Orioles vs Guardians Prediction, Odds & Player Prop Bets Today – MLB, Sep 22

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MLB betting odds, predictions and betting odds for today's games
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BetMGM Betting @BETMGM Sep 22, 2023, 3:31 PM
  • The Guardians are -120 favorites vs the Orioles
  • Orioles starting pitcher: Dean Kremer
  • Guardians starting pitcher: Shane Bieber
  • Watch the game on BSGL

The Baltimore Orioles (+100) visit Progressive Field to take on the Cleveland Guardians (-120) on Friday, September 22, 2023. First pitch is scheduled for 7:10pm EDT in Cleveland.

The Guardians are the betting favorite in this game, with the run line sitting at -1.5 (+165).

The Orioles vs Guardians Over/Under is 8 total runs for the game.

This season, the Orioles are 95-58 against the spread (ATS), while the Guardians are 78-76 ATS.

Orioles vs. Guardians Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Orioles+1.5 -200O 8 -110+100
Guardians -1.5 +165U 8 -110-120

Orioles vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Orioles will win Friday‘s MLB matchup with 55.8% confidence.

This prediction factors in starting pitchers, recent team and player hitting performances, the last 5 games for both the Orioles and Guardians and up-to-date player injuries.


Bet now on Orioles vs Guardians and all games with BetMGM


We’ve highlighted some favorite MLB player prop bets for Orioles players for Friday‘s game, looking at profitable historical betting trends:

Best Orioles Player Prop Bets Today:

  • Gunnar Henderson has hit the Hits Over in 23 of his last 35 games (+14.10 Units / 25% ROI)
  • Kyle Bradish has hit the Pitching Outs Over in 19 of his last 24 games (+13.65 Units / 46% ROI)
  • Ryan O’Hearn has hit the Singles Over in 18 of his last 25 away games (+11.30 Units / 41% ROI)
  • Ryan O’Hearn has hit the RBIs Over in 12 of his last 18 games (+11.15 Units / 62% ROI)
  • Ryan O’Hearn has hit the Runs Over in 13 of his last 19 away games (+10.00 Units / 53% ROI)

And here are some favorite MLB player prop bets for Guardians players for Friday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

  • Cal Quantrill has hit the Strikeouts Under in 15 of his last 17 games (+12.45 Units / 47% ROI)
  • Andres Gimenez has hit the Singles Over in 13 of his last 14 games (+11.85 Units / 70% ROI)
  • Jose Ramirez has hit the Runs Under in 19 of his last 24 games at home (+11.70 Units / 34% ROI)
  • Gabriel Arias has hit the Hits Runs and RBIs Over in 13 of his last 15 games at home (+11.10 Units / 55% ROI)
  • Myles Straw has hit the Runs Under in his last 11 games (+11.00 Units / 41% ROI)

Guardians vs Orioles Home Run Prop Bets Today

Over Under
Will Brennan 0.5 +950 0.5 -10000
Steven Kwan 0.5 +1050 0.5
Ryan O'Hearn 0.5 +450 0.5 -900
Ramon Urias 0.5 +650 0.5 -2000
Kole Calhoun 0.5 +425 0.5 -800

Guardians vs Orioles Total Hits Prop Bets Today

Over Under
Will Brennan 0.5 -250 0.5 +175
Steven Kwan 1.5 +185 1.5 -250
Ryan O'Hearn 1.5 +175 1.5 -250
Ramon Urias 0.5 -135 0.5 +100
Kole Calhoun 0.5 -155 0.5 +120

Guardians vs Orioles RBI Prop Bets Today

Over Under
Will Brennan 0.5 +220 0.5 -300
Steven Kwan 0.5 +230 0.5 -350
Ryan O'Hearn 0.5 +140 0.5 -185
Ramon Urias 0.5 +240 0.5 -350
Kole Calhoun 0.5 +170 0.5 -225

