- – (3-5) are point favorites vs – (3-5)
- Total (Over/Under): points
- Watch the game on ESPN Networks
The Pittsburgh Panthers (4-4) visit Cardinal Stadium to take on the Louisville Cardinals (5-3) on Oct. 22. Kickoff is scheduled for 1:00pm EDT in Louisville.
– are betting favorites in Week 8, with the spread sitting at ().
The Over/Under for Pittsburgh vs. Louisville is total points.
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Pittsburgh vs. Louisville Odds, Spread, Over/Under for Week 8
| Spread | Total (O/U) | Moneyline | |
| Pittsburgh | |||
| Louisville |
Pittsburgh vs Louisville Prediction for Week 8
Based on recent trends, the winning team model predicts Louisville will win this game with 50.7% confidence.
Pittsburgh vs Louisville Spread Prediction for Week 8
Based on recent against-the-spread trends, the model predicts Louisville will cover the spread with 59.7% confidence.
Both predictions factor in up-to-date player injuries for both Pittsburgh and Louisville, plus offensive & defensive matchups, recent games and key player performances this season.
Best Pittsburgh Player Prop Bets Today
We’ve highlighted some favorite college football player prop bets for Pittsburgh players for Week 8, looking at profitable historical betting trends:
Best Louisville Player Prop Best Bets Today
Top NCAAF player prop bets for Louisville players for Week 8, looking at profitable historical betting trends:
Pittsburgh Best Bets & Trends for ATS, Moneyline & Totals
Louisville Best Bets & Trends for ATS, Moneyline & Totals
Pittsburgh Against the Spread (ATS) Record
Pittsburgh has gone against the spread this college football season ( Units / ROI).
- Pittsburgh is when betting on the Moneyline for Units / ROI
- Pittsburgh is when betting the Over for Units / ROI
- Pittsburgh is when betting the Under for Units / ROI
Louisville Against the Spread (ATS) Record
Louisville has gone against the spread this college football season ( Units / ROI).
- Louisville is when betting on the Moneyline for Units / ROI
- Louisville is when betting the Over for Units / ROI
- Louisville is when betting the Under for Units / ROI
Pittsburgh: Keys to the Game vs. Louisville
Pittsburgh is 8-2 (.727) when not losing a fumble — tied for 2nd-best among Power 5 Teams; Average: .433
Pittsburgh is 10-4 (.556) when averaging more than 5 yards on first down plays — 10th-best among Power 5 Teams; Average: .411
Pittsburgh is 9-3 (.750) when the opposing team rushes more than 30 times — tied for 8th-best among Power 5 Teams; Average: .420
Pittsburgh is 13-3 (.650) when rushing for more than 100 yards since the 2020 season– 9th-best among Power 5 Teams; Average: .470
Louisville: Keys to the Game vs. Pittsburgh
Louisville is 1-7 (.125) when not forcing a fumble — 6th-worst among Power 5 Teams; Average: .445
Louisville is 2-12 (.143) when allowing 5 or more explosive passes since the 2020 season– 3rd-worst among Power 5 Teams; Average: .450
Louisville is 4-13 (.235) when allowing 200 or more passing yards since the 2020 season– 6th-worst among Power 5 Teams; Average: .465
Louisville is 2-11 (.154) when not forcing a fumble since the 2020 season– 4th-worst among Power 5 Teams; Average: .448
Matchup Notes for Pittsburgh vs. Louisville
Louisville’s TEs has 75 receptions in 18 games (4.2 per game) since the 2021 season — third-best among ACC TEs. Pittsburgh’s defense has allowed 20.8 receptions per game since the 2021 season — tied for third-worst among ACC defenses.
Louisville’s TEs has 20 receptions in 5 games (4.0 per game) this season — fourth-best among ACC TEs. Pittsburgh’s defense has allowed just 18.6 receptions per game this season — fifth-best among ACC defenses.
Louisville’s TEs has been targeted 106 times since the 2021 season — third-most among ACC TEs. Pittsburgh’s defense has allowed 4,748 receiving yards since the 2021 season — second-most among ACC defenses.
