Chiefs vs. Saints Prediction, Odds, Pick: Week 5, MNF

Patrick Mahomes and the Chiefs take center stage on Monday night as they welcome the Saints to Kansas City. 

Kansas City moved to 4-0 with a 17-10 win over the Chargers last Sunday. It’s the Chiefs’ 10th straight victory, with seven straight coming by seven or fewer points. 

New Orleans suffered a second consecutive defeat on Sunday. Despite keeping Atlanta’s offense out of the endzone, they fell 26-24 to Atlanta on the road. 

Here’s a look at the NFL betting lines and my Chiefs vs. Saints prediction. 

Chiefs vs. Saints Odds, MNF

• Kansas City Chiefs Moneyline: -250
• New Orleans Saints Moneyline: +200
• Game Spread: Kansas City Chiefs -5.5 (-110)
• Game Over/Under: 43 Points

Chiefs vs. Saints Prediction, MNF

As a function of Kansas City’s lucky run this season and New Orleans’ unlucky result in Week 4, my prediction for Chiefs vs. Saints is the New Orleans Saints Spread (+5, -110). 

Variance resigned the Saints to a 26-24 defeat in Week 4 against the Falcons. However, it came in a game where they allowed zero offensive touchdowns. 

Atlanta’s 26 points came from four field goals, a fumble recovery in the end zone off a muffed punt and an interception return for a touchdown. 

New Orleans remains a strong defense – they’re sixth in PFF’s defensive grades – while sitting second in the offensive rankings. 

They’re also a 2-2 team with an expected win-loss record of 3.2-0.8, according to pro-football-reference.com. 

Kansas City’s offense is also decimated by injuries right now. 

Rashee Rice is likely joining Hollywood Brown on the sidelines for the remainder of the season while Isiah Pacheco is out on Monday. 

Kansas City’s pass defense is also 21st in PFF’s coverage grades, and New Orleans leads the league in the corresponding offensive category. 

Finally, Derek Carr is 29-19 ATS as an underdog of +5 or higher, including 19-8 ATS as dog of +5 or higher off a loss. 

Take the Saints at +4.5 or better in Week 5.