- The Eagles (-7) open the season at home against the Cowboys.
- Based on current spreads, eight road favorites feature across the slate.
- The Chicago Bears (+1.5) open as a home underdog on MNF.
Following the release of the 2025 NFL schedule, bettors can find the current spreads for all Week 1 games below.
Eagles vs. Cowboys opens the schedule with the Eagles listed as seven-point favorites. On Friday, the Chiefs and Chargers battle in Brazil with the Chiefs listed as three-point favorites.
Other standalone games include a Bills vs Ravens rematch on Sunday Night Football. On Monday, the Ben Johnson era begins in Chicago with a division matchup against Minnesota.
Here’s a look at the current spreads based on NFL odds at BetMGM.
NFL Week 1 Spreads
| Game | Current Spread |
|---|---|
| Cowboys at Eagles | Eagles -7 (-110) |
| Chiefs vs Chargers (Brazil) | Chiefs -2.5 (-115) |
| Cardinals at Saints | Cardinals -4.5 (-110) |
| Buccaneers at Falcons | Buccaneers -1.5 (-115) |
| Panthers at Jaguars | Jaguars -3 (-110) |
| Bengals at Browns | Bengals -5.5 (-110) |
| Dolphins at Colts | Colts -1.5 (-110) |
| Giants at Commanders | Commanders -7 (-110) |
| Steelers at Jets | Steelers -3 (-110) |
| Raiders at Patriots | Patriots -2.5 (-110) |
| Titans at Broncos | Broncos -7 (-110) |
| 49ers at Seahawks | 49ers -1.5 (-115) |
| Lions at Packers | Lions -1.5 (-105) |
| Texans at Rams | Rams -2.5 (-115) |
| Ravens at Bills | Bills -1.5 (-110) |
| Vikings at Bears | Vikings -1.5 (-105) |
NFL Picks Week 1
Check back periodically for my NFL Week 1 predictions.
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NFL Same Game Parlays
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