Guardians vs Cardinals Prediction, Odds & Player Prop Bets Today – MLB, Sep 20

St. Louis Cardinals' Jordan Walker warms up before a baseball game against the Milwaukee Brewers Thursday, Sept. 28, 2023, in Milwaukee. (AP Photo/Aaron Gash)
(AP Photo/Aaron Gash)
  • The Guardians are -110 favorites vs the Cardinals
  • Guardians vs Cardinals Over / Under today: 8 Runs
  • Guardians / Cardinals TV Channel: BSGL | BSMW

The Cleveland Guardians (-105) visit Busch Stadium to take on the St. Louis Cardinals (-115) on Friday, September 20, 2024. First pitch is scheduled for 8:15pm EDT in St. Louis, MO.

This season, the Guardians are 89-65 against the spread (ATS), while the Cardinals are 78-75 ATS.

Guardians vs Cardinals Starting Pitchers Today:

  • Guardians starting pitcher: Ben Lively 12-9, 3.86 ERA
  • Cardinals starting pitcher: Kyle Gibson 8-7, 4.10 ERA

Guardians vs. Cardinals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Guardians-1.5 +155O 8 -105-105
Cardinals +1.5 -190U 8 -115-115

Guardians vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Friday‘s MLB game with 51.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Guardians players for Friday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

  • Lane Thomas has hit the Home Runs Over in 5 of his last 16 games (+16.60 Units / 104% ROI)
  • Jose Ramirez has hit the RBIs Under in 19 of his last 22 games (+13.80 Units / 36% ROI)
  • Jose Ramirez has hit the Total Bases Under in 13 of his last 14 away games (+11.75 Units / 60% ROI)
  • Andres Gimenez has hit the Runs Under in 18 of his last 23 away games (+10.10 Units / 25% ROI)
  • Bo Naylor has hit the Hits Runs and RBIs Under in 10 of his last 11 games (+9.90 Units / 76% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Friday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

  • Masyn Winn has hit the Home Runs Over in 6 of his last 25 games at home (+30.50 Units / 122% ROI)
  • Nolan Arenado has hit the Total Bases Over in 17 of his last 24 games at home (+12.70 Units / 40% ROI)
  • Jordan Walker has hit the Singles Under in 17 of his last 21 games (+11.45 Units / 39% ROI)
  • Masyn Winn has hit the Hits Over in 19 of his last 25 games at home (+10.20 Units / 19% ROI)
  • Michael Siani has hit the Hits Runs and RBIs Under in 12 of his last 16 games (+9.20 Units / 45% ROI)
  • The Cleveland Guardians have hit the Game Total Under in 42 of their last 71 away games (+15.80 Units / 20% ROI)
  • The Cleveland Guardians have hit the Team Total Under in 29 of their last 42 away games (+14.70 Units / 30% ROI)
  • The Cleveland Guardians have hit the Moneyline in 89 of their last 154 games (+12.82 Units / 6% ROI)
  • The Cleveland Guardians have covered the Run Line in 16 of their last 26 games (+8.05 Units / 25% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in their last 7 games (+7.05 Units / 72% ROI)
  • The St. Louis Cardinals have hit the Game Total Under in 16 of their last 24 games at home (+8.20 Units / 31% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 10 of their last 13 games (+7.05 Units / 44% ROI)
  • The St. Louis Cardinals have hit the Moneyline in 16 of their last 28 games (+5.75 Units / 18% ROI)
  • The St. Louis Cardinals have covered the Run Line in 20 of their last 32 games (+5.70 Units / 12% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 78-76 against the Run Line (+4.45 Units / 2.31% ROI).

  • 89-65 when betting on the Moneyline for +12.82 Units / 6.42% ROI
  • 68-76 when betting on the total runs Over for -16.05 Units / -9.43% ROI
  • 76-68 when betting on the total runs Under for +1.25 Units / 0.74% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 78-75 against the Run Line (-5.3 Units / -2.54% ROI).

  • 77-76 when betting on the Moneyline for -9.05 Units / -4.93% ROI
  • 70-77 when betting on the total runs Over for -15.27 Units / -9.12% ROI
  • 77-70 when betting on the total runs Under for -0.25 Units / -0.15% ROI

Cardinals vs Guardians Home Run Prop Bets Today

Over Under
Paul Goldschmidt (STL) 0.5 +425 0.5 -600
Jose Ramirez (CLE) 0.5 +500 0.5 -750
Jhonkensy Noel (CLE) 0.5 +525 0.5 -750
Kyle Manzardo (CLE) 0.5 +525 0.5 -750
Jordan Walker (STL) 0.5 +575 0.5 -800

Cardinals vs Guardians Total Hits Prop Bets Today

Over Under
Paul Goldschmidt (STL) 0.5 -250 0.5 +195
Brendan Donovan (STL) 0.5 -250 0.5 +190
Jose Ramirez (CLE) 0.5 -250 0.5 +190
Andres Gimenez (CLE) 0.5 -250 0.5 +175
Nolan Arenado (STL) 0.5 -225 0.5 +165

Cardinals vs Guardians RBI Prop Bets Today

Over Under
Paul Goldschmidt (STL) 0.5 +150 0.5 -200
Josh Naylor (CLE) 0.5 +160 0.5 -210
Jose Ramirez (CLE) 0.5 +165 0.5 -225
Nolan Arenado (STL) 0.5 +170 0.5 -225
Jordan Walker (STL) 0.5 +170 0.5 -225

Cardinals vs Guardians Strikeout Prop Bets Today

Over Under
Kyle Gibson (STL) 4.5 -115 4.5 -110
Ben Lively (CLE) 3.5 +120 3.5 -155

13 of Ben Lively’s 38 breaking pitch strikeouts (34%) have been backdoor this season — 2nd highest in MLB among starting pitchers with at least 61 total IP; League Avg: 14% — 98th Percentile.

