- The San Francisco 49ers are -180 to make the postseason in 2025-26.
- Last season, San Francisco missed the postseason, ending a three-year streak.
- I predict the 49ers make the playoffs and earn the NFC’s top seed.
Based on NFL odds and 49ers playoff odds, the San Francisco 49ers are predicted to make the postseason this year.
San Francisco, which disappointed with a 6-11 campaign after a Super Bowl appearance in 2023, is -180 to reach the playoffs.
Comparatively, head coach Kyle Shanahan’s team is +150 to miss the playoffs next year.
Prediction: Will the San Francisco 49ers Make the Playoffs?
Based on San Francisco’s easy schedule and potent offense, I predict the 49ers Make the Playoffs (-180) and earn the NFC 1st Seed (+1100).
It appears I’m the lone occupant of 49ers Island this season. How that’s the case is a mystery to me.
Based on opponent win totals, San Francisco faces the league’s easiest schedule. Plus, a notable change occurs in San Francisco’s scheduling makeup.
Last season, the 49ers faced a cumulative -21 rest differential to their opponents. This season, it vaults to a +9 differential, per sharpfootballanalysis.com.
Offensively, I’m not worried about San Francisco, which returns Robert Saleh as defensive coordinator.
Despite losing 65 adjusted games to injury last season on offense, the 49ers ranked ninth in offensive DVOA, per ftnfantasy.com.
That marks the fourth straight season the 49ers ranked ninth or better in that category.
San Francisco’s defensive outlook remains the biggest mystery. Despite losing Dre Greenlaw, Talanoa Hufanga and Charvarius Ward, the set of opponents is quite favorable.
Last season, the 49ers ranked 13th in defensive DVOA against the fourth-hardest set of offenses.
Based on 2024 offensive DVOA ratings, Saleh’s defense projects to face the second-easiest set of offenses.
According to lookahead lines, oddsmakers have the 49ers favored in 15 games this season. Across all 17 games, they close no higher than +1.5.
If the 49ers convert regularly as a favorite, it likely bolsters San Francisco’s chances at earning the NFC’s top seed.
For that reason, I’ll take a flier at +1100 and lay a price on Shanahan’s side to return to the postseason.
San Francisco 49ers Week-by-Week Playoff Chances
| Week Number | Odds to Make Playoffs | Implied Probability |
|---|---|---|
| Preseason | -180 | 64.3% |
When Was the Last Time the San Francisco 49ers Won the Super Bowl?
The 49ers’ most recent Super Bowl win came in 1995 over the Chargers. They’ve appeared in three Super Bowls since, but have lost all three by a combined 17 points.
San Francisco owns five Super Bowl crowns in franchise history and are amongst the favorites in this year’s Super Bowl odds.
San Francisco 49ers Week-by-Week Super Bowl Odds
| Week Number | Odds to Win Super Bowl | Implied Probability |
|---|---|---|
| Preseason | +2000 | 4.76% |
Related Articles
NFL Betting Odds at BetMGM
BetMGM is the premier destination for NFL betting odds throughout the season.
Whether you’re a new bettor checking out weekly spreads, a casual fan tracking live NFL betting odds, or a longtime football building moneyline parlays, and more there’s something for everyone at the best online sportsbook.
If you’re new to the online sportsbook, register today with a sportsbook welcome bonus. And check out sportsbook promos each time you log in.
