Cardinals vs Brewers Prediction, Odds & Player Prop Bets Today – MLB, Sep 28

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MLB betting odds, predictions and betting odds for today's games
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BetMGM Betting @BETMGM Sep 28, 2022, 3:30 PM
  • The Brewers (82-72) are -160 favorites vs the Cardinals (90-65)
  • Cardinals starting pitcher: José Quintana (6-6), 3.02 ERA
  • Brewers starting pitcher: Brandon Woodruff (12-4), 3.18 ERA
  • Watch the game on BSWI

The St. Louis Cardinals (+135) visit American Family Field to take on the Milwaukee Brewers (-160) on Wednesday, September 28, 2022. First pitch is scheduled for 7:40pm EDT in Milwaukee.

The Brewers are betting favorites in this MLB matchup, with the run line sitting at -1.5 (+135).

The Cardinals vs Brewers Over/Under is 7 total runs for the game.

So far this season, the Cardinals are 90-65 against the spread (ATS), while the Brewers are 65-88 ATS.

Cardinals vs. Brewers Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Cardinals+1.5 -160O 7 +100+135
Brewers -1.5 +135U 7 -120-160

Cardinals vs Brewers Prediction for Today’s Game

Based on recent trends the model predicts the Brewers will win Wednesday‘s matchup with 57.8% confidence.

This prediction factors in starting pitchers, recent team and player hitting performances, the last 5 games for both the Cardinals and Brewers and up-to-date player injuries.


Looking for a risk-free bet up to $1,000? Bet now on Brewers vs Cardinals and all MLB games with BetMGM


Best Cardinals Player Prop Bets Today

We’ve highlighted some favorite MLB player prop bets for Cardinals players for Wednesday‘s game, looking at profitable historical betting trends:

  • Jose Quintana has hit the Earned Runs Under in 20 of his last 25 games (+14.30 Units / 47% ROI)
  • Paul Goldschmidt has hit the RBIs Under in his last 11 away games (+11.00 Units / 50% ROI)
  • Paul Goldschmidt has hit the Runs Under in 11 of his last 12 games (+9.80 Units / 56% ROI)
  • Tommy Edman has hit the Hits Under in 8 of his last 11 games (+8.40 Units / 62% ROI)
  • Tommy Edman has hit the Runs Under in 14 of his last 18 games (+8.05 Units / 29% ROI)

Best Brewers Player Prop Best Bets Today

And here are some favorite MLB player prop bets for Brewers players for Wednesday‘s game, looking at profitable historical betting trends:

  • Willy Adames has hit the RBIs Over in 24 of his last 45 games at home (+11.25 Units / 25% ROI)
  • Willy Adames has hit the Total Bases Over in 17 of his last 24 games at home (+10.85 Units / 39% ROI)
  • Eric Lauer has hit the Strikeouts Under in 16 of his last 21 games (+9.35 Units / 30% ROI)
  • Freddy Peralta has hit the Strikeouts Under in his last 9 games (+9.05 Units / 68% ROI)
  • Hunter Renfroe has hit the Singles Over in 25 of his last 46 games (+9.05 Units / 19% ROI)

Brewers vs Cardinals Home Run Prop Bets Today

Over Under
Andrew McCutchen 0.5 +475 0.5 -1000
Christian Yelich 0.5 +800 0.5 -3000
Hunter Renfroe 0.5 +425 0.5 -800
Keston Hiura 0.5 +750 0.5 -3000
Luis Urias 0.5 +800 0.5 -3000

Brewers vs Cardinals Total Hits Prop Bets Today

Over Under
Andrew McCutchen 0.5 -250 0.5 +160
Christian Yelich 0.5 -165 0.5 +115
Hunter Renfroe 0.5 -200 0.5 +145
Keston Hiura 0.5 -135 0.5 -105
Luis Urias 0.5 -145 0.5 +105

Brewers vs Cardinals RBI Prop Bets Today

Over Under
Andrew McCutchen 0.5 +195 0.5 -300
Christian Yelich 0.5 +250 0.5 -400
Hunter Renfroe 0.5 +145 0.5 -200
Keston Hiura 0.5 +270 0.5 -450
Luis Urias 0.5 +240 0.5 -375

Brewers vs Cardinals Strikeout Prop Bets Today

Over Under
Brandon Woodruff 6.5 -150 6.5 +105
Jose Quintana 5.5 +100 5.5 -140
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 10 of their last 12 away games (+8.10 Units / 56% ROI)
  • The Milwaukee Brewers have hit the 1st Five Innings (F5) Team Total Under in 4 of their last 6 games (+2.20 Units / 31% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this MLB season, the Cardinals have gone 85-69 against the Run Line (+10.7 Units / 5.53% ROI).

  • 90-65 when betting on the Moneyline for +8.4 Units / 3.77% ROI
  • 73-77 when betting on the total runs Over for -12 Units / -7.02% ROI
  • 77-73 when betting on the total runs Under for -2.9 Units / -1.7% ROI

Brewers Against the Spread (ATS) Record

Against the spread this MLB season, the Cardinals have gone 65-88 against the Run Line (-30.75 Units / -16.66% ROI).

  • 82-72 when betting on the Moneyline for -20.75 Units / -8.52% ROI
  • 75-72 when betting on the total runs Over for -3.75 Units / -2.2% ROI
  • 72-75 when betting on the total runs Under for -9.25 Units / -5.46% ROI

Jose Quintana has walked 1 of 91 batters (1%) this month (4 games) — best among qualified SPs in MLB; League Avg: 6% — 100th Percentile.

