Ohio State vs Northwestern Prediction, Odds & Best Prop Bets โ€“ NCAAF, Week 12

Northwestern running back Cam Porter (4) runs with the ball against Duke during the first half of an NCAA football game on Saturday, Sept. 10, 2022, in Evanston, Ill. (AP Photo/Kamil Krzaczynski)
(AP Photo/Kamil Krzaczynski)
  • Ohio State is a -28.5 point favorite vs. Northwestern
  • Ohio State vs. Northwestern Total (Over/Under): 44.5 points
  • TV Channel: BTN

The Ohio State Buckeyes (8-1) visit Wrigley Field to take on the Northwestern Wildcats (4-5) on Nov. 16 in Chicago, IL. Kickoff is scheduled for 12:00pm EST.

Ohio State is a betting favorite in Week 12, with the spread sitting at -28.5 (-115).

The Ohio State vs. Northwestern Over/Under is 44.5 total points.

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Ohio State vs. Northwestern Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
Ohio State-28.5 -11544.5 -110+
Northwestern +28.5 -10544.5 -110+

Ohio State vs Northwestern Prediction:

The winning team model predicts Ohio State will win this game with 95.0% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Ohio State and Northwestern, key player performances this season and recent team trends.

Ohio State vs Northwestern Spread Prediction:

Based on recent against-the-spread trends, the model predicts Northwestern will cover the spread with 86.4% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


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  • Ohio State has hit the 1H Game Total Over in their last 4 away games (+4.00 Units / 90% ROI)
  • Ohio State has hit the Moneyline in 8 of their last 11 games (+3.45 Units / 0% ROI)
  • Ohio State has hit the 1H Moneyline in 6 of their last 8 games (+3.40 Units / 5% ROI)
  • Ohio State has hit the 1Q Moneyline in 5 of their last 7 games (+2.65 Units / 11% ROI)
  • Ohio State has hit the Game Total Under in 7 of their last 12 games (+1.55 Units / 12% ROI)
  • Northwestern has hit the 1H Moneyline in 7 of their last 12 games (+6.25 Units / 10% ROI)
  • Northwestern has hit the Moneyline in 7 of their last 12 games (+6.15 Units / 10% ROI)
  • Northwestern have covered the 1Q Spread in 7 of their last 10 games (+4.25 Units / 40% ROI)
  • Northwestern has hit the 1Q Game Total Under in 7 of their last 10 games (+4.15 Units / 33% ROI)
  • Northwestern has hit the 1H Game Total Under in 5 of their last 7 games at home (+3.90 Units / 51% ROI)

We’ve highlighted some favorite college football player prop bets for Ohio State players, looking at profitable historical betting trends:

Best Ohio State Player Prop Bets Today

  • Will Howard has hit the TD Passes Over in his last 3 games (+3.40 Units / 97% ROI)
  • TreVeyon Henderson has hit the Receiving Yards Under in his last 2 games (+2.00 Units / 83% ROI)
  • TreVeyon Henderson has hit the Rushing Yards Over in his last 2 games (+2.00 Units / 83% ROI)
  • Will Howard has hit the Rushing Yards Under in 3 of his last 4 games (+1.80 Units / 38% ROI)
  • Quinshon Judkins has hit the Rushing Yards Under in 3 of his last 4 games (+1.80 Units / 38% ROI)

Top NCAAF player prop bets for Northwestern players, looking at profitable historical betting trends:

Best Northwestern Player Prop Best Bets Today

  • Jack Lausch has hit the Rushing Yards Under in his last game (+1.00 Units / 83% ROI)
  • Cam Porter has hit the Rushing Yards Over in his last game (+1.00 Units / 83% ROI)
  • A.J. Henning has hit the Receiving Yards Under in his last game (+1.00 Units / 83% ROI)
  • Mike Wright has hit the Passing Yards Under in his last game (+1.00 Units / 80% ROI)
  • Mike Wright has hit the TD Passes Under in his last game (+1.00 Units / 45% ROI)

Ohio State Against the Spread (ATS) Record

Ohio State is 5-4 against the spread this college football season (+0.6 Units / 6.06% ROI).

