- The Bills (1-0) are -10 point favorites vs the Titans (0-1)
- Total (Over/Under): 48.5 points
- Watch the game on ESPN
The Tennessee Titans (0-1) visit Highmark Stadium to take on the Buffalo Bills (1-0) on Sep. 19. Kickoff is scheduled for 7:15pm EDT in Orchard Park.
The Bills are betting favorites in Week 2, with the spread sitting at -10 (-110).
The Titans vs. Bills Over/Under is 48.5 total points for the game.
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Titans vs. Bills Odds, Spread, Over/Under Week 2
| Spread | Total (O/U) | Moneyline | |
| Tennessee Titans | +10 -110 | 48.5 -110 | +350 |
| Buffalo Bills | -10 -110 | 48.5 -110 | -450 |
Titans vs. Bills Prediction for Week 2
Based on recent trends, the winning team model predicts the Bills will win this Week 2 game with 86.0% confidence.
Titans vs Bills Spread Prediction for Week 2
Based on recent against-the-spread trends, the model predicts the Bills will cover the spread this Week 2 with 60.0% confidence.
Both predictions factor in up-to-date player injuries for both the Titans and Bills, plus offensive & defensive matchups, recent games and key player performances this season.
Best Titans Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for Titans players for Week 2, looking at profitable historical betting trends:
- Geoff Swaim has hit the Receiving Yards Under in his last 6 away games (+6.00 Units / 78% ROI)
- Derrick Henry has hit the Carries Over in 7 of his last 9 games (+4.80 Units / 45% ROI)
- Derrick Henry has hit the Receiving Yards Under in 7 of his last 9 games (+4.60 Units / 42% ROI)
- Ryan Tannehill has hit the TD Passes Under in 12 of his last 17 games (+3.85 Units / 15% ROI)
- Derrick Henry has hit the Rushing Yards Over in 3 of his last 4 away games (+2.05 Units / 47% ROI)
Best Bills Player Prop Best Bets Today
And here are some top NFL player prop bets for Bills players for Week 2, looking at profitable historical betting trends:
- Gabriel Davis has hit the Receiving Yards Over in 10 of his last 13 games (+6.50 Units / 43% ROI)
- Josh Allen has hit the Rushing Yards Over in 13 of his last 19 games (+6.05 Units / 27% ROI)
- Stefon Diggs has hit the Receptions Under in 7 of his last 9 games at home (+5.85 Units / 49% ROI)
- Devin Singletary has hit the Receiving Yards Under in 7 of his last 8 games at home (+5.75 Units / 54% ROI)
- Josh Allen has hit the Passing Yards Under in 7 of his last 8 games at home (+5.65 Units / 56% ROI)
Titans Betting Trends: ATS, Moneyline, Over/Under
- The Tennessee Titans have hit the 2Q Moneyline in 11 of their last 15 games (+9.20 Units / 42% ROI)
- The Tennessee Titans have hit the 1Q Game Total Under in 13 of their last 18 games (+8.30 Units / 40% ROI)
- The Tennessee Titans have hit the 1H Game Total Under in 9 of their last 11 games (+7.90 Units / 63% ROI)
- The Tennessee Titans have covered the 2Q Spread in 11 of their last 15 games (+7.80 Units / 48% ROI)
- The Tennessee Titans have covered the 1H Spread in 11 of their last 15 games (+6.80 Units / 42% ROI)
Bills Betting Trends: ATS, Moneyline, Over/Under
- The Buffalo Bills have hit the 4Q Moneyline in 10 of their last 11 games (+8.80 Units / 53% ROI)
- The Buffalo Bills have hit the 1Q Moneyline in 13 of their last 19 games (+8.70 Units / 22% ROI)
- The Buffalo Bills have covered the 2H Spread in 14 of their last 19 games (+8.60 Units / 41% ROI)
- The Buffalo Bills have hit the 2H Moneyline in 8 of their last 10 games (+7.30 Units / 37% ROI)
- The Buffalo Bills have covered the 4Q Spread in 9 of their last 11 games (+7.25 Units / 59% ROI)
Tennessee Titans: Keys to the Game vs. the Buffalo Bills
The Titans were 1-2 (.333) when the opposing team rushes more than 30 times last season — tied for 3rd-best in NFL; League Avg: .165.
