Buffalo vs Missouri Prediction, Odds & Best Prop Bets โ€“ NCAAF, Week 2

Missouri head coach Eliah Drinkwitz yells during the second half of the team's Cotton Bowl NCAA college football game against Ohio State on Friday, Dec. 29, 2023, in Arlington, Texas. (AP Photo/Julio Cortez)
(AP Photo/Julio Cortez)
  • Missouri is a -34.5 point favorite vs. Buffalo
  • Buffalo vs. Missouri Total(Over/Under): 51.5 points
  • TV Channel: ESPN+

The Buffalo Bulls (1-0) visit Memorial Stadium/Faurot Field to take on the Missouri Tigers (1-0) on Sep. 7 in Columbia, MO. Kickoff is scheduled for 7:00pm EDT.

Missouri is a betting favorite in Week 2, with the spread sitting at -34.5 (-110).

The Buffalo vs. Missouri Over/Under is 51.5 total points.

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Buffalo vs. Missouri Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
Buffalo+34.5 -11051.5 -110+
Missouri -34.5 -11051.5 -110+

Buffalo vs Missouri Prediction:

The winning team model predicts Missouri will win this game with 95.0% confidence, based on game simulations, offensive & defensive matchups and recent game results.

Buffalo vs Missouri Spread Prediction:

Based on recent against-the-spread trends, the model predicts Buffalo will cover the spread with 89.2% confidence.

Both predictions factor in up-to-date player injuries for both Buffalo U and Missouri and key player performances this season.


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      We’ve highlighted some favorite college football player prop bets for Buffalo players, looking at profitable historical betting trends:

      Best Buffalo Player Prop Bets Today

        Top NCAAF player prop bets for Missouri players, looking at profitable historical betting trends:

        Best Missouri Player Prop Best Bets Today

          Buffalo: Keys to the Game vs. Missouri

          Buffalo is 8-3 (.727) when allowing less than 5 yards per rush since the 2022 season– 13th-best among Non-Power Conference Teams; Average: .570

          Buffalo was 1-7 (.125) when their opponent rushed more than 30 times in the 2023 season– T-4th-worst among Non-Power Conference Teams; Average: .415

          Buffalo was winless (0-4) when losing at least one fumble in the 2023 season– T-worst among Non-Power Conference Teams; Average: .338

          Buffalo was 2-8 (.182) when converting less than 50% of third down conversion opportunities in the 2023 season– T-22nd-worst in FBS; Average: .403

          Missouri: Keys to the Game vs. Buffalo

          Missouri is 9-4 (.600) when committing less than 60 yards in penalties since the 2022 season– T-28th-best in FBS; Average: .446

          Missouri was 8-1 (.889) when allowing less than 50% of third down conversion opportunities in the 2023 season– 7th-best among Power Conference Teams; Average: .562

          Missouri is 9-4 (.692) when allowing less than 5 explosive passes since the 2022 season– T-40th-best in FBS; Average: .570

          Missouri was 10-1 (.909) when allowing less than 50% of third down conversion opportunities in the 2023 season– 7th-best in FBS; Average: .572

          Matchup Notes for Buffalo vs. Missouri

          Missouri gained 3,383 yards on 246 receptions (13.8 YPR) last season — 16th-best among FBS skill players. Buffalo’s defense allowed just 10.8 Yards Per Reception last season — T-23rd-best among FBS defenses.

          Missouri’s offense threw for 20 or more yards on 14.2% of 373 attempts last season — T-12th-best among FBS offenses. Buffalo’s defense allowed 20+ yards on just 7.7% of attempts last season — T-14th-worst among FBS defenses.

          Missouri’s RBs averaged 9.8 yards after the catch last season — 18th-best among FBS RBs. Buffalo’s defense allowed just 6.2 RAC to RBs last season — T-23rd-best among FBS defenses.

          Buffalo’s RBs averaged just 5.5 yards after the catch last season — T-13th-worst among FBS RBs. Missouri’s defense allowed just 10.8 RAC last season — T-23rd-best among FBS defenses.

          Buffalo gained 2,223 yards on 212 receptions (just 10.5 YPR) last season — 16th-worst among FBS skill players. Missouri’s defense allowed just 11.1 Yards Per Reception last season — T-30th-best among FBS defenses.