  • Ohio State is 7-1 when betting on the Moneyline for +5.25 Units / 0.27% ROI
  • Ohio State is 4-5 when betting the Over for -1.5 Units / -15.15% ROI
  • Ohio State is 5-4 when betting the Under for +0.6 Units / 6.06% ROI

Northwestern Against the Spread (ATS) Record

Northwestern is 3-6 against the spread this college football season (-3.6 Units / -36.55% ROI).

  • Northwestern is 4-5 when betting on the Moneyline for +1.1 Units / 1.87% ROI
  • Northwestern is 6-3 when betting the Over for +2.7 Units / 27.27% ROI
  • Northwestern is 3-6 when betting the Under for -3.6 Units / -36.36% ROI

Ohio State: Keys to the Game vs. Northwestern

Ohio State is 13-3 (.812) when the opposing team rushes more than 30 times since the 2023 season– T-5th-best in FBS; Average: .446

Ohio State is winless (0-2) when allowing 22 or more points since the 2023 season– T-worst in FBS; Average: .285

Ohio State is 11-2 (.846) when sacking the QB less than 3 times since the 2023 season– T-2nd-best in FBS; Average: .429

Ohio State is 11-2 (.846) when sacking the QB less than 3 times since the 2023 season– T-2nd-best among Power Conference Teams; Average: .478

Northwestern: Keys to the Game vs. Ohio State

Northwestern is undefeated (6-0) when making 5 or more explosive passes in a game since the 2023 season– best among Power Conference Teams; Average: .659

Northwestern is 6-9 (.400) when having a turnover margin within one of the opposing team since the 2023 season– T-13th-worst among Power Conference Teams; Average: .596

Northwestern is 1-5 (.167) when allowing 10 or more rushes of four or more yards this season– T-4th-worst among Power Conference Teams; Average: .540

Northwestern is 6-9 (.400) when having a turnover margin within one of the opposing team since the 2023 season– T-36th-worst in FBS; Average: .537

Matchup Notes for Ohio State vs. Northwestern

Northwestern’s offense has thrown for 20 or more yards on just 7.8% of 270 attempts this season — T-20th-worst among FBS offenses. Ohio State’s defense allowed 20+ yards on just 7.9% of attempts this season — T-31st-best among FBS defenses.

Northwestern’s offense has thrown for 1,584 passing yards in 9 games (just 176.0 YPG) this season — 16th-worst among FBS offenses. Ohio State’s defense has allowed just 155.6 passing yards per game this season — 4th-best among FBS defenses.

Northwestern has gained 1,584 yards on 148 receptions (just 10.7 YPR) this season — T-12th-worst among FBS skill players. Ohio State’s defense has allowed just 9.9 Yards Per Reception this season — T-6th-best among FBS defenses.

Ohio State’s offense has thrown for 20 or more yards on 12.6% of 261 attempts this season — T-27th-best among FBS offenses. Northwestern’s defense allowed 20+ yards on just 7.0% of attempts this season — T-12th-best among FBS defenses.

Ohio State’s offense has thrown for 2,429 passing yards in 9 games (269.9 YPG) this season — 29th-best among FBS offenses. Northwestern’s defense has allowed 241.0 passing yards per game this season — 4th-worst among Big Ten defenses.

Ohio State’s TEs has 22 receptions in 9 games (just 2.4 per game) this season — 3rd-worst among Big Ten TEs. Northwestern’s defense has allowed 3.9 receptions per game to TEs this season — T-25th-worst among FBS defenses.

Ohio State Offensive Stats & Trends

Ohio State’s offense has thrown for 20 or more yards on 12.6% of 261 attempts this season — T-27th-best among FBS offenses. Northwestern’s defense allowed 20+ yards on just 7.0% of attempts this season — T-12th-best among FBS defenses.

