Reds vs Guardians Prediction, Odds & Player Prop Bets Today – MLB, Sep 25

Cleveland Guardians catcher Bo Naylor sits near the bullpen during spring training baseball workouts in Goodyear, Ariz., Friday, Feb. 16, 2024.
(AP Photo/Carolyn Kaster)
  • The Guardians are -150 favorites vs the Reds
  • Reds vs Guardians Over / Under today: 8 Runs
  • Reds / Guardians TV Channel: BSGL | BSOH

The Cincinnati Reds (+125) visit Progressive Field to take on the Cleveland Guardians (-150) on Wednesday, September 25, 2024. First pitch is scheduled for 6:40pm EDT in Cleveland, OH.

This season, the Reds are 76-82 against the spread (ATS), while the Guardians are 81-77 ATS.

Reds vs Guardians Starting Pitchers Today:

  • Reds starting pitcher: Jakob Junis 4-0, 2.63 ERA
  • Guardians starting pitcher: Joey Cantillo 2-3, 4.77 ERA

Reds vs. Guardians Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Reds+1.5 -175O 8 -115+125
Guardians -1.5 +145U 8 -105-150

Reds vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Wednesday‘s MLB game with 52.3% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Reds players for Wednesday‘s game, looking at profitable historical betting trends:

Best Reds Player Prop Bets Today:

  • TJ Friedl has hit the Home Runs Over in 3 of his last 10 away games (+20.75 Units / 208% ROI)
  • Santiago Espinal has hit the Total Bases Under in 15 of his last 18 games (+14.55 Units / 56% ROI)
  • Jonathan India has hit the Hits Under in 15 of his last 25 away games (+13.30 Units / 53% ROI)
  • Santiago Espinal has hit the Runs Under in 14 of his last 15 away games (+11.25 Units / 33% ROI)
  • Spencer Steer has hit the Singles Under in 13 of his last 15 games (+10.45 Units / 52% ROI)

And here are some favorite MLB player prop bets for Guardians players for Wednesday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

  • Lane Thomas has hit the Home Runs Over in 7 of his last 19 games (+25.60 Units / 135% ROI)
  • Jose Ramirez has hit the RBIs Under in 21 of his last 26 games (+11.70 Units / 25% ROI)
  • Lane Thomas has hit the Hits Over in 19 of his last 24 games (+11.45 Units / 25% ROI)
  • Josh Naylor has hit the Singles Under in 30 of his last 47 games (+9.25 Units / 16% ROI)
  • Lane Thomas has hit the Runs Under in 17 of his last 23 games at home (+8.80 Units / 24% ROI)
  • The Cincinnati Reds have covered the Run Line in 80 of their last 140 games (+13.05 Units / 7% ROI)
  • The Cincinnati Reds have hit the Team Total Under in 82 of their last 143 games (+13.00 Units / 8% ROI)
  • The Cincinnati Reds have hit the Moneyline in 27 of their last 52 away games (+7.45 Units / 13% ROI)
  • The Cincinnati Reds have hit the Game Total Under in 73 of their last 142 games (+5.90 Units / 4% ROI)
  • The Cincinnati Reds have hit the 1st Five Innings (F5) Team Total Under in 7 of their last 10 away games (+4.25 Units / 39% ROI)
  • The Cleveland Guardians have hit the Game Total Under in 40 of their last 66 games (+15.70 Units / 22% ROI)
  • The Cleveland Guardians have hit the Moneyline in 91 of their last 158 games (+12.45 Units / 6% ROI)
  • The Cleveland Guardians have covered the Run Line in 37 of their last 73 games at home (+11.85 Units / 15% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in 9 of their last 11 games (+7.15 Units / 51% ROI)
  • The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 12 of their last 22 games (+0.93 Units / 4% ROI)

Reds Against the Spread (ATS) Record

Against the spread this season, the Reds are 88-70 against the Run Line (+9.2 Units / 4.38% ROI).

  • 76-82 when betting on the Moneyline for -5.95 Units / -3.21% ROI
  • 73-77 when betting on the total runs Over for -12.55 Units / -7.19% ROI
  • 77-73 when betting on the total runs Under for -3.45 Units / -1.99% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 81-77 against the Run Line (+6.45 Units / 3.24% ROI).

  • 91-67 when betting on the Moneyline for +12.45 Units / 6.07% ROI
  • 69-79 when betting on the total runs Over for -18.15 Units / -10.41% ROI
  • 79-69 when betting on the total runs Under for +3.05 Units / 1.76% ROI

Guardians vs Reds Home Run Prop Bets Today

Over Under
Kyle Manzardo (CLE) 0.5 +450 0.5 -650
Jose Ramirez (CLE) 0.5 +475 0.5 -650
Tyler Stephenson (CIN) 0.5 +525 0.5 -750
Josh Naylor (CLE) 0.5 +550 0.5 -800
Spencer Steer (CIN) 0.5 +600 0.5 -1000

Guardians vs Reds Total Hits Prop Bets Today

Over Under
Tyler Stephenson (CIN) 0.5 -250 0.5 +175
Jose Ramirez (CLE) 0.5 -250 0.5 +180
Josh Naylor (CLE) 0.5 -225 0.5 +165
Will Brennan (CLE) 0.5 -210 0.5 +155
Ty France (CIN) 0.5 -210 0.5 +160

Guardians vs Reds RBI Prop Bets Today

Over Under
Josh Naylor (CLE) 0.5 +170 0.5 -225
Jose Ramirez (CLE) 0.5 +170 0.5 -225
Tyler Stephenson (CIN) 0.5 +180 0.5 -250
Spencer Steer (CIN) 0.5 +180 0.5 -250
Ty France (CIN) 0.5 +190 0.5 -250

Guardians vs Reds Strikeout Prop Bets Today

Over Under
Joey Cantillo (CLE) 5.5 +120 5.5 -160
Jakob Junis (CIN) 3.5 +125 3.5 -165

Jakob Junis has a first-pitch strike rate of 74% (174/234) this season — highest among NL Relievers; League Avg: 63% — 100th Percentile.

