Cubs vs Cardinals Prediction, Odds & Player Prop Bets Today – MLB, Jun 25

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BetMGM Betting @BETMGM Jun 25, 2022, 3:35 PM
  • The Cardinals (40-33) are -225 favorites vs the Cubs (27-44)
  • Cubs starting pitcher: Adrian Sampson (0-0), 0.00 ERA
  • Cardinals starting pitcher: Miles Mikolas (5-5), 2.63 ERA
  • Watch the game on BSMW

The Chicago Cubs (+185) visit Busch Stadium to take on the St. Louis Cardinals (-225) on Saturday, June 25, 2022. First pitch is scheduled for 2:15pm EDT in St. Louis.

The Cardinals are betting favorites in this MLB matchup, with the run line sitting at -1.5 (-115).

The Cubs vs Cardinals Over/Under is 9 total runs for the game.

So far this season, the Cubs are 27-44 against the spread (ATS), while the Cardinals are 40-33 ATS.

Cubs vs. Cardinals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Cubs+1.5 -105O 9 -120+185
Cardinals -1.5 -115U 9 +100-225

Cubs vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Saturday‘s matchup with 72.9% confidence.

This prediction factors in starting pitchers, recent team and player hitting performances, the last 5 games for both the Cubs and Cardinals and up-to-date player injuries.


Looking for a risk-free bet up to $1,000? Bet now on Cardinals vs Cubs and all MLB games with BetMGM


Best Cubs Player Prop Bets Today

We’ve highlighted some favorite MLB player prop bets for Cubs players for Saturday‘s game, looking at profitable historical betting trends:

  • Ian Happ has hit the Hits Over in 16 of his last 18 games (+12.65 Units / 33% ROI)
  • Willson Contreras has hit the Total Bases Under in 12 of his last 14 games (+9.85 Units / 47% ROI)
  • Willson Contreras has hit the Runs Under in 12 of his last 15 games (+8.85 Units / 46% ROI)
  • Willson Contreras has hit the Hits Under in 6 of his last 7 away games (+7.75 Units / 76% ROI)
  • Ian Happ has hit the RBIs Over in 5 of his last 6 away games (+7.30 Units / 122% ROI)

Best Cardinals Player Prop Best Bets Today

And here are some favorite MLB player prop bets for Cardinals players for Saturday‘s game, looking at profitable historical betting trends:

  • Tommy Edman has hit the Hits Under in his last 7 games (+7.65 Units / 48% ROI)
  • Juan Yepez has hit the Runs Under in his last 5 games (+5.00 Units / 50% ROI)
  • Tommy Edman has hit the Total Bases Under in 6 of his last 7 games (+4.60 Units / 44% ROI)
  • Dylan Carlson has hit the Total Bases Under in 5 of his last 6 games (+4.50 Units / 48% ROI)
  • Tommy Edman has hit the Runs Under in 5 of his last 6 games (+4.00 Units / 55% ROI)

Cardinals vs Cubs Home Run Prop Bets Today

Over Under
Andrew Knizner 0.5 +550 0.5 -1400
Brendan Donovan 0.5 +550 0.5 -1400
Dylan Carlson 0.5 +575 0.5 -1400
Harrison Bader 0.5 +450 0.5 -900
Juan Yepez 0.5 +400 0.5 -700

Cardinals vs Cubs Total Hits Prop Bets Today

Over Under
Andrew Knizner 0.5 -175 0.5 +120
Brendan Donovan 0.5 -250 0.5 +170
Dylan Carlson 0.5 -250 0.5 +165
Harrison Bader 0.5 -200 0.5 +140
Juan Yepez 0.5 -200 0.5 +145

Cardinals vs Cubs RBI Prop Bets Today

Over Under
Andrew Knizner 0.5 +195 0.5 -300
Brendan Donovan 0.5 +185 0.5 -275
Dylan Carlson 0.5 +170 0.5 -250
Harrison Bader 0.5 +165 0.5 -250
Juan Yepez 0.5 +145 0.5 -200