Guardians vs Orioles Strikeout Prop Bets Today

Over Under
Shane Bieber 4.5 -105 4.5 -120
Dean Kremer 4.5 +115 4.5 -150
  • The Baltimore Orioles have hit the Moneyline in 94 of their last 150 games (+34.70 Units / 18% ROI)
  • The Baltimore Orioles have covered the Run Line in 55 of their last 78 away games (+27.20 Units / 25% ROI)
  • The Baltimore Orioles have hit the Game Total Over in 44 of their last 78 away games (+13.25 Units / 15% ROI)
  • The Baltimore Orioles have hit the Team Total Over in 47 of their last 78 away games (+10.55 Units / 11% ROI)
  • The Baltimore Orioles have hit the 1st Five Innings (F5) Team Total Over in 26 of their last 45 away games (+4.27 Units / 8% ROI)
  • The Cleveland Guardians have hit the Game Total Under in 81 of their last 138 games (+22.05 Units / 15% ROI)
  • The Cleveland Guardians have covered the Run Line in 62 of their last 112 games (+10.60 Units / 7% ROI)
  • The Cleveland Guardians have hit the Moneyline in 33 of their last 57 games at home (+5.55 Units / 7% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Over in 5 of their last 6 games at home (+4.00 Units / 52% ROI)

Orioles Against the Spread (ATS) Record

Against the spread this MLB season, the Orioles have gone 91-62 against the Run Line (+24.15 Units / 12.23% ROI).

  • 95-58 when betting on the Moneyline for +33.75 Units / 16.97% ROI
  • 78-63 when betting on the total runs Over for +9 Units / 5.37% ROI
  • 63-78 when betting on the total runs Under for -23.05 Units / -13.59% ROI

Guardians Against the Spread (ATS) Record

Against the spread this MLB season, the Guardians have gone 78-76 against the Run Line (-1.65 Units / -0.84% ROI).

  • 73-81 when betting on the Moneyline for -18.75 Units / -9.79% ROI
  • 63-87 when betting on the total runs Over for -33.4 Units / -19.64% ROI
  • 87-63 when betting on the total runs Under for +18.2 Units / 10.76% ROI

65% of Dean Kremer’s non-fastball strikeouts are located away this season — 3rd highest among qualified SPs in MLB; League Avg: 47% — 95th Percentile.

Dean Kremer has located his pitches away 56% of the time (1,539/2,746) this season — highest among in MLB; League Avg: 46% — 100th Percentile.

Dean Kremer has located his pitches away 56% of the time (1,539/2,746) this season — highest among qualified SPs in MLB; League Avg: 46% — 100th Percentile.

Opponents have a chase percentage of just 25% (343/1,354) against Dean Kremer this season — 2nd lowest among qualified SPs in MLB; League Avg: 30% — fourth Percentile.

Guardians Starting Pitcher Stats & Trends

Shane Bieber has located his fastball away 64% of the time (393/611) this season — highest in MLB among starting pitchers with at least 60 total IP; League Avg: 41% — 100th Percentile.

Shane Bieber has located his fastball away 59% of the time (953/1,601) since last season — highest among qualified SPs in MLB; League Avg: 42% — 100th Percentile.

Shane Bieber has located his pitches away 59% of the time (760/1,281) on the first pitch of at-bats since last season — highest among qualified SPs in MLB; League Avg: 48% — 100th Percentile.

Shane Bieber has thrown breaking pitches 65% of the time (847/1,296) with two-strikes since last season — highest among qualified SPs in MLB; League Avg: 35% — 100th Percentile.

Orioles Keys to the Game vs. the Guardians

keys to the game – away

Guardians Keys to the Game vs. the Orioles

keys to the game – home

team hitters – away

team hitters – home

team pitchers – away

team pitchers – home

Guardians vs. Orioles Injuries Tonight That May Affect Prop Bets 

  • Triston McKenzie (Guardians): Elbow, D60
  • Tanner Bibee (Guardians): Hip, D15
  • Terrin Vavra (Orioles): Shoulder, D60
  • Dillon Tate (Orioles): Elbow, D60
  • Ryan Mountcastle (Orioles): Shoulder, D10
  • Félix Bautista (Orioles): Arm, D15
  • Keegan Akin (Orioles): Back, D60

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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.