Rams vs Cardinals Prediction, Odds & Best Prop Bets โ€“ NFL, Week 2

Arizona Cardinals quarterback Kyler Murray throws a pass against the Philadelphia Eagles during the second half of an NFL football game, Sunday, Dec. 31, 2023, in Philadelphia. (AP Photo/Derik Hamilton)
(AP Photo/Derik Hamilton)
  • The Cardinals are -1.5 point favorites vs the Rams
  • Total (Over/Under): 49.5 points
  • Watch this game on FOX

The Los Angeles Rams (0-1-0) visit State Farm Stadium to take on the Arizona Cardinals (0-1-0) on Sep. 15. Kickoff is scheduled for 4:05pm EDT in Glendale, AZ.

The Cardinals are betting favorites in this matchup, with the spread sitting at -1.5 (-110).

The Rams vs. Cardinals Over/Under is 49.5 total points for the game.

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Rams vs. Cardinals Odds, Spread, Over/Under

SpreadTotal (O/U)Moneyline
Rams+1.5 -11049.5 -110+105
Cardinals -1.5 -11049.5 -110-125

Rams vs. Cardinals Prediction

The winning team model predicts the Rams will win this game with 51.5% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Rams vs Cardinals Spread Prediction

Based on recent against-the-spread trends, the model predicts the Rams will cover the spread with 51.5% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


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We’ve highlighted some favorite NFL player prop bets for Rams players this playoff game, looking at profitable historical betting trends:

Best Rams Player Prop Bets Today

  • Colby Parkinson has hit the Receiving Yards Over in 9 of his last 11 games (+6.50 Units / 50% ROI)
  • Colby Parkinson has hit the Receptions Over in 6 of his last 7 games (+6.05 Units / 69% ROI)
  • Jimmy Garoppolo has hit the Interceptions Over in his last 6 games (+6.00 Units / 69% ROI)
  • Kyren Williams has hit the Carries Over in 9 of his last 12 games (+6.00 Units / 46% ROI)
  • Kyren Williams has hit the Rushing Yards Over in 9 of his last 12 games (+5.65 Units / 41% ROI)

And here are some top NFL player prop bets for Cardinals players for this matchup, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today

  • James Conner has hit the Longest Reception Under in 7 of his last 8 games (+5.75 Units / 58% ROI)
  • Desmond Ridder has hit the Rushing Yards Over in his last 5 games at home (+5.00 Units / 86% ROI)
  • James Conner has hit the Longest Rush Over in his last 5 games (+5.00 Units / 85% ROI)
  • Chris Moore has hit the Receiving Yards Over in 6 of his last 7 games (+4.85 Units / 58% ROI)
  • James Conner has hit the Receiving Yards Under in 10 of his last 14 games (+4.85 Units / 26% ROI)
  • The Los Angeles Rams have covered the 1Q Spread in 14 of their last 21 games (+7.00 Units / 28% ROI)
  • The Los Angeles Rams have hit the Team Total Over in 7 of their last 8 games (+5.90 Units / 58% ROI)
  • The Los Angeles Rams have hit the Moneyline in 12 of their last 21 games (+5.80 Units / 19% ROI)
  • The Los Angeles Rams have covered the Spread in 12 of their last 21 games (+4.30 Units / 19% ROI)
  • The Los Angeles Rams have hit the 3Q Moneyline in 7 of their last 13 games (+4.25 Units / 24% ROI)
  • The Arizona Cardinals have hit the 2Q Game Total Over in 13 of their last 18 games (+7.85 Units / 38% ROI)
  • The Arizona Cardinals have hit the 2H Moneyline in 6 of their last 8 games (+7.10 Units / 89% ROI)
  • The Arizona Cardinals have hit the Game Total Over in 7 of their last 9 games at home (+4.80 Units / 48% ROI)
  • The Arizona Cardinals have scored last in 5 of their last 7 games at home (+4.35 Units / 60% ROI)
  • The Arizona Cardinals have hit the Team Total Over in 6 of their last 8 games at home (+3.95 Units / 40% ROI)

Rams Against the Spread (ATS) Record

Against the spread this NFL preseason, the Rams went 0-1 (-1.1 Units / -100% ROI).

  • Rams are 0-1 when betting on the Moneyline for -1 Units / -100% ROI
  • Rams are 0-1 when betting the Over for -1.15 Units / -100% ROI
  • Rams are 1-0 when betting the Under for +1 Units / ROI

Cardinals Against the Spread (ATS) Record

Against the spread this NFL preseason, the Cardinals went 1-0 (+1 Units / 90.91% ROI).

  • Cardinals are 0-1 when betting on the Moneyline for -1 Units / -100% ROI
  • Cardinals are 1-0 when betting the Over for +1 Units / 90.91% ROI
  • Cardinals are 0-1 when betting the Under for -1.1 Units / -100% ROI

Los Angeles Rams: Keys to the Game vs. the Arizona Cardinals

The Rams were 1-4 (.200) vs top 10 offenses last season — T-7th-worst in NFL; League Avg: .359.