Cardinals vs Cubs Strikeout Prop Bets Today

Over Under
Miles Mikolas 4.5 -200 4.5 +150
Miles Mikolas 5.5 +100 5.5 -145
  • The Chicago Cubs have hit the 1st Five Innings (F5) Total Over in 42 of their last 70 games (+14.15 Units / 18% ROI)
  • The Chicago Cubs have covered the 1st Five Innings (F5) Run Line in 26 of their last 44 games (+6.75 Units / 13% ROI)
  • The Chicago Cubs have covered the Run Line in 15 of their last 22 away games (+6.55 Units / 21% ROI)
  • The Chicago Cubs have hit the Game Total Over in 20 of their last 34 games (+4.75 Units / 13% ROI)
  • The Chicago Cubs have hit the Moneyline in 4 of their last 8 games (+1.75 Units / 21% ROI)
  • The St. Louis Cardinals have covered the Run Line in 38 of their last 68 games (+5.65 Units / 6% ROI)
  • The St. Louis Cardinals have hit the Game Total Over in 31 of their last 57 games (+5.15 Units / 8% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Total Under in 15 of their last 26 games (+5.05 Units / 18% ROI)
  • The St. Louis Cardinals have hit the Moneyline in 23 of their last 41 games (+3.00 Units / 6% ROI)

Cubs Against the Spread (ATS) Record

Against the spread this MLB season, the Cubs have gone 35-36 against the Run Line (-8.05 Units / -8.64% ROI).

  • 27-44 when betting on the Moneyline for -15.2 Units / -19.23% ROI
  • 35-34 when betting on the total runs Over for -2.2 Units / -2.8% ROI
  • 34-35 when betting on the total runs Under for -4.3 Units / -5.52% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this MLB season, the Cubs have gone 40-33 against the Run Line (+4.3 Units / 4.52% ROI).

  • 40-33 when betting on the Moneyline for +0.55 Units / 0.58% ROI
  • 37-32 when betting on the total runs Over for +1.4 Units / 1.74% ROI
  • 32-37 when betting on the total runs Under for -8.5 Units / -10.59% ROI

Adrian Sampson has not allowed a walk in his last 70 PAs against a RHH dating back to August 27th, 2021 — Chris Martin has the longest active streak at 111.

Adrian Sampson allowed an OBP of just .067 (15 PA’s) — 2nd best among qualified RPs in MLB; League Avg: .296 — 99th Percentile.

Adrian Sampson has pitched 9.2 straight innings without allowing an earned run — Dylan Cease has the longest active streak at 27.2.

Adrian Sampson allowed an OPS of just .200 (15 PA’s) — tied for 9th best among qualified RPs in MLB; League Avg: .663 — 96th Percentile.

Miles Mikolas: Cardinals Starting Pitcher Stats & Trends

Opponents are hitting just .225 (9-for-40) against Miles Mikolas on the first pitch of at-bats this season — 3rd best among qualified SPs in MLB; League Avg: .326 — 96th Percentile.

Miles Mikolas has allowed an OBP of just .249 (169 PA’s) against right-handed batters this season — 6th best among qualified SPs in MLB; League Avg: .294 — 93rd Percentile.

Miles Mikolas has a strikeout rate of 24% (18 SO in 74 PAs) in PAs ending on inside fastballs this season — 8th best among qualified SPs in MLB; League Avg: 15% — 87th Percentile.

Opponents have a two strike miss rate of just 17% (49/284) against Miles Mikolas this season — 7th lowest among qualified SPs in MLB; League Avg: 25% — ninth Percentile.

Cubs Keys to the Game vs. the Cardinals

The Cubs are just 2-22 (.083) when allowing 2 or more home runs this season — lowest in MLB; League Avg: .282.

The Cubs are just 2-15 (.118) when their opponents score in the first inning this season — 2nd lowest in MLB; League Avg: .326.

The Cubs are just 20-91 (.180) when allowing 2 or more home runs since the 2020 season — lowest in MLB; League Avg: .294.

The Cubs are just 0-35 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .099.

Cardinals Keys to the Game vs. the Cubs

The Cardinals are 32-0 (1.000) when leading entering the 7th inning this season — tied for best in MLB; League Avg: .901.

