- The 49ers are -7.5 point favorites vs the Rams
- Total (Over/Under): 44.5 points
- Watch this game on FOX
The San Francisco 49ers (1-1-0) visit SoFi Stadium to take on the Los Angeles Rams (0-2-0) on Sep. 22. Kickoff is scheduled for 4:25pm EDT in Inglewood, CA.
The 49ers are betting favorites in this matchup, with the spread sitting at -7.5 (-105).
The 49ers vs. Rams Over/Under is 44.5 total points for the game.
Bet now on Rams vs 49ers & all NFL games with BetMGM
49ers vs. Rams Odds, Spread, Over/Under
| Spread | Total (O/U) | Moneyline | |
| 49ers | -7.5 -105 | 44.5 -110 | -350 |
| Rams | +7.5 -115 | 44.5 -110 | +280 |
49ers vs. Rams Prediction
The winning team model predicts the 49ers will win this game with 70.0% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.
49ers vs Rams Spread Prediction
Based on recent against-the-spread trends, the model predicts the Rams will cover the spread with 67.0% confidence.
This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.
Bet now on Rams vs 49ers and all NFL games with BetMGM
We’ve highlighted some favorite NFL player prop bets for 49ers players this playoff game, looking at profitable historical betting trends:
Best 49ers Player Prop Bets Today
- Christian McCaffrey has hit the Rushing Yards Over in 9 of his last 10 games (+7.85 Units / 67% ROI)
- George Kittle has hit the Longest Reception Over in 10 of his last 12 games (+7.60 Units / 54% ROI)
- Christian McCaffrey has hit the Longest Rush Over in 9 of his last 11 games (+6.75 Units / 53% ROI)
- Kyle Juszczyk has hit the Receiving Yards Over in his last 6 games (+6.00 Units / 89% ROI)
- Christian McCaffrey has hit the Carries Under in 10 of his last 13 games (+6.00 Units / 34% ROI)
And here are some top NFL player prop bets for Rams players for this matchup, looking at profitable historical betting trends:
Best Rams Player Prop Best Bets Today
- Demarcus Robinson has hit the Receiving Yards Over in his last 6 games (+6.00 Units / 86% ROI)
- Kyren Williams has hit the Carries Over in 9 of his last 12 games (+6.00 Units / 46% ROI)
- Tyler Higbee has hit the Receiving Yards Over in his last 5 games (+5.00 Units / 89% ROI)
- Colby Parkinson has hit the Receiving Yards Over in his last 5 games at home (+5.00 Units / 85% ROI)
- Kyren Williams has hit the Rushing Yards Over in his last 5 games at home (+5.00 Units / 83% ROI)
Receiving Props: Total Receiving Yards for Rams vs 49ers
| Player Name | Over | Under |
|---|---|---|
| Brandon Aiyuk (SF) | 61.5 -120 | 61.5 -110 |
| George Kittle (SF) | 49.5 -125 | 49.5 -105 |
Rushing Props: Total Rushing Yards for Rams vs 49ers
| Player Name | Over | Under |
|---|---|---|
| Brock Purdy (SF) | 8.5 -115 | 8.5 -115 |
| Kyren Williams (LAR) | 64.5 -115 | 64.5 -115 |
49ers Best Bets:
- The San Francisco 49ers have hit the 1H Game Total Over in 15 of their last 22 games (+7.25 Units / 30% ROI)
- The San Francisco 49ers have hit the 4Q Moneyline in 14 of their last 19 games (+6.15 Units / 17% ROI)
- The San Francisco 49ers have covered the 4Q Spread in 13 of their last 19 games (+5.85 Units / 27% ROI)
- The San Francisco 49ers have hit the 1H Moneyline in 16 of their last 22 games (+4.50 Units / 7% ROI)
- The San Francisco 49ers have covered the 1Q Spread in 7 of their last 10 away games (+4.15 Units / 37% ROI)
Rams Best Bets:
- The Los Angeles Rams have covered the 1Q Spread in 13 of their last 20 games (+5.55 Units / 23% ROI)
- The Los Angeles Rams have hit the Moneyline in 6 of their last 8 games at home (+4.35 Units / 28% ROI)
- The Los Angeles Rams have hit the 2Q Moneyline in 4 of their last 5 games at home (+4.00 Units / 52% ROI)
- The Los Angeles Rams have hit the 3Q Game Total Over in 11 of their last 17 games (+4.00 Units / 20% ROI)
- The Los Angeles Rams have covered the 3Q Spread in 5 of their last 7 games at home (+3.00 Units / 39% ROI)
49ers Against the Spread (ATS) Record
Against the spread this NFL season, the 49ers art 1-1 (-0.1 Units / -4.55% ROI).
- 49ers are 1-1 when betting on the Moneyline for -1.1 Units / -26.83% ROI
- 49ers are 1-1 when betting the Over for -0.1 Units / -4.55% ROI
- 49ers are 1-1 when betting the Under for -0.1 Units / ROI
Rams Against the Spread (ATS) Record
Against the spread this NFL season, the Rams are 0-2 (-2.2 Units / -100% ROI).
- Rams are 0-2 when betting on the Moneyline for -2.1 Units / -100% ROI
- Rams are 1-1 when betting the Over for -0.15 Units / -6.67% ROI
- Rams are 1-1 when betting the Under for -0.1 Units / -4.65% ROI
San Francisco 49ers: Keys to the Game vs. the Los Angeles Rams
The 49ers are winless (0-3) when within 7 points at the two minute warning since the 2022 season — worst in NFL; League Avg: .500.
The 49ers were winless (0-3) when within 7 points at the two minute warning last season — worst in NFL; League Avg: .500.
