- The 49ers are point favorites vs the Chargers
- Total (Over/Under):
Total points - Watch the game on NBC
The Los Angeles Chargers (5-3) visit Levi’s Stadium to take on the San Francisco 49ers (4-4) on Nov. 13. Kickoff is scheduled for 8:20pm EST in Santa Clara.
The 49ers are betting favorites in Week 10, with the spread sitting at -7 (-110).
The Chargers vs. 49ers Over/Under is 45.5 total points for the game.
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Chargers vs. 49ers Odds, Spread, Over/Under Week 10
| Spread | Total (O/U) | Moneyline | |
| Chargers | +7 -110 | 45.5 -110 | +240 |
| 49ers | -7 -110 | 45.5 -110 | -300 |
Chargers vs. 49ers Prediction for Week 10
Based on recent trends, the winning team model predicts the 49ers will win this Week 10 game with 69.3% confidence.
Chargers vs 49ers Spread Prediction for Week 10
Based on recent against-the-spread trends, the model predicts the Chargers will cover the spread this Week 10 with 58.0% confidence.
Both predictions factor in up-to-date player injuries for both the Chargers and 49ers, plus offensive & defensive matchups, recent games and key player performances this season.
Best Chargers Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for Chargers players for Week 10, looking at profitable historical betting trends:
player high – away
Best 49ers Player Prop Best Bets Today
And here are some top NFL player prop bets for 49ers players for Week 10, looking at profitable historical betting trends:
player high – home
Chargers Best Bets for Week 10:
team high – away
49ers Best Bets for Week 10:
team high – home
Chargers Against the Spread (ATS) Record
Against the spread this NFL season, the Chargers have gone 5-3 (+1.7 Units / 19.32% ROI).
- Chargers are when betting on the Moneyline for Units / ROI
- Chargers are when betting the Over for Units / ROI
- Chargers are when betting the Under for Units / ROI
49ers Against the Spread (ATS) Record
Against the spread this NFL season, the 49ers have gone 4-4 (-0.4 Units / -4.57% ROI).
- 49ers are when betting on the Moneyline for Units / ROI
- 49ers are when betting the Over for Units / ROI
- 49ers are when betting the Under for Units / ROI
Los Angeles Chargers: Keys to the Game vs. the San Francisco 49ers
The Chargers are undefeated (9-0) when not throwing an interception since the 2021 season — tied for best in NFL; League Avg: .648.
The Chargers are winless (0-1) when allowing 3 or more sacks this season — tied for worst in NFL; League Avg: .386.
The Chargers are 5-1 (.833) when forcing 1 or more turnovers this season — tied for 5th-best in NFL; League Avg: .590.
The Chargers are 6-4 (.600) on the road since the 2021 season — tied for 8th-best in NFL; League Avg: .469.
San Francisco 49ers: Keys to the Game vs. the Los Angeles Chargers
The 49ers are undefeated (9-0) when the opposing team converts less than 55% of its red zone chances into touchdowns since the 2021 season — best in NFL; League Avg: .540.
The 49ers are winless (0-1) when allowing an average of more than 5 yards on first down plays this season — tied for worst in NFL; League Avg: .434.
The 49ers are winless (0-2) when allowing more than 3 explosive runs this season — tied for worst in NFL; League Avg: .413.
The 49ers are undefeated (4-0) when not throwing an interception this season — tied for best in NFL; League Avg: .634.
Additional Matchup Notes for Los Angeles Chargers vs. San Francisco 49ers
The 49ers have a third down conversion rate of 44.4% on 3rd and 10+ YTG this season — second-best in NFL. The Chargers defense has allowed a third down conversion rate of 36.8% on 3rd and 10+ YTG this season — worst in NFL.
49ers TEs have gained 439 yards on 33 receptions (13.3 YPR) this season — third-best in NFL. The Chargers have allowed 13.5 Yards Per Reception to TEs this season — fourth-worst in NFL.
The 49ers have a third down conversion rate of 50.0% in the second half this season — third-best in NFL. The Chargers defense has allowed a third down conversion rate of 47.8% in the second half this season — fifth-worst in NFL.
The Chargers have run successful plays on just 36.8% of rush attempts this season — third-worst in NFL. 49ers have allowed successful plays on just 37.2% of rush attempts this season — third-best in NFL.
The Chargers have thrown the ball 68.9% of the time since Week 6 — second-highest in NFL. The 49ers have allowed 8.5 yards per dropback since Week 6 — worst in NFL.
Chargers RBs have rushed for 10 or more yards on just 5.4% of 56 carries since Week 6 — fourth-worst in NFL. The 49ers have allowed 10+ yards on just 4.5% of carries to RBs since Week 6 — fourth-best in NFL.
Los Angeles Chargers Offense: Important Stats for Week 10
The Chargers averaged 121.6 yards from scrimmage per game (2,067 yards / 17 games) in the 4th quarter last season — best in NFL; League Avg: 94.8.
The Chargers had a third down conversion rate of 35% on third and 10+ yards to go last season — best in NFL; League Avg: 20%.
The Chargers converted first downs on 114 of 333 plays (34%) in the 4th quarter last season — 2nd-best in NFL; League Avg: 29%.
The Chargers are averaging 23.0 drives per TD in close and late situations this season — 2nd-worst Drives Per TD rate in NFL; League Avg: 5.0.
San Francisco 49ers Offense: Important Stats for Week 10
The 49ers have a third down conversion rate of 44% on third and 10+ yards to go this season — 2nd-best in NFL; League Avg: 19%.
The 49ers have gone three and out on 8% of their drives this season — best in NFL; League Avg: 21%.
The 49ers have run 36% of their plays in their opponent’s territory in the 4th quarter this season — worst in NFL; League Avg: 49%.
The 49ers have an average drive start position from the 14.3 yard line in the 4th quarter this season — worst in NFL; League Avg: 24.4.
Los Angeles Chargers Defense: Important Stats for Week 10
The Chargers defense has allowed an average of 2.8 yards after contact per carry (198 carries) this season — worst in NFL; League Avg: 1.8.
The Chargers defense has allowed scores on 88% of opponent drives in the 1st quarter since Week 6 — worst in NFL; League Avg: 27%.
The Chargers defense has allowed an average of 2.3 yards after contact per carry (697 carries) since the 2021 season — worst in NFL; League Avg: 1.9.
The Chargers defense has allowed an average of 3.0 yards after contact per carry (177 carries) to RBs this season — worst in NFL; League Avg: 1.9.
San Francisco 49ers Defense: Important Stats for Week 10
The 49ers defense has allowed passes of 20+ yards on 3 of 7 attempts (43%) on 3rd and long since Week 6 — worst in NFL; League Avg: 8%.
The 49ers defense has allowed a third down conversion rate of 80% on 3rd and short this season — worst in NFL; League Avg: 59%.
The 49ers defense have forced three and outs on 32% of opponent drives this season — 2nd-best in NFL; League Avg: 21%.
The 49ers defense has allowed first downs on 80% of plays on 3rd and short this season — worst in NFL; League Avg: 59%.
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