White Sox vs Guardians Prediction, Odds & Player Prop Bets Today – MLB, Sep 15

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MLB betting odds, predictions and betting odds for today's games
(AP Photo)
BetMGM Betting @BETMGM Sep 15, 2022, 3:30 PM
  • The (98-44) are favorites vs the (98-44)
  • White Sox starting pitcher: Michael Lynn (6-5), 4.06 ERA
  • Guardians starting pitcher: Hunter Gaddis (0-1), 21.60 ERA
  • Watch the game on MLB Network

The Chicago White Sox () visit Progressive Field to take on the Cleveland Guardians () on Thursday, September 15, 2022. First pitch is scheduled for 1:10pm EDT in Cleveland.

The are betting favorites in this MLB matchup, with the run line sitting at ().

The White Sox vs Guardians Over/Under is total runs for the game.

So far this season, the White Sox are 72-69 against the spread (ATS), while the Guardians are 73-66 ATS.

White Sox vs. Guardians Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
White Sox O
Guardians U

White Sox vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the will win Thursday‘s matchup with confidence.

This prediction factors in starting pitchers, recent team and player hitting performances, the last 5 games for both the White Sox and Guardians and up-to-date player injuries.


Looking for a risk-free bet up to $1,000? Bet now on Guardians vs White Sox and all MLB games with BetMGM


Best White Sox Player Prop Bets Today

We’ve highlighted some favorite MLB player prop bets for White Sox players for Thursday‘s game, looking at profitable historical betting trends:

  • Jose Abreu has hit the Singles Over in 68 of his last 100 games (+31.00 Units / 26% ROI)
  • Jose Abreu has hit the Hits Over in 70 of his last 102 games (+23.30 Units / 11% ROI)
  • Jose Abreu has hit the Total Bases Over in 57 of his last 102 games (+18.80 Units / 17% ROI)
  • Danny Mendick has hit the Runs Over in 10 of his last 11 games (+15.60 Units / 142% ROI)
  • Elvis Andrus has hit the Total Bases Over in 14 of his last 17 games (+13.90 Units / 71% ROI)

Best Guardians Player Prop Best Bets Today

And here are some favorite MLB player prop bets for Guardians players for Thursday‘s game, looking at profitable historical betting trends:

  • Josh Naylor has hit the Runs Under in 19 of his last 22 games at home (+14.65 Units / 39% ROI)
  • Jose Ramirez has hit the Runs Under in 27 of his last 39 games at home (+12.25 Units / 24% ROI)
  • Jose Ramirez has hit the Singles Over in 34 of his last 59 games (+12.05 Units / 20% ROI)
  • Owen Miller has hit the Runs Under in 23 of his last 28 games at home (+12.00 Units / 20% ROI)
  • Amed Rosario has hit the Total Bases Under in 30 of his last 43 games (+11.45 Units / 18% ROI)

Guardians vs White Sox Home Run Prop Bets Today

Over Under
Amed Rosario 0.5 +800 0.5 -3000
Andres Gimenez 0.5 +750 0.5 -3000
Austin Hedges 0.5 +1050 0.5
Jose Ramirez 0.5 +500 0.5 -1100
Josh Naylor 0.5 +475 0.5 -1000

Guardians vs White Sox Total Hits Prop Bets Today

Over Under
Amed Rosario 0.5 -225 0.5 +155
Andres Gimenez 0.5 -155 0.5 +110
Austin Hedges 0.5 +120 0.5 -165
Jose Ramirez 0.5 -190 0.5 +130
Josh Naylor 0.5 -200 0.5 +140

Guardians vs White Sox RBI Prop Bets Today

Over Under
Amed Rosario 0.5 +220 0.5 -350
Andres Gimenez 0.5 +250 0.5 -400
Austin Hedges 0.5 +360 0.5 -650
Jose Ramirez 0.5 +185 0.5 -275
Josh Naylor 0.5 +175 0.5 -250

Guardians vs White Sox Strikeout Prop Bets Today

Over Under
Lance Lynn 5.5 +105 5.5 -145
  • The Chicago White Sox have hit the 1st Five Innings (F5) Total Under in 76 of their last 143 games (+12.95 Units / 8% ROI)
  • The Chicago White Sox have hit the Moneyline in 10 of their last 14 games (+4.25 Units / 19% ROI)
  • The Chicago White Sox have covered the Run Line in 9 of their last 14 games (+3.90 Units / 24% ROI)
  • The Chicago White Sox have hit the Game Total Under in 8 of their last 14 games (+2.45 Units / 16% ROI)
  • The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 8 of their last 14 games (+1.30 Units / 8% ROI)
  • The Cleveland Guardians have hit the Moneyline in 8 of their last 9 games (+6.60 Units / 55% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Total Under in 19 of their last 35 games (+5.55 Units / 14% ROI)
  • The Cleveland Guardians have covered the Run Line in 4 of their last 5 games (+4.90 Units / 98% ROI)
  • The Cleveland Guardians have hit the Game Total Over in 4 of their last 6 games (+1.85 Units / 29% ROI)
  • The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 5 of their last 8 games (+1.75 Units / 18% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this MLB season, the White Sox have gone 64-77 against the Run Line (-14.7 Units / -8.79% ROI).