The Cardinals are just 2-28 (.067) when trailing entering the 7th inning this season — tied for 10th lowest in MLB; League Avg: .099.

The Cardinals are just 1-31 (.031) when trailing entering the 8th inning this season — 6th lowest in MLB; League Avg: .075.

The Cardinals are 24-5 (.828) when totaling 10 or more hits this season — 3rd best in MLB; League Avg: .714.

Cubs hitters have 578 strikeouts in 2,338 PA’s (25%) against LHP since the start of last season — 2nd highest in MLB; League Avg: 22%.

Cubs hitters have an OPS of just .394 (58 PA’s) in lefty-lefty matchups this season — 2nd lowest in MLB; League Avg: .657.

Cubs hitters have grounded into 36 double plays in 267 opportunities (14%) in close and late situations since the start of last season — highest in MLB; League Avg: 9%.

The Cubs are batting .381 on the first pitch of at-bats this season — tied for best in MLB; League Avg: .336.

Cardinals hitters have 179 extra-base hits out of 415 total hits (43%) against LHP since the start of last season — 2nd best in MLB; League Avg: 35%.

Cardinals hitters are slugging .459 against LHP since the start of last season — 2nd best in MLB; League Avg: .409.

Cardinals hitters have 206 extra-base hits out of 487 total hits (42%) against LHP since the start of 2020 — 2nd best in MLB; League Avg: 36%.

The Cardinals are batting .265 against LHP this season — 4th best in MLB; League Avg: .244.

The Cubs have won just 8% of home games in which their opponents scored first this season — lowest in MLB; League Avg: 31%.

The Cubs have won just 8% of games in which their opponents scored first this season — lowest in MLB; League Avg: 29%.

The Cubs pitchers have allowed their opponents to score first in just 34% of their games this season — lowest in MLB; League Avg: 50%.

The Cubs pitchers have allowed their opponents to score first in just 33% of their games on the road this season — 2nd lowest in MLB; League Avg: 47%.

Cardinals pitchers have walked 65 of 647 batters (10%) when facing the leadoff batter in the inning this season — highest in MLB; League Avg: 8%.

Opponents have a miss rate of just 22% against Cardinals pitchers this season — lowest in MLB; League Avg: 26%.

Cardinals pitchers have a strikeout rate of just 18% with runners in scoring position since the start of last season — 2nd lowest in MLB; League Avg: 22%.

Cardinals pitchers have walked 193 of 2,066 batters (9%) when facing the leadoff batter in the inning since the start of last season — 2nd highest in MLB; League Avg: 8%.

Cardinals vs. Cubs Injuries Tonight That May Affect Prop Bets 

  • Alexander Reyes (Cardinals): Shoulder, D60
  • Tyler O’Neill (Cardinals): Hamstring, D10
  • McKenzie Dickerson (Cardinals): Calf, D10
  • Jordan Hicks (Cardinals): Forearm, D15
  • Génesis Cabrera (Cardinals): COVID-19, D10
  • Steven Matz (Cardinals): Shoulder, D15
  • Timothy McFarland (Cardinals): Undisclosed, D15
  • Drew VerHagen (Cardinals): Shoulder, D15
  • Yadier Molina (Cardinals): Knee, D10
  • Nicklaus Madrigal (Cubs): Groin, D10
  • Todd Smyly (Cubs): Oblique, D15
  • Wade Miley (Cubs): Shoulder, D15
  • Frank J. Schwindel (Cubs): Back, D10
  • Manuel Rodríguez (Cubs): Elbow, D60
  • Bradley Wieck (Cubs): Elbow, D60
  • Codi Heuer (Cubs): Elbow, D60
  • Michael Hermosillo (Cubs): COVID, D10
  • Seiya Suzuki (Cubs): Finger, D10
  • Adbert Alzolay (Cubs): Shoulder, D60
  • Marcus Stroman (Cubs): Shoulder, D15
  • Ethan Roberts (Cubs): Shoulder, D60
  • Daniel Norris (Cubs): Finger, D15

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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.