The Titans are winless (0-1) when allowing more than 3 explosive runs since the 2021 season — tied for worst in NFL; League Avg: .415.
The Titans were 6-2 (.750) when averaging more than 5 yards on first down plays last season — tied for 2nd-best in NFL; League Avg: .545.
The Titans were 5-2 (.714) when making 7 or more explosive plays last season — 8th-best in NFL; League Avg: .572.
Buffalo Bills: Keys to the Game vs. the Tennessee Titans
The Bills were winless (0-4) when within 7 points at the two minute warning last season — tied for worst in NFL; League Avg: .495.
The Bills were winless (0-3) when allowing 27 or more points last season — tied for worst in NFL; League Avg: .198.
The Bills were winless (0-4) when allowing 22 or more points last season — tied for worst in NFL; League Avg: .267.
The Bills are 18-6 (.750) when passing for 250 or more yards since the 2020 season — fifth-best in NFL. The Titans have allowed 256.5 passing yards per game since the 2020 season — fifth-worst in NFL.
Additional Matchup Notes for Tennessee Titans vs. Buffalo Bills
The Bills went three and out on 15.3% of their drives last season — tied for second-best in NFL. Titans forced three and outs on 17.6% of opponent drives last season — fifth-worst in NFL.
Bills WRs averaged 26.1 targets per game last season — highest in NFL. The Titans allowed 14.5 receptions per game to WRs last season — second-worst in NFL.
Bills WRs had 284 receptions in 17 games (16.7 per game) last season — second-best in NFL. The Titans allowed 14.5 receptions per game to WRs last season — second-worst in NFL.
The Titans threw the ball just 47.3% of the time last season — second-lowest in NFL. The Bills allowed just 5.2 yards per dropback last season — best in NFL.
Titans RBs have averaged 2.4 yards after contact per carry since the 2020 season — tied for second-best in NFL. The Bills have allowed 2.2 yards after contact per carry since the 2020 season — tied for worst in NFL.
The Titans have thrown the ball just 47.7% of the time since the 2021 season — second-lowest in NFL. The Bills have allowed just 5.2 yards per dropback since the 2021 season — best in NFL.
Tennessee Titans Offense: Important Stats for Week 2
The Titans threw the ball 37% of the time (183 Pass Attempts/494 plays) on 1st down last season — lowest in NFL; League Avg: 46%.
The Titans have thrown the ball 37% of the time (193 Pass Attempts/523 plays) on 1st down since the 2021 season — lowest in NFL; League Avg: 46%.
The Titans converted first downs on 46 of 67 plays (69%) on 3rd and short last season — 4th-best in NFL; League Avg: 62%.
The Titans ran successful plays on 33% of rush attempts in the 1st quarter last season — 2nd-worst in NFL; League Avg: 42%.
Buffalo Bills Offense: Important Stats for Week 2
The Bills had an average drive start position from the 37.0 yard line in the 1st quarter last season — best in NFL; League Avg: 25.7.
The Bills have an average drive start position from the 36.2 yard line in the 1st quarter since the 2021 season — best in NFL; League Avg: 25.6.
The Bills started 4 drives inside their own 20 yard line in the 1st quarter last season — tied for fewest in NFL.
The Bills have run 28% of their plays in the red zone in the 4th quarter since the 2021 season — best in NFL; League Avg: 17%.
Tennessee Titans Defense: Important Stats for Week 2
The Titans defense sacked opposing QBs on 19% of pass attempts (5/26) in Week 1 — best in NFL; League Avg: 7%.
The Titans defense pressured opposing QBs on 67% of pass attempts in Week 1 — best in NFL; League Avg: 28%.
The Titans defense hit opposing QBs on 38% of pass attempts in Week 1 — best in NFL; League Avg: 17%.
The Titans defense allowed 141 yards after contact in Week 1 — most in NFL.
Buffalo Bills Defense: Important Stats for Week 2
The Bills defense allowed a passer rating of just 65.4 (531 Pass Attempts) last season — best in NFL; League Avg: 90.8.
The Bills defense allowed 12 of 31 (39%) TDs through the air last season — lowest in NFL; League Avg: 62%.
The Bills defense has allowed 13 TD passes since the 2021 season — fewest in NFL.
The Bills defense allowed just 179.2 receiving yards per game (3,047/17) last season — best in NFL; League Avg: 244.0.
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