30 of Jakob Junis’ breaking pitch strikeouts are backdoor since the 2022 season — most among NL Relievers; League Avg: nan — 100th Percentile.

Jakob Junis has walked 53 of 1,080 batters (5%) since the 2022 season — 4th best among qualified RPs in MLB*; League Avg: 9% — 98th Percentile.

8 of Jakob Junis’ 25 breaking pitch strikeouts (32%) have been backdoor this season — 4th highest among qualified RPs in MLB*; League Avg: 12% — 96th Percentile.

Guardians Starting Pitcher Stats & Trends

Joey Cantillo has not allowed a home run in any of the last 19.2 innings he’s appeared — Cionel Perez has the longest active streak at 87.1.

Joey Cantillo has a strikeout rate of 37% (22 SO in 60 PAs) this month (3 games) — 4th best in MLB among starting pitchers with at least 7 total IP; League Avg: 23% — 98th Percentile.

Joey Cantillo has not allowed a hit in the first inning in any of his last three games dating back to September 9th — Jakob Junis has the longest active streak at 6.

Opponents are hitting just .143 (8-for-56) against Joey Cantillo this month (3 games) — 6th best in MLB among starting pitchers with at least 7 total IP; League Avg: .239 — 96th Percentile.

Reds Keys to the Game vs. the Guardians

The Reds are just 5-15 (.250) when tied entering the 8th inning this season — lowest in MLB; League Avg: .500.

The Reds are just 13-26 (.333) when tied entering the 8th inning since the 2023 season — lowest in MLB; League Avg: .500.

The Reds are just 34-37 (.479) after a loss as favorites since the 2022 season — 2nd lowest in MLB; League Avg: .589.

The Reds are just 58-65 (.472) vs bottom 10 scoring offenses since the 2022 season — 4th lowest in MLB; League Avg: .568.

Guardians Keys to the Game vs. the Reds

The Guardians are 69-2 (.972) when leading entering the 7th inning this season — best in MLB; League Avg: .856.

The Guardians are 80-0 (1.000) when leading entering the 9th inning this season — best in MLB; League Avg: .949.

The Guardians are just 9-16 (.360) after a loss as underdogs this season — 4th lowest in MLB; League Avg: .434.

The Guardians are 75-2 (.974) when leading entering the 8th inning this season — best in MLB; League Avg: .900.

Reds hitters are slugging just .150 on pitches out of the zone this season — lowest in MLB; League Avg: .205.

The Reds are batting just .127 on pitches out of the zone since last season — 2nd lowest in MLB; League Avg: .151.

Reds hitters are slugging just .170 on pitches out of the zone since last season — 2nd lowest in MLB; League Avg: .208.

Reds hitters have 2,153 strikeouts in 8,711 PA’s (25%) against RHP since last season — tied for 4th highest in MLB; League Avg: 23%.

Guardians hitters have put just 34% of balls in play to the left side of the field since last season — lowest in MLB; League Avg: 38%.

Guardians hitters have put just 35% of balls in play to the left side of the field since the 2022 season — lowest in MLB; League Avg: 38%.

Guardians hitters are slugging just .378 against LHP since the 2022 season — 2nd lowest in MLB; League Avg: .405.

Guardians hitters have a swing rate of 64% with two-strikes since last season — highest in MLB; League Avg: 60%.

Opponents have a groundball rate of just 39% against Reds pitchers since last season — lowest in MLB; League Avg: 43%.

Opponents have a groundball rate of just 40% against Reds pitchers since the 2022 season — lowest in MLB; League Avg: 43%.

Opponents have a groundball rate of just 33% against Reds pitchers over the last 14 days — lowest in MLB; League Avg: 43%.

Opponents have a groundball batting average of .294 against Reds pitchers with runners on base since the 2022 season — highest in MLB; League Avg: .256.

Opponents have a groundball batting average of just .203 against Guardians pitchers with runners on base this season — best in MLB; League Avg: .262.

The Guardians have allowed 0.87 runs per game (138/158) in late innings this season — best in MLB; League Avg: 1.29.

Opponents have a groundball batting average of just .221 against Guardians pitchers this season — best in MLB; League Avg: .249.

Guardians pitchers have walked 7 of 195 batters (4%) when facing the leadoff batter in the inning this month (22 games) — best in MLB; League Avg: 8%.

Guardians vs. Reds Injuries Tonight That May Affect Prop Bets 

  • Cleveland Guardians – No Injuries Reported
  • Cincinnati Reds – No Injuries Reported

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About the Author

Shane Jackson

Read More @Sjacksonmgm

Shane Jackson is a Web Content Writer for BetMGM, covering MLB and NBA. After graduating from the University of Kansas, his previous stops include MLB.com, Lawrence Journal-World, Manhattan Mercury, Bet Chicago Sports, WynnBET, and Sportsbook Review.

Shane Jackson is a Web Content Writer for BetMGM, covering MLB and NBA. After graduating from the University of Kansas, his previous stops include MLB.com, Lawrence Journal-World, Manhattan Mercury, Bet Chicago Sports, WynnBET, and Sportsbook Review.