The Rams were 3-1 (.750) when forcing at least one fumble last season — 8th-best in NFL; League Avg: .618.

The Rams were 3-2 (.600) when sacking the QB 3 or more times last season — T-10th-worst in NFL; League Avg: .650.

The Rams were 5-2 (.714) at home last season — 7th-best in NFL; League Avg: .558.

Arizona Cardinals: Keys to the Game vs. the Los Angeles Rams

The Cardinals were winless (0-3) when forcing 2 or more turnovers last season — worst in NFL; League Avg: .707.

The Cardinals were winless (0-10) when scoring less than 22 points last season — T-worst in NFL; League Avg: .254.

The Cardinals are winless (0-13) when losing at least one fumble since the 2022 season — worst in NFL; League Avg: .384.

The Cardinals were 1-6 (.143) when sacking the QB 3 or more times last season — 2nd-worst in NFL; League Avg: .650.

Additional Matchup Notes for Los Angeles Rams vs. Arizona Cardinals

The Cardinals ran successful plays on 46.6% of rush attempts with motion last season — 4th-best in NFL. The Rams allowed successful plays on 46.9% of rush attempts against motion last season — 3rd-worst in NFL.

The Cardinals ran successful plays on just 40.6% of pass attempts against a stacked front last season — 5th-worst in NFL. The Rams allowed successful plays on just 30.8% of pass attempts with a stacked front last season — 4th-best in NFL.

The Cardinals ran successful plays on just 29.6% of pass attempts against a heavy rush last season — worst in NFL. The Rams allowed successful plays on just 26.7% of pass attempts with a heavy rush last season — 3rd-best in NFL.

The Rams ran successful plays on 49.7% of pass attempts against a light front last season — 5th-best in NFL. The Cardinals allowed successful plays on 46.6% of pass attempts with a light front last season — 5th-worst in NFL.

The Rams were successful on 46.0% of plays they have run against a light front last season — 4th-best in NFL. The Cardinals allowed their opponents to be successful on 44.8% of plays with a light front last season — 3rd-worst in NFL.

The Rams ran successful plays on just 33.3% of pass attempts against a heavy rush last season — 3rd-worst in NFL. The Cardinals allowed successful plays on just 18.8% of pass attempts with a heavy rush last season — best in NFL.

Los Angeles Rams Offense: Important Stats

The Rams started 10 drives inside their own 10 yard line last season — 2nd-fewest in NFL.

The Rams went three and out on 6% of their drives in the 1st quarter last season — best in NFL; League Avg: 22%.

The Rams have targeted RBs 11% of the time (124 Pass Attempts/1,108 plays) since the 2022 season — lowest in NFL; League Avg: 18%.

The Rams averaged -0.51 epa per play against a light rush last season — 3rd-worst in NFL; League Avg: -0.04.

Arizona Cardinals Offense: Important Stats

The Cardinals had 23 rushes of 20+ yards last season — most in NFL.

The Cardinals went for two on 36% of PATs last season — highest in NFL; League Avg: 10%.

The Cardinals had 8 rushes of 20+ yards in the last 4 weeks of the regular season — most in NFL.

The Cardinals ran successful plays on 75% of rush attempts against a base rush last season — best in NFL; League Avg: 57%.

Los Angeles Rams Defense: Important Stats

The Rams defense allowed an average of 1.4 yards after contact per carry (388 carries) last season — T-best in NFL; League Avg: 1.8.

The Rams defense allowed successful plays on 59% of pass attempts in the 1st quarter last season — worst in NFL; League Avg: 47%.

Only 12% of the plays ran against the Rams were in the red zone last season — 2nd-best in NFL; League Avg: 14%.

The Rams defense allowed successful plays on 71% of rush attempts in Week 1 — worst in NFL; League Avg: 46%.

Arizona Cardinals Defense: Important Stats

19% of the plays ran against the Cardinals were in the red zone last season — worst in NFL; League Avg: 14%.

18% of the plays run against the Cardinals have been in the red zone since the 2022 season — worst in NFL; League Avg: 14%.

50% of the plays run against the Cardinals have been in their own territory since the 2022 season — worst in NFL; League Avg: 44%.

The Cardinals defense allowed scores on 44% of opponent drives last season — 2nd-worst in NFL; League Avg: 35%.

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Our BetMGM editors and authors are sports experts with a wealth of knowledge of the sports industry at all levels. Their coverage includes sports news, previews and predictions, fun facts, and betting.

Our BetMGM editors and authors are sports experts with a wealth of knowledge of the sports industry at all levels. Their coverage includes sports news, previews and predictions, fun facts, and betting.