Pittsburgh’s TEs has 83 receptions in 19 games (4.4 per game) since the 2021 season — tied for best among ACC TEs. Louisville’s defense has allowed 20.9 receptions per game since the 2021 season — second-worst among ACC defenses.
Pittsburgh’s TEs has gained 260 yards on 16 receptions (16.2 YPR) this season — best among ACC TEs. Louisville’s defense has allowed 13.1 Yards Per Reception this season — second-worst among ACC defenses.
Pittsburgh has gained 1,243 yards on 87 receptions (14.3 YPR) this season — second-best among ACC skill players. Louisville’s defense has allowed 13.1 Yards Per Reception this season — second-worst among ACC defenses.
Pittsburgh Offensive Stats & Trends
Pittsburgh’s TEs has 83 receptions in 19 games (4.4 per game) since the 2021 season — tied for best among ACC TEs. Louisville’s defense has allowed 20.9 receptions per game since the 2021 season — second-worst among ACC defenses.
Pittsburgh’s TEs has gained 260 yards on 16 receptions (16.2 YPR) this season — best among ACC TEs. Louisville’s defense has allowed 13.1 Yards Per Reception this season — second-worst among ACC defenses.
Pittsburgh QBs have 93 completions for 20 or more yards since last season– 4th most among FBS Teams
Pittsburgh has gained 1,243 yards on 87 receptions (14.3 YPR) this season — second-best among ACC skill players. Louisville’s defense has allowed 13.1 Yards Per Reception this season — second-worst among ACC defenses.
Pittsburgh have 314.0 receiving yards per game since the 2021 season — fifth-best among Power 5 skill players. Louisville’s defense has allowed 247.4 receiving yards per game since the 2021 season — fifth-worst among ACC defenses.
Louisville Offensive Stats & Trends
Louisville WRs have just one touchdown on 56 receptions this season– 2nd worst Receptions Per TD among FBS Teams; Average: 10.9
Louisville WRs have just one touchdown on 56 receptions this season– worst Receptions Per TD among Power 5 Teams; Average: 10.4
Louisville’s TEs has 75 receptions in 18 games (4.2 per game) since the 2021 season — third-best among ACC TEs. Pittsburgh’s defense has allowed 20.8 receptions per game since the 2021 season — tied for third-worst among ACC defenses.
Louisville Skill Players have averaged a touchdown every 29.7 receptions (89 Rec/3 TDs) this season– 2nd worst Receptions Per TD among Power 5 Teams; Average: 11.2
Louisville QBs have rushed for 20 TDs in the Red Zone since last season– most among FBS Teams
Pittsburgh Panthers Defensive Stats & Trends
Pittsburgh has averaged 3.6 sacks per game since last season– best in FBS; Average: 2.2
Pittsburgh has averaged 3.6 sacks per game since last season– best among Power 5 Teams; Average: 2.2
Pittsburgh has allowed 9.4 yards from scrimmage per touch (151 yards / 16 touches) on 3rd and short this season– worst among Power 5 Teams; Average: 4.5
Pittsburgh has sacked opponents 69 times since last season– 2nd most among Power 5 Teams
Pittsburgh has sacked opposing QBs on 10% of pass attempts (69/677) since last season– 3rd best among Power 5 Teams; Average: 7%
Louisville Cardinals Defensive Stats & Trends
Louisville has allowed passes of 40+ yards on 7 of 142 attempts (5%) this season– 3rd worst among Power 5 Teams; Average: 2%
Louisville has sacked opposing QBs on 13% of pass attempts (18/142) this season– 4th best in FBS; Average: 7%
Louisville has sacked opposing QBs on 13% of pass attempts (18/142) this season– 2nd best among Power 5 Teams; Average: 7%
Louisville has allowed opponents to rush for 20+ yards on 13 of their 175 carries (7%) this season– 3rd worst among Power 5 Teams; Average: 3%
Louisville has allowed opponents to rush for 20+ yards on 13 of their 175 carries (7%) this season– 3rd worst in FBS; Average: 3%
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