Jose Quintana has a strike rate of just 63% (1,633/2,605) this season — 3rd lowest among qualified SPs in MLB; League Avg: 66% — sixth Percentile.

Jose Quintana has thrown his changeup for a strike just 51% (354/694) of the time since the start of last season — lowest in MLB among starting pitchers with at least 157 total IP; League Avg: 61% — first Percentile.

Jose Quintana has not allowed a HR in any of his last nine starts dating back to August 10th — George Kirby has the longest active streak at 13.

Brandon Woodruff: Brewers Starting Pitcher Stats & Trends

Opponents have a miss rate of 47% (191/408) against Brandon Woodruff on changeups since the start of last season — 2nd best in MLB among starting pitchers with at least 157 total IP; League Avg: 30% — 98th Percentile.

Brandon Woodruff has a strikeout rate of 72% (21 SO in 29 PAs) with two-strikes — best in MLB over the last two weeks; League Avg: 43% — 100th Percentile.

Brandon Woodruff has struck out 34% (90/262) of left-handed batters he faced this season — 2nd best in MLB among starting pitchers with at least 76 total IP; League Avg: 22% — 98th Percentile.

Opponents have a miss rate of 53% (102/191) against Brandon Woodruff on changeups this season — best in MLB among starting pitchers with at least 76 total IP; League Avg: 29% — 100th Percentile.

Cardinals Keys to the Game vs. the Brewers

The Cardinals are 46-10 (.821) when totaling 10 or more hits this season — 6th best in MLB; League Avg: .726.

The Cardinals are 66-3 (.957) when leading entering the 7th inning this season — 3rd best in MLB; League Avg: .882.

The Cardinals are 69-3 (.958) when leading entering the 8th inning this season — 3rd best in MLB; League Avg: .915.

The Cardinals are 15-4 (.789) when tied entering the 8th inning this season — best in MLB; League Avg: .500.

Brewers Keys to the Game vs. the Cardinals

The Brewers are 16-8 (.667) when tied entering the 7th inning this season — tied for 3rd best in MLB; League Avg: .500.

The Brewers are 8-53 (.131) when trailing entering the 7th inning this season — 10th best in MLB; League Avg: .118.

The Brewers are just 9-33 (.214) when allowing 10 or more hits this season — 9th lowest in MLB; League Avg: .274.

The Brewers are just 58-11 (.841) when leading entering the 7th inning this season — 9th lowest in MLB; League Avg: .882.

Cardinals hitters have 259 extra-base hits out of 596 total hits (43%) against LHP since the start of last season — best in MLB; League Avg: 35%.

Cardinals hitters have an OPS of .811 (1,345 PA’s) against LHP this season — best in MLB; League Avg: .717.

Cardinals hitters have an OPS of .805 (2,590 PA’s) against LHP since the start of last season — best in MLB; League Avg: .726.

Cardinals hitters are slugging .468 against LHP this season — best in MLB; League Avg: .401.

The Brewers are batting just .224 against LHP since the start of last season — 2nd lowest in MLB; League Avg: .247.

Brewers hitters are averaging 4.05 pitches per plate appearance against RHP this season — highest in MLB; League Avg: 3.89.

Brewers hitters have an OPS of .750 (4,222 PA’s) against RHP this season — 5th best in MLB; League Avg: .705.

Brewers hitters have chased 20% of pitches out of the zone in non-two strike counts this season — lowest in MLB; League Avg: 24%.

Opponents have a miss rate of just 22% against Cardinals pitchers this season — lowest in MLB; League Avg: 26%.

Opponents have a groundball rate of 47% against Cardinals pitchers this season — 2nd highest in MLB; League Avg: 43%.

Opponents have a miss rate of just 23% against Cardinals pitchers since the start of last season — 2nd lowest in MLB; League Avg: 26%.

Opponents have a groundball rate of 46% against Cardinals pitchers since the start of last season — 2nd highest in MLB; League Avg: 43%.

Brewers pitchers have a strikeout rate of 31% in close and late situations since the start of last season — best in MLB; League Avg: 25%.

Brewers pitchers have a strikeout rate of 32% in close and late situations since the start of 2020 — best in MLB; League Avg: 25%.

Opponents have a miss rate of 28% against Brewers pitchers this season — 4th best in MLB; League Avg: 26%.

Opponents have a groundball rate of 49% against Brewers pitchers this month (25 games) — highest in MLB; League Avg: 43%.

Brewers vs. Cardinals Injuries Tonight That May Affect Prop Bets 

  • Luis Perdomo (Brewers): Calf, D15
  • Alex J Jackson (Brewers): Wrist, D60
  • Trevor Rosenthal (Brewers): Hamstring, D15
  • Adrian Houser (Brewers): Groin, Day-to-Day
  • Miguel Sánchez (Brewers): Elbow, D60
  • Jandel Gustave (Brewers): Forearm, D15
  • Jonathan Davis (Brewers): Elbow, D10
  • Alexander Reyes (Cardinals): Shoulder, D60
  • Tyler O’Neill (Cardinals): Hamstring, D10
  • Jordan Hicks (Cardinals): Neck, D15
  • Drew VerHagen (Cardinals): Hip, D60

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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.