rams WRs have averaged 23.9 targets per game this season — highest in NFL. The 49ers have allowed 13.9 receptions per game to WRs this season — T-4th-worst in NFL.
Rams WRs have 241 receptions in 16 games (15.1 per game) this season — T-2nd-best in NFL. The 49ers have allowed 13.9 receptions per game to WRs this season — T-4th-worst in NFL.
Rams WRs have 241 receptions in 16 games (15.1 per game) this season — T-2nd-best in NFL. The 49ers have allowed 24.6 receptions per game this season — T-3rd-worst in NFL.
Los Angeles Rams Offense: Important Stats
The Rams have gone three and out on 6% of their drives in the 1st quarter this season — best in NFL; League Avg: 22%.
The Rams have targeted RBs 12% of the time (68 Pass Attempts/558 plays) this season — lowest in NFL; League Avg: 17%.
The Rams ran 8% of their plays in their opponent’s territory in the 2nd half in Week 17 — worst in NFL; League Avg: 48%.
The Rams have run 20% of their plays in the red zone in the 1st quarter this season — 3rd-best in NFL; League Avg: 13%.
San Francisco 49ers Offense: Important Stats
The 49ers have run successful plays on 55% of pass attempts this season — best in NFL; League Avg: 45%.
The 49ers have averaged 9.4 yards per attempt (4,388 yards/465 attempts) this season — best in NFL; League Avg: 7.0.
The 49ers have completed passes for 20+ yards on 129 of their 977 total passing attempts (13%) since the 2022 season — best in NFL; League Avg: 9%.
The 49ers have run successful plays on 51% of plays this season — best in NFL; League Avg: 42%.
Los Angeles Rams Defense: Important Stats
The Rams defense has not allowed any rushing touchdowns on 6 carries in the red zone since Week 14 — best Carries Per TD rate in NFL; League Avg: 5.5.
The Rams defense have allowed 8 TDs that were 20+ yards since Week 14 — most in NFL.
Only 12% of the plays run against the Rams have been in the red zone this season — 2nd-best in NFL; League Avg: 14%.
The Rams defense has allowed a Completion Pct of just 47% (36 completions/77 attempts) on 3rd and long this season — best in NFL; League Avg: 60%.
San Francisco 49ers Defense: Important Stats
The 49ers defense has allowed successful plays on 32% of rush attempts in the 1st quarter since the 2022 season — best in NFL; League Avg: 43%.
The 49ers defense allowed successful plays on 9% of plays in the 4th quarter in Week 17 — best in NFL; League Avg: 40%.
Opponents have run the ball 20.4 times per game against The 49ers defense (327 carries / 16 games) this season — lowest in NFL; League Avg: 26.0.
The 49ers defense has allowed scores on 29% of opponent drives since the 2022 season — best in NFL; League Avg: 36%.
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