Ohio State’s offense has thrown for 2,429 passing yards in 9 games (269.9 YPG) this season — 29th-best among FBS offenses. Northwestern’s defense has allowed 241.0 passing yards per game this season — 4th-worst among Big Ten defenses.

Ohio State’s TEs has 22 receptions in 9 games (just 2.4 per game) this season — 3rd-worst among Big Ten TEs. Northwestern’s defense has allowed 3.9 receptions per game to TEs this season — T-25th-worst among FBS defenses.

Ohio State Skill Players picked up first downs on 5 receptions on 1st down last week– most among Big Ten Teams

Ohio State’s offense has thrown for 20 or more yards on 12.6% of 261 attempts this season — T-27th-best among FBS offenses. Northwestern’s defense allowed 20+ yards on just 7.0% of attempts this season — 5th-best among Big Ten defenses.

Northwestern Offensive Stats & Trends

Northwestern’s offense has thrown for 20 or more yards on just 7.8% of 270 attempts this season — T-20th-worst among FBS offenses. Ohio State’s defense allowed 20+ yards on just 7.9% of attempts this season — T-31st-best among FBS defenses.

Northwestern’s offense has thrown for 1,584 passing yards in 9 games (just 176.0 YPG) this season — 16th-worst among FBS offenses. Ohio State’s defense has allowed just 155.6 passing yards per game this season — 4th-best among FBS defenses.

Northwestern has gained 1,584 yards on 148 receptions (just 10.7 YPR) this season — T-12th-worst among FBS skill players. Ohio State’s defense has allowed just 9.9 Yards Per Reception this season — T-6th-best among FBS defenses.

Northwestern has gained 1,584 yards on 148 receptions (just 10.7 YPR) this season — T-3rd-worst among Big Ten skill players. Ohio State’s defense has allowed just 9.9 Yards Per Reception this season — T-6th-best among FBS defenses.

Northwestern’s QBs has thrown for 1,584 passing yards in 9 games (just 176.0 YPG) this season — 17th-worst among FBS teams. Ohio State’s defense has allowed just 155.6 passing yards per game this season — 4th-best among FBS defenses.

Ohio State Buckeyes Defensive Stats & Trends

Ohio State opponents has averaged 46.4 Passing Attempts per TD (603 Pass Attempts/13 Passing TDs) since the 2023 season– best among Power Conference Teams; Average: 21.7

Ohio State opponents has averaged 46.4 Passing Attempts per TD (603 Pass Attempts/13 Passing TDs) since the 2023 season– best in the Big Ten; Average: 23.6

Ohio State has not recorded a sack (18 pass attempts) in the Red Zone this season– T-worst in the Big Ten; Average: 15.9

Ohio State opponents has averaged 56.8 Passing Attempts per TD (227 Pass Attempts/4 Passing TDs) this season– 2nd-best among Power Conference Teams; Average: 22.4

Ohio State opponents has averaged 46.4 Passing Attempts per TD (603 Pass Attempts/13 Passing TDs) since the 2023 season– best in FBS; Average: 20.4

Northwestern Wildcats Defensive Stats & Trends

Northwestern has allowed opponents to catch just 11 of 32 passes (34% Reception Pct) on 3rd and long this season– best in the Big Ten; Average: 53%

Northwestern has allowed a Completion Pct of just 34% (11 completions/32 attempts) on 3rd and long this season– best in the Big Ten; Average: 53%

Northwestern has no interceptions (82 pass attempts) in the Red Zone since the 2023 season– T-worst in the Big Ten; Average: 45.5

Northwestern has no interceptions and 20 TD passes allowed in the Red Zone since the 2023 season– T-worst in FBS; Average: 10.0

Northwestern has allowed a Completion Pct of just 34% (11 completions/32 attempts) on 3rd and long this season– 2nd-best among Power Conference Teams; Average: 54%


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