          Buffalo’s offense threw for 20 or more yards on just 7.1% of 394 attempts last season — 9th-worst among FBS offenses. Missouri’s defense allowed 20+ yards on 11.4% of attempts last season — T-29th-best among FBS defenses.

          Buffalo Offensive Stats & Trends

          Buffalo TEs have just one touchdown on 51 receptions since the 2022 season– 4th-worst Receptions Per TD among FBS Teams; Average: 9.3

          Buffalo RBs did not rush for 0a TD on 50 carries (inf Carries Per TD) in close and late situations in the 2023 season– T-worst Carries Per TD among FBS Teams; Average: 23.8

          Buffalo’s RBs averaged just 5.5 yards after the catch last season — T-13th-worst among FBS RBs. Missouri’s defense allowed just 10.8 RAC last season — T-23rd-best among FBS defenses.

          Buffalo gained 2,223 yards on 212 receptions (just 10.5 YPR) last season — 16th-worst among FBS skill players. Missouri’s defense allowed just 11.1 Yards Per Reception last season — T-30th-best among FBS defenses.

          Buffalo’s offense threw for 20 or more yards on just 7.1% of 394 attempts last season — 9th-worst among FBS offenses. Missouri’s defense allowed 20+ yards on 11.4% of attempts last season — T-29th-best among FBS defenses.

          Missouri Offensive Stats & Trends

          Missouri gained 3,383 yards on 246 receptions (13.8 YPR) last season — 16th-best among FBS skill players. Buffalo’s defense allowed just 10.8 Yards Per Reception last season — T-23rd-best among FBS defenses.

          Missouri TEs have averaged just 6.0 yards per reception (18 yards/3 catches) in the 4th quarter since the 2022 season– worst among SEC Teams; Average: 11.8

          Missouri’s offense threw for 20 or more yards on 14.2% of 373 attempts last season — T-12th-best among FBS offenses. Buffalo’s defense allowed 20+ yards on just 7.7% of attempts last season — T-14th-worst among FBS defenses.

          Missouri’s RBs averaged 9.8 yards after the catch last season — 18th-best among FBS RBs. Buffalo’s defense allowed just 6.2 RAC to RBs last season — T-23rd-best among FBS defenses.

          Missouri’s RBs averaged 9.8 yards after the catch last season — 18th-best among FBS RBs. Buffalo’s defense allowed just 10.8 RAC last season — T-23rd-best among FBS defenses.

          Buffalo Bulls Defensive Stats & Trends

          Buffalo has tackled opponents for a loss on 16 of 56 rushing attempts (29% TFL%) on 3rd and short since the 2022 season– best among Non-Power Conference Teams; Average: 12%.

          Buffalo has tackled opponents for a loss on 16 of 56 rushing attempts (29% TFL%) on 3rd and short since the 2022 season– 2nd-best in FBS; Average: 11%.

          Buffalo has allowed first downs on 39% of rush attempts on 3rd and short since the 2022 season– best among Non-Power Conference Teams; Average: 60%

          Buffalo allowed first downs on 32% of rush attempts on 3rd and short in the 2023 season– best in FBS; Average: 60%

          Buffalo tackled opponents for a loss on 13 of 66 rushing attempts (20% TFL%) in the Red Zone in the 2023 season– 25th-best in FBS; Average: 15%.

          Missouri Tigers Defensive Stats & Trends

          Missouri allowed 6 rushing TDs on 60 carries (10 Carries Per TD) in the Red Zone in the 2023 season– 3rd-best among Power Conference Teams; Average: 4.7

          Missouri allowed 6 rushing TDs on 60 carries (10 Carries Per TD) in the Red Zone in the 2023 season– 4th-best in FBS; Average: 4.7

          Missouri allowed 8 rushing TDs on 421 carries (52.6 Carries Per TD) in the 2023 season– 5th-best in FBS; Average: 24

          Missouri has sacked opposing QBs on 10% of pass attempts (78/808) since the 2022 season– best in the SEC; Average: 7%

          Missouri allowed 6 rushing TDs on 60 carries (10 Carries Per TD) in the Red Zone in the 2023 season– 2nd-best in the SEC; Average: 5.3


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