Chiefs vs. Bills Prediction: AFC Championship Odds, Betting Picks

Kansas City Chiefs quarterback Patrick Mahomes looks to throw during the first half of an NFL football game against the Detroit Lions Thursday, Sept. 7, 2023, in Kansas City, Mo.
(Charlie Riedel/AP Photo)
  • The Chiefs are a 1.5-point home favorite against the Bills.
  • Patrick Mahomes is 27-9-1 ATS when listed between -3 and +4.5 in his career.
  • My Chiefs vs. Bills prediction is for Kansas City to reach the Super Bowl.

On Sunday in Kansas City, the Bills will try to end the Chiefsโ€™ bid for a three-peat.ย 

Kansas City cruised to victory on Saturday against the Texans with a 23-14 win. While the Chiefs won outright, they failed to cover the closing spread thanks to a last-gasp safety.ย 

Buffalo survived a two-point conversion attempt to capture a 27-25 win over the Ravens. Now, theyโ€™ll look to beat the Chiefs for the second time this season after winning 30-21 in Buffalo.ย 

Bet on Chiefs vs. Bills and other NFL matchups with up-to-date NFL odds.ย 

AFC Championship Odds: Chiefs vs. Billsย 

Jan 26 - 6 pm EST

Bills at Chiefs

Chiefs vs. Bills Prediction

Based on Patrick Mahomesโ€™ strong record as s short favorite and the Billsโ€™ lackluster defensive play, my Chiefs vs. Bills prediction is the Chiefs Moneyline (-125).ย 

The prominent takeaway from Buffaloโ€™s win over Baltimore in the divisional round? Their defense could not get off the field without the Ravens getting in their own way.ย 

Baltimore never punted once in Buffalo. They either drove the field and scored or turned the ball over to Buffalo.ย 

So much had to go right for Buffalo to win that game. Lamar Jackson fumbled on the Bills 28-yard line, and the Ravens missed a pair of two-point conversions.ย 

Ask yourself whether you think the same will transpire for Kansas City, which also has an extra day of rest over the Bills, who are forced to travel for Sundayโ€™s game.ย 

Thereโ€™s also the small matter that Mahomes rarely fails ATS as a short favorite.ย 

For his career, the three-time Super Bowl MVP is 27-9-1 ATS when listed between -3 and +4.5, including 14-7 ATS between -3 and -0.5.ย 

Meaningful differences exist from the Week 11 meeting between these teams.ย 

Isiah Pacheco missed that game for Kansas City, while corner Jaylen Watson also failed to feature.ย 

Buffalo sustained some key injuries that could further affect their defensive outlook on Sunday. Both Taylor Rapp and Taron Johnson exited with injuries.ย 

The Billsโ€™ struggles defending the middle also continued as Andrews and Isaiah Likely combined to record nine catches for 134 yards and a touchdown.ย 

If the Bills canโ€™t defend playoff Travis Kelce, their defense likely struggles once again. As a result, back the Chiefs to reach their third consecutive Super Bowl.ย 

Betting Chiefs vs. Bills: NFL Public Betting

First Bet Offer $1,500 FBO
Bets% (ATS)Money% (ATS)Bets% (ML)Money% (ML)
Bills56%38%71%67%
Chiefs44%62%29%33%
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About the Author

Ryan Hannable

Read More @RyanHannable

Ryan Hannable is a Content Managing Editor on the Web Content Team for BetMGM. Previously, he was a New England Patriots beat writer for WEEI in Boston. He also has published a golf book, โ€œThe Ultimate Book of Golf Trivia: 600 Questions and Answers.โ€

Ryan Hannable is a Content Managing Editor on the Web Content Team for BetMGM. Previously, he was a New England Patriots beat writer for WEEI in Boston. He also has published a golf book, โ€œThe Ultimate Book of Golf Trivia: 600 Questions and Answers.โ€