  • 72-69 when betting on the Moneyline for -15.35 Units / -7.91% ROI
  • 62-69 when betting on the total runs Over for -12.35 Units / -8% ROI
  • 69-62 when betting on the total runs Under for +1.3 Units / 0.83% ROI

Guardians Against the Spread (ATS) Record

Against the spread this MLB season, the White Sox have gone 73-66 against the Run Line (+2.95 Units / 1.7% ROI).

  • 76-64 when betting on the Moneyline for +12.05 Units / 6.9% ROI
  • 61-70 when betting on the total runs Over for -15.65 Units / -10.19% ROI
  • 70-61 when betting on the total runs Under for +2.6 Units / 1.68% ROI

Right-handed hitters have a line drive rate of just 18% (56/311) against Lance Lynn since the start of last season — 3rd lowest in MLB among starting pitchers with at least 151 total IP; League Avg: 24% — 98th Percentile.

Lance Lynn has allowed no extra-base hits in his last 12.0 innings pitched — Brayan Bello has the longest active streak at 25.1.

Opponents have a miss rate of 35% (31/88) against Lance Lynn on pitches in the strike zone this month (2 games) — best among qualified SPs in MLB; League Avg: 17% — 100th Percentile.

Lance Lynn has allowed a slugging percentage of .688 (33 Total Bases / 48 ABs) on low fastballs this season — 4th highest in MLB among starting pitchers with at least 70 total IP; League Avg: .427 — third Percentile.

Hunter Gaddis: Guardians Starting Pitcher Stats & Trends

No Matchup notes for this Game

White Sox Keys to the Game vs. the Guardians

The White Sox are just 6-59 (.092) when trailing entering the 7th inning this season — 9th lowest in MLB; League Avg: .117.

The White Sox are 10-4 (.714) when tied entering the 7th inning this season — 2nd best in MLB; League Avg: .500.

The White Sox are just 6-51 (.105) when allowing 5 or more runs this season — 2nd lowest in MLB; League Avg: .199.

The White Sox are 13-2 (.867) when totaling 5 or more extra base hits this season — 7th best in MLB; League Avg: .804.

Guardians Keys to the Game vs. the White Sox

The Guardians are 11-56 (.164) when trailing entering the 8th inning this season — 2nd best in MLB; League Avg: .085.

The Guardians are 40-35 (.533) on the road this season — 10th best in MLB; League Avg: .474.

The Guardians are 11-6 (.647) when tied entering the 8th inning this season — tied for 5th best in MLB; League Avg: .500.

The Guardians are 52-3 (.945) when leading entering the 7th inning this season — 6th best in MLB; League Avg: .883.

White Sox hitters have an OPS of just .444 (267 PA’s) in lefty-lefty matchups since the start of last season — lowest in MLB; League Avg: .653.

White Sox hitters have pulled just 40% of balls they’ve put into play against LHP this season — lowest in MLB; League Avg: 46%.

White Sox hitters have an OBP of .342 (2,758 PA’s) against LHP since the start of last season — best in MLB; League Avg: .319.

White Sox hitters have an OBP of .346 (3,264 PA’s) against LHP since the start of 2020 — best in MLB; League Avg: .319.

Guardians hitters are slugging just .339 against LHP this season — 2nd lowest in MLB; League Avg: .400.

Guardians hitters have missed on just 21% of swings this season — best in MLB; League Avg: 25%.

Guardians hitters have an OPS of just .990 (2,117 PA’s) with the pitcher behind in the count since the start of last season — 2nd lowest in MLB; League Avg: 1.084.

Guardians hitters have put 40% of their swings in play this season — highest in MLB; League Avg: 37%.

White Sox pitchers have an ERA of 3.53 (612.0 IP) on the road this season — 3rd best in MLB; League Avg: 4.13.

Opponents have a miss rate of 28% against White Sox pitchers since the start of last season — 3rd best in MLB; League Avg: 26%.

White Sox pitchers have a strikeout rate of 25% since the start of last season — 4th best in MLB; League Avg: 23%.

White Sox pitchers have a strikeout rate of 46% with two-strikes since the start of last season — 4th best in MLB; League Avg: 43%.

Guardians pitchers have won only 15% of games in which they have allowed their opponent to score in three different innings at home this season — tied for 2nd lowest in MLB; League Avg: 27%.

The Guardians pitchers have allowed their opponents to score first in just 35% of their games on the road this season — 2nd lowest in MLB; League Avg: 46%.

Opponents have a groundball batting average of just .197 against Guardians pitchers with the shift since the start of last season — 2nd best in MLB; League Avg: .223.

The Guardians pitchers have allowed division opponents to score first in just 39% of their games this season — 3rd lowest in MLB; League Avg: 50%.

Guardians vs. White Sox Injuries Tonight That May Affect Prop Bets 

  • Aaron Civale (Guardians): Forearm, D15
  • Anthony Gose (Guardians): Triceps, D60
  • Zach Plesac (Guardians): Hand, D15
  • Kyle Crick (White Sox): Elbow, D60
  • Jonathan Stiever (White Sox): Lat, D60
  • Timothy Anderson (White Sox): Finger, D10
  • Garrett Crochet (White Sox): Elbow, D60
  • Daniel Mendick (White Sox): Knee, D60
  • Luis Robert (White Sox): Hand/Wrist, Day-to-Day

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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.