Ben Lively has allowed a slugging percentage of .604 (61 Total Bases / 101 ABs) when going through the lineup the third time in a game this season — 2nd highest in MLB among starting pitchers with at least 61 total IP; League Avg: .427 — second Percentile.

Ben Lively has allowed a slugging percentage of .602 (103 Total Bases / 171 ABs) when going through the lineup the third time in a game since last season — highest in MLB among starting pitchers with at least 125 total IP; League Avg: .436 — 0 Percentile.

Ben Lively has averaged 90.1 MPH on fastballs this season — 4th lowest in MLB among starting pitchers with at least 61 total IP; League Avg: 93.6 — third Percentile.

Cardinals Starting Pitcher Stats & Trends

Kyle Gibson has a strike rate of just 55% (335/606) with runners in scoring position this season — lowest among qualified SPs in MLB; League Avg: 64% — second Percentile.

Kyle Gibson has a strike rate of just 60% (1,563/2,611) this season — 2nd lowest among qualified SPs in MLB; League Avg: 65% — third Percentile.

Kyle Gibson has walked 24 of 156 batters (15%) with runners in scoring position this season — highest among qualified SPs in MLB; League Avg: 8% — second Percentile.

Kyle Gibson has thrown his fastball for a strike just 59% (614/1,036) of the time this season — lowest among qualified SPs in MLB; League Avg: 67% — first Percentile.

Guardians Keys to the Game vs. the Cardinals

The Guardians are 24-29 (.453) when allowing 2 or more home runs this season — best in MLB; League Avg: .292.

The Guardians are 29-15 (.659) after a home win this season — 3rd best in MLB; League Avg: .516.

The Guardians are 73-2 (.973) when leading entering the 8th inning this season — best in MLB; League Avg: .900.

The Guardians are 62-8 (.886) when scoring 5 or more runs this season — tied for 2nd best in MLB; League Avg: .803.

Cardinals Keys to the Game vs. the Guardians

The Cardinals are just 24-38 (.387) after a win as favorites since the 2023 season — 3rd lowest in MLB; League Avg: .574.

The Cardinals are 39-20 (.661) when tied entering the 8th inning since the 2022 season — best in MLB; League Avg: .500.

The Cardinals are 21-13 (.618) after a loss as underdogs this season — best in MLB; League Avg: .434.

The Cardinals are 53-56 (.486) after a loss as underdogs since the 2022 season — 5th best in MLB; League Avg: .415.

The Guardians are batting just .296 on the first pitch of at-bats this season — 2nd lowest in MLB; League Avg: .332.

Guardians hitters have put just 35% of balls in play to the left side of the field since the 2022 season — lowest in MLB; League Avg: 38%.

The Guardians have barrels in 4% of PA’s since last season (445/11,778) — lowest in MLB; League Avg: 5%.

Guardians hitters have a Hard-Hit Rate of just 33% on the first pitch of at-bats this season — lowest in MLB; League Avg: 42%.

Cardinals hitters are slugging just .381 against LHP since last season — tied for 3rd lowest in MLB; League Avg: .408.

Cardinals hitters have an OPS of just .660 (1,662 PA’s) against LHP this season — 5th lowest in MLB; League Avg: .711.

The Cardinals are batting just .238 against LHP since last season — tied for 5th lowest in MLB; League Avg: .250.

The Cardinals are batting .249 with two outs since the 2022 season — tied for 2nd best in MLB; League Avg: .236.

Opponents have a groundball batting average of just .206 against Guardians pitchers with runners on base this season — best in MLB; League Avg: .263.

Opponents have a groundball batting average of just .222 against Guardians pitchers this season — best in MLB; League Avg: .249.

The Guardians have allowed 0.86 runs per game (133/154) in late innings this season — best in MLB; League Avg: 1.30.

Guardians pitchers have walked 5 of 161 batters (3%) when facing the leadoff batter in the inning this month (18 games) — best in MLB; League Avg: 8%.

Opponents have a groundball rate of 46% against Cardinals pitchers since the 2022 season — 2nd highest in MLB; League Avg: 43%.

Opponents have a miss rate of just 23% against Cardinals pitchers since the 2022 season — 2nd lowest in MLB; League Avg: 26%.

Opponents have a miss rate of just 23% against Cardinals pitchers since last season — 2nd lowest in MLB; League Avg: 26%.

Cardinals pitchers have a strikeout rate of just 39% with two-strikes since the 2022 season — 3rd lowest in MLB; League Avg: 42%.

Cardinals vs. Guardians Injuries Tonight That May Affect Prop Bets 

  • St. Louis Cardinals – No Injuries Reported
  • Cleveland Guardians – No Injuries Reported

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About the Author

Shane Jackson

Read More @Sjacksonmgm

Shane Jackson is a Web Content Writer for BetMGM, covering MLB and NBA. After graduating from the University of Kansas, his previous stops include MLB.com, Lawrence Journal-World, Manhattan Mercury, Bet Chicago Sports, WynnBET, and Sportsbook Review.

Shane Jackson is a Web Content Writer for BetMGM, covering MLB and NBA. After graduating from the University of Kansas, his previous stops include MLB.com, Lawrence Journal-World, Manhattan Mercury, Bet Chicago Sports, WynnBET, and Sportsbook Review.