The 49ers were winless (0-5) when scoring less than 22 points last season — T-worst in NFL; League Avg: .253.
The 49ers are undefeated (4-0) when committing less than 30 yards in penalties since the 2022 season — T-best in NFL; League Avg: .466.
Los Angeles Rams: Keys to the Game vs. the San Francisco 49ers
The Rams were 8-3 (.727) when averaging more than 5 yards on first down plays last season — T-7th-best in NFL; League Avg: .579.
The Rams were 1-4 (.200) vs top 10 offenses last season — T-7th-worst in NFL; League Avg: .359.
The Rams were 6-1 (.857) when leading at the end of first quarter last season — 9th-best in NFL; League Avg: .737.
The Rams are 1-6 (.143) vs top 10 offenses since the 2022 season — T-6th-worst in NFL; League Avg: .358.
Additional Matchup Notes for San Francisco 49ers vs. Los Angeles Rams
The Rams have been successful on just 23.8% of plays they have ran against a light rush since the 2023 season — 3rd-worst in NFL. The 49ers have allowed their opponents to be successful on just 10.0% of plays with a light rush since the 2023 season — best in NFL.
The Rams have run successful plays on just 22.2% of pass attempts against a light rush since the 2023 season — 3rd-worst in NFL. The 49ers have allowed successful plays on just 14.3% of pass attempts with a light rush since the 2023 season — 2nd-best in NFL.
The Rams have thrown the ball 60.3% of the time this season — 2nd-highest in NFL. The 49ers have allowed 8.3 yards per dropback this season — T-2nd-worst in NFL.
The 49ers have scored on 52.4% of their drives this season — T-4th-best in NFL. The Rams defense has allowed scores on 55% of opponent drives this season — T-4th-worst in NFL.
The 49ers have run successful plays on 49.4% of rush attempts since the 2023 season — 2nd-best in NFL. The Rams have allowed successful plays on 46.2% of rush attempts since the 2023 season — 4th-worst in NFL.
The 49ers ran successful plays on 58.3% of pass attempts last week — 2nd-best in NFL. The Rams allowed successful plays on 61.9% of pass attempts last week — worst in NFL.
San Francisco 49ers Offense: Important Stats
The 49ers have run successful plays on 52% of rush attempts against a base front since the 2022 season — best in NFL; League Avg: 41%.
The 49ers averaged 0.16 epa per play on the road last season — best in NFL; League Avg: -0.04.
The 49ers averaged 9.3 yards per attempt (4,577 yards/491 attempts) last season — best in NFL; League Avg: 7.0.
The 49ers have averaged 9.2 yards per attempt (5,127 yards/556 attempts) since the 2022 season — best in NFL; League Avg: 7.0.
Los Angeles Rams Offense: Important Stats
The Rams have averaged -0.50 epa per play against a light rush since the 2022 season — 3rd-worst in NFL; League Avg: -0.03.
The Rams went three and out on 6% of their drives in the 1st quarter last season — best in NFL; League Avg: 22%.
The Rams had a third down conversion rate of 50% on third and 10+ yards to go in the last 4 weeks of the regular season — T-best in NFL; League Avg: 19%.
The Rams averaged -0.51 epa per play against a light rush last season — 3rd-worst in NFL; League Avg: -0.04.
San Francisco 49ers Defense: Important Stats
The 49ers defense has allowed first downs on 73% of plays on 3rd and long this season — worst in NFL; League Avg: 24%.
The 49ers defense allowed successful plays on 10% of plays with a light rush last season — best in NFL; League Avg: 39%.
The 49ers defense has allowed successful plays on 32% of rush attempts in the 1st quarter since the 2022 season — best in NFL; League Avg: 43%.
The 49ers defense has allowed successful plays on 10% of plays with a light rush since the 2022 season — best in NFL; League Avg: 39%.
Los Angeles Rams Defense: Important Stats
The Rams defense has missed 33 tackles this season — most in NFL.
The Rams defense has allowed a passer rating of 158.3 when they have pressured the QB (5 Pass Attempts) this season — worst in NFL; League Avg: 57.3.
The Rams defense allowed 12.3 yards per dropback (258 yards/21 attempts) in Week 2 — 2nd-worst in NFL; League Avg: 6.6.
The Rams defense has allowed a passer rating of 158.3 when the opposing QB has scrambled (3 Pass Attempts) this season — worst in NFL; League Avg: 61.0.
Looking to place a bet on this game with a First Bet Offer up to $1,500? Bet now on Rams vs 49ers and all NFL games with BetMGM
More NFL Betting Predictions:
- Anytime & First Touchdown Scorer Predictions
- Receiving Yards Prop Predictions
- Rushing Yards Prop Predictions
- Passing Yards Prop Predictions
- Receptions Made Prop Predictions
- Rushing Attempts Prop Predictions
- Passing Touchdowns Prop Predictions
- QB Interception Prop Predictions
- Field Goals Made Prop Predictions
- NFL Betting Previews: Every Game
More NFL Odds at BetMGM
Take your football entertainment to the next level with NFL betting at the online sportsbook.
From futures like Chiefs Super Bowl odds, Lions odds to win the division, or Ravens playoff odds, to weekly odds like spreads, moneylines, and over/under totals, there’s something for everyone.
And with the best sportsbook promotions, you could land a welcome offer, sports betting Odds Boost, or a Parlay Boost! You can also check out NFL picks and predictions and updated Super Bowl predictions throughout the year.
Log in to your BetMGM account today — or sign up for a new account via the online sportsbook or BetMGM iOS app or BetMGM Android app — to start betting!
